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Volume 113, Issue 8
February 19 2009
Issue Cover

Table of Contents

INSIDE BLOOD

IMMUNOBIOLOGY
Another Notch on the belt
Lynn M. Schnapp
View Articletitled, Another Notch on the belt
CLINICAL TRIALS
A role for ionizing radiation in myelomagenesis?
Ola Landgren
View Articletitled, A role for ionizing radiation in myelomagenesis?
PLATELETS & THROMBOPOIESIS
Mpl and thrombocytosis: levels matter
Stefan N. Constantinescu
View Articletitled, Mpl and thrombocytosis: levels matter

REVIEW ARTICLES

Molecular biology of bcr-abl1–positive chronic myeloid leukemia
Alfonso Quintás-Cardama,Jorge Cortes
View Articletitled, Molecular biology of <em>bcr-abl1</em>–positive chronic myeloid leukemia

CLINICAL TRIALS AND OBSERVATIONS

Disease-specific analyses of unrelated cord blood transplantation compared with unrelated bone marrow transplantation in adult patients with acute leukemia
Clinical Trials & Observations
Yoshiko Atsuta,Ritsuro Suzuki,Tokiko Nagamura-Inoue,Shuichi Taniguchi,Satoshi Takahashi,Shunro Kai,Hisashi Sakamaki,Yasushi Kouzai,Masaharu Kasai,Takahiro Fukuda,Hiroshi Azuma,Minoko Takanashi,Shinichiro Okamoto,Masahiro Tsuchida,Keisei Kawa,Yasuo Morishima,Yoshihisa Kodera,Shunichi Kato,for the Japan Marrow Donor Program and the Japan Cord Blood Bank Network
View Articletitled, Disease-specific analyses of unrelated cord blood transplantation compared with unrelated bone marrow transplantation in adult patients with acute leukemia
Supplemental data
Relationship between monoclonal gammopathy of undetermined significance and radiation exposure in Nagasaki atomic bomb survivors
Clinical Trials & Observations
Masako Iwanaga,Masuko Tagawa,Kunihiro Tsukasaki,Tatsuki Matsuo,Ken-ichi Yokota,Yasushi Miyazaki,Takuya Fukushima,Tomoko Hata,Yoshitaka Imaizumi,Daisuke Imanishi,Jun Taguchi,Sabro Momita,Shimeru Kamihira,Masao Tomonaga
View Articletitled, Relationship between monoclonal gammopathy of undetermined significance and radiation exposure in Nagasaki atomic bomb survivors
Supplemental data

GENE THERAPY

Peripheral blood lymphocytes genetically modified to express the self/tumor antigen MAGE-A3 induce antitumor immune responses in cancer patients
Raffaella Fontana,Marco Bregni,Arcadi Cipponi,Laura Raccosta,Cristina Rainelli,Daniela Maggioni,Francesca Lunghi,Fabio Ciceri,Sylvain Mukenge,Claudio Doglioni,Didier Colau,Pierre G. Coulie,Claudio Bordignon,Catia Traversari,Vincenzo Russo
View Articletitled, Peripheral blood lymphocytes genetically modified to express the self/tumor antigen MAGE-A3 induce antitumor immune responses in cancer patients
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Menin regulates the function of hematopoietic stem cells and lymphoid progenitors
Ivan Maillard,Ya-Xiong Chen,Ann Friedman,Yuqing Yang,Anthony T. Tubbs,Olga Shestova,Warren S. Pear,Xianxin Hua
View Articletitled, Menin regulates the function of hematopoietic stem cells and lymphoid progenitors
Supplemental data
Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems
Boaz P. Levi,Ömer H. Yilmaz,Gregg Duester,Sean J. Morrison
View Articletitled, Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems
Supplemental data

IMMUNOBIOLOGY

Protein disulfide isomerases are antibody targets during immune-mediated tumor destruction
Catia Fonseca,Robert Soiffer,Vincent Ho,Matthew Vanneman,Masahisa Jinushi,Jerome Ritz,Donna Neuberg,Richard Stone,Dan DeAngelo,Glenn Dranoff
View Articletitled, Protein disulfide isomerases are antibody targets during immune-mediated tumor destruction
Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases
Ila Joshi,Lisa M. Minter,Janice Telfer,Renée M. Demarest,Anthony J. Capobianco,Jon C. Aster,Piotr Sicinski,Abdul Fauq,Todd E. Golde,Barbara A. Osborne
View Articletitled, Notch signaling mediates G<sub>1</sub>/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases
Supplemental data
Ligand-engaged urokinase-type plasminogen activator receptor and activation of the CD11b/CD18 integrin inhibit late events of HIV expression in monocytic cells
Massimo Alfano,Samanta A. Mariani,Chiara Elia,Ruggero Pardi,Francesco Blasi,Guido Poli
View Articletitled, Ligand-engaged urokinase-type plasminogen activator receptor and activation of the CD11b/CD18 integrin inhibit late events of HIV expression in monocytic cells
Supplemental data

LYMPHOID NEOPLASIA

Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2–mediated resistance
Melanie Fakler,Sandra Loeder,Meike Vogler,Katja Schneider,Irmela Jeremias,Klaus-Michael Debatin,Simone Fulda
View Articletitled, Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2–mediated resistance
Supplemental data
AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines
Dana S. Levy,Jason A. Kahana,Rakesh Kumar
View Articletitled, AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines
Supplemental data
NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity
Florence Armstrong,Philippe Brunet de la Grange,Bastien Gerby,Marie-Christine Rouyez,Julien Calvo,Michaéla Fontenay,Nicolas Boissel,Hervé Dombret,André Baruchel,Judith Landman-Parker,Paul-Henri Roméo,Paola Ballerini,Françoise Pflumio
View Articletitled, NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity
Supplemental data

MYELOID NEOPLASIA

Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations
Tadayuki Akagi,Lee-Yung Shih,Motohiro Kato,Norihiko Kawamata,Go Yamamoto,Masashi Sanada,Ryoko Okamoto,Carl W. Miller,Der-Cherng Liang,Seishi Ogawa,H. Phillip Koeffler
View Articletitled, Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations
Supplemental data
High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients
Jeffrey W. Tyner,Heidi Erickson,Michael W. N. Deininger,Stephanie G. Willis,Christopher A. Eide,Ross L. Levine,Michael C. Heinrich,Norbert Gattermann,D. Gary Gilliland,Brian J. Druker,Marc M. Loriaux
View Articletitled, High-throughput sequencing screen reveals novel, transforming <em>RAS</em> mutations in myeloid leukemia patients
Supplemental data
A role for MEIS1 in MLL-fusion gene leukemia
Brief Report
Ashish R. Kumar,Quanzhi Li,Wendy A. Hudson,Weili Chen,Thien Sam,Qing Yao,Erik A. Lund,Baolin Wu,Branden J. Kowal,John H. Kersey
View Articletitled, A role for MEIS1 in <em>MLL</em>-fusion gene leukemia
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

B7-H4–deficient mice display augmented neutrophil-mediated innate immunity
Gefeng Zhu,Mathew M. Augustine,Takeshi Azuma,Liqun Luo,Sheng Yao,Sudarshan Anand,A. Cecilia Rietz,Jiaqiang Huang,Haiying Xu,Andrew S. Flies,Sarah J. Flies,Koji Tamada,Marco Colonna,Jan M. A. van Deursen,Lieping Chen
View Articletitled, B7-H4–deficient mice display augmented neutrophil-mediated innate immunity
Supplemental data

PLATELETS AND THROMBOPOIESIS

Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes
Ralph Tiedt,Jörn Coers,Sandra Ziegler,Adrian Wiestner,Hui Hao-Shen,Caroline Bornmann,Johannes Schenkel,Svetlana Karakhanova,Frederic J. de Sauvage,Carl W. Jackson,Radek C. Skoda
View Articletitled, Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes
Incomplete restoration of Mpl expression in the mpl−/− mouse produces partial correction of the stem cell–repopulating defect and paradoxical thrombocytosis
Brian J. Lannutti,Angela Epp,Jacqueline Roy,Junmei Chen,Neil C. Josephson
View Articletitled, Incomplete restoration of Mpl expression in the <em>mpl</em><sup>−/−</sup> mouse produces partial correction of the stem cell–repopulating defect and paradoxical thrombocytosis
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Processing of hemojuvelin requires retrograde trafficking to the Golgi in HepG2 cells
Julia E. Maxson,Caroline A. Enns,An-Sheng Zhang
View Articletitled, Processing of hemojuvelin requires retrograde trafficking to the Golgi in HepG2 cells
miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2
Luke Pase,Judith E. Layton,Wigard P. Kloosterman,Duncan Carradice,Peter M. Waterhouse,Graham J. Lieschke
View Articletitled, miR-451 regulates zebrafish erythroid maturation in vivo via its target <em>gata2</em>
Supplemental data
Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism
Brief Report
Teresa Lambe,Robert J. Simpson,Sara Dawson,Tiphaine Bouriez-Jones,Tanya L. Crockford,Michelle Lepherd,Gladys O. Latunde-Dada,Hannah Robinson,Kishor B. Raja,Dean R. Campagna,Guadalupe Villarreal, Jr,J. Clive Ellory,Christopher C. Goodnow,Mark D. Fleming,Andrew T. McKie,Richard J. Cornall
View Articletitled, Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism
Supplemental data

THROMBOSIS AND HEMOSTASIS

Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor
Adili Reheman,Hong Yang,Guangheng Zhu,Wuxun Jin,Feng He,Christopher M. Spring,Xufang Bai,Peter L. Gross,John Freedman,Heyu Ni
View Articletitled, Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor
CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo
Cyndi Wong,Yong Liu,Jana Yip,Rochna Chand,Janet L. Wee,Lisa Oates,Bernhard Nieswandt,Adili Reheman,Heyu Ni,Nicole Beauchemin,Denise E. Jackson
View Articletitled, CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo

TRANSPLANTATION

Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens
Kazutoshi Aoyama,Motoko Koyama,Ken-ichi Matsuoka,Daigo Hashimoto,Tatsuo Ichinohe,Mine Harada,Koichi Akashi,Mitsune Tanimoto,Takanori Teshima
View Articletitled, Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens
Donor-derived oral squamous cell carcinoma after allogeneic bone marrow transplantation
Anne Janin,Hideyuki Murata,Christophe Leboeuf,Jean-Michel Cayuela,Eliane Gluckman,Luc Legrès,Allison Desveaux,Mariana Varna,Philippe Ratajczak,Jean Soulier,Hugues de Thé,Philippe Bertheau,Gérard Socié
View Articletitled, Donor-derived oral squamous cell carcinoma after allogeneic bone marrow transplantation
Supplemental data
Transplantation of allogeneic T cells alters iron homeostasis in NOD/SCID mice
Brief Report
Steven Bair,Emily Spaulding,Jaakko Parkkinen,Howard M. Shulman,Vladimir Lesnikov,Mary Beauchamp,François Canonne-Hergaux,Kris V. Kowdley,H. Joachim Deeg
View Articletitled, Transplantation of allogeneic T cells alters iron homeostasis in NOD/SCID mice

VASCULAR BIOLOGY

Cooperation between integrin α5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity
Suyong Choi,Sin-Ae Lee,Tae Kyoung Kwak,Hyeon Jung Kim,Mi Ji Lee,Sang-Kyu Ye,Sung-Hoon Kim,Semi Kim,Jung Weon Lee
View Articletitled, Cooperation between integrin α<sub>5</sub> and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity
Supplemental data
Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate
Brief Report
Sunju Lee,Jinjoo Kang,Jaehyuk Yoo,Sathish K. Ganesan,Sarah C. Cook,Berenice Aguilar,Swapnika Ramu,Juneyong Lee,Young-Kwon Hong
View Articletitled, Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate
Supplemental data

CORRESPONDENCE

P-selectin ready for prime time?
Punam Rana,Jim Julian,Mark Levine
View Articletitled, P-selectin ready for prime time?
Response: P-selectin ready for the “News at Six”
Cihan Ay,Ingrid Pabinger
View Articletitled, Response: P-selectin ready for the “News at Six”
Insurance policies in the United States may explain part of the outcome differences of adolescents and young adults with acute lymphoblastic leukemia treated on adult versus pediatric regimens
Hagop M. Kantarjian,Susan O'Brien
View Articletitled, Insurance policies in the United States may explain part of the outcome differences of adolescents and young adults with acute lymphoblastic leukemia treated on adult versus pediatric regimens
Response: Disparity in outcome of young adults with ALL
Wendy Stock, MD
View Articletitled, Response: Disparity in outcome of young adults with ALL
AID splice variants lack deaminase activity
Febe van Maldegem,Ferenc A. Scheeren,R. Aarti Jibodh,Richard J. Bende,Heinz Jacobs,Carel J. M. van Noesel
View Articletitled, AID splice variants lack deaminase activity
Response: Cautious interpretation of assessment of AID variant activities using cells with endogenous AID expression
Xiaosheng Wu,Diane F. Jelinek
View Articletitled, Response: Cautious interpretation of assessment of AID variant activities using cells with endogenous AID expression
C/EBPA methylation is common in T-ALL but not in M0 AML
Louis Terriou,Raouf Ben Abdelali,Christophe Roumier,Ludovic Lhermitte,John de Vos,Pascale Cornillet,Olivier Nibourel,Kheira Beldjord,Hervé Dombret,Guy Leverger,Vahid Asnafi,Claude Preudhomme,Elizabeth Macintyre
View Articletitled, C/EBPA methylation is common in T-ALL but not in M0 AML
Response: CEBPA promoter hypermethylation in a subset of myeloid/T-lymphoid leukemias with a distinct gene expression profile
Bas Wouters,Ruud Delwel
View Articletitled, Response: <em>CEBPA</em> promoter hypermethylation in a subset of myeloid/T-lymphoid leukemias with a distinct gene expression profile
JAK2-V617F–triggered preemptive and salvage adoptive immunotherapy with donor-lymphocyte infusion in patients with myelofibrosis after allogeneic stem cell transplantation
Nicolaus Kröger,Haefaa Alchalby,Evgeny Klyuchnikov,Anita Badbaran,York Hildebrandt,Francis Ayuk,Ulrike Bacher,Oliver Bock,Michael Kvasnicka,Boris Fehse,Axel Zander
View Articletitled, JAK2-V617F–triggered preemptive and salvage adoptive immunotherapy with donor-lymphocyte infusion in patients with myelofibrosis after allogeneic stem cell transplantation
Older age does not influence allogeneic peripheral blood stem cell mobilization in a donor population of mostly white ethnic origin
Hugues de Lavallade,Patrick Ladaique,Claude Lemarié,Sabine Fürst,Catherine Faucher,Didier Blaise,Christian Chabannon,Boris Calmels
View Articletitled, Older age does not influence allogeneic peripheral blood stem cell mobilization in a donor population of mostly white ethnic origin
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