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IL-7 administration drives T cell–cycle entry and expansion in HIV-1 infection
Delayed achievement of cytogenetic and molecular response is associated with increased risk of progression among patients with chronic myeloid leukemia in early chronic phase receiving high-dose or standard-dose imatinib therapy
Phase 3 study of dasatinib 140 mg once daily versus 70 mg twice daily in patients with chronic myeloid leukemia in accelerated phase resistant or intolerant to imatinib: 15-month median follow-up
Prognostic significance of CD20 expression in adults with de novo precursor B-lineage acute lymphoblastic leukemia
Pralatrexate-induced tumor cell apoptosis in the epidermis of a patient with HTLV-1 adult T-cell lymphoma/leukemia causing skin erosions
Issue Archive
June 18 2009
In this Issue
Table of Contents
INSIDE BLOOD
PLENARY PAPERS
REVIEW ARTICLES
HOW I TREAT
CLINICAL TRIALS AND OBSERVATIONS
IL-7 administration drives T cell–cycle entry and expansion in HIV-1 infection
Clinical Trials & Observations
Irini Sereti,Richard M. Dunham,John Spritzler,Evgenia Aga,Michael A. Proschan,Kathy Medvik,Catherine A. Battaglia,Alan L. Landay,Savita Pahwa,Margaret A. Fischl,David M. Asmuth,Allan R. Tenorio,John D. Altman,Lawrence Fox,Susan Moir,Angela Malaspina,Michel Morre,Renaud Buffet,Guido Silvestri,Michael M. Lederman,for the ACTG 5214 Study Team
Delayed achievement of cytogenetic and molecular response is associated with increased risk of progression among patients with chronic myeloid leukemia in early chronic phase receiving high-dose or standard-dose imatinib therapy
Clinical Trials & Observations
Alfonso Quintás-Cardama,Hagop Kantarjian,Dan Jones,Jianqin Shan,Gautam Borthakur,Deborah Thomas,Steven Kornblau,Susan O'Brien,Jorge Cortes
Phase 3 study of dasatinib 140 mg once daily versus 70 mg twice daily in patients with chronic myeloid leukemia in accelerated phase resistant or intolerant to imatinib: 15-month median follow-up
Clinical Trials & Observations
Hagop Kantarjian,Jorge Cortes,Dong-Wook Kim,Pedro Dorlhiac-Llacer,Ricardo Pasquini,John DiPersio,Martin C. Müller,Jerald P. Radich,H. Jean Khoury,Nina Khoroshko,M. Brigid Bradley-Garelik,Chao Zhu,Martin S. Tallman
Prognostic significance of CD20 expression in adults with de novo precursor B-lineage acute lymphoblastic leukemia
Clinical Trials & Observations
Deborah A. Thomas,Susan O'Brien,Jeffrey L. Jorgensen,Jorge Cortes,Stefan Faderl,Guillermo Garcia-Manero,Srdan Verstovsek,Charles Koller,Sherry Pierce,Yang Huh,William Wierda,Michael J. Keating,Hagop M. Kantarjian
Pralatrexate-induced tumor cell apoptosis in the epidermis of a patient with HTLV-1 adult T-cell lymphoma/leukemia causing skin erosions
Brief Report
Alexander G. Marneros,Marc E. Grossman,David N. Silvers,Sameera Husain,Gerard J. Nuovo,Barbara MacGregor-Cortelli,Ellen Neylon,Molly Patterson,Owen A. O'Connor,Jasmine M. Zain
HEMATOPOIESIS AND STEM CELLS
Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential
David G. Kent,Michael R. Copley,Claudia Benz,Stefan Wöhrer,Brad J. Dykstra,Elaine Ma,John Cheyne,Yongjun Zhao,Michelle B. Bowie,Yun Zhao,Maura Gasparetto,Allen Delaney,Clayton Smith,Marco Marra,Connie J. Eaves
IMMUNOBIOLOGY
LYMPHOID NEOPLASIA
T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model
Antonio Di Stasi,Biagio De Angelis,Cliona M. Rooney,Lan Zhang,Aruna Mahendravada,Aaron E. Foster,Helen E. Heslop,Malcolm K. Brenner,Gianpietro Dotti,Barbara Savoldo
MYELOID NEOPLASIA
MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1
Ramiro Garzon,Shujun Liu,Muller Fabbri,Zhongfa Liu,Catherine E.A. Heaphy,Elisa Callegari,Sebastian Schwind,Jiuxia Pang,Jianhua Yu,Natarajan Muthusamy,Violaine Havelange,Stefano Volinia,William Blum,Laura J. Rush,Danilo Perrotti,Michael Andreeff,Clara D. Bloomfield,John C. Byrd,Kenneth Chan,Lai-Chu Wu,Carlo M. Croce,Guido Marcucci
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates
Christian C. Yost,Mark J. Cody,Estelle S. Harris,Nathan L. Thornton,Alison M. McInturff,Mark L. Martinez,Nancy B. Chandler,Christopher K. Rodesch,Kurt H. Albertine,Cathy A. Petti,Andrew S. Weyrich,Guy A. Zimmerman
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
TRANSPLANTATION
Impact of donor CMV status on viral infection and reconstitution of multifunction CMV-specific T cells in CMV-positive transplant recipients
Wendi Zhou,Jeff Longmate,Simon F. Lacey,Joycelynne M. Palmer,Ghislaine Gallez-Hawkins,Lia Thao,Ricardo Spielberger,Ryotaro Nakamura,Stephen J. Forman,John A. Zaia,Don J. Diamond
Acute graft-versus-host disease transiently impairs thymic output in young patients after allogeneic hematopoietic stem cell transplantation
Emmanuel Clave,Marc Busson,Corinne Douay,Régis Peffault de Latour,Jeannig Berrou,Claire Rabian,Maryvonnick Carmagnat,Vanderson Rocha,Dominique Charron,Gérard Socié,Antoine Toubert
VASCULAR BIOLOGY
CORRESPONDENCE
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Cover Image
Cover Image
![issue cover]()
A scanning electron micrograph demonstrates a neutrophil extracellular trap (NET), formed in vitro by stimulated neutrophils from human adults. An adult neutrophil is shown in the upper right. The white NET lattice, composed of strands of extruded nuclear chromatin and antibacterial factors, has captured Staphylococcus aureus bacteria (blue-green spheres). Neonatal neutrophils have developmentally impaired ability to form NETs, a previously unrecognized innate immune defect that may contribute to frequent and lethal infections in premature newborn infants. See the article by Yost et al on page 6419.
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