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Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma
Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study
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INSIDE BLOOD
PLENARY PAPERS
C-terminal ADAMTS-18 fragment induces oxidative platelet fragmentation, dissolves platelet aggregates, and protects against carotid artery occlusion and cerebral stroke
Zongdong Li,Michael A. Nardi,Yong-Sheng Li,Wei Zhang,Ruimin Pan,Suying Dang,Herman Yee,David Quartermain,Saran Jonas,Simon Karpatkin
REVIEW ARTICLES
CLINICAL TRIALS AND OBSERVATIONS
Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma
Clinical Trials & Observations
Kieron Dunleavy,Stefania Pittaluga,Myron S. Czuczman,Sandeep S. Dave,George Wright,Nicole Grant,Margaret Shovlin,Elaine S. Jaffe,John E. Janik,Louis M. Staudt,Wyndham H. Wilson
Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study
Clinical Trials & Observations
Kjeld Schmiegelow,Ibrahim Al-Modhwahi,Mette Klarskov Andersen,Mikael Behrendtz,Erik Forestier,Henrik Hasle,Mats Heyman,Jon Kristinsson,Jacob Nersting,Randi Nygaard,Anne Louise Svendsen,Kim Vettenranta,Richard Weinshilboum,for the Nordic Society for Paediatric Haematology and Oncology
HEMATOPOIESIS AND STEM CELLS
IMMUNOBIOLOGY
Plasmacytoid dendritic cells accumulate in spleens from chronically HIV-infected patients but barely participate in interferon-α expression
Michelina Nascimbeni,Leïla Perié,Laurent Chorro,Seckou Diocou,Louis Kreitmann,Stéphanie Louis,Laurent Garderet,Bettina Fabiani,Anne Berger,Jürgen Schmitz,Jean-Pierre Marie,Thierry Jo Molina,Jérôme Pacanowski,Jean-Paul Viard,Eric Oksenhendler,Stéphanie Beq,Orly Abehsira-Amar,Rémi Cheynier,Anne Hosmalin
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms
Francis H. Grand,Claire E. Hidalgo-Curtis,Thomas Ernst,Katerina Zoi,Christine Zoi,Carolann McGuire,Sebastian Kreil,Amy Jones,Joannah Score,Georgia Metzgeroth,David Oscier,Andrew Hall,Christian Brandts,Hubert Serve,Andreas Reiter,Andrew J. Chase,Nicholas C. P. Cross
Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML
Zhihong Zeng,Yue Xi Shi,Ismael J. Samudio,Rui-Yu Wang,Xiaoyang Ling,Olga Frolova,Mark Levis,Joshua B. Rubin,Robert R. Negrin,Elihu H. Estey,Sergej Konoplev,Michael Andreeff,Marina Konopleva
RED CELLS, IRON, AND ERYTHROPOIESIS
Hepcidin, the hormone of iron metabolism, is bound specifically to α-2-macroglobulin in blood
Gabriela Peslova,Jiri Petrak,Katerina Kuzelova,Ivan Hrdy,Petr Halada,Philip W. Kuchel,Shan Soe-Lin,Prem Ponka,Robert Sutak,Erika Becker,Michael Li-Hsuan Huang,Yohan Suryo Rahmanto,Des R. Richardson,Daniel Vyoral
VASCULAR BIOLOGY
CORRESPONDENCE
Response: Could mutations in the hypoxanthine-guanine phosphoribosyl transferase gene induced by thiopurine therapy promote the development of second malignant neoplasms?
Kjeld Schmiegelow,Ibrahim Al-Modhawi,Mette Klarskov Andersen,Mikael Berendtz,Erik Forestier,Henrik Hasle,Mats Heyman,Jon Kristinsson,Jacob Nersting,Randi Nygaard,Anne Louise Svendsen,Kim Vettenranta,Richard Weinshilboum,the Nordic Society for Paediatric Haematology and Oncology
RETRACTIONS
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Tiam1 is a Rac activator involved in PKCζ/Par polarity signaling, essential for stabilization of polarization during T-cell migration. T cells (green) crawl on top of endothelial monolayers (purple) to reach suitable transmigration sites at endothelial junctions (paracellular migration). Tiam1-deficient T cells are unable to crawl on endothelial cells and, as a consequence, initiate an alternative transmigration route through individual endothelial cells (transcellular migration). This suggests that T cells are able to change their route of transendothelial migration according to their polarization status and crawling capacity. See the article by Gérard et al on page 6138.
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Response: Could mutations in the hypoxanthine-guanine phosphoribosyl transferase gene induced by thiopurine therapy promote the development of second malignant neoplasms?