Table of Contents
Be fruitful, multiply, and replenish
In this issue, Bains and colleagues show that T-cell proliferation plays a major role in the establishment of the T-cell pool, even in the very young, despite their high thymus output.
Are all myelomas preceded by MGUS?
In this issue of Blood, 2 independent articles report for the first time that an MGUS virtually precedes all cases on multiple myeloma.
Enolase-1 as a plasminogen receptor
In this issue of Blood, Wygrecka and colleagues assign a major role to cell-surface enolase-1 as a plasminogen receptor, mediating LPS-induced invasion of monocytes into lungs in mice and humans.
Where spectrin snuggles with ankyrin
Using the crystal structure of β-spectrin repeats 14 and 15 that bind ankyrin, together with a crystal structure of a fragment of ankyrin that binds spectrin, and detailed site-directed mutagenesis, Stabach and Ipsaro and their respective colleagues analyze for the first time the structure of the ankyrin-β-spectrin bridge that connects band 3 (AE1) and other proteins to the membrane skeleton.
A team player: the disintegrin domain of ADAMTS13
In this issue of Blood, de Groot and colleagues identify novel interactions between the disintegrin domain of ADAMTS13 and the A2 domain of VWF. This provides another piece in the puzzle of how this domain of ADAMTS13 works in concert with other domains to bind and process VWF.
RTEs: lazy T-cell teenagers
In this issue of Blood, Opiela and colleagues analyze the phenotype and function of the lymphoid periphery's youngest T cells, RTEs.
Dll1 and Dll4: similar, but not the same
The VEGF-Dll4-Notch1 signaling cascade has taken center stage in angiogenesis, but it now appears that Dll1 ligands have precedence in arteries and even seem to control VEGF signaling.
HOW I TREAT
CLINICAL TRIALS AND OBSERVATIONS
Prevalence, determinants, and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukemia: the ADAGIO study
Clinical Trials & Observations
Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study
Clinical Trials & Observations
Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector–transduced CD34+ cells
HEMATOPOIESIS AND STEM CELLS
The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development
Notch1, Notch2, and Epstein-Barr virus–encoded nuclear antigen 2 signaling differentially affects proliferation and survival of Epstein-Barr virus–infected B cells
The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL
Isoform-selective phosphoinositide 3′-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell–mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach
TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia
Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells
Genome-wide association study to identify novel loci associated with therapy-related myeloid leukemia susceptibility
High frequency of RUNX1 biallelic alteration in acute myeloid leukemia secondary to familial platelet disorder
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemia
THROMBOSIS AND HEMOSTASIS
Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity
Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation
HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells
Selective engraftment of donor CD4+25high FOXP3-positive T cells in IPEX syndrome after nonmyeloablative hematopoietic stem cell transplantation
The structure of the ankyrin-binding site (red) in beta spectrin suggests a mechanism by which spectrin might couple mechanical deformation to ligand binding. See the article by Stabach et al on page 5377.
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkBack Matter
- PDF Icon PDF LinkAdvertising
- PDF Icon PDF LinkEditorial Board