Issue Archive

In this issue, Bains and colleagues show that T-cell proliferation plays a major role in the establishment of the T-cell pool, even in the very young, despite their high thymus output.

In this issue of Blood, 2 independent articles report for the first time that an MGUS virtually precedes all cases on multiple myeloma.

In this issue of Blood, Wygrecka and colleagues assign a major role to cell-surface enolase-1 as a plasminogen receptor, mediating LPS-induced invasion of monocytes into lungs in mice and humans.

Using the crystal structure of β-spectrin repeats 14 and 15 that bind ankyrin, together with a crystal structure of a fragment of ankyrin that binds spectrin, and detailed site-directed mutagenesis, Stabach and Ipsaro and their respective colleagues analyze for the first time the structure of the ankyrin-β-spectrin bridge that connects band 3 (AE1) and other proteins to the membrane skeleton.

In this issue of Blood, de Groot and colleagues identify novel interactions between the disintegrin domain of ADAMTS13 and the A2 domain of VWF. This provides another piece in the puzzle of how this domain of ADAMTS13 works in concert with other domains to bind and process VWF.

In this issue of Blood, Opiela and colleagues analyze the phenotype and function of the lymphoid periphery's youngest T cells, RTEs.

The VEGF-Dll4-Notch1 signaling cascade has taken center stage in angiogenesis, but it now appears that Dll1 ligands have precedence in arteries and even seem to control VEGF signaling.