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Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome–positive acute lymphoblastic leukemia confirms superiority of allogeneic transplantation over chemotherapy in the pre-imatinib era: results from the International ALL Trial MRC UKALLXII/ECOG2993
Comparison of imatinib 400 mg and 800 mg daily in the front-line treatment of high-risk, Philadelphia-positive chronic myeloid leukemia: a European LeukemiaNet Study
Prognostic impact of WT1 mutations in cytogenetically normal acute myeloid leukemia: a study of the German-Austrian AML Study Group
Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia
A HaemAtlas: characterizing gene expression in differentiated human blood cells
Issue Archive
May 7 2009
In this Issue
Table of Contents
INSIDE BLOOD
BLOOD WORK
EDITORIALS
CLINICAL TRIALS AND OBSERVATIONS
Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome–positive acute lymphoblastic leukemia confirms superiority of allogeneic transplantation over chemotherapy in the pre-imatinib era: results from the International ALL Trial MRC UKALLXII/ECOG2993
Clinical Trials & Observations
Adele K. Fielding,Jacob M. Rowe,Susan M. Richards,Georgina Buck,Anthony V. Moorman,I. Jill Durrant,David I. Marks,Andrew K. McMillan,Mark R. Litzow,Hillard M. Lazarus,Letizia Foroni,Gordon Dewald,Ian M. Franklin,Selina M. Luger,Elisabeth Paietta,Peter H. Wiernik,Martin S. Tallman,Anthony H. Goldstone
Comparison of imatinib 400 mg and 800 mg daily in the front-line treatment of high-risk, Philadelphia-positive chronic myeloid leukemia: a European LeukemiaNet Study
Clinical Trials & Observations
Michele Baccarani,Gianantonio Rosti,Fausto Castagnetti,Ibrahim Haznedaroglu,Kimmo Porkka,Elisabetta Abruzzese,Giuliana Alimena,Hans Ehrencrona,Henrik Hjorth-Hansen,Veli Kairisto,Luciano Levato,Giovanni Martinelli,Arnon Nagler,Johan Lanng Nielsen,Ugur Ozbek,Francesca Palandri,Fausto Palmieri,Fabrizio Pane,Giovanna Rege-Cambrin,Domenico Russo,Giorgina Specchia,Nicoletta Testoni,Ole Weiss-Bjerrum,Giuseppe Saglio,Bengt Simonsson
Prognostic impact of WT1 mutations in cytogenetically normal acute myeloid leukemia: a study of the German-Austrian AML Study Group
Clinical Trials & Observations
Verena Ingeborg Gaidzik,for the German-Austrian AML Study Group,Richard Friedrich Schlenk,for the German-Austrian AML Study Group,Simone Moschny,for the German-Austrian AML Study Group,Annegret Becker,for the German-Austrian AML Study Group,Lars Bullinger,for the German-Austrian AML Study Group,Andrea Corbacioglu,for the German-Austrian AML Study Group,Jürgen Krauter,for the German-Austrian AML Study Group,Brigitte Schlegelberger,for the German-Austrian AML Study Group,Arnold Ganser,for the German-Austrian AML Study Group,Hartmut Döhner,for the German-Austrian AML Study Group,Konstanze Döhner,for the German-Austrian AML Study Group
Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia
Clinical Trials & Observations
Deborah French,Wenjian Yang,Cheng Cheng,Susana C. Raimondi,Charles G. Mullighan,James R. Downing,William E. Evans,Ching-Hon Pui,Mary V. Relling
GENE THERAPY
HEMATOPOIESIS AND STEM CELLS
A HaemAtlas: characterizing gene expression in differentiated human blood cells
e-blood
Nicholas A. Watkins,on behalf of the Bloodomics Consortium,Arief Gusnanto,on behalf of the Bloodomics Consortium,Bernard de Bono,on behalf of the Bloodomics Consortium,Subhajyoti De,on behalf of the Bloodomics Consortium,Diego Miranda-Saavedra,on behalf of the Bloodomics Consortium,Debbie L. Hardie,on behalf of the Bloodomics Consortium,Will G. J. Angenent,on behalf of the Bloodomics Consortium,Antony P. Attwood,on behalf of the Bloodomics Consortium,Peter D. Ellis,on behalf of the Bloodomics Consortium,Wendy Erber,on behalf of the Bloodomics Consortium,Nicola S. Foad,on behalf of the Bloodomics Consortium,Stephen F. Garner,on behalf of the Bloodomics Consortium,Clare M. Isacke,on behalf of the Bloodomics Consortium,Jennifer Jolley,on behalf of the Bloodomics Consortium,Kerstin Koch,on behalf of the Bloodomics Consortium,Iain C. Macaulay,on behalf of the Bloodomics Consortium,Sarah L. Morley,on behalf of the Bloodomics Consortium,Augusto Rendon,on behalf of the Bloodomics Consortium,Kate M. Rice,on behalf of the Bloodomics Consortium,Niall Taylor,on behalf of the Bloodomics Consortium,Daphne C. Thijssen-Timmer,on behalf of the Bloodomics Consortium,Marloes R. Tijssen,on behalf of the Bloodomics Consortium,C. Ellen van der Schoot,on behalf of the Bloodomics Consortium,Lorenz Wernisch,on behalf of the Bloodomics Consortium,Thilo Winzer,on behalf of the Bloodomics Consortium,Frank Dudbridge,on behalf of the Bloodomics Consortium,Christopher D. Buckley,on behalf of the Bloodomics Consortium,Cordelia F. Langford,on behalf of the Bloodomics Consortium,Sarah Teichmann,on behalf of the Bloodomics Consortium,Berthold Göttgens,on behalf of the Bloodomics Consortium,Willem H. Ouwehand,on behalf of the Bloodomics Consortium
IMMUNOBIOLOGY
LYMPHOID NEOPLASIA
The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor
Anne Catherine Sprynski,Dirk Hose,Laurent Caillot,Thierry Réme,John D. Shaughnessy, Jr,Bart Barlogie,Anja Seckinger,Jérôme Moreaux,Michael Hundemer,Michel Jourdan,Tobias Meißner,Anna Jauch,Karène Mahtouk,Alboukadel Kassambara,Uta Bertsch,Jean François Rossi,Hartmut Goldschmidt,Bernard Klein
The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo
David M. Lucas,Ryan B. Edwards,Gerard Lozanski,Derek A. West,Jungook D. Shin,Melissa A. Vargo,Melanie E. Davis,Darlene M. Rozewski,Amy J. Johnson,Bao-Ning Su,Virginia M. Goettl,Nyla A. Heerema,Thomas S. Lin,Amy Lehman,Xiaoli Zhang,David Jarjoura,David J. Newman,John C. Byrd,A. Douglas Kinghorn,Michael R. Grever
MYELOID NEOPLASIA
Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia
Kazuko Miyazaki,Norimasa Yamasaki,Hideaki Oda,Takeshi Kuwata,Yohei Kanno,Masaki Miyazaki,Yukiko Komeno,Jiro Kitaura,Zen-ichiro Honda,Søren Warming,Nancy A. Jenkins,Neal G. Copeland,Toshio Kitamura,Takuro Nakamura,Hiroaki Honda
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
PLATELETS AND THROMBOPOIESIS
Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins
Marie N. O'Connor,Isabelle I. Salles,Ana Cvejic,Nicholas A. Watkins,Adam Walker,Stephen F. Garner,Chris I. Jones,Iain C. Macaulay,Michael Steward,Jaap-Jan Zwaginga,Sarah L. Bray,Frank Dudbridge,Bernard de Bono,Alison H. Goodall,Hans Deckmyn,Derek L. Stemple,Willem H. Ouwehand,on behalf of the Bloodomics Consortium
RED CELLS, IRON, AND ERYTHROPOIESIS
TRANSPLANTATION
Haploidentical stem cell transplantation after a reduced-intensity conditioning regimen for the treatment of advanced hematologic malignancies: posttransplantation CD8-depleted donor lymphocyte infusions contribute to improve T-cell recovery
Anna Dodero,Cristiana Carniti,Anna Raganato,Antonio Vendramin,Lucia Farina,Francesco Spina,Carmelo Carlo-Stella,Simona Di Terlizzi,Marco Milanesi,Paolo Longoni,Lorenza Gandola,Claudia Lombardo,Paolo Corradini
Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease
Kaori Sato,Kawori Eizumi,Tomohiro Fukaya,Shigeharu Fujita,Yumiko Sato,Hideaki Takagi,Mai Yamamoto,Naohide Yamashita,Atsushi Hijikata,Hiroshi Kitamura,Osamu Ohara,Sho Yamasaki,Takashi Saito,Katsuaki Sato
VASCULAR BIOLOGY
CORRESPONDENCE
Vascular endothelial growth factor inhibition is not an effective therapeutic strategy for relapsed or refractory multiple myeloma: a phase 2 study of pazopanib (GW786034)
H. Miles Prince,Dirk Hönemann,Andrew Spencer,David A. Rizzieri,Edward A. Stadtmauer,Andrew W. Roberts,Nizar Bahlis,Guido Tricot,Bill Bell,Douglas J. DeMarini,A. Benjamin Suttle,Katherine L. Baker,Lini N. Pandite
ERRATUM
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Cover Image
Cover Image
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Discovery of molecular defects that account for leukocyte adhesion deficiency (LAD) syndromes yield novel insights into mechanisms that govern signaling, targeting, and emigration of leukocyte subtypes, in addition to clinically relevant information relevant to rare but important human diseases. Mutations in FERMT3, leading to deficiency of the protein kindlin-3, account for the disease phenotype in a variant form of LAD (LAD-1v, also called LADIII) in which inside-out signaling of surface integrins is disrupted. For details, see the commentary by Zimmerman on page 4485 and the article by Kuijpers et al on page 4740.
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