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Issue Archive

Volume 113, Issue 18
April 30 2009
Blood Cover Image for Volume 113, Issue 18

Table of Contents

INSIDE BLOOD

CLINICAL TRIALS
Closer to the truth in AML
Jacob M. Rowe
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CLINICAL TRIALS
The changing definition of CLL
Gerald E. Marti
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HEMATOPOIESIS & STEM CELLS
Mesenchymally “stemming” angiogenesis
Michael A. Matthay
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INSIDE BLOOD
Hiding from ABT-737 in lymph nodes
Anthony Letai
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INSIDE BLOOD
MicroRNAs to know in Waldenström macroglobulinemia
Angelo Vacca,Franco Dammacco
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THROMBOSIS & HEMOSTASIS
How can fibrinolysis induce cell death?
Margarethe Geiger
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VASCULAR BIOLOGY
Lymphangiogenesis factors: a target for therapy?
Arjan W. Griffioen
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CLINICAL TRIALS AND OBSERVATIONS

Lenalidomide, adriamycin, and dexamethasone (RAD) in patients with relapsed and refractory multiple myeloma: a report from the German Myeloma Study Group DSMM (Deutsche Studiengruppe Multiples Myelom)
Clinical Trials & Observations
Stefan Knop,Christian Gerecke,Peter Liebisch,Max S. Topp,Uwe Platzbecker,Orhan Sezer,Christina Vollmuth,Karina Falk,Axel Glasmacher,Uwe Maeder,Hermann Einsele,Ralf C. Bargou
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Mature results of the M. D. Anderson Cancer Center risk-adapted transplantation strategy in mantle cell lymphoma
Clinical Trials & Observations
Constantine S. Tam,Roland Bassett,Celina Ledesma,Martin Korbling,Amin Alousi,Chitra Hosing,Partow Kebraei,Robyn Harrell,Gabriela Rondon,Sergio A. Giralt,Paolo Anderlini,Uday Popat,Barbara Pro,Barry Samuels,Frederick Hagemeister,L. Jeffrey Medeiros,Richard E. Champlin,Issa F. Khouri
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Improved risk classification for risk-specific therapy based on the molecular study of minimal residual disease (MRD) in adult acute lymphoblastic leukemia (ALL)
Clinical Trials & Observations
Renato Bassan,Orietta Spinelli,Elena Oldani,Tamara Intermesoli,Manuela Tosi,Barbara Peruta,Giuseppe Rossi,Erika Borlenghi,Enrico M. Pogliani,Elisabetta Terruzzi,Pietro Fabris,Vincenzo Cassibba,Giorgio Lambertenghi-Deliliers,Agostino Cortelezzi,Alberto Bosi,Giacomo Gianfaldoni,Fabio Ciceri,Massimo Bernardi,Andrea Gallamini,Daniele Mattei,Eros Di Bona,Claudio Romani,Anna Maria Scattolin,Tiziano Barbui,Alessandro Rambaldi
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Supplemental data
International prognostic scoring system for Waldenström macroglobulinemia
Clinical Trials & Observations
Pierre Morel,Alain Duhamel,Paolo Gobbi,Meletios A. Dimopoulos,Madhav V. Dhodapkar,Jason McCoy,John Crowley,Enrique M. Ocio,Ramon Garcia-Sanz,Steven P. Treon,Veronique Leblond,Robert A. Kyle,Bart Barlogie,Giampaolo Merlini
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Supplemental data
The role of cytogenetic abnormalities as a prognostic marker in primary myelofibrosis: applicability at the time of diagnosis and later during disease course
Clinical Trials & Observations
Constantine S. Tam,Lynne V. Abruzzo,Katherine I. Lin,Jorge Cortes,Alice Lynn,Michael J. Keating,Deborah A. Thomas,Sherry Pierce,Hagop Kantarjian,Srdan Verstovsek
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Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry
Clinical Trials & Observations
Gunnar Juliusson,Petar Antunovic,Åsa Derolf,Sören Lehmann,Lars Möllgård,Dick Stockelberg,Ulf Tidefelt,Anders Wahlin,Martin Höglund
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B-cell count and survival: differentiating chronic lymphocytic leukemia from monoclonal B-cell lymphocytosis based on clinical outcome
Clinical Trials & Observations
Tait D. Shanafelt,Neil E. Kay,Greg Jenkins,Timothy G. Call,Clive S. Zent,Diane F. Jelinek,William G. Morice,Justin Boysen,Liam Zakko,Susan Schwager,Susan L. Slager,Curtis A. Hanson
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HEMATOPOIESIS AND STEM CELLS

Concentration-dependent inhibition of angiogenesis by mesenchymal stem cells
Keishi Otsu,Shonit Das,Sandra D. Houser,Sadiqa K. Quadri,Sunita Bhattacharya,Jahar Bhattacharya
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Supplemental data

IMMUNOBIOLOGY

Impaired maintenance of naturally acquired T-cell memory to the meningococcus in patients with B-cell immunodeficiency
Begonia Morales-Aza,Sarah J. Glennie,Tomaz Pereira Garcez,Victoria Davenport,Sarah L. Johnston,Neil A. Williams,Robert S. Heyderman
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Th-1 polarization is regulated by dendritic-cell comparison of MHC class I and class II antigens
William K. Decker,Dongxia Xing,Sufang Li,Simon N. Robinson,Hong Yang,David Steiner,Krishna V. Komanduri,Elizabeth J. Shpall
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A TLR2 ligand suppresses inflammation by modulation of chemokine receptors and redirection of leukocyte migration
Clive S. McKimmie,Mark Moore,Alasdair R. Fraser,Thomas Jamieson,Damo Xu,Claire Burt,Nick I. Pitman,Robert J. Nibbs,Iain B. McInnes,Foo Y. Liew,Gerard J. Graham
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Supplemental data
Human plasmacytoid dendritic cells are unresponsive to bacterial stimulation and require a novel type of cooperation with myeloid dendritic cells for maturation
Diego Piccioli,Chiara Sammicheli,Simona Tavarini,Sandra Nuti,Elisabetta Frigimelica,Andrea G.O. Manetti,Annalisa Nuccitelli,Susanna Aprea,Sara Valentini,Erica Borgogni,Andreas Wack,Nicholas M. Valiante
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Supplemental data
IL-17–producing human peripheral regulatory T cells retain suppressive function
Gaëlle Beriou,Cristina M. Costantino,Charles W. Ashley,Li Yang,Vijay K. Kuchroo,Clare Baecher-Allan,David A. Hafler
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Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain
Thaidra Gaufin,Rajeev Gautam,Melissa Kasheta,Ruy Ribeiro,Erin Ribka,Mary Barnes,Melissa Pattison,Coty Tatum,Jeanne MacFarland,David Montefiori,Amitinder Kaur,Ivona Pandrea,Cristian Apetrei
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Supplemental data
Antigen mRNA-transfected, allogeneic fibroblasts loaded with NKT-cell ligand confer antitumor immunity
Shin-ichiro Fujii,Akira Goto,Kanako Shimizu
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Supplemental data
Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell–specific dominant minor histocompatibility antigen, H60
Su Jeong Ryu,Kyung Min Jung,Hyun Seung Yoo,Tae Woo Kim,Sol Kim,Jun Chang,Eun Young Choi
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Supplemental data

LYMPHOID NEOPLASIA

Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine
Andreas Höglund,Lisa M. Nilsson,Linus Plym Forshell,Kirsteen H. Maclean,Jonas A. Nilsson
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Supplemental data
Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells
Claudia P. Miller,Sharmistha Rudra,Michael J. Keating,William G. Wierda,Michael Palladino,Joya Chandra
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Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism
Paola Secchiero,Elisabetta Melloni,Maria Grazia di Iasio,Mario Tiribelli,Erika Rimondi,Federica Corallini,Valter Gattei,Giorgio Zauli
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CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf–mediated interactions with bone marrow stromal cells
Yu-Tzu Tai,Ender Soydan,Weihua Song,Mariateresa Fulciniti,Kihyun Kim,Fangxin Hong,Xian-Feng Li,Peter Burger,Matthew J. Rumizen,Sabikun Nahar,Klaus Podar,Teru Hideshima,Nikhil C. Munshi,Giovanni Tonon,Ruben D. Carrasco,Daniel E. H. Afar,Kenneth C. Anderson
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Bortezomib induces osteoblast differentiation via Wnt-independent activation of β-catenin/TCF signaling
Ya-Wei Qiang,Bo Hu,Yu Chen,Ying Zhong,Bingyin Shi,Bart Barlogie,John D. Shaughnessy, Jr
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Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma
Dirk Hose,Thierry Rème,Tobias Meissner,Jérôme Moreaux,Anja Seckinger,Joe Lewis,Vladimir Benes,Axel Benner,Michael Hundemer,Thomas Hielscher,John D. Shaughnessy, Jr,Bart Barlogie,Kai Neben,Alwin Krämer,Jens Hillengass,Uta Bertsch,Anna Jauch,John De Vos,Jean-François Rossi,Thomas Möhler,Jonathon Blake,Jürgen Zimmermann,Bernard Klein,Hartmut Goldschmidt
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Supplemental data
CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy
Abdel Kareem Azab,Judith M. Runnels,Costas Pitsillides,Anne-Sophie Moreau,Feda Azab,Xavier Leleu,Xiaoying Jia,Renee Wright,Beatriz Ospina,Alicia L. Carlson,Clemens Alt,Nicholas Burwick,Aldo M. Roccaro,Hai T. Ngo,Mena Farag,Molly R. Melhem,Antonio Sacco,Nikhil C. Munshi,Teru Hideshima,Barrett J. Rollins,Kenneth C. Anderson,Andrew L. Kung,Charles P. Lin,Irene M. Ghobrial
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Supplemental data
Potent antitumor activity of the anti-CD19 auristatin antibody drug conjugate hBU12-vcMMAE against rituximab-sensitive and -resistant lymphomas
Hans-Peter Gerber,May Kung-Sutherland,Ivan Stone,Carol Morris-Tilden,Jamie Miyamoto,Renee McCormick,Stephen C. Alley,Nicole Okeley,Brad Hayes,Francisco J. Hernandez-Ilizaliturri,Charlotte F. McDonagh,Paul J. Carter,Dennis Benjamin,Iqbal S. Grewal
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Supplemental data
Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia
Michal Stark,Chen Wichman,Irit Avivi,Yehuda G. Assaraf
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PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation
Pengrong Yan,Jing Fu,Zhaoxia Qu,Shirong Li,Takashi Tanaka,Michael J. Grusby,Gutian Xiao
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Supplemental data
Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL
Wendy R. Gordon,Monideepa Roy,Didem Vardar-Ulu,Megan Garfinkel,Marc R. Mansour,Jon C. Aster,Stephen C. Blacklow
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Supplemental data
microRNA expression in the biology, prognosis, and therapy of Waldenström macroglobulinemia
Aldo M. Roccaro,Antonio Sacco,Changzhong Chen,Judith Runnels,Xavier Leleu,Feda Azab,Abdel Kareem Azab,Xiaoying Jia,Hai T. Ngo,Molly R. Melhem,Nicholas Burwick,Lyuba Varticovski,Carl D. Novina,Barrett J. Rollins,Kenneth C. Anderson,Irene M. Ghobrial
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Supplemental data
Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia
Meike Vogler,Michael Butterworth,Aneela Majid,Renata J. Walewska,Xiao-Ming Sun,Martin J. S. Dyer,Gerald M. Cohen
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Supplemental data

MYELOID NEOPLASIA

Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis
Gordon Chan,Demetrios Kalaitzidis,Tatiana Usenko,Jeffery L. Kutok,Wentian Yang,M. Golam Mohi,Benjamin G. Neel
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Supplemental data

THROMBOSIS AND HEMOSTASIS

Fibrinogen variant BβD432A has normal polymerization but does not bind knob “B”
Sheryl R. Bowley,Susan T. Lord
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Supplemental data
Caveolin-1–dependent apoptosis induced by fibrin degradation products
Yi-He Guo,Irene Hernandez,Berend Isermann,Tae-bong Kang,Leonid Medved,Rashmi Sood,Edward J. Kerschen,Trudy Holyst,Michael W. Mosesson,Hartmut Weiler
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TRANSPLANTATION

Donor T cells primed on leukemia lysate-pulsed recipient APCs mediate strong graft-versus-leukemia effects across MHC barriers in full chimeras
Arnab Ghosh,Wolfgang Koestner,Martin Hapke,Verena Schlaphoff,Florian Länger,Rolf Baumann,Christian Koenecke,Markus Cornberg,Karl Welte,Bruce R. Blazar,Martin G. Sauer
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Depletion of CD4 T cells enhances immunotherapy for neuroblastoma after syngeneic HSCT but compromises development of antitumor immune memory
Weiqing Jing,Jill A. Gershan,Bryon D. Johnson
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Supplemental data
Host natural killer T cells induce an interleukin-4–dependent expansion of donor CD4+CD25+Foxp3+ T regulatory cells that protects against graft-versus-host disease
Asha B. Pillai,Tracy I. George,Suparna Dutt,Samuel Strober
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Supplemental data

VASCULAR BIOLOGY

Vascular endothelial growth factor-D transgenic mice show enhanced blood capillary density, improved postischemic muscle regeneration, and increased susceptibility to tumor formation
Anna-Mari Kärkkäinen,Antti Kotimaa,Jenni Huusko,Ivana Kholova,Suvi Elina Heinonen,Anna Stefanska,Marike Hinke Dijkstra,Hanna Purhonen,Eveliina Hämäläinen,Petri Ilmari Mäkinen,Mikko Petri Turunen,Seppo Ylä-Herttuala
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CORRESPONDENCE

Malignant stem cells in childhood ALL: the debate continues!
Olaf Heidenreich,Josef Vormoor
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Stem cells in childhood acute lymphoblastic leukemia: identifying the most relevant targets for therapy
Paraskevi Diamanti,Allison Blair
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ERRATUM

Möricke et al. Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95. Blood. 2008;111:4477-4489.
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Argyriou et al. Bortezomib-induced peripheral neuropathy in multiple myeloma: a comprehensive review of the literature. Blood. 2008;112:1593-1599.
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Flowers et al. A multicenter prospective phase 2 randomized study of extracorporeal photopheresis for treatment of chronic graft-versus-host disease. Blood. 2008;112:2667-2674.
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