Issue Archive

INSIDE BLOOD

CLINICAL TRIALS

Closer to the truth in AML

Jacob M. Rowe

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CLINICAL TRIALS

The changing definition of CLL

Gerald E. Marti

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HEMATOPOIESIS & STEM CELLS

Mesenchymally “stemming” angiogenesis

Michael A. Matthay

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INSIDE BLOOD

Hiding from ABT-737 in lymph nodes

Anthony Letai

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INSIDE BLOOD

MicroRNAs to know in Waldenström macroglobulinemia

Angelo Vacca,Franco Dammacco

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THROMBOSIS & HEMOSTASIS

How can fibrinolysis induce cell death?

Margarethe Geiger

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VASCULAR BIOLOGY

Lymphangiogenesis factors: a target for therapy?

Arjan W. Griffioen

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CLINICAL TRIALS AND OBSERVATIONS

Lenalidomide, adriamycin, and dexamethasone (RAD) in patients with relapsed and refractory multiple myeloma: a report from the German Myeloma Study Group DSMM (Deutsche Studiengruppe Multiples Myelom)

Clinical Trials & Observations

Stefan Knop,Christian Gerecke,Peter Liebisch,Max S. Topp,Uwe Platzbecker,Orhan Sezer,Christina Vollmuth,Karina Falk,Axel Glasmacher,Uwe Maeder,Hermann Einsele,Ralf C. Bargou

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Mature results of the M. D. Anderson Cancer Center risk-adapted transplantation strategy in mantle cell lymphoma

Clinical Trials & Observations

Constantine S. Tam,Roland Bassett,Celina Ledesma,Martin Korbling,Amin Alousi,Chitra Hosing,Partow Kebraei,Robyn Harrell,Gabriela Rondon,Sergio A. Giralt,Paolo Anderlini,Uday Popat,Barbara Pro,Barry Samuels,Frederick Hagemeister,L. Jeffrey Medeiros,Richard E. Champlin,Issa F. Khouri

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Improved risk classification for risk-specific therapy based on the molecular study of minimal residual disease (MRD) in adult acute lymphoblastic leukemia (ALL)

Clinical Trials & Observations

Renato Bassan,Orietta Spinelli,Elena Oldani,Tamara Intermesoli,Manuela Tosi,Barbara Peruta,Giuseppe Rossi,Erika Borlenghi,Enrico M. Pogliani,Elisabetta Terruzzi,Pietro Fabris,Vincenzo Cassibba,Giorgio Lambertenghi-Deliliers,Agostino Cortelezzi,Alberto Bosi,Giacomo Gianfaldoni,Fabio Ciceri,Massimo Bernardi,Andrea Gallamini,Daniele Mattei,Eros Di Bona,Claudio Romani,Anna Maria Scattolin,Tiziano Barbui,Alessandro Rambaldi

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International prognostic scoring system for Waldenström macroglobulinemia

Clinical Trials & Observations

Pierre Morel,Alain Duhamel,Paolo Gobbi,Meletios A. Dimopoulos,Madhav V. Dhodapkar,Jason McCoy,John Crowley,Enrique M. Ocio,Ramon Garcia-Sanz,Steven P. Treon,Veronique Leblond,Robert A. Kyle,Bart Barlogie,Giampaolo Merlini

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The role of cytogenetic abnormalities as a prognostic marker in primary myelofibrosis: applicability at the time of diagnosis and later during disease course

Clinical Trials & Observations

Constantine S. Tam,Lynne V. Abruzzo,Katherine I. Lin,Jorge Cortes,Alice Lynn,Michael J. Keating,Deborah A. Thomas,Sherry Pierce,Hagop Kantarjian,Srdan Verstovsek

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Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry

Clinical Trials & Observations

Gunnar Juliusson,Petar Antunovic,Åsa Derolf,Sören Lehmann,Lars Möllgård,Dick Stockelberg,Ulf Tidefelt,Anders Wahlin,Martin Höglund

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B-cell count and survival: differentiating chronic lymphocytic leukemia from monoclonal B-cell lymphocytosis based on clinical outcome

Clinical Trials & Observations

Tait D. Shanafelt,Neil E. Kay,Greg Jenkins,Timothy G. Call,Clive S. Zent,Diane F. Jelinek,William G. Morice,Justin Boysen,Liam Zakko,Susan Schwager,Susan L. Slager,Curtis A. Hanson

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HEMATOPOIESIS AND STEM CELLS

Concentration-dependent inhibition of angiogenesis by mesenchymal stem cells

Keishi Otsu,Shonit Das,Sandra D. Houser,Sadiqa K. Quadri,Sunita Bhattacharya,Jahar Bhattacharya

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IMMUNOBIOLOGY

Impaired maintenance of naturally acquired T-cell memory to the meningococcus in patients with B-cell immunodeficiency

Begonia Morales-Aza,Sarah J. Glennie,Tomaz Pereira Garcez,Victoria Davenport,Sarah L. Johnston,Neil A. Williams,Robert S. Heyderman

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Th-1 polarization is regulated by dendritic-cell comparison of MHC class I and class II antigens

William K. Decker,Dongxia Xing,Sufang Li,Simon N. Robinson,Hong Yang,David Steiner,Krishna V. Komanduri,Elizabeth J. Shpall

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A TLR2 ligand suppresses inflammation by modulation of chemokine receptors and redirection of leukocyte migration

Clive S. McKimmie,Mark Moore,Alasdair R. Fraser,Thomas Jamieson,Damo Xu,Claire Burt,Nick I. Pitman,Robert J. Nibbs,Iain B. McInnes,Foo Y. Liew,Gerard J. Graham

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Human plasmacytoid dendritic cells are unresponsive to bacterial stimulation and require a novel type of cooperation with myeloid dendritic cells for maturation

Diego Piccioli,Chiara Sammicheli,Simona Tavarini,Sandra Nuti,Elisabetta Frigimelica,Andrea G.O. Manetti,Annalisa Nuccitelli,Susanna Aprea,Sara Valentini,Erica Borgogni,Andreas Wack,Nicholas M. Valiante

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IL-17–producing human peripheral regulatory T cells retain suppressive function

Gaëlle Beriou,Cristina M. Costantino,Charles W. Ashley,Li Yang,Vijay K. Kuchroo,Clare Baecher-Allan,David A. Hafler

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Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain

Thaidra Gaufin,Rajeev Gautam,Melissa Kasheta,Ruy Ribeiro,Erin Ribka,Mary Barnes,Melissa Pattison,Coty Tatum,Jeanne MacFarland,David Montefiori,Amitinder Kaur,Ivona Pandrea,Cristian Apetrei

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Antigen mRNA-transfected, allogeneic fibroblasts loaded with NKT-cell ligand confer antitumor immunity

Shin-ichiro Fujii,Akira Goto,Kanako Shimizu

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Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell–specific dominant minor histocompatibility antigen, H60

Su Jeong Ryu,Kyung Min Jung,Hyun Seung Yoo,Tae Woo Kim,Sol Kim,Jun Chang,Eun Young Choi

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LYMPHOID NEOPLASIA

Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine

Andreas Höglund,Lisa M. Nilsson,Linus Plym Forshell,Kirsteen H. Maclean,Jonas A. Nilsson

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Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells

Claudia P. Miller,Sharmistha Rudra,Michael J. Keating,William G. Wierda,Michael Palladino,Joya Chandra

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Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism

Paola Secchiero,Elisabetta Melloni,Maria Grazia di Iasio,Mario Tiribelli,Erika Rimondi,Federica Corallini,Valter Gattei,Giorgio Zauli

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CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf–mediated interactions with bone marrow stromal cells

Yu-Tzu Tai,Ender Soydan,Weihua Song,Mariateresa Fulciniti,Kihyun Kim,Fangxin Hong,Xian-Feng Li,Peter Burger,Matthew J. Rumizen,Sabikun Nahar,Klaus Podar,Teru Hideshima,Nikhil C. Munshi,Giovanni Tonon,Ruben D. Carrasco,Daniel E. H. Afar,Kenneth C. Anderson

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Bortezomib induces osteoblast differentiation via Wnt-independent activation of β-catenin/TCF signaling

Ya-Wei Qiang,Bo Hu,Yu Chen,Ying Zhong,Bingyin Shi,Bart Barlogie,John D. Shaughnessy, Jr

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Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma

Dirk Hose,Thierry Rème,Tobias Meissner,Jérôme Moreaux,Anja Seckinger,Joe Lewis,Vladimir Benes,Axel Benner,Michael Hundemer,Thomas Hielscher,John D. Shaughnessy, Jr,Bart Barlogie,Kai Neben,Alwin Krämer,Jens Hillengass,Uta Bertsch,Anna Jauch,John De Vos,Jean-François Rossi,Thomas Möhler,Jonathon Blake,Jürgen Zimmermann,Bernard Klein,Hartmut Goldschmidt

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CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy

Abdel Kareem Azab,Judith M. Runnels,Costas Pitsillides,Anne-Sophie Moreau,Feda Azab,Xavier Leleu,Xiaoying Jia,Renee Wright,Beatriz Ospina,Alicia L. Carlson,Clemens Alt,Nicholas Burwick,Aldo M. Roccaro,Hai T. Ngo,Mena Farag,Molly R. Melhem,Antonio Sacco,Nikhil C. Munshi,Teru Hideshima,Barrett J. Rollins,Kenneth C. Anderson,Andrew L. Kung,Charles P. Lin,Irene M. Ghobrial

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Potent antitumor activity of the anti-CD19 auristatin antibody drug conjugate hBU12-vcMMAE against rituximab-sensitive and -resistant lymphomas

Hans-Peter Gerber,May Kung-Sutherland,Ivan Stone,Carol Morris-Tilden,Jamie Miyamoto,Renee McCormick,Stephen C. Alley,Nicole Okeley,Brad Hayes,Francisco J. Hernandez-Ilizaliturri,Charlotte F. McDonagh,Paul J. Carter,Dennis Benjamin,Iqbal S. Grewal

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Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia

Michal Stark,Chen Wichman,Irit Avivi,Yehuda G. Assaraf

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PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation

Pengrong Yan,Jing Fu,Zhaoxia Qu,Shirong Li,Takashi Tanaka,Michael J. Grusby,Gutian Xiao

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Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

Wendy R. Gordon,Monideepa Roy,Didem Vardar-Ulu,Megan Garfinkel,Marc R. Mansour,Jon C. Aster,Stephen C. Blacklow

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microRNA expression in the biology, prognosis, and therapy of Waldenström macroglobulinemia

Aldo M. Roccaro,Antonio Sacco,Changzhong Chen,Judith Runnels,Xavier Leleu,Feda Azab,Abdel Kareem Azab,Xiaoying Jia,Hai T. Ngo,Molly R. Melhem,Nicholas Burwick,Lyuba Varticovski,Carl D. Novina,Barrett J. Rollins,Kenneth C. Anderson,Irene M. Ghobrial

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Concurrent up-regulation of BCL-X_L and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia

Meike Vogler,Michael Butterworth,Aneela Majid,Renata J. Walewska,Xiao-Ming Sun,Martin J. S. Dyer,Gerald M. Cohen

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MYELOID NEOPLASIA

Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis

Gordon Chan,Demetrios Kalaitzidis,Tatiana Usenko,Jeffery L. Kutok,Wentian Yang,M. Golam Mohi,Benjamin G. Neel

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THROMBOSIS AND HEMOSTASIS

Fibrinogen variant BβD432A has normal polymerization but does not bind knob “B”

Sheryl R. Bowley,Susan T. Lord

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Caveolin-1–dependent apoptosis induced by fibrin degradation products

Yi-He Guo,Irene Hernandez,Berend Isermann,Tae-bong Kang,Leonid Medved,Rashmi Sood,Edward J. Kerschen,Trudy Holyst,Michael W. Mosesson,Hartmut Weiler

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TRANSPLANTATION

Donor T cells primed on leukemia lysate-pulsed recipient APCs mediate strong graft-versus-leukemia effects across MHC barriers in full chimeras

Arnab Ghosh,Wolfgang Koestner,Martin Hapke,Verena Schlaphoff,Florian Länger,Rolf Baumann,Christian Koenecke,Markus Cornberg,Karl Welte,Bruce R. Blazar,Martin G. Sauer

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Depletion of CD4 T cells enhances immunotherapy for neuroblastoma after syngeneic HSCT but compromises development of antitumor immune memory

Weiqing Jing,Jill A. Gershan,Bryon D. Johnson

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Host natural killer T cells induce an interleukin-4–dependent expansion of donor CD4⁺CD25⁺Foxp3⁺ T regulatory cells that protects against graft-versus-host disease

Asha B. Pillai,Tracy I. George,Suparna Dutt,Samuel Strober

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VASCULAR BIOLOGY

Vascular endothelial growth factor-D transgenic mice show enhanced blood capillary density, improved postischemic muscle regeneration, and increased susceptibility to tumor formation

Anna-Mari Kärkkäinen,Antti Kotimaa,Jenni Huusko,Ivana Kholova,Suvi Elina Heinonen,Anna Stefanska,Marike Hinke Dijkstra,Hanna Purhonen,Eveliina Hämäläinen,Petri Ilmari Mäkinen,Mikko Petri Turunen,Seppo Ylä-Herttuala

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CORRESPONDENCE

Malignant stem cells in childhood ALL: the debate continues!

Olaf Heidenreich,Josef Vormoor

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Stem cells in childhood acute lymphoblastic leukemia: identifying the most relevant targets for therapy

Paraskevi Diamanti,Allison Blair

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ERRATUM

Möricke et al. Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95. Blood. 2008;111:4477-4489.

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Argyriou et al. Bortezomib-induced peripheral neuropathy in multiple myeloma: a comprehensive review of the literature. Blood. 2008;112:1593-1599.

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Flowers et al. A multicenter prospective phase 2 randomized study of extracorporeal photopheresis for treatment of chronic graft-versus-host disease. Blood. 2008;112:2667-2674.

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