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Dose-dense induction with sequential high-dose cytarabine and mitoxantone (S-HAM) and pegfilgrastim results in a high efficacy and a short duration of critical neutropenia in de novo acute myeloid leukemia: a pilot study of the AMLCG
Venous thromboembolism in patients with acute leukemia: incidence, risk factors, and effect on survival
NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study
Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: a study of 136 cases from the International Peripheral T-Cell Lymphoma Project
A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response
Efficacy and safety of lenalidomide in intermediate-2 or high-risk myelodysplastic syndromes with 5q deletion: results of a phase 2 study
Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH17 cytokine interleukin-22
Identification and characterization of a novel P2Y12 variant in a patient diagnosed with type 1 von Willebrand disease in the European MCMDM-1VWD study
Issue Archive
April 23 2009
In this Issue
Table of Contents
INSIDE BLOOD
PERSPECTIVE
CLINICAL TRIALS AND OBSERVATIONS
Dose-dense induction with sequential high-dose cytarabine and mitoxantone (S-HAM) and pegfilgrastim results in a high efficacy and a short duration of critical neutropenia in de novo acute myeloid leukemia: a pilot study of the AMLCG
Clinical Trials & Observations
Jan Braess,Karsten Spiekermann,Peter Staib,Andreas Grüneisen,Bernhard Wörmann,Wolf-Dieter Ludwig,Hubert Serve,Albrecht Reichle,Rudolf Peceny,Daniel Oruzio,Christoph Schmid,Xaver Schiel,Marcus Hentrich,Christina Sauerland,Michael Unterhalt,Michael Fiegl,Wolfgang Kern,Christian Buske,Stefan Bohlander,Achim Heinecke,Herrad Baurmann,Dietrich W. Beelen,Wolfgang E. Berdel,Thomas Büchner,Wolfgang Hiddemann
Venous thromboembolism in patients with acute leukemia: incidence, risk factors, and effect on survival
Clinical Trials & Observations
NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study
Clinical Trials & Observations
Vahid Asnafi,Agnès Buzyn,Sandrine Le Noir,Frédéric Baleydier,Arnauld Simon,Kheira Beldjord,Oumedaly Reman,Francis Witz,Thierry Fagot,Emmanuelle Tavernier,Pascal Turlure,Thibaut Leguay,Françoise Huguet,Jean-Paul Vernant,Francis Daniel,Marie-Christine Béné,Norbert Ifrah,Xavier Thomas,Hervé Dombret,Elizabeth Macintyre
Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: a study of 136 cases from the International Peripheral T-Cell Lymphoma Project
Clinical Trials & Observations
Wing-yan Au,Dennis D. Weisenburger,Tanin Intragumtornchai,Shigeo Nakamura,Won-Seog Kim,Ivy Sng,Julie Vose,James O. Armitage,Raymond Liang,for the International Peripheral T-Cell Lymphoma Project
A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response
Clinical Trials & Observations
Keith W. Pratz,Jorge Cortes,Gail J. Roboz,Niranjan Rao,Omotayo Arowojolu,Adam Stine,Yukimasa Shiotsu,Aiko Shudo,Shiro Akinaga,Donald Small,Judith E. Karp,Mark Levis
Efficacy and safety of lenalidomide in intermediate-2 or high-risk myelodysplastic syndromes with 5q deletion: results of a phase 2 study
Clinical Trials & Observations
Lionel Adès,Simone Boehrer,Thomas Prebet,Odile Beyne-Rauzy,Laurence Legros,Christophe Ravoet,François Dreyfus,Aspasia Stamatoullas,Marie Pierre Chaury,Jacques Delaunay,Guy Laurent,Norbert Vey,Sara Burcheri,Rose-Marie Mbida,Natacha Hoarau,Claude Gardin,Pierre Fenaux
HEMATOPOIESIS AND STEM CELLS
IMMUNOBIOLOGY
Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH17 cytokine interleukin-22
Brief Report
Tiffany Hughes,Brian Becknell,Susan McClory,Edward Briercheck,Aharon G. Freud,Xiaoli Zhang,Hsiaoyin Mao,Gerard Nuovo,Jianhua Yu,Michael A. Caligiuri
LYMPHOID NEOPLASIA
The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study group
Thomas Burmeister,Claus Meyer,Stefan Schwartz,Julia Hofmann,Mara Molkentin,Eric Kowarz,Björn Schneider,Thorsten Raff,Richard Reinhardt,Nicola Gökbuget,Dieter Hoelzer,Eckhard Thiel,Rolf Marschalek
Gene expression profiling of ATL patients: compilation of disease-related genes and evidence for TCF4 involvement in BIRC5 gene expression and cell viability
Cynthia A. Pise-Masison,Michael Radonovich,Kathleen Dohoney,John C. Morris,Deirdre O'Mahony,Min-Jung Lee,Jane Trepel,Thomas A. Waldmann,John E. Janik,John N. Brady
Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-κB with antimyeloma activity in vitro and in vivo
Rodger E. Tiedemann,Jessica Schmidt,Jonathan J. Keats,Chang-Xin Shi,Yuan Xiao Zhu,Stephen E. Palmer,Xinliang Mao,Aaron D. Schimmer,A. Keith Stewart
Cotreatment with BCL-2 antagonist sensitizes cutaneous T-cell lymphoma to lethal action of HDAC7-Nur77–based mechanism
Jianguang Chen,Warren Fiskus,Kelly Eaton,Pravina Fernandez,Yongchao Wang,Rekha Rao,Pearl Lee,Rajeshree Joshi,Yonghua Yang,Ravindra Kolhe,Ramesh Balusu,Prasanthi Chappa,Kavita Natarajan,Anand Jillella,Peter Atadja,Kapil N. Bhalla
MYELOID NEOPLASIA
Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML
Jianbiao Zhou,Chonglei Bi,Jasinghe V. Janakakumara,Shaw-Cheng Liu,Wee-Joo Chng,Kian-Ghee Tay,Lai-Fong Poon,Zhigang Xie,Senthilnathan Palaniyandi,Hanry Yu,Keith B. Glaser,Daniel H. Albert,Steven K. Davidsen,Chien-Shing Chen
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
Complement fraction 3 binding on erythrocytes as additional mechanism of disease in paroxysmal nocturnal hemoglobinuria patients treated by eculizumab
Antonio M. Risitano,Rosario Notaro,Ludovica Marando,Bianca Serio,Danilo Ranaldi,Elisa Seneca,Patrizia Ricci,Fiorella Alfinito,Andrea Camera,Giacomo Gianfaldoni,Angela Amendola,Carla Boschetti,Eros Di Bona,Giorgio Fratellanza,Filippo Barbano,Francesco Rodeghiero,Alberto Zanella,Anna Paola Iori,Carmine Selleri,Lucio Luzzatto,Bruno Rotoli
THROMBOSIS AND HEMOSTASIS
Identification and characterization of a novel P2Y12 variant in a patient diagnosed with type 1 von Willebrand disease in the European MCMDM-1VWD study
Brief Report
Martina E. Daly,Ban B. Dawood,William A. Lester,Ian R. Peake,Francesco Rodeghiero,Anne C. Goodeve,Michael Makris,Jonathan T. Wilde,Andrew D. Mumford,Stephen P. Watson,Stuart J. Mundell
TRANSPLANTATION
Long-term outcome after hematopoietic stem cell transplantation of a single-center cohort of 90 patients with severe combined immunodeficiency
Bénédicte Neven,Sandrine Leroy,Hélène Decaluwe,Francoise Le Deist,Capucine Picard,Despina Moshous,Nizar Mahlaoui,Marianne Debré,Jean-Laurent Casanova,Liliane Dal Cortivo,Yoann Madec,Salima Hacein-Bey-Abina,Geneviève de Saint Basile,Jean-Pierre de Villartay,Stéphane Blanche,Marina Cavazzana-Calvo,Alain Fischer
CORRESPONDENCE
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Cover Image
Cover Image
![issue cover]()
Dendritic cells are present in greatly reduced numbers in spleens of IL-7-deficient mice, but localize normally to the bridging channels. The cover shows a cryosection across a splenic white pulp cord of an IL-7-/- mouse stained for B cells (B220, red), T cells (CD3, green), extracellular matrix (laminin, blue), and dendritic cells (CD11c, white). See the article by Vogt et al on page 3961.
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