Table of Contents
New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling
Syk to death
Using elegant mouse models of B-cell lymphoma, Young and colleagues validate targeting syk-mediated B-cell receptor signaling as an effective antitumor strategy for the treatment of non-Hodgkin lymphoma.
Might as well face it: MLL's addicted to HOX
Overexpression of HOXA9 is a hallmark of MLL-rearranged leukemias. In this issue of Blood, Faber and colleagues show that HOXA9 is critical for proliferation and survival of leukemic cells.
Platelet antigen-induced regulation in ITP
Tregs maintain self-tolerance and, although they are significantly deficient in patients with ITP,1,,,,–6 it now seems that their antigen-specific counterparts can be generated de novo from the patient's other nonregulatory T cells. This may set the future stage for platelet-induced cellular therapy as a treatment for ITP.
Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group
CLINICAL TRIALS AND OBSERVATIONS
Enhancing the in vivo expansion of adoptively transferred EBV-specific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients
Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
Granulocyte/macrophage–colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects
PLATELETS AND THROMBOPOIESIS
De novo induction of platelet-specific CD4+CD25+ regulatory T cells from CD4+CD25− cells in patients with idiopathic thrombocytopenic purpura
RED CELLS, IRON, AND ERYTHROPOIESIS
Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification
THROMBOSIS AND HEMOSTASIS
Under severe peroxidative conditions, haptoglobin preserves hemoglobin structural integrity and maintains clearance of the Hb-Hp complex by the macrophage scavenger receptor CD163. As a result, oxidative stress-exposed Hb (red) is sequestered within lysosomes (green) as illustrated in the 3-dimensional reconstruction of confocal laser scanning microscopy data (yellow indicates colocalization). See the article by Buehler et al on page 2578.
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