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Issue Archive

Volume 113, Issue 1
January 1 2009
Issue Cover

Table of Contents

INSIDE BLOOD

CLINICAL TRIALS
Cancer vaccines: up, down, … up again?
Sattva S. Neelapu,Larry W. Kwak
View Articletitled, Cancer vaccines: up, down, … up again?
TRANSPLANTATION
Resetting the clock
Gabor G. Illei
View Articletitled, Resetting the clock
RED CELLS & IRON
The transcobalamin receptor, redux
Donald W. Jacobsen,Alla V. Glushchenko
View Articletitled, The transcobalamin receptor, redux

BLOOD WORK

Progressive liver disease
View Articletitled, Progressive liver disease

EDITORIALS

More frequent Blood transfusions
Cynthia E. Dunbar, MD
View Articletitled, More frequent <em>Blood</em> transfusions

PERSPECTIVE

Primary lymphoma of the central nervous system: just DLBCL or not?
Manuel Montesinos-Rongen,Reiner Siebert,Martina Deckert
View Articletitled, Primary lymphoma of the central nervous system: just DLBCL or not?
Supplemental data

HOW I TREAT

How we treat a hemophilia A patient with a factor VIII inhibitor
Christine L. Kempton,Gilbert C. White, II
View Articletitled, How we treat a hemophilia A patient with a factor VIII inhibitor

CLINICAL TRIALS AND OBSERVATIONS

Vaccination with autologous tumor-loaded dendritic cells induces clinical and immunologic responses in indolent B-cell lymphoma patients with relapsed and measurable disease: a pilot study
Clinical Trials & Observations
Massimo Di Nicola,Roberta Zappasodi,Carmelo Carlo-Stella,Roberta Mortarini,Serenella M. Pupa,Michele Magni,Liliana Devizzi,Paola Matteucci,Paola Baldassari,Fernando Ravagnani,Antonello Cabras,Andrea Anichini,Alessandro M. Gianni
View Articletitled, Vaccination with autologous tumor-loaded dendritic cells induces clinical and immunologic responses in indolent B-cell lymphoma patients with relapsed and measurable disease: a pilot study
Supplemental data
Time from diagnosis to treatment initiation predicts survival in younger, but not older, acute myeloid leukemia patients
Clinical Trials & Observations
Mikkael A. Sekeres,Paul Elson,Matt E. Kalaycio,Anjali S. Advani,Edward A. Copelan,Stefan Faderl,Hagop M. Kantarjian,Elihu Estey
View Articletitled, Time from diagnosis to treatment initiation predicts survival in younger, but not older, acute myeloid leukemia patients

GENE THERAPY

Enhancement of DNA tumor vaccine efficacy by gene gun–mediated codelivery of threshold amounts of plasmid-encoded helper antigen
Wolfgang W. Leitner,Matthew C. Baker,Thomas L. Berenberg,Michael C. Lu,P. Josef Yannie,Mark C. Udey
View Articletitled, Enhancement of DNA tumor vaccine efficacy by gene gun–mediated codelivery of threshold amounts of plasmid-encoded helper antigen
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2–dependent regulatory dendritic cell population
Bin Zhang,Rui Liu,Dan Shi,Xingxia Liu,Yuan Chen,Xiaowei Dou,Xishan Zhu,Chunhua Lu,Wei Liang,Lianming Liao,Martin Zenke,Robert C. H. Zhao
View Articletitled, Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2–dependent regulatory dendritic cell population
Supplemental data

IMMUNOBIOLOGY

Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells
Alberto Bosque,Vicente Planelles
View Articletitled, Induction of HIV-1 latency and reactivation in primary memory CD4<sup>+</sup> T cells
Supplemental data
Aurora-A kinase: a novel target of cellular immunotherapy for leukemia
Toshiki Ochi,Hiroshi Fujiwara,Koichiro Suemori,Taichi Azuma,Yoshihiro Yakushijin,Takaaki Hato,Kiyotaka Kuzushima,Masaki Yasukawa
View Articletitled, Aurora-A kinase: a novel target of cellular immunotherapy for leukemia
Supplemental data
Imaging of plasmacytoid dendritic cell interactions with T cells
María Mittelbrunn,Gloria Martínez del Hoyo,María López-Bravo,Noa B. Martín-Cofreces,Alix Scholer,Stéphanie Hugues,Luc Fetler,Sebastián Amigorena,Carlos Ardavín,Francisco Sánchez-Madrid
View Articletitled, Imaging of plasmacytoid dendritic cell interactions with T cells
Supplemental data
Immunotransplantation preferentially expands T-effector cells over T-regulatory cells and cures large lymphoma tumors
Joshua D. Brody,Matthew J. Goldstein,Debra K. Czerwinski,Ronald Levy
View Articletitled, Immunotransplantation preferentially expands T-effector cells over T-regulatory cells and cures large lymphoma tumors
Supplemental data
A high-mobility, low-cost phenotype defines human effector-memory CD8+ T cells
Brief Report
Gabriela Zenhaeusern,Patrick Gubser,Petra Eisele,Olivier Gasser,Andrea Steinhuber,Andrej Trampuz,Christoph Handschin,Andrew D. Luster,Christoph Hess
View Articletitled, A high-mobility, low-cost phenotype defines human effector-memory CD8<sup>+</sup> T cells
Supplemental data

LYMPHOID NEOPLASIA

A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups
Sarina Sulong,Anthony V. Moorman,Julie A. E. Irving,Jonathan C. Strefford,Zoe J. Konn,Marian C. Case,Lynne Minto,Kerry E. Barber,Helen Parker,Sarah L. Wright,Adam R. M. Stewart,Simon Bailey,Nick P. Bown,Andrew G. Hall,Christine J. Harrison
View Articletitled, A comprehensive analysis of the <em>CDKN2A</em> gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups
Epstein-Barr virus latent membrane protein 2A exploits Notch1 to alter B-cell identity in vivo
Leah J. Anderson,Richard Longnecker
View Articletitled, Epstein-Barr virus latent membrane protein 2A exploits Notch1 to alter B-cell identity in vivo
Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response
Eliot Marston,Victoria Weston,Jennifer Jesson,Esther Maina,Carmel McConville,Angelo Agathanggelou,Anna Skowronska,Katie Mapp,Katrin Sameith,Judith E. Powell,Sarah Lawson,Pamela Kearns,Francesco Falciani,Malcolm Taylor,Tatjana Stankovic
View Articletitled, Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response
Supplemental data
Oncogenomic analysis of mycosis fungoides reveals major differences with Sézary syndrome
Remco van Doorn,Marloes S. van Kester,Remco Dijkman,Maarten H. Vermeer,Aat A. Mulder,Karoly Szuhai,Jeroen Knijnenburg,Judith M. Boer,Rein Willemze,Cornelis P. Tensen
View Articletitled, Oncogenomic analysis of mycosis fungoides reveals major differences with Sézary syndrome
Supplemental data
Genome-wide profiling of follicular lymphoma by array comparative genomic hybridization reveals prognostically significant DNA copy number imbalances
K.-John J. Cheung,Sohrab P. Shah,Christian Steidl,Nathalie Johnson,Thomas Relander,Adele Telenius,Betty Lai,Kevin P. Murphy,Wan Lam,Abdulwahab J. Al-Tourah,Joseph M. Connors,Raymond T. Ng,Randy D. Gascoyne,Douglas E. Horsman
View Articletitled, Genome-wide profiling of follicular lymphoma by array comparative genomic hybridization reveals prognostically significant DNA copy number imbalances
Supplemental data
AT-101 induces apoptosis in CLL B cells and overcomes stromal cell–mediated Mcl-1 induction and drug resistance
Brief Report
Kumudha Balakrishnan,Jan A. Burger,William G. Wierda,Varsha Gandhi
View Articletitled, AT-101 induces apoptosis in CLL B cells and overcomes stromal cell–mediated Mcl-1 induction and drug resistance
Supplemental data

MYELOID NEOPLASIA

Functional proteomic profiling of AML predicts response and survival
Steven M. Kornblau,Raoul Tibes,Yi Hua Qiu,Wenjing Chen,Hagop M. Kantarjian,Michael Andreeff,Kevin R. Coombes,Gordon B. Mills
View Articletitled, Functional proteomic profiling of AML predicts response and survival
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Human protein S inhibits the uptake of AcLDL and expression of SR-A through Mer receptor tyrosine kinase in human macrophages
Dan Liao,Xinwen Wang,Min Li,Peter H. Lin,Qizhi Yao,Changyi Chen
View Articletitled, Human protein S inhibits the uptake of AcLDL and expression of SR-A through Mer receptor tyrosine kinase in human macrophages
Supplemental data
cIAP1-dependent TRAF2 degradation regulates the differentiation of monocytes into macrophages and their response to CD40 ligand
Alban Dupoux,Jessy Cartier,Séverine Cathelin,Rodolphe Filomenko,Eric Solary,Laurence Dubrez-Daloz
View Articletitled, cIAP1-dependent TRAF2 degradation regulates the differentiation of monocytes into macrophages and their response to CD40 ligand
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

The protein and the gene encoding the receptor for the cellular uptake of transcobalamin-bound cobalamin
Edward V. Quadros,Yasumi Nakayama,Jeffrey M. Sequeira
View Articletitled, The protein and the gene encoding the receptor for the cellular uptake of transcobalamin-bound cobalamin

THROMBOSIS AND HEMOSTASIS

Anti-CD3 prevents factor VIII inhibitor development in hemophilia A mice by a regulatory CD4+CD25+-dependent mechanism and by shifting cytokine production to favor a Th1 response
Braden Waters,Mohammad Qadura,Erin Burnett,Rouzbeh Chegeni,Andrea Labelle,Patrick Thompson,Christine Hough,David Lillicrap
View Articletitled, Anti-CD3 prevents factor VIII inhibitor development in hemophilia A mice by a regulatory CD4<sup>+</sup>CD25<sup>+</sup>-dependent mechanism and by shifting cytokine production to favor a Th1 response
Supplemental data

TRANSPLANTATION

Androgen depletion increases the efficacy of bone marrow transplantation in ameliorating experimental autoimmune encephalomyelitis
Adele L. Barnard,Ann P. Chidgey,Claude C. Bernard,Richard L. Boyd
View Articletitled, Androgen depletion increases the efficacy of bone marrow transplantation in ameliorating experimental autoimmune encephalomyelitis
Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system
Tobias Alexander,Andreas Thiel,Oliver Rosen,Gero Massenkeil,Arne Sattler,Siegfried Kohler,Henrik Mei,Hartmut Radtke,Erika Gromnica-Ihle,Gerd-Rüdiger Burmester,Renate Arnold,Andreas Radbruch,Falk Hiepe
View Articletitled, Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system

VASCULAR BIOLOGY

Central role of Sp1-regulated CD39 in hypoxia/ischemia protection
Holger K. Eltzschig,David Köhler,Tobias Eckle,Tianqing Kong,Simon C. Robson,Sean P. Colgan
View Articletitled, Central role of Sp1-regulated CD39 in hypoxia/ischemia protection
Supplemental data
Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCβ2 axis
Yong-Sun Maeng,Hyun-Jung Choi,Ja-Young Kwon,Yong-Won Park,Kyu-Sil Choi,Jeong-Ki Min,Yun-Hee Kim,Pann-Ghill Suh,Kyung-Sun Kang,Moo-Ho Won,Young-Myeong Kim,Young-Guen Kwon
View Articletitled, Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCβ2 axis
Supplemental data
The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells
Mira Ernkvist,Nathalie Luna Persson,Stéphane Audebert,Patrick Lecine,Indranil Sinha,Miaoliang Liu,Marc Schlueter,Arie Horowitz,Karin Aase,Thomas Weide,Jean-Paul Borg,Arindam Majumdar,Lars Holmgren
View Articletitled, The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells
Supplemental data
The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade
Jeffrey S. Scehnet,Eric J. Ley,Valery Krasnoperov,Ren Liu,Parmeet K. Manchanda,Eric Sjoberg,Anna P. Kostecke,Sachin Gupta,S. Ram Kumar,Parkash S. Gill
View Articletitled, The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade

CORRESPONDENCE

Dendritic cells differentiate into osteoclasts in bone marrow microenvironment in vivo
Mawadda Alnaeeli,Yen-Tung A. Teng
View Articletitled, Dendritic cells differentiate into osteoclasts in bone marrow microenvironment in vivo
More on the differentiation of dendritic cells into osteoclasts
Abdelilah Wakkach,Claudine Blin-Wakkach
View Articletitled, More on the differentiation of dendritic cells into osteoclasts
Differential gene expression in central nervous system lymphoma
James L. Rubenstein,Arthur Shen,Tracy T. Batchelor,Cigall Kadoch,Patrick Treseler,Marc A. Shuman
View Articletitled, Differential gene expression in central nervous system lymphoma
Differential gene expression of central nervous system lymphoma
Han W. Tun,Michael McKinney
View Articletitled, Differential gene expression of central nervous system lymphoma
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