Issue Archive

CD40, a membrane-associated receptor, is a key activator of immune and vascular cells. In this issue of Blood, Pluvinet and colleagues reveal new features of human endothelial cells activated through CD40 that include inflammatory, thrombotic, and innate immune effects.

Rosiñol and colleagues report the results of a Spanish PETHEMA trial in this issue of Blood. Their study was an attempt to address the role of additional intensive treatments for patients failing to achieve a complete or nearly complete remission after a single autologous transplantation.

In this issue of Blood, Kristinsson and colleagues provide evidence that MGUS is a risk factor for the development of DVT.

Although platelets are a rich source of latent TGF-β it has not been determined how platelet-derived latent TGF-β is activated in vivo. In this issue of Blood, Ahamed and colleagues report that shear and stirring efficiently activate the latent TGF-β.

For several years, the lineage differentiation program of HSCs was believed to be well organized and unidirectional. However, data from recent studies question the commitment of lineage-restricted progenitors to a single lineage. Now, interesting work by Welner and colleagues presented in this issue of Blood suggests that the lineage differentiation pathways may be more complicated than initially thought.

In this issue of Blood, Spiegl and colleagues show that basophils express retinaldehyde dehydrogenase-2 and thus are a new and unique cellular source of RA, known to be an important regulator of immune-cell functions.

In this issue of Blood, Nimrichter and colleagues have defined the structure and function of distinct E-selectin ligands on the plasma membrane of neutrophils. They demonstrate that as few as 60 receptors/μm² of these sialylated and fucosylated glycolipids facilitate neutrophil capture and rolling at sites of acute inflammation.

In this issue of Blood, Steele and colleagues present a series of elegant experiments that illuminate a p53 transcription-independent mechanism of apoptosis induction in primary CLL cells.

Although Mcl-1 has been established as a survival and maintenance protein during in vitro incubations of primary CLL cells, in this issue of Blood, Pepper and colleagues further demonstrate the association of Mcl-1 with other prognostic factors and the role of this antiapoptotic protein in disease progression and outcome for patients with CLL.

In this issue of Blood, Liu and colleagues present evidence that flavonoids present in plasma may compromise the ability of the proteasome inhibitor bortezomib to induce apoptosis of CLL cells.