Table of Contents
CD40, a membrane-associated receptor, is a key activator of immune and vascular cells. In this issue of Blood, Pluvinet and colleagues reveal new features of human endothelial cells activated through CD40 that include inflammatory, thrombotic, and innate immune effects.
Rosiñol and colleagues report the results of a Spanish PETHEMA trial in this issue of Blood. Their study was an attempt to address the role of additional intensive treatments for patients failing to achieve a complete or nearly complete remission after a single autologous transplantation.
Although platelets are a rich source of latent TGF-β it has not been determined how platelet-derived latent TGF-β is activated in vivo. In this issue of Blood, Ahamed and colleagues report that shear and stirring efficiently activate the latent TGF-β.
For several years, the lineage differentiation program of HSCs was believed to be well organized and unidirectional. However, data from recent studies question the commitment of lineage-restricted progenitors to a single lineage. Now, interesting work by Welner and colleagues presented in this issue of Blood suggests that the lineage differentiation pathways may be more complicated than initially thought.
In this issue of Blood, Spiegl and colleagues show that basophils express retinaldehyde dehydrogenase-2 and thus are a new and unique cellular source of RA, known to be an important regulator of immune-cell functions.
In this issue of Blood, Nimrichter and colleagues have defined the structure and function of distinct E-selectin ligands on the plasma membrane of neutrophils. They demonstrate that as few as 60 receptors/μm2 of these sialylated and fucosylated glycolipids facilitate neutrophil capture and rolling at sites of acute inflammation.
Although Mcl-1 has been established as a survival and maintenance protein during in vitro incubations of primary CLL cells, in this issue of Blood, Pepper and colleagues further demonstrate the association of Mcl-1 with other prognostic factors and the role of this antiapoptotic protein in disease progression and outcome for patients with CLL.
ASH 50TH ANNIVERSARY REVIEW
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
CLINICAL TRIALS AND OBSERVATIONS
A survey of fully haploidentical hematopoietic stem cell transplantation in adults with high-risk acute leukemia: a risk factor analysis of outcomes for patients in remission at transplantation
Clinical Trials & Observations
A prospective PETHEMA study of tandem autologous transplantation versus autograft followed by reduced-intensity conditioning allogeneic transplantation in newly diagnosed multiple myeloma
HEMATOPOIESIS AND STEM CELLS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response
Telomerase activity of HIV-1–specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors
Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers
Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance
FcγR-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome
Cognitive and behavioral abnormalities in children after hematopoietic stem cell transplantation for severe congenital immunodeficiencies
Long-term follow-up results of IFM99-03 and IFM99-04 trials comparing nonmyeloablative allotransplantation with autologous transplantation in high-risk de novo multiple myeloma
Translocation of YFP-tagged p67phox during phagocytosis of IgG-zymosan. Image shown is from time-lapse confocal microscopy used to monitor phagocytosis of IgG-zymosan by PLB-985 neutrophils expressing YFP-tagged p67phox. For more details, see Figure 4A from Tian et al beginning on page 3867.
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