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Volume 112, Issue 6

September 15 2008

In this Issue

INSIDE BLOOD
ASH 50TH ANNIVERSARY REVIEWS
PLENARY PAPERS
REVIEW ARTICLES
HOW I TREAT
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
CLINICAL TRIALS AND OBSERVATIONS
GENE THERAPY
HEMATOPOIESIS AND STEM CELLS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
CORRESPONDENCE

Table of Contents

INSIDE BLOOD

CHEMOKINES

TPO signaling: when the tyrosines go marching in(side)

Roberto Pozner,Mirta Schattner

View Articletitled, TPO signaling: when the tyrosines go marching in(side)

CLINICAL OBSERVATIONS

Test-driving CARs

Laurence J. N. Cooper

View Articletitled, Test-driving CARs

CLINICAL OBSERVATIONS

MPDs: it's all in the family

Jerry L. Spivak

View Articletitled, MPDs: it's all in the family

HEMOSTASIS

Microparticles facilitate neutrophil/platelet crosstalk

Robert K. Andrews,Michael C. Berndt

View Articletitled, Microparticles facilitate neutrophil/platelet crosstalk

GENE THERAPY

Leukemia takes center (late) stage

Utpal P. Davé

View Articletitled, Leukemia takes center (late) stage

IMMUNOBIOLOGY

HTLV-1 infection: role of CTL efficiency

Charles R. M. Bangham

View Articletitled, HTLV-1 infection: role of CTL efficiency

NEOPLASIA

Many facets of bortezomib resistance/susceptibility

Shaji Kumar,S. Vincent Rajkumar

View Articletitled, Many facets of bortezomib resistance/susceptibility

NEOPLASIA

FIP1L1/PDGFRα's Kit to stimulate mast cells

Jan Cools

View Articletitled, FIP1L1/PDGFRα's <em>Kit</em> to stimulate mast cells

TRANSFUSION MEDICINE

Mining the possibilities behind RBC alloimmunization

Laura Cooling

View Articletitled, Mining the possibilities behind RBC alloimmunization

RED CELLS

Iron homeostasis: casting new roles

Karin E. Finberg

View Articletitled, Iron homeostasis: casting new roles

ASH 50TH ANNIVERSARY REVIEWS

Chromosomal translocations: revisited yet again

Janet D. Rowley

View Articletitled, Chromosomal translocations: revisited yet again

Myeloproliferative disorders

Ross L. Levine,D. Gary Gilliland

View Articletitled, Myeloproliferative disorders

PLENARY PAPERS

Increased risks of polycythemia vera, essential thrombocythemia, and myelofibrosis among 24 577 first-degree relatives of 11 039 patients with myeloproliferative neoplasms in Sweden

Ola Landgren,Lynn R. Goldin,Sigurdur Y. Kristinsson,Elin A. Helgadottir,Jan Samuelsson,Magnus Björkholm

View Articletitled, Increased risks of polycythemia vera, essential thrombocythemia, and myelofibrosis among 24 577 first-degree relatives of 11 039 patients with myeloproliferative neoplasms in Sweden

REVIEW ARTICLES

Toll-like receptors: lessons to learn from normal and malignant human B cells

David Chiron,Isabelle Bekeredjian-Ding,Catherine Pellat-Deceunynck,Régis Bataille,Gaëtan Jego

View Articletitled, Toll-like receptors: lessons to learn from normal and malignant human B cells

HOW I TREAT

How I treat cobalamin (vitamin B₁₂) deficiency

Ralph Carmel

View Articletitled, How I treat cobalamin (vitamin B<sub>12</sub>) deficiency

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation

Ian S. Hitchcock,Maximus M. Chen,Jennifer R. King,Kenneth Kaushansky

View Articletitled, YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation

CLINICAL TRIALS AND OBSERVATIONS

Outcome of alloanergized haploidentical bone marrow transplantation after ex vivo costimulatory blockade: results of 2 phase 1 studies
Clinical Trials & Observations

Jeff K. Davies,John G. Gribben,Lisa L. Brennan,Dongin Yuk,Lee M. Nadler,Eva C. Guinan

View Articletitled, Outcome of alloanergized haploidentical bone marrow transplantation after ex vivo costimulatory blockade: results of 2 phase 1 studies

A dose-ranging study evaluating once-daily oral administration of the factor Xa inhibitor rivaroxaban in the treatment of patients with acute symptomatic deep vein thrombosis: the Einstein–DVT Dose-Ranging Study
Clinical Trials & Observations

Harry R. Buller,Anthonie W. A. Lensing,Martin H. Prins,Giancarlo Agnelli,Alexander Cohen,Alexander S. Gallus,Frank Misselwitz,Gary Raskob,Sebastian Schellong,Annelise Segers,on behalf of the Einstein–DVT Dose-Ranging Study investigators

View Articletitled, A dose-ranging study evaluating once-daily oral administration of the factor Xa inhibitor rivaroxaban in the treatment of patients with acute symptomatic deep vein thrombosis: the Einstein–DVT Dose-Ranging Study

Supplemental data

A prospective clinicopathologic study of dose-modified CODOX-M/IVAC in patients with sporadic Burkitt lymphoma defined using cytogenetic and immunophenotypic criteria (MRC/NCRI LY10 trial)
Clinical Trials & Observations

Graham M. Mead,Sharon L. Barrans,Wendi Qian,Jan Walewski,John A. Radford,Max Wolf,Simon M. Clawson,Sally P. Stenning,Claire L. Yule,Andrew S. Jack,on behalf of the UK National Cancer Research Institute Lymphoma Clinical Studies Group and the Australasian Leukaemia and Lymphoma Group

View Articletitled, A prospective clinicopathologic study of dose-modified CODOX-M/IVAC in patients with sporadic Burkitt lymphoma defined using cytogenetic and immunophenotypic criteria (MRC/NCRI LY10 trial)

Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells
Clinical Trials & Observations

Brian G. Till,Michael C. Jensen,Jinjuan Wang,Eric Y. Chen,Brent L. Wood,Harvey A. Greisman,Xiaojun Qian,Scott E. James,Andrew Raubitschek,Stephen J. Forman,Ajay K. Gopal,John M. Pagel,Catherine G. Lindgren,Philip D. Greenberg,Stanley R. Riddell,Oliver W. Press

View Articletitled, Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells

Supplemental data

Soluble CD22 as a tumor marker for hairy cell leukemia
Clinical Trials & Observations

Kakushi Matsushita,Inger Margulies,Masanori Onda,Satoshi Nagata,Maryalice Stetler-Stevenson,Robert J. Kreitman

View Articletitled, Soluble CD22 as a tumor marker for hairy cell leukemia

GENE THERAPY

Resistance of mature T cells to oncogene transformation

Sebastian Newrzela,Kerstin Cornils,Zhixiong Li,Christopher Baum,Martijn H. Brugman,Marianne Hartmann,Johann Meyer,Sylvia Hartmann,Martin-Leo Hansmann,Boris Fehse,Dorothee von Laer

View Articletitled, Resistance of mature T cells to oncogene transformation

Supplemental data

HEMATOPOIESIS AND STEM CELLS

spib is required for primitive myeloid development in Xenopus

Ricardo M. B. Costa,Ximena Soto,Yaoyao Chen,Aaron M. Zorn,Enrique Amaya

View Articletitled, <em>spib</em> is required for primitive myeloid development in <em>Xenopus</em>

Supplemental data

FLT3 ligand and not TSLP is the key regulator of IL-7–independent B-1 and B-2 B lymphopoiesis

Christina T. Jensen,Shabnam Kharazi,Charlotta Böiers,Min Cheng,Anna Lübking,Ewa Sitnicka,Sten Eirik W. Jacobsen

View Articletitled, FLT3 ligand and not TSLP is the key regulator of IL-7–independent B-1 and B-2 B lymphopoiesis

Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation

Meaghan Wall,Gretchen Poortinga,Katherine M. Hannan,Richard B. Pearson,Ross D. Hannan,Grant A. McArthur

View Articletitled, Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation

Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Transcriptional profiling of VEGF-A and VEGF-C target genes in lymphatic endothelium reveals endothelial-specific molecule-1 as a novel mediator of lymphangiogenesis

Jay W. Shin,Reto Huggenberger,Michael Detmar

View Articletitled, Transcriptional profiling of VEGF-A and VEGF-C target genes in lymphatic endothelium reveals endothelial-specific molecule-1 as a novel mediator of lymphangiogenesis

Supplemental data

Expression, activation, and function of integrin α_Mβ₂ (Mac-1) on neutrophil-derived microparticles

Elzbieta Pluskota,Neil M. Woody,Dorota Szpak,Christie M. Ballantyne,Dmitry A. Soloviev,Daniel I. Simon,Edward F. Plow

View Articletitled, Expression, activation, and function of integrin α<sub>M</sub>β<sub>2</sub> (Mac-1) on neutrophil-derived microparticles

A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo
Brief Report

Yoshiaki Okada,Enjing Jin,Vesna Nikolova-Krstevski,Kiichiro Yano,Ju Liu,David Beeler,Katherine Spokes,Mie Kitayama,Nobuaki Funahashi,Takefumi Doi,Lauren Janes,Takashi Minami,Peter Oettgen,William C. Aird

View Articletitled, A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo

Supplemental data

IMMUNOBIOLOGY

Human CD25^highFoxp3^pos regulatory T cells differentiate into IL-17–producing cells

Hans J. P. M. Koenen,Ruben L. Smeets,Paul M. Vink,Esther van Rijssen,Annemieke M. H. Boots,Irma Joosten

View Articletitled, Human CD25<sup>high</sup>Foxp3<sup>pos</sup> regulatory T cells differentiate into IL-17–producing cells

Supplemental data

A role for multidrug resistance protein 4 (MRP4; ABCC4) in human dendritic cell migration

Rieneke van de Ven,George L. Scheffer,Anneke W. Reurs,Jelle J. Lindenberg,Ruud Oerlemans,Gerrit Jansen,Jean-Pierre Gillet,Joel N. Glasgow,Alexander Pereboev,David T. Curiel,Rik J. Scheper,Tanja D. de Gruijl

View Articletitled, A role for multidrug resistance protein 4 (MRP4; ABCC4) in human dendritic cell migration

Requirement of TLR2-mediated signaling for the induction of IL-15 gene expression in human monocytic cells by HSV-1

Rasheed Ahmad,Souad El Bassam,Paulo Cordeiro,José Menezes

View Articletitled, Requirement of TLR2-mediated signaling for the induction of IL-15 gene expression in human monocytic cells by HSV-1

MHC class I–specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response

Makoto Yawata,Nobuyo Yawata,Monia Draghi,Fotini Partheniou,Ann-Margaret Little,Peter Parham

View Articletitled, MHC class I–specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response

Supplemental data

Two opposite signaling outputs are driven by the KIR2DL1 receptor in human CD4⁺ T cells

Emmanuelle Fourmentraux-Neves,Abdelali Jalil,Sylvie Da Rocha,Christophe Pichon,Salem Chouaib,Georges Bismuth,Anne Caignard

View Articletitled, Two opposite signaling outputs are driven by the KIR2DL1 receptor in human CD4<sup>+</sup> T cells

Antibody fucosylation differentially impacts cytotoxicity mediated by NK and PMN effector cells

Matthias Peipp,Jeroen J. Lammerts van Bueren,Tanja Schneider-Merck,Wim W. K. Bleeker,Michael Dechant,Thomas Beyer,Roland Repp,Patrick H. C. van Berkel,Tom Vink,Jan G. J. van de Winkel,Paul W. H. I. Parren,Thomas Valerius

View Articletitled, Antibody fucosylation differentially impacts cytotoxicity mediated by NK and PMN effector cells

Supplemental data

Retrovirally induced CTL degranulation mediated by IL-15 expression and infection of mononuclear phagocytes in patients with HTLV-I–associated neurologic disease

Yoshimi Enose-Akahata,Unsong Oh,Christian Grant,Steven Jacobson

View Articletitled, Retrovirally induced CTL degranulation mediated by IL-15 expression and infection of mononuclear phagocytes in patients with HTLV-I–associated neurologic disease

Impaired function of human T-lymphotropic virus type 1 (HTLV-1)–specific CD8⁺ T cells in HTLV-1–associated neurologic disease

Amir H. Sabouri,Koichiro Usuku,Daisuke Hayashi,Shuji Izumo,Yoshiro Ohara,Mitsuhiro Osame,Mineki Saito

View Articletitled, Impaired function of human T-lymphotropic virus type 1 (HTLV-1)–specific CD8<sup>+</sup> T cells in HTLV-1–associated neurologic disease

Supplemental data

Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-κB and MAPK activation to selectively control cytokine production

Olaf Gross,Christina Grupp,Christian Steinberg,Stephanie Zimmermann,Dominikus Strasser,Nicole Hannesschläger,Wolfgang Reindl,Helena Jonsson,Hairong Huo,Dan R. Littman,Christian Peschel,Wayne M. Yokoyama,Anne Krug,Jürgen Ruland

View Articletitled, Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-κB and MAPK activation to selectively control cytokine production

NEOPLASIA

The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneity

Chloe James,Frederic Mazurier,Sabrina Dupont,Ronan Chaligne,Isabelle Lamrissi-Garcia,Micheline Tulliez,Eric Lippert,François-Xavier Mahon,Jean-Max Pasquet,Gabriel Etienne,François Delhommeau,Stephane Giraudier,William Vainchenker,Hubert de Verneuil

View Articletitled, The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneity

Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor–induced DNA damage in vitro and in vivo in human multiple myeloma cells

Yun Dai,Shuang Chen,Xin-Yan Pei,Jorge A. Almenara,Lora B. Kramer,Charis A. Venditti,Paul Dent,Steven Grant

View Articletitled, Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor–induced DNA damage in vitro and in vivo in human multiple myeloma cells

Supplemental data

Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways

Paolo Lunghi,Nicola Giuliani,Laura Mazzera,Guerino Lombardi,Micaela Ricca,Attilio Corradi,Anna Maria Cantoni,Luigi Salvatore,Roberta Riccioni,Antonio Costanzo,Ugo Testa,Massimo Levrero,Vittorio Rizzoli,Antonio Bonati

View Articletitled, Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways

Supplemental data

Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade

Noria Harir,Cédric Boudot,Katrin Friedbichler,Karoline Sonneck,Rudin Kondo,Séverine Martin-Lannerée,Lukas Kenner,Marc Kerenyi,Saliha Yahiaoui,Valérie Gouilleux-Gruart,Jean Gondry,Laurence Bénit,Isabelle Dusanter-Fourt,Kaïss Lassoued,Peter Valent,Richard Moriggl,Fabrice Gouilleux

View Articletitled, Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade

Supplemental data

TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in mice

Yun Zhou,Wei Du,Tara Koretsky,Grover C. Bagby,Qishen Pang

View Articletitled, TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in mice

Supplemental data

Clinical and in vitro resistance to bexarotene in adult T-cell leukemia: loss of RXR-α receptor

Julie H. Lin,Ellen J. Kim,Anand Bansal,John Seykora,Stephen K. Richardson,Xian-Yuan Cha,Sarosh Zafar,Sunita Nasta,Maria Wysocka,Bernice Benoit,Alain H. Rook,Steven S. Fakharzadeh

View Articletitled, Clinical and in vitro resistance to bexarotene in adult T-cell leukemia: loss of RXR-α receptor

Molecular basis of bortezomib resistance: proteasome subunit β5 (PSMB5) gene mutation and overexpression of PSMB5 protein

Ruud Oerlemans,Niels E. Franke,Yehuda G. Assaraf,Jacqueline Cloos,Ina van Zantwijk,Celia R. Berkers,George L. Scheffer,Kabir Debipersad,Katharina Vojtekova,Clara Lemos,Joost W. van der Heijden,Bauke Ylstra,Godefridus J. Peters,Gertjan L. Kaspers,Ben A. C. Dijkmans,Rik J. Scheper,Gerrit Jansen

View Articletitled, Molecular basis of bortezomib resistance: proteasome subunit β5 (<em>PSMB5</em>) gene mutation and overexpression of PSMB5 protein

Supplemental data

FIP1L1/PDGFRα synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndrome

Yoshiyuki Yamada,Abel Sanchez-Aguilera,Eric B. Brandt,Melissa McBride,Nabeel J. H. Al-Moamen,Fred D. Finkelman,David A. Williams,Jose A. Cancelas,Marc E. Rothenberg

View Articletitled, FIP1L1/PDGFRα synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndrome

Supplemental data

The Mll partial tandem duplication: differential, tissue-specific activity in the presence or absence of the wild-type allele
Brief Report

Adrienne M. Dorrance,Shujun Liu,Anita Chong,Benjamin Pulley,David Nemer,Martin Guimond,Weifeng Yuan,Dennis Chang,Susan P. Whitman,Guido Marcucci,Michael A. Caligiuri

View Articletitled, The <em>Mll</em> partial tandem duplication: differential, tissue-specific activity in the presence or absence of the wild-type allele

PHAGOCYTES

Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles

Jesmond Dalli,Lucy V. Norling,Derek Renshaw,Dianne Cooper,Kit-Yi Leung,Mauro Perretti

View Articletitled, Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles

RED CELLS

Retention of Plasmodium falciparum ring-infected erythrocytes in the slow, open microcirculation of the human spleen

Innocent Safeukui,Jean-Michel Correas,Valentine Brousse,Déborah Hirt,Guillaume Deplaine,Sébastien Mulé,Mickael Lesurtel,Nicolas Goasguen,Alain Sauvanet,Anne Couvelard,Sophie Kerneis,Huot Khun,Inès Vigan-Womas,Catherine Ottone,Thierry Jo Molina,Jean-Marc Tréluyer,Odile Mercereau-Puijalon,Geneviève Milon,Peter H. David,Pierre A. Buffet

View Articletitled, Retention of <em>Plasmodium falciparum</em> ring-infected erythrocytes in the slow, open microcirculation of the human spleen

Supplemental data

Histopathology of experimentally induced asthma in a murine model of sickle cell disease

Sandhya D. Nandedkar,Thomas R. Feroah,William Hutchins,Dorothee Weihrauch,Kameswari S. Konduri,Jingli Wang,Robert C. Strunk,Michael R. DeBaun,Cheryl A. Hillery,Kirkwood A. Pritchard

View Articletitled, Histopathology of experimentally induced asthma in a murine model of sickle cell disease

Supplemental data

Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis

Alicia R. Folgueras,Fernando Martín de Lara,Alberto M. Pendás,Cecilia Garabaya,Francisco Rodríguez,Aurora Astudillo,Teresa Bernal,Rubén Cabanillas,Carlos López-Otín,Gloria Velasco

View Articletitled, Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis

Supplemental data

TRANSFUSION MEDICINE

Stochastic modeling of human RBC alloimmunization: evidence for a distinct population of immunologic responders

John M. Higgins,Steven R. Sloan

View Articletitled, Stochastic modeling of human RBC alloimmunization: evidence for a distinct population of immunologic responders

TRANSPLANTATION

Efficient generation of human alloantigen-specific CD4⁺ regulatory T cells from naive precursors by CD40-activated B cells

Wenwei Tu,Yu-Lung Lau,Jian Zheng,Yinping Liu,Ping-Lung Chan,Huawei Mao,Kira Dionis,Pascal Schneider,David B. Lewis

View Articletitled, Efficient generation of human alloantigen-specific CD4<sup>+</sup> regulatory T cells from naive precursors by CD40-activated B cells

Supplemental data

In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity

Ryosei Nishimura,Jeanette Baker,Andreas Beilhack,Robert Zeiser,Janelle A. Olson,Emanuela I. Sega,Mobin Karimi,Robert S. Negrin

View Articletitled, In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity

Supplemental data

Role of GM-CSF in tolerance induction by mobilized hematopoietic progenitors
Brief Report

Hassen Kared,Bertrand Leforban,Ruddy Montandon,Amédée Renand,Esther Layseca Espinosa,Lucienne Chatenoud,Yvonne Rosenstein,Elke Schneider,Michel Dy,Flora Zavala

View Articletitled, Role of GM-CSF in tolerance induction by mobilized hematopoietic progenitors

Supplemental data

Chronic graft-versus-host disease following umbilical cord blood transplantation: retrospective survey involving 1072 patients in Japan
Brief Report

Hiroto Narimatsu,Shigesaburo Miyakoshi,Takuhiro Yamaguchi,Masahiro Kami,Tomoko Matsumura,Koichiro Yuji,Naoko Murashige,Eiji Kusumi,Yuko Kodama,Tsunehiko Komatsu,Hisashi Sakamaki,Yasushi Kouzai,Masaya Okada,Yuko Osugi,Ryoji Kobayashi,Masami Inoue,Satoshi Takahashi,Shunro Kai,Koji Kato,Tokiko Inoue-Nagamura,Shuichi Taniguchi,Shunichi Kato,for the Japan Cord Blood Bank Network

View Articletitled, Chronic graft-versus-host disease following umbilical cord blood transplantation: retrospective survey involving 1072 patients in Japan

Supplemental data

CORRESPONDENCE

Mantle Cell International Prognostic Index (MIPI) not prognostic after R-hyper-CVAD

Jatin J. Shah,Luis Fayad,Jorge Romaguera

View Articletitled, Mantle Cell International Prognostic Index (MIPI) not prognostic after R-hyper-CVAD

Response: Statistical power and validation of the MIPI

Eva Hoster,Martin Dreyling,Michael Unterhalt,for the German Low-Grade Lymphoma Study Group (GLSG) and the European MCL Network

View Articletitled, Response: Statistical power and validation of the MIPI

Fully human monoclonal antibodies and targeted radionuclide therapy

Tod W. Speer

View Articletitled, Fully human monoclonal antibodies and targeted radionuclide therapy

Response: Multiple administrations of the fully human monoclonal antibody Ofatumumab

Anton Hagenbeek

View Articletitled, Response: Multiple administrations of the fully human monoclonal antibody Ofatumumab

Nonmyeloablative conditioning for relapsed follicular lymphoma

Koen van Besien,Parameswaran Hari

View Articletitled, Nonmyeloablative conditioning for relapsed follicular lymphoma

Response: Choice of conditioning for allogeneic transplantation in follicular lymphoma: nonmyeloablative or high-dose chemotherapy?

Issa F. Khouri

View Articletitled, Response: Choice of conditioning for allogeneic transplantation in follicular lymphoma: nonmyeloablative or high-dose chemotherapy?

Disease anticipation in familial myeloproliferative neoplasms

Elisa Rumi,Francesco Passamonti,Cristina Picone,Matteo Giovanni Della Porta,Cristiana Pascutto,Mario Cazzola,Mario Lazzarino

View Articletitled, Disease anticipation in familial myeloproliferative neoplasms

Response: More on disease anticipation in familial MPN

Ola Landgren,Lynn R. Goldin,Sigurdur Y. Kristinsson,Elin A. Helgadottir,Jan Samuelsson,Magnus Bjorkholm

View Articletitled, Response: More on disease anticipation in familial MPN

A mechanism for the HLA-A*01–associated risk for EBV⁺ Hodgkin lymphoma and infectious mononucleosis

Rebekah M. Brennan,Scott R. Burrows

View Articletitled, A mechanism for the HLA-A*01–associated risk for EBV<sup>+</sup> Hodgkin lymphoma and infectious mononucleosis

Kindlin-3: a new gene involved in the pathogenesis of LAD-III

Adi Mory,Sara W. Feigelson,Nese Yarali,Sara S. Kilic,Gulsum I. Bayhan,Ruth Gershoni-Baruch,Amos Etzioni,Ronen Alon

View Articletitled, Kindlin-3: a new gene involved in the pathogenesis of LAD-III

Supplemental data

Cover Image

Cover Image

Partial karyotypes of leukemia-associated chromosomal translocations discovered by Dr Janet Rowley and described in the article that begins on page 2183.
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