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Issue Archive

Volume 112, Issue 2
July 15 2008
Issue Cover

Table of Contents

INSIDE BLOOD

HEMATOPOIESIS & STEM CELLS
Culling for survival
André Catic
View Articletitled, Culling for survival
TRANSPLANTATION
Allografting in ALL: the net widens
Jacob M. Rowe
View Articletitled, Allografting in ALL: the net widens
TRANSPLANTATION
How killers kill
Jeffrey S. Miller
View Articletitled, How killers kill
IMMUNOBIOLOGY
Th17 and cancer: friends or foes?
Vincenzo Bronte
View Articletitled, Th17 and cancer: friends or foes?
HEMATOPOIESIS & STEM CELLS
Unsweetened Notch leads to myeloproliferation
Robert S. Haltiwanger
View Articletitled, Unsweetened Notch leads to myeloproliferation
CHEMOKINES
Housekeeping by chemokine scavenging
Alberto Mantovani,Massimo Locati
View Articletitled, Housekeeping by chemokine scavenging
NEOPLASIA
Wnt signaling: bone's defense against myeloma
Claire M. Edwards
View Articletitled, Wnt signaling: bone's defense against myeloma
HEMATOPOIESIS & STEM CELLS
A new window on MSCs
Ernestina Schipani
View Articletitled, A new window on MSCs
HEMOSTASIS
Endothelial cells are not all alike
Hau C. Kwaan
View Articletitled, Endothelial cells are not all alike

ASH 50TH ANNIVERSARY REVIEW

Forging a field: the golden age of iron biology
Nancy C. Andrews
View Articletitled, Forging a field: the golden age of iron biology

PERSPECTIVE

The revised World Health Organization diagnostic criteria for polycythemia vera, essential thrombocytosis, and primary myelofibrosis: an alternative proposal
Jerry L. Spivak,Richard T. Silver
View Articletitled, The revised World Health Organization diagnostic criteria for polycythemia vera, essential thrombocytosis, and primary myelofibrosis: an alternative proposal

REVIEW ARTICLES

Dynamics of factor VIII interactions determine its immunologic fate in hemophilia A
Sébastien Lacroix-Desmazes,Ana-Maria Navarrete,Sébastien André,Jagadeesh Bayry,Srinivas V. Kaveri,Suryasarathi Dasgupta
View Articletitled, Dynamics of factor VIII interactions determine its immunologic fate in hemophilia A

HOW I TREAT

Acquired factor VIII inhibitors
Massimo Franchini,Giuseppe Lippi
View Articletitled, Acquired factor VIII inhibitors

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues
Astrid E. Cardona,Margaret E. Sasse,Liping Liu,Sandra M. Cardona,Makiko Mizutani,Carine Savarin,Taofang Hu,Richard M. Ransohoff
View Articletitled, Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues
Supplemental data
Coactivator function of RIP140 for NFκB/RelA-dependent cytokine gene expression
Inka Zschiedrich,Ulrike Hardeland,Anja Krones-Herzig,Mauricio Berriel Diaz,Alexandros Vegiopoulos,Johannes Müggenburg,Dirk Sombroek,Thomas G. Hofmann,Rainer Zawatzky,Xiaolei Yu,Norbert Gretz,Mark Christian,Roger White,Malcolm G. Parker,Stephan Herzig
View Articletitled, Coactivator function of RIP140 for NFκB/RelA-dependent cytokine gene expression
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Common variable immunodeficiency disorders: division into distinct clinical phenotypes
Clinical Trials & Observations
Helen Chapel,Mary Lucas,Martin Lee,Janne Bjorkander,David Webster,Bodo Grimbacher,Claire Fieschi,Vojtech Thon,Mohammad R. Abedi,Lennart Hammarstrom
View Articletitled, Common variable immunodeficiency disorders: division into distinct clinical phenotypes
Supplemental data
Idiopathic CD4+ lymphocytopenia: natural history and prognostic factors
Clinical Trials & Observations
Dimitrios I. Zonios,Judith Falloon,John E. Bennett,Pamela A. Shaw,Doreen Chaitt,Michael W. Baseler,Joseph W. Adelsberger,Julia A. Metcalf,Michael A. Polis,Stephen J. Kovacs,Joseph A. Kovacs,Richard T. Davey,H. Clifford Lane,Henry Masur,Irini Sereti
View Articletitled, Idiopathic CD4<sup>+</sup> lymphocytopenia: natural history and prognostic factors

HEMATOPOIESIS AND STEM CELLS

PDGF, TGF-β, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages
Felicia Ng,Shayne Boucher,Susie Koh,Konduru S. R. Sastry,Lucas Chase,Uma Lakshmipathy,Cleo Choong,Zheng Yang,Mohan C. Vemuri,Mahendra S. Rao,Vivek Tanavde
View Articletitled, PDGF, TGF-β, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages
Supplemental data
Notch-dependent control of myelopoiesis is regulated by fucosylation
Lan Zhou,Lebing Wei Li,Quanjian Yan,Bronislawa Petryniak,Yunfang Man,Charles Su,Jeongsup Shim,Stephanie Chervin,John B. Lowe
View Articletitled, Notch-dependent control of myelopoiesis is regulated by fucosylation
Supplemental data
Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis
David L. Waning,Binghui Li,Nan Jia,Yahaira Naaldijk,W. Scott Goebel,Harm HogenEsch,Kristin T. Chun
View Articletitled, <em>Cul4A</em> is required for hematopoietic cell viability and its deficiency leads to apoptosis

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response
Olga V. Oskolkova,Taras Afonyushkin,Alexander Leitner,Elena von Schlieffen,Peter S. Gargalovic,Aldons J. Lusis,Bernd R. Binder,Valery N. Bochkov
View Articletitled, ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized <em>sn</em>-2 residues in activation of unfolded protein response
Supplemental data
Synergistic interactions between interferon-γ and TRAIL modulate c-FLIP in endothelial cells, mediating their lineage-specific sensitivity to thrombotic thrombocytopenic purpura plasma–associated apoptosis
Radu Stefanescu,Dustin Bassett,Rozbeh Modarresi,Francisco Santiago,Mohamad Fakruddin,Jeffrey Laurence
View Articletitled, Synergistic interactions between interferon-γ and TRAIL modulate c-FLIP in endothelial cells, mediating their lineage-specific sensitivity to thrombotic thrombocytopenic purpura plasma–associated apoptosis
Interleukin-3 promotes expansion of hemopoietic-derived CD45+ angiogenic cells and their arterial commitment via STAT5 activation
Annarita Zeoli,Patrizia Dentelli,Arturo Rosso,Gabriele Togliatto,Antonella Trombetta,Laura Damiano,Paola Francia di Celle,Luigi Pegoraro,Fiorella Altruda,Maria Felice Brizzi
View Articletitled, Interleukin-3 promotes expansion of hemopoietic-derived CD45<sup>+</sup> angiogenic cells and their arterial commitment via STAT5 activation
Supplemental data

IMMUNOBIOLOGY

Tumor-specific Th17-polarized cells eradicate large established melanoma
Pawel Muranski,Andrea Boni,Paul A. Antony,Lydie Cassard,Kari R. Irvine,Andrew Kaiser,Chrystal M. Paulos,Douglas C. Palmer,Christopher E. Touloukian,Krzysztof Ptak,Luca Gattinoni,Claudia Wrzesinski,Christian S. Hinrichs,Keith W. Kerstann,Lionel Feigenbaum,Chi-Chao Chan,Nicholas P. Restifo
View Articletitled, Tumor-specific Th17-polarized cells eradicate large established melanoma
Supplemental data

NEOPLASIA

Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth
Ya-Wei Qiang,John D. Shaughnessy, Jr,Shmuel Yaccoby
View Articletitled, Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth
Down-regulation of TCF8 is involved in the leukemogenesis of adult T-cell leukemia/lymphoma
Tomonori Hidaka,Shingo Nakahata,Kinta Hatakeyama,Makoto Hamasaki,Kiyoshi Yamashita,Takashi Kohno,Yasuhito Arai,Tomohiko Taki,Kazuhiro Nishida,Akihiko Okayama,Yujiro Asada,Ryoji Yamaguchi,Hirohito Tsubouchi,Jun Yokota,Masafumi Taniwaki,Yujiro Higashi,Kazuhiro Morishita
View Articletitled, Down-regulation of TCF8 is involved in the leukemogenesis of adult T-cell leukemia/lymphoma
Supplemental data
SAGE analysis demonstrates increased expression of TOSO contributing to Fas-mediated resistance in CLL
Brief Report
Rodrigo Proto-Siqueira,Rodrigo A. Panepucci,Francisco P. Careta,Abigail Lee,Andrew Clear,Kelly Morris,Carolyn Owen,Edgar G. Rizzatti,Wilson A. Silva, Jr,Roberto P. Falcão,Marco A. Zago,John G. Gribben
View Articletitled, SAGE analysis demonstrates increased expression of TOSO contributing to Fas-mediated resistance in CLL
Supplemental data

RED CELLS

Vascular dysfunction in a murine model of severe hemolysis
Anne C. Frei,YiHe Guo,Deron W. Jones,Kirkwood A. Pritchard, Jr,Karen A. Fagan,Neil Hogg,Nancy J. Wandersee
View Articletitled, Vascular dysfunction in a murine model of severe hemolysis
H3 K79 dimethylation marks developmental activation of the β-globin gene but is reduced upon LCR-mediated high-level transcription
Tomoyuki Sawado,Jessica Halow,Hogune Im,Tobias Ragoczy,Emery H. Bresnick,M. A. Bender,Mark Groudine
View Articletitled, H3 K79 dimethylation marks developmental activation of the β-<em>globin</em> gene but is reduced upon LCR-mediated high-level transcription
Supplemental data

TRANSPLANTATION

Reduced-toxicity conditioning with fludarabine, BCNU, and melphalan in allogeneic hematopoietic cell transplantation: particular activity against advanced hematologic malignancies
Reinhard Marks,Karin Potthoff,Joachim Hahn,Gabriele Ihorst,Hartmut Bertz,Alexandros Spyridonidis,Ernst Holler,Jürgen M. Finke
View Articletitled, Reduced-toxicity conditioning with fludarabine, BCNU, and melphalan in allogeneic hematopoietic cell transplantation: particular activity against advanced hematologic malignancies
Unrelated donor transplants in adults with Philadelphia-negative acute lymphoblastic leukemia in first complete remission
David I. Marks,Waleska S. Pérez,Wensheng He,Mei-Jie Zhang,Michael R. Bishop,Brian J. Bolwell,Christopher N. Bredeson,Edward A. Copelan,Robert Peter Gale,Vikas Gupta,Gregory A. Hale,Luis M. Isola,Ann A. Jakubowski,Armand Keating,Thomas R. Klumpp,Hillard M. Lazarus,Jane L. Liesveld,Richard T. Maziarz,Philip L. McCarthy,Mitchell Sabloff,Gary Schiller,Jorge Sierra,Martin S. Tallman,Edmund K. Waller,Peter H. Wiernik,Daniel J. Weisdorf
View Articletitled, Unrelated donor transplants in adults with Philadelphia-negative acute lymphoblastic leukemia in first complete remission
The reactivity of Bw4+ HLA-B and HLA-A alleles with KIR3DL1: implications for patient and donor suitability for haploidentical stem cell transplantations
Bree A. Foley,Dianne De Santis,Els Van Beelen,Louise J. Lathbury,Frank T. Christiansen,Campbell S. Witt
View Articletitled, The reactivity of Bw4<sup>+</sup> HLA-B and HLA-A alleles with KIR3DL1: implications for patient and donor suitability for haploidentical stem cell transplantations

CORRESPONDENCE

Conflicting data on the prognostic significance of FLT3/TKD mutations in acute myeloid leukemia might be related to the incidence of biallelic disease
Adam J. Mead,Rosemary E. Gale,Robert K. Hills,Manu Gupta,Bryan D. Young,Alan K. Burnett,David C. Linch
View Articletitled, Conflicting data on the prognostic significance of <em>FLT3</em>/TKD mutations in acute myeloid leukemia might be related to the incidence of biallelic disease
Response: Conflicting data on the prognostic significance of FLT3-TKD mutations in cytogenetically normal acute myeloid leukemia (CN-AML) might be related to many factors, including techniques used to detect FLT3-TKD, differences in patient populations studied, and treatment regimens
Susan P. Whitman,Guido Marcucci,Amy S. Ruppert,Krzysztof Mrózek,Clara D. Bloomfield
View Articletitled, Response: Conflicting data on the prognostic significance of <em>FLT3</em>-TKD mutations in cytogenetically normal acute myeloid leukemia (CN-AML) might be related to many factors, including techniques used to detect <em>FLT3</em>-TKD, differences in patient populations studied, and treatment regimens
T-cell homeostasis: the dark(ened) side of common variable immunodeficiency
Antonello Giovannetti,Marina Pierdominici,Fernando Aiuti
View Articletitled, T-cell homeostasis: the dark(ened) side of common variable immunodeficiency
Response: Improving classification in CVID
Claudia Wehr,Hans Hartmut Peter,Klaus Warnatz
View Articletitled, Response: Improving classification in CVID
Hematopoietic stem cell transplantation from unrelated donors for acute leukemia
Jayesh Mehta
View Articletitled, Hematopoietic stem cell transplantation from unrelated donors for acute leukemia
Response: Unrelated donor transplantation for adults with Ph− ALL in first complete remission
David I. Marks,Daniel J. Weisdorf,Mei-Jie Zhang
View Articletitled, Response: Unrelated donor transplantation for adults with Ph<sup>−</sup> ALL in first complete remission
Hemoglobin normalization after splenectomy in a paroxysmal nocturnal hemoglobinuria patient treated by eculizumab
Antonio M. Risitano,Ludovica Marando,Elisa Seneca,Bruno Rotoli
View Articletitled, Hemoglobin normalization after splenectomy in a paroxysmal nocturnal hemoglobinuria patient treated by eculizumab

ERRATUM

Hochhaus et al. Favorable long-term follow-up results over 6 years for response, survival, and safety with imatinib mesylate therapy in chronic-phase chronic myeloid leukemia after failure of interferon-α treatment. Blood. 2008;111:1039-1043.
View Articletitled, Hochhaus et al. Favorable long-term follow-up results over 6 years for response, survival, and safety with imatinib mesylate therapy in chronic-phase chronic myeloid leukemia after failure of interferon-α treatment. Blood. 2008;111:1039-1043.
Antica et al. Aberrant Ikaros, Aiolos, and Helios expression in Hodgkin and non-Hodgkin lymphoma. Blood. 2008;111:3296-3297.
View Articletitled, Antica et al. Aberrant Ikaros, Aiolos, and Helios expression in Hodgkin and non-Hodgkin lymphoma. Blood. 2008;111:3296-3297.
Reed. Bcl-2–family proteins and hematologic malignancies: history and future prospects. Blood. 2008;111:3322-3330.
View Articletitled, Reed. Bcl-2–family proteins and hematologic malignancies: history and future prospects. Blood. 2008;111:3322-3330.
Guasparri et al. EBV LMP2A affects LMP1-mediated NF-κB signaling and survival of lymphoma cells by regulating TRAF2 expression. Blood. 2008;111:3813-3820.
View Articletitled, Guasparri et al. EBV LMP2A affects LMP1-mediated NF-κB signaling and survival of lymphoma cells by regulating TRAF2 expression. Blood. 2008;111:3813-3820.
All Issues

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