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Volume 112, Issue 13

December 15 2008

Blood Cover Image for Volume 112, Issue 13

In this Issue

INSIDE BLOOD
ASH 50TH ANNIVERSARY REVIEW
HOW I TREAT
CLINICAL TRIALS AND OBSERVATIONS
GENE THERAPY
HEMATOPOIESIS AND STEM CELLS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
ERRATUM

Table of Contents

INSIDE BLOOD

NEOPLASIA

Wnt-erizing mantle cell lymphoma

Stephen M. Ansell

View Articletitled, Wnt-erizing mantle cell lymphoma

HEMOSTASIS

UV-C irradiation gives platelets a sunburn

Joel S. Bennett

View Articletitled, UV-C irradiation gives platelets a sunburn

NEOPLASIA

The yin and yang of lenalidomide

Neil E. Kay

View Articletitled, The yin and yang of lenalidomide

HEMATOPOIESIS & STEM CELLS

GATA-1: one TEF customer

Stephen J. Brandt

View Articletitled, GATA-1: one TEF customer

NEOPLASIA

Dis-Abl-ing CD40 buys toxic assets

John Gordon

View Articletitled, Dis-Abl-ing CD40 buys toxic assets

PHAGOCYTES

PI3K and NADPH oxidase: a class act

Adam D. Kennedy,Frank R. DeLeo

View Articletitled, PI3K and NADPH oxidase: a class act

IMMUNOBIOLOGY

Ly49 receptors: not always a class I act?

Colin G. Brooks

View Articletitled, Ly49 receptors: not always a class I act?

TRANSPLANTATION

Transplantation NK'Oed in the first trimester

Marcus O. Muench

View Articletitled, Transplantation NK'Oed in the first trimester

ASH 50TH ANNIVERSARY REVIEW

Stem cell concepts renew cancer research

John E. Dick

View Articletitled, Stem cell concepts renew cancer research

Translation of the Philadelphia chromosome into therapy for CML

Brian J. Druker

View Articletitled, Translation of the Philadelphia chromosome into therapy for CML

HOW I TREAT

How I treat rare venous thromboses

Ida Martinelli,Massimo Franchini,Pier Mannuccio Mannucci

View Articletitled, How I treat rare venous thromboses

CLINICAL TRIALS AND OBSERVATIONS

Rituximab combined with chemotherapy and interferon in follicular lymphoma patients: results of the GELA-GOELAMS FL2000 study
Clinical Trials & Observations

Gilles Salles,Nicolas Mounier,Sophie de Guibert,Franck Morschhauser,Chantal Doyen,Jean-François Rossi,Corinne Haioun,Pauline Brice,Béatrice Mahé,Reda Bouabdallah,Bruno Audhuy,Christophe Ferme,Caroline Dartigeas,Pierre Feugier,Catherine Sebban,Luc Xerri,Charles Foussard

View Articletitled, Rituximab combined with chemotherapy and interferon in follicular lymphoma patients: results of the GELA-GOELAMS FL2000 study

Supplemental data

Pharmacokinetics, pharmacodynamics, efficacy, and safety of a new recombinant asparaginase preparation in children with previously untreated acute lymphoblastic leukemia: a randomized phase 2 clinical trial
Clinical Trials & Observations

Rob Pieters,Inge Appel,Hans-Juergen Kuehnel,Iris Tetzlaff-Fohr,Uwe Pichlmeier,Inekee van der Vaart,Eline Visser,Rolinda Stigter

View Articletitled, Pharmacokinetics, pharmacodynamics, efficacy, and safety of a new recombinant asparaginase preparation in children with previously untreated acute lymphoblastic leukemia: a randomized phase 2 clinical trial

Characteristics and outcome of chronic myeloid leukemia patients with F317L BCR-ABL kinase domain mutation after therapy with tyrosine kinase inhibitors
Brief Report

Elias Jabbour,Hagop M. Kantarjian,Dan Jones,Neeli Reddy,Susan O'Brien,Guillermo Garcia-Manero,Jan Burger,Jorge Cortes

View Articletitled, Characteristics and outcome of chronic myeloid leukemia patients with F317L BCR-ABL kinase domain mutation after therapy with tyrosine kinase inhibitors

GENE THERAPY

Stable transduction of quiescent T cells without induction of cycle progression by a novel lentiviral vector pseudotyped with measles virus glycoproteins

Cecilia Frecha,Caroline Costa,Didier Nègre,Emmanuel Gauthier,Stephen J. Russell,François-Loïc Cosset,Els Verhoeyen

View Articletitled, Stable transduction of quiescent T cells without induction of cycle progression by a novel lentiviral vector pseudotyped with measles virus glycoproteins

Supplemental data

In vivo proliferation advantage of genetically corrected hematopoietic stem cells in a mouse model of Fanconi anemia FA-D1

Paula Río,Néstor W. Meza,África González-Murillo,Susana Navarro,Lara Álvarez,Jordi Surrallés,Maria Castella,Guillermo Guenechea,José C. Segovia,Helmut Hanenberg,Juan A. Bueren

View Articletitled, In vivo proliferation advantage of genetically corrected hematopoietic stem cells in a mouse model of Fanconi anemia FA-D1

HEMATOPOIESIS AND STEM CELLS

GATA-2 regulates granulocyte-macrophage progenitor cell function

Neil P. Rodrigues,Ashleigh S. Boyd,Cristina Fugazza,Gillian E. May,YanPing Guo,Alex J. Tipping,David T. Scadden,Paresh Vyas,Tariq Enver

View Articletitled, GATA-2 regulates granulocyte-macrophage progenitor cell function

Supplemental data

Characterization and quantification of clonal heterogeneity among hematopoietic stem cells: a model-based approach

Ingo Roeder,Katrin Horn,Hans-Bernd Sieburg,Rebecca Cho,Christa Muller-Sieburg,Markus Loeffler

View Articletitled, Characterization and quantification of clonal heterogeneity among hematopoietic stem cells: a model-based approach

Supplemental data

Cross-talk of GATA-1 and P-TEFb in megakaryocyte differentiation

Kamaleldin E. Elagib,Ivailo S. Mihaylov,Lorrie L. Delehanty,Grant C. Bullock,Kevin D. Ouma,Jill F. Caronia,Sara L. Gonias,Adam N. Goldfarb

View Articletitled, Cross-talk of GATA-1 and P-TEFb in megakaryocyte differentiation

Supplemental data

Interleukin-1–mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo

Claudia Orelio,Esther Haak,Marian Peeters,Elaine Dzierzak

View Articletitled, Interleukin-1–mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo

Supplemental data

Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5

Ryan D. Schulteis,Haiyan Chu,Xuezhi Dai,Yuhong Chen,Brandon Edwards,Dipica Haribhai,Calvin B. Williams,Subramaniam Malarkannan,Martin J. Hessner,Sanja Glisic-Milosavljevic,Srikanta Jana,Edward J. Kerschen,Soumitra Ghosh,Demin Wang,Anne E. Kwitek,Ake Lernmark,Jack Gorski,Hartmut Weiler

View Articletitled, Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking <em>Gimap5</em>

Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation

Akiko Shigeta,Masanori Matsumoto,Thomas F. Tedder,John B. Lowe,Masayuki Miyasaka,Takako Hirata

View Articletitled, An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation

Supplemental data

Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotyping

David C. Johnson,Sophie Corthals,Christine Ramos,Antje Hoering,Kim Cocks,Nicholas J. Dickens,Jeff Haessler,Harmut Goldschmidt,J. Anthony Child,Sue E. Bell,Graham Jackson,Dalsu Baris,S. Vincent Rajkumar,Faith E. Davies,Brian G. M. Durie,John Crowley,Pieter Sonneveld,Brian Van Ness,Gareth J. Morgan

View Articletitled, Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotyping

Supplemental data

UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin αIIbβ3

Robin Verhaar,David W. C. Dekkers,Iris M. De Cuyper,Mark H. Ginsberg,Dirk de Korte,Arthur J. Verhoeven

View Articletitled, UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin αIIbβ3

Supplemental data

Angiostatic activity of the antitumor cytokine interleukin-21

Karolien Castermans,Sebastien P. Tabruyn,Rong Zeng,Judy R. van Beijnum,Cheryl Eppolito,Warren J. Leonard,Protul A. Shrikant,Arjan W. Griffioen

View Articletitled, Angiostatic activity of the antitumor cytokine interleukin-21

Supplemental data

Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome
Brief Report

Veronique Frémeaux-Bacchi,Elizabeth C. Miller,M. Kathryn Liszewski,Lisa Strain,Jacques Blouin,Alison L. Brown,Nadeem Moghal,Bernard S. Kaplan,Robert A. Weiss,Karl Lhotta,Gaurav Kapur,Tej Mattoo,Hubert Nivet,William Wong,Sophie Gie,Bruno Hurault de Ligny,Michel Fischbach,Ritu Gupta,Richard Hauhart,Vincent Meunier,Chantal Loirat,Marie-Agnès Dragon-Durey,Wolf H. Fridman,Bert J. C. Janssen,Timothy H. J. Goodship,John P. Atkinson

View Articletitled, Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome

Supplemental data

IMMUNOBIOLOGY

FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions

Mojgan Ahmadzadeh,Aloisio Felipe-Silva,Bianca Heemskerk,Daniel J. Powell, Jr,John R. Wunderlich,Maria J. Merino,Steven A. Rosenberg

View Articletitled, FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions

Supplemental data

CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages

Xingguang Liu,Ming Yao,Nan Li,Chunmei Wang,Yuanyuan Zheng,Xuetao Cao

View Articletitled, CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages

Supplemental data

Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses

Salomé LeibundGut-Landmann,Fabiola Osorio,Gordon D. Brown,Caetano Reis e Sousa

View Articletitled, Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses

Supplemental data

Intestinal double-positive CD4⁺CD8⁺ T cells of neonatal rhesus macaques are proliferating, activated memory cells and primary targets for SIV_MAC251 infection

Xiaolei Wang,Arpita Das,Andrew A. Lackner,Ronald S. Veazey,Bapi Pahar

View Articletitled, Intestinal double-positive CD4<sup>+</sup>CD8<sup>+</sup> T cells of neonatal rhesus macaques are proliferating, activated memory cells and primary targets for SIV<sub>MAC251</sub> infection

Supplemental data

Mesenchymal stromal cell–derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction

Moutih Rafei,Jeremy Hsieh,Simon Fortier,MengYang Li,Shala Yuan,Elena Birman,Kathy Forner,Marie-Noelle Boivin,Karen Doody,Michel Tremblay,Borhane Annabi,Jacques Galipeau

View Articletitled, Mesenchymal stromal cell–derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction

CD44-specific antibody treatment and CD44 deficiency exert distinct effects on leukocyte recruitment in experimental arthritis

Gábor Hutás,Éva Bajnok,István Gál,Alison Finnegan,Tibor T. Glant,Katalin Mikecz

View Articletitled, CD44-specific antibody treatment and CD44 deficiency exert distinct effects on leukocyte recruitment in experimental arthritis

Supplemental data

Genetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates α₄ integrins

Yoichi Imai,Eun Jeong Park,Dan Peer,António Peixoto,Guiying Cheng,Ulrich H. von Andrian,Christopher V. Carman,Motomu Shimaoka

View Articletitled, Genetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates α<sub>4</sub> integrins

Supplemental data

Anti-inflammatory effects of an inflammatory chemokine: CCL2 inhibits lymphocyte homing by modulation of CCL21-triggered integrin-mediated adhesions

Liat Flaishon,Gili Hart,Einat Zelman,Christine Moussion,Valentin Grabovsky,Guy Lapidot Tal,Sara Feigelson,Raanan Margalit,Alon Harmelin,Tamar Avin-Wittenberg,David Shoseyov,Ronen Alon,Jean-Philippe Girard,Idit Shachar

View Articletitled, Anti-inflammatory effects of an inflammatory chemokine: CCL2 inhibits lymphocyte homing by modulation of CCL21-triggered integrin-mediated adhesions

Supplemental data

CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

Lucy A. Truman,Catriona A. Ford,Marta Pasikowska,John D. Pound,Sarah J. Wilkinson,Ingrid E. Dumitriu,Lynsey Melville,Lauren A. Melrose,Carol Anne Ogden,Robert Nibbs,Gerard Graham,Christophe Combadiere,Christopher D. Gregory

View Articletitled, CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

Supplemental data

Dendritic cell microvilli: a novel membrane structure associated with the multifocal synapse and T-cell clustering

Phyllis J. Fisher,Peggy A. Bulur,Stanimir Vuk-Pavlovic,Franklyn G. Prendergast,Allan B. Dietz

View Articletitled, Dendritic cell microvilli: a novel membrane structure associated with the multifocal synapse and T-cell clustering

Supplemental data

Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator

Tina Van Den Broeck,Frederik Stevenaert,Sylvie Taveirne,Veronique Debacker,Christel Vangestel,Bart Vandekerckhove,Tom Taghon,Patrick Matthys,Jean Plum,Werner Held,Mieke Dewerchin,Wayne M. Yokoyama,Georges Leclercq

View Articletitled, Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator

A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion

Gaël Ménasché,Mickaël M. Ménager,Juliette M. Lefebvre,Einat Deutsch,Rafika Athman,Nathalie Lambert,Nizar Mahlaoui,Magali Court,Jérôme Garin,Alain Fischer,Geneviève de Saint Basile

View Articletitled, A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion

NF-κB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms

Ashish Banerjee,Raelene Grumont,Raffi Gugasyan,Christine White,Andreas Strasser,Steve Gerondakis

View Articletitled, NF-κB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms

Supplemental data

Bone marrow microenvironment controls the in vivo differentiation of murine dendritic cells into osteoclasts

Abdelilah Wakkach,Anna Mansour,Romain Dacquin,Emmanuel Coste,Pierre Jurdic,Georges F. Carle,Claudine Blin-Wakkach

View Articletitled, Bone marrow microenvironment controls the in vivo differentiation of murine dendritic cells into osteoclasts

Supplemental data

Cyclic AMP plays a critical role in C3a-receptor–mediated regulation of dendritic cells in antigen uptake and T-cell stimulation

Ke Li,Katie J. Anderson,Qi Peng,Alistair Noble,Bao Lu,Adrian P. Kelly,Naiyin Wang,Steven H. Sacks,Wuding Zhou

View Articletitled, Cyclic AMP plays a critical role in C3a-receptor–mediated regulation of dendritic cells in antigen uptake and T-cell stimulation

Supplemental data

NEOPLASIA

Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3

Erik A. Nelson,Sarah R. Walker,Alicia Kepich,Laurie B. Gashin,Teru Hideshima,Hiroshi Ikeda,Dharminder Chauhan,Kenneth C. Anderson,David A. Frank

View Articletitled, Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3

Supplemental data

Defective synthesis or association of T-cell receptor chains underlies loss of surface T-cell receptor–CD3 expression in enteropathy-associated T-cell lymphoma

Jennifer M. L. Tjon,Wieke H. M. Verbeek,Yvonne M. C. Kooy-Winkelaar,Binh H. Nguyen,Arno R. van der Slik,Allan Thompson,Mirjam H. M. Heemskerk,Marco W. J. Schreurs,Liesbeth H. A. Dekking,Chris J. Mulder,Jeroen van Bergen,Frits Koning

View Articletitled, Defective synthesis or association of T-cell receptor chains underlies loss of surface T-cell receptor–CD3 expression in enteropathy-associated T-cell lymphoma

Supplemental data

Inherited and acquired variations in the hyaluronan synthase 1 (HAS1) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia

Sophia Adamia,Amanda A. Reichert,Hemalatha Kuppusamy,Jitra Kriangkum,Anirban Ghosh,Jennifer J. Hodges,Patrick M. Pilarski,Steven P. Treon,Michael J. Mant,Tony Reiman,Andrew R. Belch,Linda M. Pilarski

View Articletitled, Inherited and acquired variations in the hyaluronan synthase 1 (<em>HAS1</em>) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia

Supplemental data

Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA

Charles C. Chu,Rosa Catera,Katerina Hatzi,Xiao-Jie Yan,Lu Zhang,Xiao Bo Wang,Henry M. Fales,Steven L. Allen,Jonathan E. Kolitz,Kanti R. Rai,Nicholas Chiorazzi

View Articletitled, Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA

Supplemental data

ASB2 targets filamins A and B to proteasomal degradation

Mélina L. Heuzé,Isabelle Lamsoul,Massimiliano Baldassarre,Yatish Lad,Sophie Lévêque,Ziba Razinia,Christel Moog-Lutz,David A. Calderwood,Pierre G. Lutz

View Articletitled, ASB2 targets filamins A and B to proteasomal degradation

c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches

Delfine Y. H. Hallaert,Annelieke Jaspers,Carel J. van Noesel,Marinus H. J. van Oers,Arnon P. Kater,Eric Eldering

View Articletitled, c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches

Supplemental data

Etiologic heterogeneity among non-Hodgkin lymphoma subtypes

Lindsay M. Morton,Sophia S. Wang,Wendy Cozen,Martha S. Linet,Nilanjan Chatterjee,Scott Davis,Richard K. Severson,Joanne S. Colt,Mohammad A. Vasef,Nathaniel Rothman,Aaron Blair,Leslie Bernstein,Amanda J. Cross,Anneclaire J. De Roos,Eric A. Engels,David W. Hein,Deirdre A. Hill,Linda E. Kelemen,Unhee Lim,Charles F. Lynch,Maryjean Schenk,Sholom Wacholder,Mary H. Ward,Shelia Hoar Zahm,Stephen J. Chanock,James R. Cerhan,Patricia Hartge

View Articletitled, Etiologic heterogeneity among non-Hodgkin lymphoma subtypes

Supplemental data

Antileukemic effects of the novel, mutant FLT3 inhibitor NVP-AST487: effects on PKC412-sensitive and -resistant FLT3-expressing cells

Ellen Weisberg,Johannes Roesel,Guido Bold,Pascal Furet,Jingrui Jiang,Jan Cools,Renee D. Wright,Erik Nelson,Rosemary Barrett,Arghya Ray,Daisy Moreno,Elizabeth Hall-Meyers,Richard Stone,Ilene Galinsky,Edward Fox,Gary Gilliland,John F. Daley,Suzan Lazo-Kallanian,Andrew L. Kung,James D. Griffin

View Articletitled, Antileukemic effects of the novel, mutant FLT3 inhibitor NVP-AST487: effects on PKC412-sensitive and -resistant FLT3-expressing cells

Supplemental data

Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma

Pascal Gelebart,Mona Anand,Hanan Armanious,Anthea C. Peters,Jennifer Dien Bard,Hesham M. Amin,Raymond Lai

View Articletitled, Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma

Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells

Rosa Lapalombella,Bo Yu,Georgia Triantafillou,Qing Liu,Jonathan P. Butchar,Gerard Lozanski,Asha Ramanunni,Lisa L. Smith,William Blum,Leslie Andritsos,Da-Sheng Wang,Amy Lehman,Ching-Shih Chen,Amy J. Johnson,Guido Marcucci,Robert J. Lee,L. James Lee,Susheela Tridandapani,Natarajan Muthusamy,John C. Byrd

View Articletitled, Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells

BCR-ABL fusion transcript types and levels and their interaction with secondary genetic changes in determining the phenotype of Philadelphia chromosome–positive leukemias
Brief Report

Dan Jones,Rajyalakshmi Luthra,Jorge Cortes,Deborah Thomas,Susan O'Brien,Carlos Bueso-Ramos,Seema Hai,Farhad Ravandi,Marcos de Lima,Hagop Kantarjian,Jeffrey L. Jorgensen

View Articletitled, BCR-ABL fusion transcript types and levels and their interaction with secondary genetic changes in determining the phenotype of Philadelphia chromosome–positive leukemias

PHAGOCYTES

A key role for G-CSF–induced neutrophil production and trafficking during inflammatory arthritis

Jo L. Eyles,Michael J. Hickey,M. Ursula Norman,Ben A. Croker,Andrew W. Roberts,Sarah F. Drake,Will G. James,Donald Metcalf,Ian K. Campbell,Ian P. Wicks

View Articletitled, A key role for G-CSF–induced neutrophil production and trafficking during inflammatory arthritis

Supplemental data

CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks

Karen E. Anderson,Keith B. Boyle,Keith Davidson,Tamara A. M. Chessa,Suhasini Kulkarni,Gavin E. Jarvis,Anca Sindrilaru,Karin Scharffetter-Kochanek,Oliver Rausch,Len R. Stephens,Phillip T. Hawkins

View Articletitled, CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of <em>Escherichia coli</em> or <em>Staphylococcus aureus</em> is regulated by class III but not class I or II PI3Ks

Supplemental data

RED CELLS

Adhesive activity of Lu glycoproteins is regulated by interaction with spectrin

Xiuli An,Emilie Gauthier,Xihui Zhang,Xinhua Guo,David J. Anstee,Narla Mohandas,Joel Anne Chasis

View Articletitled, Adhesive activity of Lu glycoproteins is regulated by interaction with spectrin

Cell functions impaired by frataxin deficiency are restored by drug-mediated iron relocation

Or Kakhlon,Hila Manning,William Breuer,Naomi Melamed-Book,Chunye Lu,Gino Cortopassi,Arnold Munnich,Z. Ioav Cabantchik

View Articletitled, Cell functions impaired by frataxin deficiency are restored by drug-mediated iron relocation

Supplemental data

Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family

Nadia Danilova,Kathleen M. Sakamoto,Shuo Lin

View Articletitled, Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family

Supplemental data

Homozygous deletion of HFE produces a phenotype similar to the HFE p.C282Y/p.C282Y genotype
Brief Report

Gérald Le Gac,Isabelle Gourlaouen,Christophe Ronsin,Vanna Géromel,Anne Bourgarit,Nathalie Parquet,Sylvia Quemener,Cédric Le Maréchal,Jian-Min Chen,Claude Férec

View Articletitled, Homozygous deletion of <em>HFE</em> produces a phenotype similar to the <em>HFE</em> p.C282Y/p.C282Y genotype

Supplemental data

Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I
Brief Report

Hannah Tamary,Hanna Shalev,Galit Perez-Avraham,Meira Zoldan,Itai Levi,Dorine W. Swinkels,Toshihiko Tanno,Jeffery L. Miller

View Articletitled, Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I

Supplemental data

TRANSPLANTATION

Early chimerism threshold predicts sustained engraftment and NK-cell tolerance in prenatal allogeneic chimeras

Emily T. Durkin,Kelly A. Jones,Deepika Rajesh,Aimen F. Shaaban

View Articletitled, Early chimerism threshold predicts sustained engraftment and NK-cell tolerance in prenatal allogeneic chimeras

STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease
Brief Report

Sydney X. Lu,Onder Alpdogan,Janine Lin,Robert Balderas,Roberto Campos-Gonzalez,Xiao Wang,Guo-Jian Gao,David Suh,Christopher King,Melanie Chow,Odette M. Smith,Vanessa M. Hubbard,Johanne L. Bautista,Javier Cabrera-Perez,Johannes L. Zakrzewski,Adam A. Kochman,Andrew Chow,Gregoire Altan-Bonnet,Marcel R. M. van den Brink

View Articletitled, STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease

Supplemental data

ERRATUM

Hallek et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute–Working Group 1996 guidelines. Blood. 2008;111:5446-5456.

View Articletitled, Hallek et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute–Working Group 1996 guidelines. Blood. 2008;111:<span class="related-article">5446-5456</span>.

Martino et al. Evidence for a graft-versus-leukemia effect after allogeneic peripheral blood stem cell transplantation with reduced-intensity conditioning in acute myelogenous leukemia and myelodysplastic syndromes. Blood. 2002;100:2243-2245.

View Articletitled, Martino et al. Evidence for a graft-versus-leukemia effect after allogeneic peripheral blood stem cell transplantation with reduced-intensity conditioning in acute myelogenous leukemia and myelodysplastic syndromes. Blood. 2002;100:<span class="related-article">2243-2245</span>.

Cover Image

Cover Image

Presence of α₄ integrin–rich trailing edge “tethers” in T cells from mice with disruption of α₄ integrin salt bridges, resulting in impaired migration on VCAM-1. α₄ integrin staining in red, actin staining in green. For details see the article by Imai et al on page 5007.
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