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Interleukin-2, interleukin-12, and interferon-γ levels and risk of young adult Hodgkin lymphoma
A dynamic prognostic model to predict survival in post–polycythemia vera myelofibrosis
Causes and prognostic factors of remission induction failure in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and idarubicin
CD32B is highly expressed on clonal plasma cells from patients with systemic light-chain amyloidosis and provides a target for monoclonal antibody–based therapy
Issue Archive
April 1 2008
In this Issue
Table of Contents
INSIDE BLOOD
PLENARY PAPERS
ASH 50TH ANNIVERSARY REVIEW
REVIEW ARTICLES
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB–driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages
Laura Fantuzzi,Francesca Spadaro,Cristina Purificato,Serena Cecchetti,Franca Podo,Filippo Belardelli,Sandra Gessani,Carlo Ramoni
CLINICAL TRIALS AND OBSERVATIONS
Interleukin-2, interleukin-12, and interferon-γ levels and risk of young adult Hodgkin lymphoma
Clinical Trials & Observations
Wendy Cozen,Parkash S. Gill,Muhammad T. Salam,Alexandra Nieters,Rizwan Masood,Myles G. Cockburn,W. James Gauderman,Otoniel Martínez-Maza,Bharat N. Nathwani,Malcolm C. Pike,David J. Van Den Berg,Ann S. Hamilton,Dennis M. Deapen,Thomas M. Mack
A dynamic prognostic model to predict survival in post–polycythemia vera myelofibrosis
Clinical Trials & Observations
Francesco Passamonti,Elisa Rumi,Marianna Caramella,Chiara Elena,Luca Arcaini,Emanuela Boveri,Cecilia Del Curto,Daniela Pietra,Laura Vanelli,Paolo Bernasconi,Cristiana Pascutto,Mario Cazzola,Enrica Morra,Mario Lazzarino
Causes and prognostic factors of remission induction failure in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and idarubicin
Clinical Trials & Observations
Javier de la Serna,Pau Montesinos,Edo Vellenga,Chelo Rayón,Ricardo Parody,Angel León,Jordi Esteve,Juan M. Bergua,Gustavo Milone,Guillermo Debén,Concha Rivas,Marcos González,Mar Tormo,Joaquín Díaz-Mediavilla,Jose D. González,Silvia Negri,Elena Amutio,Salut Brunet,Bob Lowenberg,Miguel A. Sanz
CD32B is highly expressed on clonal plasma cells from patients with systemic light-chain amyloidosis and provides a target for monoclonal antibody–based therapy
Brief Report
Ping Zhou,Raymond L. Comenzo,Adam B. Olshen,Ezio Bonvini,Scott Koenig,Peter G. Maslak,Martin Fleisher,James Hoffman,Suresh Jhanwar,James W. Young,Stephen D. Nimer,Adam M. Boruchov
HEMATOPOIESIS AND STEM CELLS
A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the αIIbβ3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia
Cedric Ghevaert,Alexandre Salsmann,Nicholas A. Watkins,Elisabeth Schaffner-Reckinger,Angela Rankin,Stephen F. Garner,Jonathan Stephens,Graham A. Smith,Najet Debili,William Vainchenker,Philip G. de Groot,James A. Huntington,Mike Laffan,Nelly Kieffer,Willem H. Ouwehand
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
Identification of 31 novel mutations in the F8 gene in Spanish hemophilia A patients: structural analysis of 20 missense mutations suggests new intermolecular binding sites
Adoración Venceslá,María Ángeles Corral-Rodríguez,Manel Baena,Mónica Cornet,Montserrat Domènech,Montserrat Baiget,Pablo Fuentes-Prior,Eduardo F. Tizzano
A proangiogenic peptide derived from vascular endothelial growth factor receptor-1 acts through α5β1 integrin
Simonetta Soro,Angela Orecchia,Lucia Morbidelli,Pedro Miguel Lacal,Veronica Morea,Kurt Ballmer-Hofer,Federica Ruffini,Marina Ziche,Stefania D'Atri,Giovanna Zambruno,Anna Tramontano,Cristina Maria Failla
Response to desmopressin is influenced by the genotype and phenotype in type 1 von Willebrand disease (VWD): results from the European Study MCMDM-1VWD
Giancarlo Castaman,Stefan Lethagen,Augusto B. Federici,Alberto Tosetto,Anne Goodeve,Ulrich Budde,Javier Batlle,Dominique Meyer,Claudine Mazurier,Edith Fressinaud,Jenny Goudemand,Jeroen Eikenboom,Reinhard Schneppenheim,Jorgen Ingerslev,Zdena Vorlova,David Habart,Lars Holmberg,John Pasi,Frank Hill,Ian Peake,Francesco Rodeghiero
A shorter von Willebrand factor survival in O blood group subjects explains how ABO determinants influence plasma von Willebrand factor
Lisa Gallinaro,Maria Grazia Cattini,Maryta Sztukowska,Roberto Padrini,Francesca Sartorello,Elena Pontara,Antonella Bertomoro,Viviana Daidone,Antonio Pagnan,Alessandra Casonato
IMMUNOBIOLOGY
NEOPLASIA
Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-κB pathways in subtypes of diffuse large B-cell lymphoma
Lloyd T. Lam,George Wright,R. Eric Davis,Georg Lenz,Pedro Farinha,Lenny Dang,John W. Chan,Andreas Rosenwald,Randy D. Gascoyne,Louis M. Staudt
Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL– and mutant FLT3-expressing cells
Ellen Weisberg,Lolita Banerji,Renee D. Wright,Rosemary Barrett,Arghya Ray,Daisy Moreno,Laurence Catley,Jingrui Jiang,Elizabeth Hall-Meyers,Maira Sauveur-Michel,Richard Stone,Ilene Galinsky,Edward Fox,Andrew L. Kung,James D. Griffin
RUNX1 DNA-binding mutations and RUNX1-PRDM16 cryptic fusions in BCR-ABL+ leukemias are frequently associated with secondary trisomy 21 and may contribute to clonal evolution and imatinib resistance
Catherine Roche-Lestienne,Lauréline Deluche,Sélim Corm,Isabelle Tigaud,Sami Joha,Nathalie Philippe,Sandrine Geffroy,Jean-Luc Laï,Franck-Emmanuel Nicolini,Claude Preudhomme,on behalf of the Fi-LMC group
The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes
Gerlinde Wernig,Jeffrey R. Gonneville,Brian J. Crowley,Margret S. Rodrigues,Mamatha M. Reddy,Heidi E. Hudon,Christoph Walz,Andreas Reiter,Klaus Podar,Yohan Royer,Stefan N. Constantinescu,Michael H. Tomasson,James D. Griffin,D. Gary Gilliland,Martin Sattler
EAPB0203, a member of the imidazoquinoxaline family, inhibits growth and induces caspase-dependent apoptosis in T-cell lymphomas and HTLV-I–associated adult T-cell leukemia/lymphoma
Georges Moarbess,Hiba El-Hajj,Youmna Kfoury,Marwan E. El-Sabban,Yves Lepelletier,Olivier Hermine,Carine Deleuze-Masquéfa,Pierre-Antoine Bonnet,Ali Bazarbachi
Novel markers of normal and neoplastic human plasmacytoid dendritic cells
Teresa Marafioti,Jennifer C. Paterson,Erica Ballabio,Kaaren K. Reichard,Sara Tedoldi,Kevin Hollowood,Michael Dictor,Martin-Leo Hansmann,Stefano A. Pileri,Martin J. Dyer,Silvano Sozzani,Ivan Dikic,Andrey S. Shaw,Tony Petrella,Harald Stein,Peter G. Isaacson,Fabio Facchetti,David Y. Mason
A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies
Anna Lanemo Myhrinder,Eva Hellqvist,Ekaterina Sidorova,Anita Söderberg,Helen Baxendale,Charlotte Dahle,Kerstin Willander,Gerard Tobin,Eva Bäckman,Ola Söderberg,Richard Rosenquist,Sohvi Hörkkö,Anders Rosén
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
CORRESPONDENCE
BLOOD WORK
ERRATUM
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Cover Image
Cover Image
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Zebrafish (Danio rerio), small freshwater fish originating in the upper reaches of the Ganges river in India, have increased in popularity over the last decade as a laboratory animal model for genetic studies, developmental biology, and disease modeling. For an appraisal of their contribution to hematology research, see the review by Carradice and Lieschke beginning on page 3331.
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Screening for hemochromatosis
Response: Screening for treatable disease is better than just screening for hemochromatosis