Cover Image

Cover Image

Original watercolor drawing made by Dr James Homer Wright, with the aid of a camera lucida, from his 1910 article on the origin of platelets (Wright J. The histogenesis of the blood platelets. J Morphol. 1910;21:263–278). Picture provided with the assistance of Dr Robert H.Young, Harvard Medical School, Boston, MA. Interested readers are referred to the following article by Dr Young and colleagues: Lee RE, Young RH, Castleman B. James HomerWright: a biography of the enigmatic creater of the Wright stain on the occassion of its centennial. Am J Surg Pathol. 2002;26:88–96.
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Table of Contents

INSIDE BLOOD

ASH 50TH ANNIVERSARY REVIEW

BLOOD WORK

PLENARY PAPERS

ERRATA

PERSPECTIVE

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

CLINICAL TRIALS AND OBSERVATIONS

Copy number variation of the activating FCGR2C gene predisposes to idiopathic thrombocytopenic purpura Clinical Trials & Observations

Favorable long-term follow-up results over 6 years for response, survival, and safety with imatinib mesylate therapy in chronic-phase chronic myeloid leukemia after failure of interferon-α treatment Clinical Trials & Observations

Outcomes in CCG-2961, a Children's Oncology Group Phase 3 Trial for untreated pediatric acute myeloid leukemia: a report from the Children's Oncology Group Clinical Trials & Observations

Prospective multicenter trial comparing repeated immunosuppressive therapy with stem-cell transplantation from an alternative donor as second-line treatment for children with severe and very severe aplastic anemia Clinical Trials & Observations

Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes Clinical Trials & Observations

Identification of distinct prognostic subgroups in low- and intermediate-1–risk myelodysplastic syndromes by flow cytometry Clinical Trials & Observations

Treatment of newly diagnosed acute promyelocytic leukemia (APL): a comparison of French-Belgian-Swiss and PETHEMA results Clinical Trials & Observations

Brain parenchyma involvement as isolated central nervous system relapse of systemic non-Hodgkin lymphoma: an International Primary CNS Lymphoma Collaborative Group report Clinical Trials & Observations

Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: a phase 1-2 study Clinical Trials & Observations

BiRD (Biaxin [clarithromycin]/Revlimid [lenalidomide]/dexamethasone) combination therapy results in high complete- and overall-response rates in treatment-naive symptomatic multiple myeloma. Clinical Trials & Observations

Impact of immune thrombocytopenia on the clinical course of chronic lymphocytic leukemia Clinical Trials & Observations

Hydroxyurea nitrosylates and activates soluble guanylyl cyclase in human erythroid cells Clinical Trials & Observations

Development of an allele-specific minimal residual disease assay for patients with juvenile myelomonocytic leukemia Brief Report

Complex inheritance pattern of dyskeratosis congenita in two families with 2 different mutations in the telomerase reverse transcriptase gene Brief Report

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Functional imaging of shear-dependent activity of ADAMTS13 in regulating mural thrombus growth under whole blood flow conditions Brief Report

Deletion of 3 residues from the C-terminus of MCFD2 affects binding to ERGIC-53 and causes combined factor V and factor VIII deficiency Brief Report

Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels Brief Report

Induction of an inhibitor antibody to factor XI in a patient with severe inherited factor XI deficiency by Rh immune globulin Brief Report

IMMUNOBIOLOGY

Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency Brief Report

NEOPLASIA

Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders Brief Report

RED CELLS

STEM CELLS IN HEMATOLOGY

TRANSPLANTATION

Clinical stem-cell sources contain CD8+CD3+ T-cell receptor–negative cells that facilitate bone marrow repopulation with hematopoietic stem cells Brief Report

CORRESPONDENCE

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Copy number variation of the activating FCGR2C gene predisposes to idiopathic thrombocytopenic purpura
Clinical Trials & Observations

Favorable long-term follow-up results over 6 years for response, survival, and safety with imatinib mesylate therapy in chronic-phase chronic myeloid leukemia after failure of interferon-α treatment
Clinical Trials & Observations

Outcomes in CCG-2961, a Children's Oncology Group Phase 3 Trial for untreated pediatric acute myeloid leukemia: a report from the Children's Oncology Group
Clinical Trials & Observations

Prospective multicenter trial comparing repeated immunosuppressive therapy with stem-cell transplantation from an alternative donor as second-line treatment for children with severe and very severe aplastic anemia
Clinical Trials & Observations

Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes
Clinical Trials & Observations

Identification of distinct prognostic subgroups in low- and intermediate-1–risk myelodysplastic syndromes by flow cytometry
Clinical Trials & Observations

Treatment of newly diagnosed acute promyelocytic leukemia (APL): a comparison of French-Belgian-Swiss and PETHEMA results
Clinical Trials & Observations

Brain parenchyma involvement as isolated central nervous system relapse of systemic non-Hodgkin lymphoma: an International Primary CNS Lymphoma Collaborative Group report
Clinical Trials & Observations

Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: a phase 1-2 study
Clinical Trials & Observations

BiRD (Biaxin [clarithromycin]/Revlimid [lenalidomide]/dexamethasone) combination therapy results in high complete- and overall-response rates in treatment-naive symptomatic multiple myeloma.
Clinical Trials & Observations

Impact of immune thrombocytopenia on the clinical course of chronic lymphocytic leukemia
Clinical Trials & Observations

Hydroxyurea nitrosylates and activates soluble guanylyl cyclase in human erythroid cells
Clinical Trials & Observations

Development of an allele-specific minimal residual disease assay for patients with juvenile myelomonocytic leukemia
Brief Report

Complex inheritance pattern of dyskeratosis congenita in two families with 2 different mutations in the telomerase reverse transcriptase gene
Brief Report

Functional imaging of shear-dependent activity of ADAMTS13 in regulating mural thrombus growth under whole blood flow conditions
Brief Report

Deletion of 3 residues from the C-terminus of MCFD2 affects binding to ERGIC-53 and causes combined factor V and factor VIII deficiency
Brief Report

Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels
Brief Report

Induction of an inhibitor antibody to factor XI in a patient with severe inherited factor XI deficiency by Rh immune globulin
Brief Report

Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency
Brief Report

Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders
Brief Report

Clinical stem-cell sources contain CD8⁺CD3⁺ T-cell receptor–negative cells that facilitate bone marrow repopulation with hematopoietic stem cells
Brief Report