Issue Archive

Wilkins and colleagues evaluate the utility of the World Health Organization (WHO) diagnostic criteria intended to separate cases previously classified as essential thrombocythemia (ET) into 2 groups: “true ET” and “prefibrotic myelofibrosis.” Focusing on bone marrow histology, the authors found substantial variation in classification of cases.

In this issue of Blood, Morris and colleagues show that erythrocyte glutathione and glutamine levels are low in patients with sickle cell disease (SCD) and that these markers are linked to markers of hemolysis and pulmonary hypertension.

Glycoprotein (GP) VI and Fc receptor FcγRIIa are 2 ITAM (immunoreceptor tyrosine-activation motif)–bearing platelet surface receptors. In this issue of Blood, Gardiner and colleagues show that activation of either receptor results in simultaneous proteolytic cleavage of GPVI ectodomain and FcγRIIa cytoplasmic tail, providing distinct mechanisms for their down-regulation on platelet activation.

In this issue of Blood, Le Guyader and colleagues use a variety of elegant techniques during zebrafish development to identify a unique population of neutrophils derived from myeloid progenitors originating from primitive embryonic macrophages.

In this issue of Blood, Leseux and colleagues report rituximab-mediated inhibition of PKCζ activity in follicular lymphoma (FL) resulting in the inhibition of Raf-1 and mTOR signaling pathways and leading to inhibition of tumor cell proliferation.

Several therapeutic options are now available for patients with low-risk myelodysplastic syndrome (MDS).