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The revised WHO diagnostic criteria for Ph-negative myeloproliferative diseases are not appropriate for the diagnostic screening of childhood polycythemia vera and essential thrombocythemia
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INSIDE BLOOD
BLOOD WORK
PERSPECTIVE
REVIEW ARTICLES
REVIEW IN TRANSLATIONAL HEMATOLOGY
HOW I TREAT
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion
Catherine Léon,Anita Eckly,Béatrice Hechler,Boris Aleil,Monique Freund,Catherine Ravanat,Marie Jourdain,Christelle Nonne,Josiane Weber,Ralph Tiedt,Marie-Pierre Gratacap,Sonia Severin,Jean-Pierre Cazenave,François Lanza,Radek Skoda,Christian Gachet
IMMUNOBIOLOGY
NEOPLASIA
Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma
Deborah J. Kuhn,Qing Chen,Peter M. Voorhees,John S. Strader,Kevin D. Shenk,Congcong M. Sun,Susan D. Demo,Mark K. Bennett,Fijs W. B. van Leeuwen,Asher A. Chanan-Khan,Robert Z. Orlowski
Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma
Matthew W. Jenner,Paola E. Leone,Brian A. Walker,Fiona M. Ross,David C. Johnson,David Gonzalez,Laura Chiecchio,Elisabet Dachs Cabanas,Gian Paolo Dagrada,Mathew Nightingale,Rebecca K. M. Protheroe,David Stockley,Monica Else,Nicholas J. Dickens,Nicholas C. P. Cross,Faith E. Davies,Gareth J. Morgan
HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV+ Hodgkin lymphoma
Marijke Niens,Ruth F. Jarrett,Bouke Hepkema,Ilja M. Nolte,Arjan Diepstra,Mathieu Platteel,Niels Kouprie,Craig P. Delury,Alice Gallagher,Lydia Visser,Sibrand Poppema,Gerard J. te Meerman,Anke van den Berg
A high-density SNP genome-wide linkage search of 206 families identifies susceptibility loci for chronic lymphocytic leukemia
Gabrielle S. Sellick,Lynn R. Goldin,Ruth W. Wild,Susan L. Slager,Laura Ressenti,Sara S. Strom,Martin J. S. Dyer,Francesca R. Mauro,Gerald E. Marti,Stephen Fuller,Matthew Lyttelton,Thomas J. Kipps,Michael J. Keating,Timothy G. Call,Daniel Catovsky,Neil Caporaso,Richard S. Houlston
Expression of CYP3A4 as a predictor of response to chemotherapy in peripheral T-cell lymphomas
Cristina Rodríguez-Antona,Susanna Leskelä,Magdalena Zajac,Marta Cuadros,Javier Alvés,Maria Victoria Moneo,Carmen Martín,Juan Cruz Cigudosa,Amancio Carnero,Mercedes Robledo,Javier Benitez,Beatriz Martínez-Delgado
Prevalence and prognostic significance of allelic imbalance by single-nucleotide polymorphism analysis in low-risk myelodysplastic syndromes
Azim Mohamedali,Joop Gäken,Natalie A. Twine,Wendy Ingram,Nigel Westwood,Nicholas C. Lea,Janet Hayden,Nora Donaldson,Carlo Aul,Norbert Gattermann,Aristotle Giagounidis,Ulrich Germing,Alan F. List,Ghulam J. Mufti
The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling
Philipp B. Staber,Paul Vesely,Naznin Haq,Rene G. Ott,Kotaro Funato,Isabella Bambach,Claudia Fuchs,Silvia Schauer,Werner Linkesch,Andelko Hrzenjak,Wilhelm G. Dirks,Veronika Sexl,Helmut Bergler,Marshall E. Kadin,David W. Sternberg,Lukas Kenner,Gerald Hoefler
The revised WHO diagnostic criteria for Ph-negative myeloproliferative diseases are not appropriate for the diagnostic screening of childhood polycythemia vera and essential thrombocythemia
Brief Report
Luciana Teofili,Fiorina Giona,Maurizio Martini,Tonia Cenci,Francesco Guidi,Lorenza Torti,Giovanna Palumbo,Angela Amendola,Giuseppe Leone,Robin Foà,Luigi M. Larocca
RED CELLS
The Laminin 511/521–binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3
Tosti J. Mankelow,Nicholas Burton,Fanney O. Stefansdottir,Frances A. Spring,Stephen F. Parsons,Jan S. Pedersen,Cristiano L. P. Oliveira,Donna Lammie,Timothy Wess,Narla Mohandas,Joel Anne Chasis,R. Leo Brady,David J. Anstee
STEM CELLS IN HEMATOLOGY
Multipotent cells can be generated in vitro from several adult human organs (heart, liver, and bone marrow)
Antonio P. Beltrami,Daniela Cesselli,Natascha Bergamin,Patrizia Marcon,Silvia Rigo,Elisa Puppato,Federica D'Aurizio,Roberto Verardo,Silvano Piazza,Angela Pignatelli,Alessandra Poz,Umberto Baccarani,Daniela Damiani,Renato Fanin,Laura Mariuzzi,Nicoletta Finato,Paola Masolini,Silvia Burelli,Ottorino Belluzzi,Claudio Schneider,Carlo A. Beltrami
TRANSPLANTATION
CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation
Sung W. Choi,Gerhard C. Hildebrandt,Krystyna M. Olkiewicz,David A. Hanauer,Meghana N. Chaudhary,Ines A. Silva,Clare E. Rogers,Daphne T. Deurloo,Jacki M. Fisher,Chen Liu,David Adams,Stephen W. Chensue,Kenneth R. Cooke
Long-term follow-up of allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning for patients with chronic myeloid leukemia
Partow Kebriaei,Michelle A. Detry,Sergio Giralt,Antonio Carrasco-Yalan,Athanasios Anagnostopoulos,Daniel Couriel,Issa F. Khouri,Paolo Anderlini,Chitra Hosing,Amin Alousi,Richard E. Champlin,Marcos de Lima
Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD)
Patricia A. Taylor,Michael J. Ehrhardt,Christopher J. Lees,Jakub Tolar,Brenda J. Weigel,Angela Panoskaltsis-Mortari,Jonathan S. Serody,Volker Brinkmann,Bruce R. Blazar
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Cover Image
Cover Image
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Crystals of the 2 N-terminal immunoglobulin domains of the erythrocyte Lutheran glycoprotein play happily in their crystalization drop. See the related article by Mankelow et al, beginning on page 3398.
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