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Issue Archive

Volume 110, Issue 8
October 15 2007
Issue Cover

Table of Contents

INSIDE BLOOD

GENE THERAPY
Warrior, miscreant, suicide: making better killers
Mark E. Dudley
View Articletitled, Warrior, miscreant, suicide: making better killers
IMMUNOBIOLOGY
Phagocytic neutrophils cross-present antigen
Esther von Stebut
View Articletitled, Phagocytic neutrophils cross-present antigen
HEMATOPOIESIS
Dendritic cells reach out in different directions
David M. Bodine
View Articletitled, Dendritic cells reach out in different directions
STEM CELLS IN HEMATOLOGY
ROS-low HSCs are repopulation-high
Dov Zipori
View Articletitled, ROS-low HSCs are repopulation-high
HEMOSTASIS
Rituximab disciplines T cells, spares platelets
John W. Semple
View Articletitled, Rituximab disciplines T cells, spares platelets
HEMOSTASIS
Does angiotensin-II link arteries and monocytes?
Michael J. Hickey,Paul Kubes
View Articletitled, Does angiotensin-II link arteries and monocytes?
HEMOSTASIS
Endostatin finds a new partner: nucleolin
Judah Folkman
View Articletitled, Endostatin finds a new partner: nucleolin
HEMATOPOIESIS
Cited2: master regulator of HSC function?
Hal E. Broxmeyer
View Articletitled, Cited2: master regulator of HSC function?
TRANSPLANTATION
IL-7: griffinesque role in GVHD
Pavan Reddy
View Articletitled, IL-7: griffinesque role in GVHD
HEMATOPOIESIS
THAL for THAL?
David H. K. Chui
View Articletitled, THAL for THAL?
TRANSPLANTATION
Are 2 cords better than 1?
Elizabeth Shpall,Marcos de Lima,Roy Jones,Richard Champlin
View Articletitled, Are 2 cords better than 1?
HEMOSTASIS
Need MT1-MMP? Just say NO!
Joseph A. Madri
View Articletitled, Need MT1-MMP? Just say NO!
NEOPLASIA
Death by rafting
Suzanne Lentzsch
View Articletitled, Death by rafting

PLENARY PAPERS

Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes
Concetta Quintarelli,Juan F. Vera,Barbara Savoldo,Greta M. P. Giordano Attianese,Martin Pule,Aaron E. Foster,Helen E. Heslop,Cliona M. Rooney,Malcolm K. Brenner,Gianpietro Dotti
View Articletitled, Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes
Supplemental data
Prevention of graft-versus-host disease by anti–IL-7Rα antibody
Brile Chung,Eric P. Dudl,Dullei Min,Lora Barsky,Nancy Smiley,Kenneth I. Weinberg
View Articletitled, Prevention of graft-versus-host disease by anti–IL-7Rα antibody
Supplemental data

REVIEW ARTICLES

Cellular immune therapy for chronic lymphocytic leukemia
Arnon P. Kater,Marinus H. J. van Oers,Thomas J. Kipps
View Articletitled, Cellular immune therapy for chronic lymphocytic leukemia
Galectins in the tumor endothelium: opportunities for combined cancer therapy
Victor L. J. L. Thijssen,Françoise Poirier,Linda G. Baum,Arjan W. Griffioen
View Articletitled, Galectins in the tumor endothelium: opportunities for combined cancer therapy

ERRATUM

Erratum in Schepers et al. Reintroduction of C/EBPα in leukemic CD34+ stem/progenitor cells impairs self-renewal and partially restores myelopoiesis.
View Articletitled, Erratum in Schepers et al. Reintroduction of C/EBPα in leukemic CD34+ stem/progenitor cells impairs self-renewal and partially restores myelopoiesis.

HOW I TREAT

How I treat chronic myeloid leukemia in the imatinib era
John M. Goldman
View Articletitled, How I treat chronic myeloid leukemia in the imatinib era

CLINICAL TRIALS AND OBSERVATIONS

Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer
Clinical Trials & Observations
Catherine M. Bollard,Stephen Gottschalk,Ann M. Leen,Heidi Weiss,Karin C. Straathof,George Carrum,Mariam Khalil,Meng-fen Wu,M. Helen Huls,Chung-Che Chang,M. Victoria Gresik,Adrian P. Gee,Malcolm K. Brenner,Cliona M. Rooney,Helen E. Heslop
View Articletitled, Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer
Intensive chemotherapy regimen (LMB86) for St Jude stage IV AIDS-related Burkitt lymphoma/leukemia: a prospective study
Clinical Trials & Observations
Lionel Galicier,Claire Fieschi,Raphael Borie,Véronique Meignin,Marie-Thérèse Daniel,Laurence Gérard,Eric Oksenhendler
View Articletitled, Intensive chemotherapy regimen (LMB86) for St Jude stage IV AIDS-related Burkitt lymphoma/leukemia: a prospective study

GENE THERAPY

Hematopoietic stem-cell gene therapy of hemophilia A incorporating a porcine factor VIII transgene and nonmyeloablative conditioning regimens
Lucienne M. Ide,Bagirath Gangadharan,Kuang-Yueh Chiang,Christopher B. Doering,H. Trent Spencer
View Articletitled, Hematopoietic stem-cell gene therapy of hemophilia A incorporating a porcine factor VIII transgene and nonmyeloablative conditioning regimens
Supplemental data

HEMATOPOIESIS

Thalidomide induces γ-globin gene expression through increased reactive oxygen species–mediated p38 MAPK signaling and histone H4 acetylation in adult erythropoiesis
Wulin Aerbajinai,Jianqiong Zhu,Zhigang Gao,Kyung Chin,Griffin P. Rodgers
View Articletitled, Thalidomide induces γ-globin gene expression through increased reactive oxygen species–mediated p38 MAPK signaling and histone H4 acetylation in adult erythropoiesis
TGF-β combined with M-CSF and IL-4 induces generation of immune inhibitory cord blood dendritic cells capable of enhancing cytokine-induced ex vivo expansion of myeloid progenitors
Geling Li,Saeid Abediankenari,Young-June Kim,Timothy B. Campbell,Shigeki Ito,Barbara Graham-Evans,Scott Cooper,Hal E. Broxmeyer
View Articletitled, TGF-β combined with M-CSF and IL-4 induces generation of immune inhibitory cord blood dendritic cells capable of enhancing cytokine-induced ex vivo expansion of myeloid progenitors
STAT5 is required for long-term maintenance of normal and leukemic human stem/progenitor cells
Hein Schepers,Djoke van Gosliga,Albertus T. J. Wierenga,Bart J. L. Eggen,Jan Jacob Schuringa,Edo Vellenga
View Articletitled, STAT5 is required for long-term maintenance of normal and leukemic human stem/progenitor cells
Supplemental data
Cited2 is required for normal hematopoiesis in the murine fetal liver
Yu Chen,Peter Haviernik,Kevin D. Bunting,Yu-Chung Yang
View Articletitled, Cited2 is required for normal hematopoiesis in the murine fetal liver
Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Nucleolin is a receptor that mediates antiangiogenic and antitumor activity of endostatin
Hubing Shi,Yujie Huang,Hao Zhou,Xiaomin Song,Shaopeng Yuan,Yan Fu,Yongzhang Luo
View Articletitled, Nucleolin is a receptor that mediates antiangiogenic and antitumor activity of endostatin
Supplemental data
Interferon-α promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis
Michael F. Denny,Seth Thacker,Hemal Mehta,Emily C. Somers,Todd Dodick,Franck J. Barrat,W. Joseph McCune,Mariana J. Kaplan
View Articletitled, Interferon-α promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis
Functional interplay between endothelial nitric oxide synthase and membrane type 1–matrix metalloproteinase in migrating endothelial cells
Laura Genís,Pilar Gonzalo,Antonio S. Tutor,Beatriz G. Gálvez,Antonio Martínez-Ruiz,Carlos Zaragoza,Santiago Lamas,Karl Tryggvason,Suneel S. Apte,Alicia G. Arroyo
View Articletitled, Functional interplay between endothelial nitric oxide synthase and membrane type 1–matrix metalloproteinase in migrating endothelial cells
Supplemental data
Response to B-cell–depleting therapy with rituximab reverts the abnormalities of T-cell subsets in patients with idiopathic thrombocytopenic purpura
Roberto Stasi,Giovanni Del Poeta,Elisa Stipa,Maria Laura Evangelista,Margherita M. Trawinska,Nichola Cooper,Sergio Amadori
View Articletitled, Response to B-cell–depleting therapy with rituximab reverts the abnormalities of T-cell subsets in patients with idiopathic thrombocytopenic purpura

IMMUNOBIOLOGY

Allorestricted T cells with specificity for the FMNL1-derived peptide PP2 have potent antitumor activity against hematologic and other malignancies
Ingrid G. Schuster,Dirk H. Busch,Elfriede Eppinger,Elisabeth Kremmer,Slavoljub Milosevic,Christine Hennard,Christina Kuttler,Joachim W. Ellwart,Bernhard Frankenberger,Elfriede Nößner,Christoph Salat,Christian Bogner,Arndt Borkhardt,Hans-Jochem Kolb,Angela M. Krackhardt
View Articletitled, Allorestricted T cells with specificity for the FMNL1-derived peptide PP2 have potent antitumor activity against hematologic and other malignancies
Supplemental data
Inactivation of PI3Kγ and PI3Kδ distorts T-cell development and causes multiple organ inflammation
Hong Ji,Felix Rintelen,Caroline Waltzinger,Dominique Bertschy Meier,Antonio Bilancio,Wayne Pearce,Emilio Hirsch,Matthias P. Wymann,Thomas Rückle,Montserrat Camps,Bart Vanhaesebroeck,Klaus Okkenhaug,Christian Rommel
View Articletitled, Inactivation of PI3Kγ and PI3Kδ distorts T-cell development and causes multiple organ inflammation
Supplemental data
Decreased expression of tumor necrosis factor family receptors involved in humoral immune responses in preterm neonates
Kulwant Kaur,Shimul Chowdhury,Neil S. Greenspan,John R. Schreiber
View Articletitled, Decreased expression of tumor necrosis factor family receptors involved in humoral immune responses in preterm neonates
Critical role of FLT3 ligand in IL-7 receptor–independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors
Ewa Sitnicka,Natalija Buza-Vidas,Henrik Ahlenius,Corrado M. Cilio,Christos Gekas,Jens M. Nygren,Robert Månsson,Min Cheng,Christina T. Jensen,Marcus Svensson,Karin Leandersson,William W. Agace,Mikael Sigvardsson,Sten Eirik W. Jacobsen
View Articletitled, Critical role of FLT3 ligand in IL-7 receptor–independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors
Supplemental data
Neutrophils efficiently cross-prime naive T cells in vivo
Céline Beauvillain,Yves Delneste,Mari Scotet,Audrey Peres,Hugues Gascan,Pierre Guermonprez,Vincenzo Barnaba,Pascale Jeannin
View Articletitled, Neutrophils efficiently cross-prime naive T cells in vivo
Signaling through CD43 regulates CD4 T-cell trafficking
Purvi D. Mody,Judy L. Cannon,Hozefa S. Bandukwala,Kelly M. Blaine,Alexander B. Schilling,Kevin Swier,Anne I. Sperling
View Articletitled, Signaling through CD43 regulates CD4 T-cell trafficking
Induction of FOXP3 expression in naive human CD4+FOXP3− T cells by T-cell receptor stimulation is transforming growth factor-β–dependent but does not confer a regulatory phenotype
Dat Q. Tran,Heather Ramsey,Ethan M. Shevach
View Articletitled, Induction of FOXP3 expression in naive human CD4<sup>+</sup>FOXP3<sup>−</sup> T cells by T-cell receptor stimulation is transforming growth factor-β–dependent but does not confer a regulatory phenotype

NEOPLASIA

Chromosomal abnormalities in Philadelphia chromosome–negative metaphases appearing during imatinib mesylate therapy in patients with newly diagnosed chronic myeloid leukemia in chronic phase
Elias Jabbour,Hagop M. Kantarjian,Lynne V. Abruzzo,Susan O'Brien,Guillermo Garcia-Manero,Srdan Verstovsek,Jianqin Shan,Mary Beth Rios,Jorge Cortes
View Articletitled, Chromosomal abnormalities in Philadelphia chromosome–negative metaphases appearing during imatinib mesylate therapy in patients with newly diagnosed chronic myeloid leukemia in chronic phase
The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo
Maurice Reimann,Christoph Loddenkemper,Cornelia Rudolph,Ines Schildhauer,Bianca Teichmann,Harald Stein,Brigitte Schlegelberger,Bernd Dörken,Clemens A. Schmitt
View Articletitled, The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo
Supplemental data
The molecular signature of MDS stem cells supports a stem-cell origin of 5q− myelodysplastic syndromes
Lars Nilsson,Patrik Edén,Eleonor Olsson,Robert Månsson,Ingbritt Åstrand-Grundström,Bodil Strömbeck,Kim Theilgaard-Mönch,Kristina Anderson,Robert Hast,Eva Hellström-Lindberg,Jan Samuelsson,Gösta Bergh,Claus Nerlov,Bertil Johansson,Mikael Sigvardsson,Åke Borg,Sten Eirik W. Jacobsen
View Articletitled, The molecular signature of MDS stem cells supports a stem-cell origin of 5q− myelodysplastic syndromes
Supplemental data
Lesional gene expression profiling in cutaneous T-cell lymphoma reveals natural clusters associated with disease outcome
Jessica Shin,Stefano Monti,Daniel J. Aires,Madeleine Duvic,Todd Golub,David A. Jones,Thomas S. Kupper
View Articletitled, Lesional gene expression profiling in cutaneous T-cell lymphoma reveals natural clusters associated with disease outcome
Anti–β2-microglobulin monoclonal antibodies induce apoptosis in myeloma cells by recruiting MHC class I to and excluding growth and survival cytokine receptors from lipid rafts
Jing Yang,Xiang Zhang,Ji Wang,Jianfei Qian,Liang Zhang,Michael Wang,Larry W. Kwak,Qing Yi
View Articletitled, Anti–β<sub>2</sub>-microglobulin monoclonal antibodies induce apoptosis in myeloma cells by recruiting MHC class I to and excluding growth and survival cytokine receptors from lipid rafts
Screening for leukemia- and clone-specific markers at birth in children with T-cell precursor ALL suggests a predominantly postnatal origin
Brief Report
Susanna Fischer,Georg Mann,Marianne Konrad,Markus Metzler,Georg Ebetsberger,Neil Jones,Bertrand Nadel,Olaf Bodamer,Oskar A. Haas,Klaus Schmitt,E. Renate Panzer-Grümayer
View Articletitled, Screening for leukemia- and clone-specific markers at birth in children with T-cell precursor ALL suggests a predominantly postnatal origin
Supplemental data

PHAGOCYTES

HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA–forming microsatellite
Henry K. Bayele,Carole Peyssonnaux,Alexandra Giatromanolaki,Wagner W. Arrais-Silva,Hiba S. Mohamed,Helen Collins,Selma Giorgio,Michael Koukourakis,Randall S. Johnson,Jenefer M. Blackwell,Victor Nizet,Surjit Kaila S. Srai
View Articletitled, HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene <em>SLC11A1</em> from a Z-DNA–forming microsatellite
Supplemental data

RED CELLS

Normal erythropoiesis but severe polyposis and bleeding anemia in Smad4-deficient mice
Dejing Pan,Tibor Schomber,Christian P. Kalberer,Luigi M. Terracciano,Katrin Hafen,Werner Krenger,Hui Hao-Shen,Chuxia Deng,Radek C. Skoda
View Articletitled, Normal erythropoiesis but severe polyposis and bleeding anemia in <em>Smad4</em>-deficient mice
Supplemental data

STEM CELLS IN HEMATOLOGY

A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
Yoon-Young Jang,Saul J. Sharkis
View Articletitled, A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
Supplemental data

TRANSPLANTATION

Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease
Claudio G. Brunstein,Juliet N. Barker,Daniel J. Weisdorf,Todd E. DeFor,Jeffrey S. Miller,Bruce R. Blazar,Philip B. McGlave,John E. Wagner
View Articletitled, Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease
One-year acyclovir prophylaxis for preventing varicella-zoster virus disease after hematopoietic cell transplantation: no evidence of rebound varicella-zoster virus disease after drug discontinuation
Veronique Erard,Katherine A. Guthrie,Cara Varley,Judson Heugel,Anna Wald,Mary E. D. Flowers,Lawrence Corey,Michael Boeckh
View Articletitled, One-year acyclovir prophylaxis for preventing varicella-zoster virus disease after hematopoietic cell transplantation: no evidence of rebound varicella-zoster virus disease after drug discontinuation
G-CSF mobilizes slanDCs (6-sulfo LacNAc+ dendritic cells) with a high proinflammatory capacity
Brief Report
Susanne H. C. Baumeister,Kristina Hölig,Martin Bornhäuser,Michael Meurer,E. Peter Rieber,Knut Schäkel
View Articletitled, G-CSF mobilizes slanDCs (6-sulfo LacNAc<sup>+</sup> dendritic cells) with a high proinflammatory capacity

CORRESPONDENCE

Extracellular localization of epimorphin/syntaxin-2
Yohei Hirai,Mina J. Bissell,Derek C. Radisky
View Articletitled, Extracellular localization of epimorphin/syntaxin-2
Response: Extracellular localization of platelet SNARE proteins
Robert Flaumenhaft,Nataliya Rozenvayn,Dian Feng,Ann M. Dvorak
View Articletitled, Response: Extracellular localization of platelet SNARE proteins
Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem-cell transplantation
Uwe Platzbecker,Gerhard Ehninger,Martin Bornhäuser
View Articletitled, Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem-cell transplantation
Response: Further analysis of the relationship between pretransplantation serum ferritin and transplantation outcome: cause-of-death analysis and impact of disease duration
Philippe Armand
View Articletitled, Response: Further analysis of the relationship between pretransplantation serum ferritin and transplantation outcome: cause-of-death analysis and impact of disease duration
Immunogenicity of factor VIII concentrates in patients with hemophilia: a randomized clinical trial is warranted
Alessandro Gringeri,Pier Mannuccio Mannucci
View Articletitled, Immunogenicity of factor VIII concentrates in patients with hemophilia: a randomized clinical trial is warranted
Response: Immunogenicity of factor VIII concentrates in patients with hemophilia: the next sensible step
Johanna G. van der Bom,Samantha C. Gouw,H. Marijke van den Berg
View Articletitled, Response: Immunogenicity of factor VIII concentrates in patients with hemophilia: the next sensible step
Chronic megakaryocytic leukemia, misnamed chronic idiopathic myelofibrosis, has neoplastic not hyperplastic megakaryocytopoiesis
Marshall A. Lichtman
View Articletitled, Chronic megakaryocytic leukemia, misnamed chronic idiopathic myelofibrosis, has neoplastic not hyperplastic megakaryocytopoiesis
Philadelphia-negative clonal hematopoiesis is a significant feature of dasatinib therapy for chronic myeloid leukemia
Valeria A. S. De Melo,Dragana Milojkovic,Jamshid S. Khorashad,David Marin,John M. Goldman,Jane F. Apperley,Alistair G. Reid
View Articletitled, Philadelphia-negative clonal hematopoiesis is a significant feature of dasatinib therapy for chronic myeloid leukemia
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