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Treatment of severe aplastic anemia with antithymocyte globulin and cyclosporin A with or without G-CSF in adults: a multicenter randomized study in Japan
A phase 1 clinical-laboratory study of clofarabine followed by cyclophosphamide for adults with refractory acute leukemias
Issue Archive
September 15 2007
In this Issue
Table of Contents
INSIDE BLOOD
PERSPECTIVE
Revisions to the staging and classification of mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC)
Elise Olsen,Eric Vonderheid,Nicola Pimpinelli,Rein Willemze,Youn Kim,Robert Knobler,Herschel Zackheim,Madeleine Duvic,Teresa Estrach,Stanford Lamberg,Gary Wood,Reinhard Dummer,Annamari Ranki,Gunter Burg,Peter Heald,Mark Pittelkow,Maria-Grazia Bernengo,Wolfram Sterry,Liliane Laroche,Franz Trautinger,Sean Whittaker,for the ISCL/EORTC
REVIEW IN TRANSLATIONAL HEMATOLOGY
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
CLINICAL TRIALS AND OBSERVATIONS
Treatment of severe aplastic anemia with antithymocyte globulin and cyclosporin A with or without G-CSF in adults: a multicenter randomized study in Japan
Clinical Trials & Observations
Masanao Teramura,Akiro Kimura,Satsuki Iwase,Yuji Yonemura,Shinji Nakao,Akio Urabe,Mitsuhiro Omine,Hideaki Mizoguchi
A phase 1 clinical-laboratory study of clofarabine followed by cyclophosphamide for adults with refractory acute leukemias
Clinical Trials & Observations
Judith E. Karp,Rebecca M. Ricklis,Kumudha Balakrishnan,Janet Briel,Jacqueline Greer,Steven D. Gore,B. Douglas Smith,Michael A. McDevitt,Hetty Carraway,Mark J. Levis,Varsha Gandhi
GENE THERAPY
Hot spots of retroviral integration in human CD34+ hematopoietic cells
Claudia Cattoglio,Giulia Facchini,Daniela Sartori,Antonella Antonelli,Annarita Miccio,Barbara Cassani,Manfred Schmidt,Christof von Kalle,Steve Howe,Adrian J. Thrasher,Alessandro Aiuti,Giuliana Ferrari,Alessandra Recchia,Fulvio Mavilio
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration
Abigail Woodfin,Christoph Andreas Reichel,Andrej Khandoga,Monica Corada,Mathieu-Benoit Voisin,Christoph Scheiermann,Dorian O. Haskard,Elisabetta Dejana,Fritz Krombach,Sussan Nourshargh
A critical role for TNFα in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles
Teresa Mateo,Yafa Naim Abu Nabah,Mercedes Losada,Rossana Estellés,Chantal Company,Begoña Bedrina,Jose Miguel Cerdá-Nicolás,Stephen Poole,Peter J. Jose,Julio Cortijo,Esteban J. Morcillo,Maria-Jesus Sanz
IMMUNOBIOLOGY
Defective cytotoxic lymphocyte degranulation in syntaxin-11–deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients
Yenan T. Bryceson,Eva Rudd,Chengyun Zheng,Josefine Edner,Daoxin Ma,Stephanie M. Wood,Anne Grete Bechensteen,Jaap J. Boelens,Tiraje Celkan,Roula A. Farah,Kjell Hultenby,Jacek Winiarski,Paul A. Roche,Magnus Nordenskjöld,Jan-Inge Henter,Eric O. Long,Hans-Gustaf Ljunggren
Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines
Nia Tatsis,Julie C. Fitzgerald,Arturo Reyes-Sandoval,Kimberly C. Harris-McCoy,Scott E. Hensley,Dongming Zhou,Shih-Wen Lin,Ang Bian,Zhi Quan Xiang,Amaya Iparraguirre,Cesar Lopez-Camacho,E. John Wherry,Hildegund C. J. Ertl
Graft-versus-leukemia effects associated with detectable Wilms tumor-1–specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia
Katayoun Rezvani,Agnes S. M. Yong,Bipin N. Savani,Stephan Mielke,Keyvan Keyvanfar,Emma Gostick,David A. Price,Daniel C. Douek,A. John Barrett
Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells
Christopher J. Ong,Andrew Ming-Lum,Matt Nodwell,Ali Ghanipour,Lu Yang,David E. Williams,Joseph Kim,Loutfig Demirjian,Pooran Qasimi,Jens Ruschmann,Li-Ping Cao,Kewei Ma,Stephen W. Chung,Vincent Duronio,Raymond J. Andersen,Gerald Krystal,Alice L.-F. Mui
Cytotoxic T lymphocytes carrying a pattern recognition protein Tag7 can detect evasive, HLA-negative but Hsp70-exposing tumor cells, thereby ensuring FasL/Fas-mediated contact killing
Lidia P. Sashchenko,Elena A. Dukhanina,Yury V. Shatalov,Denis V. Yashin,Tamara I. Lukyanova,Olga D. Kabanova,Elena A. Romanova,Sergei V. Khaidukov,Alexander V. Galkin,Nikolai V. Gnuchev,Georgii P. Georgiev
NEOPLASIA
AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo
Jing Yang,Takayuki Ikezoe,Chie Nishioka,Taizo Tasaka,Ayuko Taniguchi,Yoshio Kuwayama,Naoki Komatsu,Kentaro Bandobashi,Kazuto Togitani,H. Phillip Koeffler,Hirokuni Taguchi,Akihito Yokoyama
The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy
Yang Yang,Veronica MacLeod,Yuemeng Dai,Yekaterina Khotskaya-Sample,Zachary Shriver,Ganesh Venkataraman,Ram Sasisekharan,Annamaria Naggi,Giangiacomo Torri,Benito Casu,Israel Vlodavsky,Larry J. Suva,Joshua Epstein,Shmuel Yaccoby,John D. Shaughnessy, Jr,Bart Barlogie,Ralph D. Sanderson
RED CELLS
HIF–prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques
Matthew M. Hsieh,N. Seth Linde,Aisha Wynter,Mark Metzger,Carol Wong,Ingrid Langsetmo,Al Lin,Reginald Smith,Griffin P. Rodgers,Robert E. Donahue,Stephen J. Klaus,John F. Tisdale
Mosaicism due to myeloid lineage–restricted loss of heterozygosity as cause of spontaneous Rh phenotype splitting
Günther F. Körmöczi,Eva-Maria Dauber,Oskar A. Haas,Tobias J. Legler,Frederik B. Clausen,Gerhard Fritsch,Markus Raderer,Christoph Buchta,Andreas L. Petzer,Diether Schönitzer,Wolfgang R. Mayr,Christoph Gassner
STEM CELLS IN HEMATOLOGY
TRANSFUSION MEDICINE
TRANSPLANTATION
Successful treatment of lymphoproliferative disease complicating primary immunodeficiency/immunodysregulatory disorders with reduced-intensity allogeneic stem-cell transplantation
Jonathan M. Cohen,Neil J. Sebire,Julia Harvey,H. Bobby Gaspar,Cale Cathy,Alison Jones,Kanchan Rao,David Cubitt,Persis J. Amrolia,E. Graham Davies,Paul Veys
CORRESPONDENCE
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Cover Image
Cover Image
![issue cover]()
Spread neutrophils (red) colocalize with annexin 5–positive platelets (green) on the margins of thrombi. PAF production by these platelets induces localized neutrophil spreading under flow. See the related article by Kulkarni et al, beginning on page 1879.
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