Jianbiao Zhou,for the Dana-Farber Cancer Institute ALL Consortium,Meredith A Goldwasser,for the Dana-Farber Cancer Institute ALL Consortium,Aihong Li,for the Dana-Farber Cancer Institute ALL Consortium,Suzanne E. Dahlberg,for the Dana-Farber Cancer Institute ALL Consortium,Donna Neuberg,for the Dana-Farber Cancer Institute ALL Consortium,Hongjun Wang,for the Dana-Farber Cancer Institute ALL Consortium,Virginia Dalton,for the Dana-Farber Cancer Institute ALL Consortium,Kathryn D McBride,for the Dana-Farber Cancer Institute ALL Consortium,Stephen E. Sallan,for the Dana-Farber Cancer Institute ALL Consortium,Lewis B Silverman,for the Dana-Farber Cancer Institute ALL Consortium,John G. Gribben,for the Dana-Farber Cancer Institute ALL Consortium

View Articletitled, Quantitative analysis of minimal residual disease predicts relapse in children with B-lineage acute lymphoblastic leukemia in DFCI ALL Consortium Protocol 95-01

Supplemental data

Genetic and pharmacologic evidence implicating the p85α, but not p85β, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis

Veerendra Munugalavadla,Emily C. Sims,Jovencio Borneo,Rebecca J. Chan,Reuben Kapur

View Articletitled, Genetic and pharmacologic evidence implicating the p85α, but not p85β, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis

NPM-ALK oncogenic kinase promotes cell-cycle progression through activation of JNK/cJun signaling in anaplastic large-cell lymphoma

Vasiliki Leventaki,Elias Drakos,L. Jeffrey Medeiros,Megan S. Lim,Kojo S. Elenitoba-Johnson,Francois X. Claret,George Z. Rassidakis

View Articletitled, NPM-ALK oncogenic kinase promotes cell-cycle progression through activation of JNK/cJun signaling in anaplastic large-cell lymphoma

Supplemental data

Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCF^Skp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas

Tint Lwin,Lori A. Hazlehurst,Sophie Dessureault,Raymond Lai,Wenlong Bai,Eduardo Sotomayor,Lynn C. Moscinski,William S. Dalton,Jianguo Tao

View Articletitled, Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas

MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML

Michael Heuser,Bob Argiropoulos,Florian Kuchenbauer,Eric Yung,Jessica Piper,Stephen Fung,Richard F. Schlenk,Konstanze Dohner,Tanja Hinrichsen,Cornelia Rudolph,Axel Schambach,Christopher Baum,Brigitte Schlegelberger,Hartmut Dohner,Arnold Ganser,R. Keith Humphries

View Articletitled, MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML

Supplemental data

Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia

Daniel C. Link,Ghada Kunter,Yumi Kasai,Yu Zhao,Tracie Miner,Michael D. McLellan,Rhonda E. Ries,Deepak Kapur,Rakesh Nagarajan,David C. Dale,Audrey Anna Bolyard,Laurence A. Boxer,Karl Welte,Cornelia Zeidler,Jean Donadieu,Christine Bellanné-Chantelot,James W. Vardiman,Michael A. Caligiuri,Clara D. Bloomfield,John F. DiPersio,Michael H. Tomasson,Timothy A. Graubert,Peter Westervelt,Mark Watson,William Shannon,Jack Baty,Elaine R. Mardis,Richard K. Wilson,Timothy J. Ley

View Articletitled, Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia

Supplemental data

RETRACTED: Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis

Yu-Tzu Tai,Mariateresa Fulciniti,Teru Hideshima,Weihua Song,Merav Leiba,Xian-Feng Li,Matthew Rumizen,Peter Burger,Aileen Morrison,Klaus Podar,Dharminder Chauhan,Pierfrancesco Tassone,Paul Richardson,Nikhil C. Munshi,Irene M. Ghobrial,Kenneth C. Anderson

View Articletitled, RETRACTED: Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis

A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Δ^{12, 14} prostaglandin J₂ production

Hiroo Hasegawa,Yasuaki Yamada,Kanki Komiyama,Masahiko Hayashi,Masami Ishibashi,Toshiaki Sunazuka,Takeshi Izuhara,Kazuyuki Sugahara,Kazuto Tsuruda,Masato Masuda,Nobuyuki Takasu,Kunihiro Tsukasaki,Masao Tomonaga,Shimeru Kamihira

View Articletitled, A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Δ12, 14 prostaglandin J2 production

JAK2 617V>F–positive polycythemia rubra vera maintained by approximately 18 stochastic stem-cell divisions per year, explaining age of onset by a single rate-limiting mutation

Mark A. Vickers

View Articletitled, JAK2 617V>F–positive polycythemia rubra vera maintained by approximately 18 stochastic stem-cell divisions per year, explaining age of onset by a single rate-limiting mutation

Supplemental data

TRANSPLANTATION

Respiratory virus infection among hematopoietic cell transplant recipients: evidence for asymptomatic parainfluenza virus infection

Angela J. Peck,Janet A. Englund,Jane Kuypers,Katherine A. Guthrie,Lawrence Corey,Rhoda Morrow,Robert C. Hackman,Anne Cent,Michael Boeckh

View Articletitled, Respiratory virus infection among hematopoietic cell transplant recipients: evidence for asymptomatic parainfluenza virus infection

Reconstitution of FOXP3⁺ regulatory T cells (T_regs) after CD25-depleted allotransplantion in elderly patients and association with acute graft-versus-host disease

Stephan Mielke,Katayoun Rezvani,Bipin N. Savani,Raquel Nunes,Agnes S. M. Yong,John Schindler,Roger Kurlander,Victor Ghetie,Elizabeth J. Read,Scott R. Solomon,Ellen S. Vitetta,A. John Barrett

View Articletitled, Reconstitution of FOXP3+ regulatory T cells (Tregs) after CD25-depleted allotransplantion in elderly patients and association with acute graft-versus-host disease

CORRESPONDENCE

Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia

Marc C. Chamberlain,Michael J. Glantz

View Articletitled, Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia

Neurologic toxicity of intrathecal liposomal cytarabine when used for CNS prophylaxis in conjunction with the hyper-CVAD regimen

Deborah A. Thomas,Elias Jabbour,Hagop Kantarjian,Susan O'Brien

View Articletitled, Neurologic toxicity of intrathecal liposomal cytarabine when used for CNS prophylaxis in conjunction with the hyper-CVAD regimen

Therapeutic drug monitoring in CML patients on imatinib

Carolyn Blasdel,Merrill J. Egorin,Theodore F. Lagattuta,Brian J. Druker,Michael W. Deininger

View Articletitled, Therapeutic drug monitoring in CML patients on imatinib

Use of therapeutic drug monitoring in CML patients on imatinib

François-Xavier Mahon,Stéphane Picard,Gerald Marit,Philip Robinson,Mathieu Molimard

View Articletitled, Use of therapeutic drug monitoring in CML patients on imatinib

Cover Image

Cover Image

A naive, antigen-specific T cell is seen (red) contacting a dendritic cell (DC, green), which presents cognate antigen. Ultimately, the T cell will be activated by this interaction. Red staining shows the distribution of the T-cell receptor (TCR) signal by staining with a clonotypic antibody; green shows staining for actin by phalloidin-FITC. Both figures show the same cell pair as a volume-rendered Z-stack. However, the lower image is rotated 180° on the vertical axis to show the back of the DC with membrane veils more precisely. Note the homogeneous distribution of the TCR on the T-cell surface despite its effective interaction with the DC. No enrichment of the TCR signal indicative of the formation of a classic mature immunological synapse can be detected at the T-DC interface.
Front Matter
Table of Contents
Advertising
Editorial Board

All Issues

Advertisement intended for health care professionals

Email alerts

First Edition Alert

Latest Issue Alert

Latest
Most Read
Most Cited

Introduction to a How I Treat series on iron overload in hematologic disorders

VenEx precisely predicts ven-aza response

“Complementing” hemolytic anemias: what’s next?

Another cryo-EM success: structure of FXIII

CD5-positive high-grade B-cell lymphoma with MYC, BCL2, and BCL6 rearrangements

Advertisement intended for health care professionals

Issue Archive

Table of Contents

INSIDE BLOOD

BLOOD WORK

REVIEW IN TRANSLATIONAL HEMATOLOGY

ERRATUM

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

CLINICAL TRIALS AND OBSERVATIONS

Identification of genomic classifiers that distinguish induction failure in T-lineage acute lymphoblastic leukemia: a report from the Children's Oncology Group Clinical Trials & Observations

Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Anti–factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome Brief Report

IMMUNOBIOLOGY

Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia Brief Report

NEOPLASIA

TRANSPLANTATION

CORRESPONDENCE

Cover Image

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

Identification of genomic classifiers that distinguish induction failure in T-lineage acute lymphoblastic leukemia: a report from the Children's Oncology Group
Clinical Trials & Observations

Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita
Clinical Trials & Observations

Anti–factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome
Brief Report

Deficient CD4⁺ CD25⁺ FOXP3⁺ T regulatory cells in acquired aplastic anemia
Brief Report