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Identification of genomic classifiers that distinguish induction failure in T-lineage acute lymphoblastic leukemia: a report from the Children's Oncology Group
Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita
Issue Archive
September 1 2007
Table of Contents
INSIDE BLOOD
BLOOD WORK
REVIEW IN TRANSLATIONAL HEMATOLOGY
ERRATUM
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
CLINICAL TRIALS AND OBSERVATIONS
Identification of genomic classifiers that distinguish induction failure in T-lineage acute lymphoblastic leukemia: a report from the Children's Oncology Group
Clinical Trials & Observations
Stuart S. Winter,Zeyu Jiang,Hadya M. Khawaja,Timothy Griffin,Meenakshi Devidas,Barbara L. Asselin,Richard S. Larson
Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita
Clinical Trials & Observations
Blanche P. Alter,Gabriela M. Baerlocher,Sharon A. Savage,Stephen J. Chanock,Babette B. Weksler,Judith P. Willner,June A. Peters,Neelam Giri,Peter M. Lansdorp
GENE THERAPY
Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells
Fang Zhang,Susannah I. Thornhill,Steven J. Howe,Meera Ulaganathan,Axel Schambach,Joanna Sinclair,Christine Kinnon,H. Bobby Gaspar,Michael Antoniou,Adrian J. Thrasher
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
Noncanonical NF-κB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation
Sander W. Tas,Margriet J. Vervoordeldonk,Najat Hajji,Joost H. N. Schuitemaker,Koen F. van der Sluijs,Michael J. May,Sankar Ghosh,Martien L. Kapsenberg,Paul P. Tak,Esther C. de Jong
Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function
Jan Kubach,Petra Lutter,Tobias Bopp,Sabine Stoll,Christian Becker,Eva Huter,Christoph Richter,Petra Weingarten,Tobias Warger,Jürgen Knop,Stefan Müllner,John Wijdenes,Hansjörg Schild,Edgar Schmitt,Helmut Jonuleit
Immunologic evidence for lack of heterologous protection following resolution of HCV in patients with non–genotype 1 infection
Julian Schulze zur Wiesch,Georg M. Lauer,Joerg Timm,Thomas Kuntzen,Martin Neukamm,Andrew Berical,Andrea M. Jones,Brian E. Nolan,Steve A. Longworth,Victoria Kasprowicz,Cory McMahon,Alysse Wurcel,Ansgar W. Lohse,Lia L. Lewis-Ximenez,Raymond T. Chung,Arthur Y. Kim,Todd M. Allen,Bruce D. Walker
NEOPLASIA
Quantitative analysis of minimal residual disease predicts relapse in children with B-lineage acute lymphoblastic leukemia in DFCI ALL Consortium Protocol 95-01
Jianbiao Zhou,Meredith A Goldwasser,Aihong Li,Suzanne E. Dahlberg,Donna Neuberg,Hongjun Wang,Virginia Dalton,Kathryn D McBride,Stephen E. Sallan,Lewis B Silverman,John G. Gribben,for the Dana-Farber Cancer Institute ALL Consortium
Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas
Tint Lwin,Lori A. Hazlehurst,Sophie Dessureault,Raymond Lai,Wenlong Bai,Eduardo Sotomayor,Lynn C. Moscinski,William S. Dalton,Jianguo Tao
MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML
Michael Heuser,Bob Argiropoulos,Florian Kuchenbauer,Eric Yung,Jessica Piper,Stephen Fung,Richard F. Schlenk,Konstanze Dohner,Tanja Hinrichsen,Cornelia Rudolph,Axel Schambach,Christopher Baum,Brigitte Schlegelberger,Hartmut Dohner,Arnold Ganser,R. Keith Humphries
Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia
Daniel C. Link,Ghada Kunter,Yumi Kasai,Yu Zhao,Tracie Miner,Michael D. McLellan,Rhonda E. Ries,Deepak Kapur,Rakesh Nagarajan,David C. Dale,Audrey Anna Bolyard,Laurence A. Boxer,Karl Welte,Cornelia Zeidler,Jean Donadieu,Christine Bellanné-Chantelot,James W. Vardiman,Michael A. Caligiuri,Clara D. Bloomfield,John F. DiPersio,Michael H. Tomasson,Timothy A. Graubert,Peter Westervelt,Mark Watson,William Shannon,Jack Baty,Elaine R. Mardis,Richard K. Wilson,Timothy J. Ley
Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis
Yu-Tzu Tai,Mariateresa Fulciniti,Teru Hideshima,Weihua Song,Merav Leiba,Xian-Feng Li,Matthew Rumizen,Peter Burger,Aileen Morrison,Klaus Podar,Dharminder Chauhan,Pierfrancesco Tassone,Paul Richardson,Nikhil C. Munshi,Irene M. Ghobrial,Kenneth C. Anderson
A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Δ12, 14 prostaglandin J2 production
Hiroo Hasegawa,Yasuaki Yamada,Kanki Komiyama,Masahiko Hayashi,Masami Ishibashi,Toshiaki Sunazuka,Takeshi Izuhara,Kazuyuki Sugahara,Kazuto Tsuruda,Masato Masuda,Nobuyuki Takasu,Kunihiro Tsukasaki,Masao Tomonaga,Shimeru Kamihira
TRANSPLANTATION
Reconstitution of FOXP3+ regulatory T cells (Tregs) after CD25-depleted allotransplantion in elderly patients and association with acute graft-versus-host disease
Stephan Mielke,Katayoun Rezvani,Bipin N. Savani,Raquel Nunes,Agnes S. M. Yong,John Schindler,Roger Kurlander,Victor Ghetie,Elizabeth J. Read,Scott R. Solomon,Ellen S. Vitetta,A. John Barrett
CORRESPONDENCE
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Cover Image
Cover Image
![issue cover]()
A naive, antigen-specific T cell is seen (red) contacting a dendritic cell (DC, green), which presents cognate antigen. Ultimately, the T cell will be activated by this interaction. Red staining shows the distribution of the T-cell receptor (TCR) signal by staining with a clonotypic antibody; green shows staining for actin by phalloidin-FITC. Both figures show the same cell pair as a volume-rendered Z-stack. However, the lower image is rotated 180° on the vertical axis to show the back of the DC with membrane veils more precisely. Note the homogeneous distribution of the TCR on the T-cell surface despite its effective interaction with the DC. No enrichment of the TCR signal indicative of the formation of a classic mature immunological synapse can be detected at the T-DC interface.
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