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An actuarial GPS for hemophilic longevity
Mortality rates, life expectancy, and causes of death in people with hemophilia A or B in the United Kingdom who were not infected with HIV
High serum-free light chain levels and their rapid reduction in response to therapy define an aggressive multiple myeloma subtype with poor prognosis
A screening and intervention program aimed to reduce mortality and serious morbidity associated with severe neonatal alloimmune thrombocytopenia
Clinical profile of homozygous JAK2 617V>F mutation in patients with polycythemia vera or essential thrombocythemia
Constitutive phosphoinositide 3-kinase/Akt activation represents a favorable prognostic factor in de novo acute myelogenous leukemia patients
Issue Archive
Table of Contents
INSIDE BLOOD
CLINICAL TRIALS AND OBSERVATIONS
An actuarial GPS for hemophilic longevity
Clinical Trials & Observations
BLOOD WORK
REVIEW ARTICLES
REVIEW IN TRANSLATIONAL HEMATOLOGY
CLINICAL TRIALS AND OBSERVATIONS
Mortality rates, life expectancy, and causes of death in people with hemophilia A or B in the United Kingdom who were not infected with HIV
Clinical Trials & Observations
Sarah C. Darby,Sau Wan Kan,Rosemary J. Spooner,Paul L. F. Giangrande,Frank G. H. Hill,Charles R. M. Hay,Christine A. Lee,Christopher A. Ludlam,Michael Williams,for the UK Haemophilia Centre Doctors' Organisation
High serum-free light chain levels and their rapid reduction in response to therapy define an aggressive multiple myeloma subtype with poor prognosis
Clinical Trials & Observations
Frits van Rhee,Vanessa Bolejack,Klaus Hollmig,Mauricio Pineda-Roman,Elias Anaissie,Joshua Epstein,John D. Shaughnessy, Jr,Maurizio Zangari,Guido Tricot,Abid Mohiuddin,Yazan Alsayed,Gail Woods,John Crowley,Bart Barlogie
A screening and intervention program aimed to reduce mortality and serious morbidity associated with severe neonatal alloimmune thrombocytopenia
Clinical Trials & Observations
Jens Kjeldsen-Kragh,Mette Kjær Killie,Geir Tomter,Elzbieta Golebiowska,Ingrid Randen,Reidun Hauge,Berit Aune,Pål Øian,Lauritz B. Dahl,Jouko Pirhonen,Rolf Lindeman,Henrik Husby,Guttorm Haugen,Morten Grønn,Bjørn Skogen,Anne Husebekk
Clinical profile of homozygous JAK2 617V>F mutation in patients with polycythemia vera or essential thrombocythemia
Clinical Trials & Observations
Alessandro M. Vannucchi,Elisabetta Antonioli,Paola Guglielmelli,Alessandro Rambaldi,Giovanni Barosi,Roberto Marchioli,Rosa Maria Marfisi,Guido Finazzi,Vittoria Guerini,Fabrizio Fabris,Maria Luigia Randi,Valerio De Stefano,Sabrina Caberlon,Agostino Tafuri,Marco Ruggeri,Giorgina Specchia,Vincenzo Liso,Edoardo Rossi,Enrico Pogliani,Luigi Gugliotta,Alberto Bosi,Tiziano Barbui,for the Italian Group for Malignant Hematologic Disorders of the Adult–Myeloproliferative Disorder Working Party (GIMEMA-MPD WP)
ERRATUM
HEMATOPOIESIS
Disruption of palladin leads to defects in definitive erythropoiesis by interfering with erythroblastic island formation in mouse fetal liver
Xue-Song Liu,Xi-Hua Li,Yi Wang,Run-Zhe Shu,Long Wang,Shun-Yuan Lu,Hui Kong,Yue-E Jin,Li-Jun Zhang,Jian Fei,Sai-Juan Chen,Zhu Chen,Ming-Min Gu,Zhen-Yu Lu,Zhu-Gang Wang
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection
Constantinos Petrovas,David A. Price,Joseph Mattapallil,David R. Ambrozak,Christof Geldmacher,Valentina Cecchinato,Monica Vaccari,Elzbieta Tryniszewska,Emma Gostick,Mario Roederer,Daniel C. Douek,Sara H. Morgan,Simon J. Davis,Genoveffa Franchini,Richard A. Koup
Mast cells are crucial for early inflammation, migration of Langerhans cells, and CTL responses following topical application of TLR7 ligand in mice
Valeska Heib,Marc Becker,Tobias Warger,Gerd Rechtsteiner,Christine Tertilt,Matthias Klein,Tobias Bopp,Christian Taube,Hansjörg Schild,Edgar Schmitt,Michael Stassen
NEOPLASIA
High levels of the BCR/ABL oncoprotein are required for the MAPK-hnRNP-E2–dependent suppression of C/EBPα-driven myeloid differentiation
Ji Suk Chang,Ramasamy Santhanam,Rossana Trotta,Paolo Neviani,Anna M. Eiring,Edward Briercheck,Mattia Ronchetti,Denis C. Roy,Bruno Calabretta,Michael A. Caligiuri,Danilo Perrotti
Flt3-dependent transformation by inactivating c-Cbl mutations in AML
Bülent Sargin,Chunaram Choudhary,Nicola Crosetto,Mirko H. H. Schmidt,Rebekka Grundler,Marion Rensinghoff,Christine Thiessen,Lara Tickenbrock,Joachim Schwäble,Christian Brandts,Benjamin August,Steffen Koschmieder,Srinivasa Rao Bandi,Justus Duyster,Wolfgang E. Berdel,Carsten Müller-Tidow,Ivan Dikic,Hubert Serve
The JAK2 617V>F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia vera
Sabrina Dupont,Aline Massé,Chloé James,Irène Teyssandier,Yann Lécluse,Frédéric Larbret,Valérie Ugo,Patrick Saulnier,Serge Koscielny,Jean Pierre Le Couédic,Nicole Casadevall,William Vainchenker,François Delhommeau
Constitutive phosphoinositide 3-kinase/Akt activation represents a favorable prognostic factor in de novo acute myelogenous leukemia patients
Brief Report
Jerome Tamburini,Caroline Elie,Valérie Bardet,Nicolas Chapuis,Sophie Park,Philippe Broët,Pascale Cornillet-Lefebvre,Bruno Lioure,Valérie Ugo,Odile Blanchet,Norbert Ifrah,Francis Witz,François Dreyfus,Patrick Mayeux,Catherine Lacombe,Didier Bouscary
PHAGOCYTES
RED CELLS
TRANSPLANTATION
Alternative splicing due to an intronic SNP in HMSD generates a novel minor histocompatibility antigen
Takakazu Kawase,Yoshiki Akatsuka,Hiroki Torikai,Satoko Morishima,Akira Oka,Akane Tsujimura,Mikinori Miyazaki,Kunio Tsujimura,Koichi Miyamura,Seishi Ogawa,Hidetoshi Inoko,Yasuo Morishima,Yoshihisa Kodera,Kiyotaka Kuzushima,Toshitada Takahashi
IFNγ differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract
Angela C. Burman,Tatjana Banovic,Rachel D. Kuns,Andrew D. Clouston,Amanda C. Stanley,Edward S. Morris,Vanessa Rowe,Helen Bofinger,Renae Skoczylas,Neil Raffelt,Olivier Fahy,Shaun R. McColl,Christian R. Engwerda,Kelli P. A. McDonald,Geoffrey R. Hill
CORRESPONDENCE
Analysis of JAK3, JAK2, and C-MPL mutations in transient myeloproliferative disorder and myeloid leukemia of Down syndrome blasts in children with Down syndrome
Alice Norton,Chris Fisher,Hui Liu,Qiang Wen,Gina Mundschau,Jose Luis Fuster,Henrik Hasle,Bernward Zeller,David K. Webb,Aengus O'Marcaigh,April Sorrell,Joanne Hilden,Alan Gamis,John D. Crispino,Paresh Vyas
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Cover Image
Cover Image
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Insulitis of a pancreatic islet in a young GM-CSF/IL-3–deficient mouse treated with an anti–CTLA-4 monoclonal antibody. See the related article by Enzler et al, beginning on page 954.
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