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Issue Archive

Volume 110, Issue 2
July 15 2007
Issue Cover

Table of Contents

INSIDE BLOOD

NEOPLASIA
Hsp32: MASTer of KIT?
Michel A. Arock
View Articletitled, Hsp32: MASTer of KIT?
NEOPLASIA
Ph+ ALL: resistance seeds sown early
Timothy Hughes,Susan Branford
View Articletitled, Ph<sup>+</sup> ALL: resistance seeds sown early
CLINICAL OBSERVATIONS
Thrombocytosis, pregnancy, and regression toward mean
Jerry L. Spivak
View Articletitled, Thrombocytosis, pregnancy, and regression toward mean
NEOPLASIA
Del(5q): gene dosage matters
Matthew J. Walter
View Articletitled, Del(5q): gene dosage matters
RED CELLS
Cell-cycle regulation by iron depletion
Chaim Hershko
View Articletitled, Cell-cycle regulation by iron depletion
IMMUNOBIOLOGY
Orphan granzyme turned lethal weapon
Todd A. Fehniger
View Articletitled, Orphan granzyme turned lethal weapon
NEOPLASIA
ATRA: Finding targeted APL therapy targets
Arati Khanna-Gupta,Nancy Berliner
View Articletitled, ATRA: Finding targeted APL therapy targets

REVIEW ARTICLES

TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the Cutaneous Lymphoma Task Force of the European Organization of Research and Treatment of Cancer (EORTC)
Youn H. Kim,Rein Willemze,Nicola Pimpinelli,Sean Whittaker,Elise A. Olsen,Annamari Ranki,Reinhard Dummer,Richard T. Hoppe,for the ISCL and the EORTC
View Articletitled, TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the Cutaneous Lymphoma Task Force of the European Organization of Research and Treatment of Cancer (EORTC)
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Increased risk of pregnancy complications in patients with essential thrombocythemia carrying the JAK2 (617V>F) mutation
Clinical Trials & Observations
Francesco Passamonti,Maria Luigia Randi,Elisa Rumi,Ester Pungolino,Chiara Elena,Daniela Pietra,Margherita Scapin,Luca Arcaini,Fabiana Tezza,Remigio Moratti,Cristiana Pascutto,Fabrizio Fabris,Enrica Morra,Mario Cazzola,Mario Lazzarino
View Articletitled, Increased risk of pregnancy complications in patients with essential thrombocythemia carrying the <em>JAK2</em> (617V&gt;F) mutation
Sirolimus-based graft-versus-host disease prophylaxis protects against cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation: a cohort analysis
Clinical Trials & Observations
Francisco M. Marty,Julie Bryar,Sarah K. Browne,Talya Schwarzberg,Vincent T. Ho,Ingrid V. Bassett,John Koreth,Edwin P. Alyea,Robert J. Soiffer,Corey S. Cutler,Joseph H. Antin,Lindsey R. Baden
View Articletitled, Sirolimus-based graft-versus-host disease prophylaxis protects against cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation: a cohort analysis
Bovine apolipoprotein B-100 is a dominant immunogen in therapeutic cell populations cultured in fetal calf serum in mice and humans
Clinical Trials & Observations
Norihisa Sakamoto,Kazuhide Tsuji,Linda M. Muul,Ann M. Lawler,Emanuel F. Petricoin,Fabio Candotti,Julia A. Metcalf,Jorge A. Tavel,H. Clifford Lane,Walter J. Urba,Bernard A. Fox,Ajit Varki,Joan K. Lunney,Amy S. Rosenberg
View Articletitled, Bovine apolipoprotein B-100 is a dominant immunogen in therapeutic cell populations cultured in fetal calf serum in mice and humans
Supplemental data

HEMATOPOIESIS

Erythropoietin modulation of podocalyxin and a proposed erythroblast niche
Pradeep Sathyanarayana,Madhu P. Menon,Olga Bogacheva,Oleg Bogachev,Knut Niss,William S. Kapelle,Estelle Houde,Jing Fang,Don M. Wojchowski
View Articletitled, Erythropoietin modulation of podocalyxin and a proposed erythroblast niche
Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Mechanisms of induction of endothelial cell E-selectin expression by smooth muscle cells and its inhibition by shear stress
Jeng-Jiann Chiu,Li-Jing Chen,Chih-I Lee,Pei-Ling Lee,Ding-Yu Lee,Min-Chien Tsai,Chia-Wen Lin,Shunichi Usami,Shu Chien
View Articletitled, Mechanisms of induction of endothelial cell E-selectin expression by smooth muscle cells and its inhibition by shear stress
Supplemental data
Diverging signaling events control the pathway of GPVI down-regulation in vivo
Tamer Rabie,David Varga-Szabo,Markus Bender,Rastislav Pozgaj,Francois Lanza,Takashi Saito,Stephen P. Watson,Bernhard Nieswandt
View Articletitled, Diverging signaling events control the pathway of GPVI down-regulation in vivo
Osteoprotegerin increases leukocyte adhesion to endothelial cells both in vitro and in vivo
Giorgio Zauli,Federica Corallini,Fleur Bossi,Fabio Fischetti,Paolo Durigutto,Claudio Celeghini,Francesco Tedesco,Paola Secchiero
View Articletitled, Osteoprotegerin increases leukocyte adhesion to endothelial cells both in vitro and in vivo

IMMUNOBIOLOGY

Natural killer cell–derived human granzyme H induces an alternative, caspase-independent cell-death program
Edward Fellows,Shirley Gil-Parrado,Dieter E. Jenne,Florian C. Kurschus
View Articletitled, Natural killer cell–derived human granzyme H induces an alternative, caspase-independent cell-death program
Supplemental data
Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-γ production and the induction of Th1 cell differentiation
Naoki Tokumasa,Akira Suto,Shin-ichiro Kagami,Shunsuke Furuta,Koichi Hirose,Norihiko Watanabe,Yasushi Saito,Kazuya Shimoda,Itsuo Iwamoto,Hiroshi Nakajima
View Articletitled, Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-γ production and the induction of Th1 cell differentiation
Group V secretory PLA2 regulates TLR2-dependent eicosanoid generation in mouse mast cells through amplification of ERK and cPLA2α activation
Eriya Kikawada,Joseph V. Bonventre,Jonathan P. Arm
View Articletitled, Group V secretory PLA<sub>2</sub> regulates TLR2-dependent eicosanoid generation in mouse mast cells through amplification of ERK and cPLA<sub>2</sub>α activation
HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation
Ute Feger,Eva Tolosa,Yu-Hwa Huang,Anne Waschbisch,Tilo Biedermann,Arthur Melms,Heinz Wiendl
View Articletitled, HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation
Supplemental data
A subpopulation of human peripheral blood NK cells that lacks inhibitory receptors for self-MHC is developmentally immature
Sarah Cooley,Feng Xiao,Michelle Pitt,Michelle Gleason,Valarie McCullar,Tracy L. Bergemann,Karina L. McQueen,Lisbeth A. Guethlein,Peter Parham,Jeffrey S. Miller
View Articletitled, A subpopulation of human peripheral blood NK cells that lacks inhibitory receptors for self-MHC is developmentally immature
Supplemental data
Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes
Dong-Ming Kuang,Yan Wu,Nini Chen,Jiasen Cheng,Shi-Mei Zhuang,Limin Zheng
View Articletitled, Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes
Supplemental data
A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation
Michal Smida,Anita Posevitz-Fejfar,Vaclav Horejsi,Burkhart Schraven,Jonathan A. Lindquist
View Articletitled, A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation
Supplemental data
Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis
Cristina Cerboni,Alessandra Zingoni,Marco Cippitelli,Mario Piccoli,Luigi Frati,Angela Santoni
View Articletitled, Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis
Supplemental data

NEOPLASIA

Antibody-drug conjugates targeted to CD79 for the treatment of non-Hodgkin lymphoma
Andrew G. Polson,Shang-Fan Yu,Kristi Elkins,Bing Zheng,Suzanna Clark,Gladys S. Ingle,Dionysos S. Slaga,Lynne Giere,Changchun Du,Christine Tan,Jo-Anne Hongo,Alvin Gogineni,Mary J. Cole,Richard Vandlen,Jean-Philippe Stephan,Judy Young,Wesley Chang,Suzie J. Scales,Sarajane Ross,Dan Eaton,Allen Ebens
View Articletitled, Antibody-drug conjugates targeted to CD79 for the treatment of non-Hodgkin lymphoma
Supplemental data
Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF
Yuhui Huang,Xiaolan Chen,Mikhail M. Dikov,Sergey V. Novitskiy,Claudio A. Mosse,Li Yang,David P. Carbone
View Articletitled, Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF
Relapse in children with acute lymphoblastic leukemia involving selection of a preexisting drug-resistant subclone
Seoyeon Choi,Michelle J. Henderson,Edward Kwan,Alex H. Beesley,Rosemary Sutton,Anita Y. Bahar,Jodie Giles,Nicola C. Venn,Luciano Dalla Pozza,David L. Baker,Glenn M. Marshall,Ursula R. Kees,Michelle Haber,Murray D. Norris
View Articletitled, Relapse in children with acute lymphoblastic leukemia involving selection of a preexisting drug-resistant subclone
RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells
Hidenori Hattori,Xueqing Zhang,Yonghui Jia,Kulandayan K. Subramanian,Hakryul Jo,Fabien Loison,Peter E. Newburger,Hongbo R. Luo
View Articletitled, RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells
Supplemental data
Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells
Lori Rink,Artur Slupianek,Tomasz Stoklosa,Margaret Nieborowska-Skorska,Katarzyna Urbanska,Ilona Seferynska,Krzysztof Reiss,Tomasz Skorski
View Articletitled, Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells
Supplemental data
Identification of heat shock protein 32 (Hsp32) as a novel survival factor and therapeutic target in neoplastic mast cells
Rudin Kondo,Karoline V. Gleixner,Matthias Mayerhofer,Anja Vales,Alexander Gruze,Puchit Samorapoompichit,Khaled Greish,Maria-Theresa Krauth,Karl J. Aichberger,Winfried F. Pickl,Harald Esterbauer,Christian Sillaber,Hiroshi Maeda,Peter Valent
View Articletitled, Identification of heat shock protein 32 (Hsp32) as a novel survival factor and therapeutic target in neoplastic mast cells
Supplemental data
Prognostic significance of circulating tumor cells in bone marrow or peripheral blood as detected by qualitative and quantitative PCR in pediatric NPM-ALK–positive anaplastic large-cell lymphoma
Christine Damm-Welk,Kerstin Busch,Birgit Burkhardt,Jutta Schieferstein,Susanne Viehmann,Ilske Oschlies,Wolfram Klapper,Martin Zimmermann,Jochen Harbott,Alfred Reiter,Willi Woessmann
View Articletitled, Prognostic significance of circulating tumor cells in bone marrow or peripheral blood as detected by qualitative and quantitative PCR in pediatric <em>NPM-ALK</em>–positive anaplastic large-cell lymphoma
Supplemental data
Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I–induced leukemia and suppresses leukemic stem cells
Cong Peng,Julia Brain,Yiguo Hu,Ami Goodrich,Linghong Kong,David Grayzel,Roger Pak,Margaret Read,Shaoguang Li
View Articletitled, Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I–induced leukemia and suppresses leukemic stem cells
Arginine 595 is duplicated in patients with acute leukemias carrying internal tandem duplications of FLT3 and modulates its transforming potential
Sridhar Vempati,Carola Reindl,Seshu Kumar Kaza,Ruth Kern,Theodora Malamoussi,Martin Dugas,Gudrun Mellert,Susanne Schnittger,Wolfgang Hiddemann,Karsten Spiekermann
View Articletitled, Arginine 595 is duplicated in patients with acute leukemias carrying internal tandem duplications of FLT3 and modulates its transforming potential
Proposed classification of lymphoid neoplasms for epidemiologic research from the Pathology Working Group of the International Lymphoma Epidemiology Consortium (InterLymph)
Lindsay M. Morton,Jennifer J. Turner,James R. Cerhan,Martha S. Linet,Patrick A. Treseler,Christina A. Clarke,Andrew Jack,Wendy Cozen,Marc Maynadié,John J. Spinelli,Adele Seniori Costantini,Thomas Rüdiger,Aldo Scarpa,Tongzhang Zheng,Dennis D. Weisenburger
View Articletitled, Proposed classification of lymphoid neoplasms for epidemiologic research from the Pathology Working Group of the International Lymphoma Epidemiology Consortium (InterLymph)
Supplemental data
JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells
Tanyel Kiziltepe,Teru Hideshima,Kenji Ishitsuka,Enrique M. Ocio,Noopur Raje,Laurence Catley,Chun-Qi Li,Laura J. Trudel,Hiroshi Yasui,Sonia Vallet,Jeffery L. Kutok,Dharminder Chauhan,Constantine S. Mitsiades,Joseph E. Saavedra,Gerald N. Wogan,Larry K. Keefer,Paul J. Shami,Kenneth C. Anderson
View Articletitled, JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells
Supplemental data
Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders
John M. Joslin,Anthony A. Fernald,Thelma R. Tennant,Elizabeth M. Davis,Scott C. Kogan,John Anastasi,John D. Crispino,Michelle M. Le Beau
View Articletitled, Haploinsufficiency of <em>EGR1</em>, a candidate gene in the del(5q), leads to the development of myeloid disorders
Supplemental data
Kinase domain mutations of BCR-ABL frequently precede imatinib-based therapy and give rise to relapse in patients with de novo Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL)
Heike Pfeifer,Barbara Wassmann,Anna Pavlova,Lydia Wunderle,Johannes Oldenburg,Anja Binckebanck,Thoralf Lange,Andreas Hochhaus,Silvia Wystub,Patrick Brück,Dieter Hoelzer,Oliver G. Ottmann
View Articletitled, Kinase domain mutations of BCR-ABL frequently precede imatinib-based therapy and give rise to relapse in patients with de novo Philadelphia-positive acute lymphoblastic leukemia (Ph<sup>+</sup> ALL)
Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor κB target genes and induction of apoptosis in chronic lymphocytic leukemia B cells
Andrei V. Ougolkov,Nancy D. Bone,Martin E. Fernandez-Zapico,Neil E. Kay,Daniel D. Billadeau
View Articletitled, Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor κB target genes and induction of apoptosis in chronic lymphocytic leukemia B cells
NF-κB2 mutation targets TRAF1 to induce lymphomagenesis
Baochun Zhang,Zhe Wang,Tai Li,Erdyni N. Tsitsikov,Han-Fei Ding
View Articletitled, NF-κB2 mutation targets TRAF1 to induce lymphomagenesis
Supplemental data

RED CELLS

Iron chelation and regulation of the cell cycle: 2 mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21CIP1/WAF1 by iron depletion
Dong Fu,Des R. Richardson
View Articletitled, Iron chelation and regulation of the cell cycle: 2 mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21<sup>CIP1/WAF1</sup> by iron depletion
Enhanced erythro-phagocytosis in polycythemic mice overexpressing erythropoietin
Anna Bogdanova,Deyan Mihov,Hans Lutz,Bianca Saam,Max Gassmann,Johannes Vogel
View Articletitled, Enhanced erythro-phagocytosis in polycythemic mice overexpressing erythropoietin

TRANSPLANTATION

High PR3 or ELA2 expression by CD34+ cells in advanced-phase chronic myeloid leukemia is associated with improved outcome following allogeneic stem cell transplantation and may improve PR1 peptide–driven graft-versus-leukemia effects
Agnes S. M. Yong,Katayoun Rezvani,Bipin N. Savani,Rhoda Eniafe,Stephan Mielke,John M. Goldman,A. John Barrett
View Articletitled, High <em>PR3</em> or <em>ELA2</em> expression by CD34<sup>+</sup> cells in advanced-phase chronic myeloid leukemia is associated with improved outcome following allogeneic stem cell transplantation and may improve PR1 peptide–driven graft-versus-leukemia effects
Costimulatory molecule-targeted immunotherapy of cutaneous graft-versus-host disease
Juyang Kim,Hye J. Kim,Keunhee Park,Jiyoung Kim,Hye-Jeong Choi,Hideo Yagita,Seok H. Nam,Hong R. Cho,Byungsuk Kwon
View Articletitled, Costimulatory molecule-targeted immunotherapy of cutaneous graft-versus-host disease
Absence of donor T-cell–derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity
Brief Report
Chiara Borsotti,Anna R. K. Franklin,Sydney X. Lu,Theo D. Kim,Odette M. Smith,David Suh,Chris G. King,Andrew Chow,Chen Liu,Onder Alpdogan,Marcel R. M. van den Brink
View Articletitled, Absence of donor T-cell–derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity
Supplemental data

CORRESPONDENCE

Treatment with oral melphalan plus dexamethasone produces long-term remissions in AL amyloidosis
Giovanni Palladini,Paola Russo,Mario Nuvolone,Francesca Lavatelli,Vittorio Perfetti,Laura Obici,Giampaolo Merlini
View Articletitled, Treatment with oral melphalan plus dexamethasone produces long-term remissions in AL amyloidosis
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