Table of Contents
The article by Komanduri et al in this issue of Blood describes immune reconstitution after human leukocyte antigen (HLA)-mismatched cord-blood transplantation. As expected, a profound reconstitution deficiency was observed; a study of some subpopulations could be predictive of the outcome.
In this issue of Blood, Brown and colleagues deliver lentiviral vectors that express human factor IX from the livers of mice.
Newly formed lymphatic capillaries closely associated with malignant tumors have a key role in metastasis, but much remains to be learned about the trigger and mechanisms of lymphangiogenesis. In this issue of Blood, Kilic and colleagues report that CEACAM1, recognized as a possible lymphangiogenic switch, is expressed in newly formed tumor-associated lymphatic capillaries, and that it can trigger reprogramming of microvascular endothelial cells to lymphatic endothelial cells.
In this issue of Blood, Guzman and colleagues describe 2 significant advances in the selective targeting of leukemic progenitor cells. First, they identify a novel agent, TDZD-8, that induces apoptosis of leukemic stem cells (LSCs) with extremely rapid kinetics. Second, they describe the development of an orally bioavailable parthenolide (PTL) analog, DMAPT, that is now heading to phase 1 clinical trial following the preclinical work described in this issue.
In this issue of Blood, Yamaguchi and colleagues demonstrated the essential role of the β2-glycoprotein I (β2GPI)/phosphatidylserine complex opsonized by IgG anti-β2GPI antibodies in the proliferation of CD4+ T cells in patients with anti-phospholipid syndrome. Their findings provide novel clues for specific targeting therapies in the affected patients.
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
CLINICAL TRIALS AND OBSERVATIONS
Phase 2 study of pegylated liposomal doxorubicin in combination with interleukin-12 for AIDS-related Kaposi sarcoma
Clinical Trials & Observations
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
Lymphatic reprogramming of microvascular endothelial cells by CEA-related cell adhesion molecule-1 via interaction with VEGFR-3 and Prox1
Perforin-dependent apoptosis functionally compensates Fas deficiency in activation-induced cell death of human T lymphocytes
Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells
New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patients
Mutations in the DNA-binding codons of TP53, which are associated with decreased expression of TRAILreceptor-2, predict for poor survival in diffuse large B-cell lymphoma
An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells
The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 α (HIF-1α) activity: involvement in myeloma-induced angiogenesis
Regulation of FcγR-stimulated phagocytosis by the 72-kDa inositol polyphosphate 5-phosphatase: SHIP1, but not the 72-kDa 5-phosphatase, regulates complement receptor 3–mediated phagocytosis by differential recruitment of these 5-phosphatases to the phagocytic cup
Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing
T cell–depleted stem-cell transplantation for adults with hematologic malignancies: sustained engraftment of HLA-matched related donor grafts without the use of antithymocyte globulin
The persistent elimination of B cells responding to blood group A carbohydrates by synthetic group A carbohydrates and B-1 cell differentiation blockade: novel concept in preventing antibody-mediated rejection in ABO-incompatible transplantation
High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation
A prospective study of G-CSF–primed bone marrow as a stem-cell source for allogeneic bone marrow transplantation in children: a Pediatric Blood and Marrow Transplant Consortium (PBMTC) study
Hematopoietic cell transplantation–specific comorbidity index as an outcome predictor for patients with acute myeloid leukemia in first remission: combined FHCRC and MDACC experiences
Posttransplantation imatinib as a strategy to postpone the requirement for immunotherapy in patients undergoing reduced-intensity allografts for chronic myeloid leukemia
The spectrum of anti-factor VIII C2 domain antibody epitopes. Venn diagram representing overlapping anti-C2 monoclonal antibodies. See the related article by Meeks et al, beginning on page 4234.
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