Skip to Main Content

Advertisement

Umbrella Alt Text
Cart
header search
Search
Skip Nav Destination

Issue Archive

Volume 110, Issue 10
November 15 2007
Issue Cover

Table of Contents

INSIDE BLOOD

HEMATOPOIESIS
Lycat: new targets in hemangioblast differentiation?
Burcin Özüyaman,Malte Kelm
View Articletitled, <em>Lycat:</em> new targets in hemangioblast differentiation?
CLINICAL OBSERVATIONS
Amyloidosis: graviores morbos, asperis remedii
Jayesh Mehta
View Articletitled, Amyloidosis: graviores morbos, asperis remedii
CLINICAL OBSERVATIONS
AML: treatment-related toxicity or not?
Giuseppe Avvisati
View Articletitled, AML: treatment-related toxicity or not?
IMMUNOBIOLOGY
Taxol therapy revisited
Shida Yousefi,Hans-Uwe Simon
View Articletitled, Taxol therapy revisited
HEMATOPOIESIS
A wrinkle in the unfolding of hypoxic response: HIF and ATF4
Alexander Weidemann,Randall S. Johnson
View Articletitled, A wrinkle in the unfolding of hypoxic response: HIF and ATF4
TRANSPLANTATION
Hematopoietic cell transplantation: a lifelong commitment
André Tichelli
View Articletitled, Hematopoietic cell transplantation: a lifelong commitment
NEOPLASIA
Viral mimic for B-cell survival
Ralf Küppers
View Articletitled, Viral mimic for B-cell survival
HEMOSTASIS
Hyperhomocysteinemia: DNA hypomethylation and endothelial degeneration
Ming-Hui Zou
View Articletitled, Hyperhomocysteinemia: DNA hypomethylation and endothelial degeneration
IMMUNOBIOLOGY
Rap1: selective activator of β2 integrins?
Philip J. S. Stork
View Articletitled, Rap1: selective activator of β2 integrins?
TRANSPLANTATION
Regulatory T cells and the pursuit of self-tolerance
Allan D. Hess
View Articletitled, Regulatory T cells and the pursuit of self-tolerance

REVIEW IN TRANSLATIONAL HEMATOLOGY

Immunomodulatory properties of mesenchymal stromal cells
Alma J. Nauta,Willem E. Fibbe
View Articletitled, Immunomodulatory properties of mesenchymal stromal cells
The role of FDG-PET scans in patients with lymphoma
Pamela Seam,Malik E. Juweid,Bruce D. Cheson
View Articletitled, The role of FDG-PET scans in patients with lymphoma

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway
Manoj K. Pandey,Bokyung Sung,Kwang Seok Ahn,Ajaikumar B. Kunnumakkara,Madan M. Chaturvedi,Bharat B. Aggarwal
View Articletitled, Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway

CLINICAL TRIALS AND OBSERVATIONS

Multiagent induction and maintenance therapy for patients with refractory immune thrombocytopenic purpura (ITP)
Clinical Trials & Observations
Donna M. Boruchov,Sri Gururangan,M. Catherine Driscoll,James B. Bussel
View Articletitled, Multiagent induction and maintenance therapy for patients with refractory immune thrombocytopenic purpura (ITP)
Microbiologically documented infections and infection-related mortality in children with acute myeloid leukemia
Clinical Trials & Observations
Lillian Sung,Beverly J. Lange,Robert B. Gerbing,Todd A. Alonzo,James Feusner
View Articletitled, Microbiologically documented infections and infection-related mortality in children with acute myeloid leukemia
Supplemental data
Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome–positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance
Clinical Trials & Observations
Hagop M. Kantarjian,Francis Giles,Norbert Gattermann,Kapil Bhalla,Giuliana Alimena,Francesca Palandri,Gert J. Ossenkoppele,Franck-Emmanuel Nicolini,Stephen G. O'Brien,Mark Litzow,Ravi Bhatia,Francisco Cervantes,Ariful Haque,Yaping Shou,Debra J. Resta,Aaron Weitzman,Andreas Hochhaus,Philipp le Coutre
View Articletitled, Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome–positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance
Supplemental data
Establishment of baseline toxicity expectations with standard frontline chemotherapy in acute myelogenous leukemia
Clinical Trials & Observations
Ehab Atallah,Jorge Cortes,Susan O'Brien,Sherry Pierce,Mary Beth Rios,Elihu Estey,Maurie Markman,Michael Keating,Emil J. Freireich,Hagop Kantarjian
View Articletitled, Establishment of baseline toxicity expectations with standard frontline chemotherapy in acute myelogenous leukemia
Relapse following discontinuation of imatinib mesylate therapy for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia: implications for optimal dosing
Clinical Trials & Observations
Amy D. Klion,Jamie Robyn,Irina Maric,Weiming Fu,Laura Schmid,Steven Lemery,Pierre Noel,Melissa A. Law,Marilyn Hartsell,Cheryl Talar-Williams,Michael P. Fay,Cynthia E. Dunbar,Thomas B. Nutman
View Articletitled, Relapse following discontinuation of imatinib mesylate therapy for <em>FIP1L1/PDGFRA</em>-positive chronic eosinophilic leukemia: implications for optimal dosing
Extended follow-up of a phase 3 trial in relapsed multiple myeloma: final time-to-event results of the APEX trial
Brief Report
Paul G. Richardson,Pieter Sonneveld,Michael Schuster,David Irwin,Edward Stadtmauer,Thierry Facon,Jean-Luc Harousseau,Dina Ben-Yehuda,Sagar Lonial,Hartmut Goldschmidt,Donna Reece,Jesus San Miguel,Joan Bladé,Mario Boccadoro,Jamie Cavenagh,Melissa Alsina,S. Vincent Rajkumar,Martha Lacy,Andrzej Jakubowiak,William Dalton,Anthony Boral,Dixie-Lee Esseltine,David Schenkein,Kenneth C. Anderson
View Articletitled, Extended follow-up of a phase 3 trial in relapsed multiple myeloma: final time-to-event results of the APEX trial
Supplemental data
Long-term outcome of patients with AL amyloidosis treated with high-dose melphalan and stem-cell transplantation
Brief Report
Vaishali Sanchorawala,Martha Skinner,Karen Quillen,Kathleen T. Finn,Gheorghe Doros,David C. Seldin
View Articletitled, Long-term outcome of patients with AL amyloidosis treated with high-dose melphalan and stem-cell transplantation

GENE THERAPY

Selecting highly affine and well-expressed TCRs for gene therapy of melanoma
Annelies Jorritsma,Raquel Gomez-Eerland,Maarten Dokter,Willeke van de Kasteele,Yvonne M. Zoet,Ilias I. N. Doxiadis,Nathalie Rufer,Pedro Romero,Richard A. Morgan,Ton N. M. Schumacher,John B. A. G. Haanen
View Articletitled, Selecting highly affine and well-expressed TCRs for gene therapy of melanoma
Supplemental data

HEMATOPOIESIS

Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene
Jessica M. Salmon,Nicholas J. Slater,Mark A. Hall,Matthew P. McCormack,Stephen L. Nutt,Stephen M. Jane,David J. Curtis
View Articletitled, Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene
The Shc-binding site of the βc subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis
Hayley S. Ramshaw,Mark A. Guthridge,Frank C. Stomski,Emma F. Barry,Lisa Ooms,Christina A. Mitchell,C. Glenn Begley,Angel F. Lopez
View Articletitled, The Shc-binding site of the β<sub>c</sub> subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis
Supplemental data
The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways
Fumihiko Ishikawa,Hiroaki Niiro,Tadafumi Iino,Shuro Yoshida,Noriyuki Saito,Shinya Onohara,Toshihiro Miyamoto,Hiroko Minagawa,Shin-ichiro Fujii,Leonard D. Shultz,Mine Harada,Koichi Akashi
View Articletitled, The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways
Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation
Chengyan Wang,Patrick W. Faloon,Zhijia Tan,Yaxin Lv,Pengbo Zhang,Yu Ge,Hongkui Deng,Jing-Wei Xiong
View Articletitled, Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation
Supplemental data
Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor
Jens Köditz,Jutta Nesper,Marieke Wottawa,Daniel P. Stiehl,Gieri Camenisch,Corinna Franke,Johanna Myllyharju,Roland H. Wenger,Dörthe M. Katschinski
View Articletitled, Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor
The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development
Lizi Wu,Ivan Maillard,Makoto Nakamura,Warren S. Pear,James D. Griffin
View Articletitled, The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development
The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans
Brief Report
Stephan Menzel,Jie Jiang,Nicholas Silver,Joy Gallagher,Juliette Cunningham,Gabriela Surdulescu,Mark Lathrop,Martin Farrall,Tim D. Spector,Swee Lay Thein
View Articletitled, The <em>HBS1L-MYB</em> intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Duplicate VegfA genes and orthologues of the KDR receptor tyrosine kinase family mediate vascular development in the zebrafish
Nathan Bahary,Katsutoshi Goishi,Carsten Stuckenholz,Gerhard Weber,Jocelyn LeBlanc,Christopher A. Schafer,Sarah S. Berman,Michael Klagsbrun,Leonard I. Zon
View Articletitled, Duplicate VegfA genes and orthologues of the KDR receptor tyrosine kinase family mediate vascular development in the zebrafish
Supplemental data
The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery
Koji Eto,Hidekazu Nishikii,Takunori Ogaeri,Shiro Suetsugu,Akihide Kamiya,Toshihiro Kobayashi,Daisuke Yamazaki,Atsushi Oda,Tadaomi Takenawa,Hiromitsu Nakauchi
View Articletitled, The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery
Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin Agene
Md S. Jamaluddin,Irene Chen,Fan Yang,Xiaohua Jiang,Michael Jan,Xiaoming Liu,Andrew I. Schafer,William Durante,Xiaofeng Yang,Hong Wang
View Articletitled, Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the <em>cyclin A</em>gene
Delays in maturation among adolescents with hemophilia and a history of inhibitors
Sharyne M. Donfield,Henry S. Lynn,Alice E. Lail,W. Keith Hoots,Erik Berntorp,Edward D. Gomperts,for the Hemophilia Growth and Development Study Group
View Articletitled, Delays in maturation among adolescents with hemophilia and a history of inhibitors
Supplemental data

IMMUNOBIOLOGY

Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment
Katja Janssen,Stephan Pohlmann,Reiner U. Jänicke,Klaus Schulze-Osthoff,Ute Fischer
View Articletitled, Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment
Supplemental data
Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis
Philip O. Scumpia,Matthew J. Delano,Kindra M. Kelly-Scumpia,Jason S. Weinstein,James L. Wynn,Robert D. Winfield,Changqing Xia,Chun Shiang Chung,Alfred Ayala,Mark A. Atkinson,Westley H. Reeves,Michael J. Clare-Salzler,Lyle L. Moldawer
View Articletitled, Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis
Supplemental data
Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin–mediated human T-cell adhesion
Haifa Ghandour,Xavier Cullere,Angeles Alvarez,Francis W. Luscinskas,Tanya N. Mayadas
View Articletitled, Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin–mediated human T-cell adhesion
Supplemental data
A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells
Brief Report
Dominique Chabannes,Marcelo Hill,Emmanuel Merieau,Julien Rossignol,Régis Brion,Jean Paul Soulillou,Ignacio Anegon,Maria Cristina Cuturi
View Articletitled, A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells
Supplemental data

NEOPLASIA

CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer–binding protein alpha
Steffen Koschmieder,Francesco D'Alò,Hanna Radomska,Christine Schöneich,Ji Suk Chang,Marina Konopleva,Susumu Kobayashi,Elena Levantini,Nanjoo Suh,Annalisa Di Ruscio,Maria Teresa Voso,Julie C. Watt,Ramasamy Santhanam,Bülent Sargin,Hagop Kantarjian,Michael Andreeff,Michael B. Sporn,Danilo Perrotti,Wolfgang E. Berdel,Carsten Müller-Tidow,Hubert Serve,Daniel G. Tenen
View Articletitled, CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer–binding protein alpha
Supplemental data
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1
Bas J. Wouters,Meritxell Alberich Jordà,Karen Keeshan,Irene Louwers,Claudia A. J. Erpelinck-Verschueren,Dennis Tielemans,Anton W. Langerak,Yiping He,Yumi Yashiro-Ohtani,Pu Zhang,Christopher J. Hetherington,Roel G. W. Verhaak,Peter J. M. Valk,Bob Löwenberg,Daniel G. Tenen,Warren S. Pear,Ruud Delwel
View Articletitled, Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced <em>CEBPA</em> and mutations in <em>NOTCH1</em>
Supplemental data
Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survival
Christoph Mancao,Wolfgang Hammerschmidt
View Articletitled, Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survival
Histone deacetylase–mediated transcriptional activation reduces proviral loads in HTLV-1–associated myelopathy/tropical spastic paraparesis patients
Agnès Lezin,Nicolas Gillet,Stéphane Olindo,Aïssatou Signaté,Nathalie Grandvaux,Olivier Verlaeten,Gildas Belrose,Marcelo de Carvalho Bittencourt,John Hiscott,Becca Asquith,Arsène Burny,Didier Smadja,Raymond Césaire,Luc Willems
View Articletitled, Histone deacetylase–mediated transcriptional activation reduces proviral loads in HTLV-1–associated myelopathy/tropical spastic paraparesis patients
Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome
Andrew Chase,Francis H. Grand,Nicholas C. P. Cross
View Articletitled, Activity of TKI258 against primary cells and cell lines with <em>FGFR1</em> fusion genes associated with the 8p11 myeloproliferative syndrome
Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis
Ronan Chaligné,Chloé James,Carole Tonetti,Rodolphe Besancenot,Jean Pierre Le Couédic,Fanny Fava,Fréderic Mazurier,Isabelle Godin,Karim Maloum,Frédéric Larbret,Yann Lécluse,William Vainchenker,Stéphane Giraudier
View Articletitled, Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis
MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts
Sonia Vallet,Noopur Raje,Kenji Ishitsuka,Teru Hideshima,Klaus Podar,Shweta Chhetri,Samantha Pozzi,Iris Breitkreutz,Tanyel Kiziltepe,Hiroshi Yasui,Enrique M. Ocio,Norihiko Shiraishi,Janice Jin,Yutaka Okawa,Hiroshi Ikeda,Siddhartha Mukherjee,Nileshwari Vaghela,Diana Cirstea,Marco Ladetto,Mario Boccadoro,Kenneth C. Anderson
View Articletitled, MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts
Supplemental data
NOTCH1 pathway activation is an early hallmark of SCL T leukemogenesis
Joachim R. Göthert,Rachael L. Brake,Monique Smeets,Ulrich Dührsen,C. Glenn Begley,David J. Izon
View Articletitled, NOTCH1 pathway activation is an early hallmark of SCL T leukemogenesis
Supplemental data

PHAGOCYTES

Histone H2B as a functionally important plasminogen receptor on macrophages
Riku Das,Tim Burke,Edward F. Plow
View Articletitled, Histone H2B as a functionally important plasminogen receptor on macrophages
Supplemental data
Gαi2 is required for chemokine-induced neutrophil arrest
Alexander Zarbock,Tracy L. Deem,Tracy L. Burcin,Klaus Ley
View Articletitled, Gα<sub>i2</sub> is required for chemokine-induced neutrophil arrest

RED CELLS

Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations
Brief Report
Ivana De Domenico,Michael B. Vaughn,Donghoon Yoon,James P. Kushner,Diane M. Ward,Jerry Kaplan
View Articletitled, Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations

TRANSPLANTATION

Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor Study
Smita Bhatia,Liton Francisco,Andrea Carter,Can-Lan Sun,K. Scott Baker,James G. Gurney,Philip B. McGlave,Auayporn Nademanee,Margaret O'Donnell,Norma K. C. Ramsay,Leslie L. Robison,David Snyder,Anthony Stein,Stephen J. Forman,Daniel J. Weisdorf
View Articletitled, Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor Study
Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4+CD25+Foxp3+ regulatory T cells
Shigeharu Fujita,Yumiko Sato,Kaori Sato,Kawori Eizumi,Tomohiro Fukaya,Masato Kubo,Naohide Yamashita,Katsuaki Sato
View Articletitled, Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells
Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease
Xiao Chen,Sanja Vodanovic-Jankovic,Bryon Johnson,Melissa Keller,Richard Komorowski,William R. Drobyski
View Articletitled, Absence of regulatory T-cell control of T<sub>H</sub>1 and T<sub>H</sub>17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease
Supplemental data

CORRESPONDENCE

Lenalidomide-induced severe hepatotoxicity
Subuhee Hussain,Royston Browne,Julie Chen,Samir Parekh
View Articletitled, Lenalidomide-induced severe hepatotoxicity
All Issues

Advertisement

Novel biomarker-based probability engine
Help on the way to unsilence HbF
Improved survival in cHL with novel agents
Targeted therapy in mediastinal gray zone lymphoma
Kemps PG, Picarsic J, Durham BH, et al. ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition. Blood. 2022;139(2):256-280.

Advertisement

Advertisement

  • American Society of Hematology
  • 2021 L Street NW, Suite 900
  • Washington, DC 20036
  • TEL +1 202-776-0544
  • FAX +1 202-776-0545

ASH Publications

American Society of Hematology

Copyright ©2023 by American Society of Hematology
 
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal

Advertisement