Skip Nav Destination

Issue Archive

Select Decade

Select Year

Issue

INSIDE BLOOD

NEOPLASIA

Filgrastim therapy: a bone of contention

Elisabeth G. Blanchard,Seth J. Corey

View Articletitled, Filgrastim therapy: a bone of contention

CLINICAL TRIALS AND OBSERVATIONS

Genomics in myeloma: the philosopher's stone?
Clinical Trials & Observations

Andreas Rosenwald

View Articletitled, Genomics in myeloma: the philosopher's stone?

CLINICAL TRIALS AND OBSERVATIONS

Karyng about karyotyping in adult ALL
Clinical Trials & Observations

Frederick R. Appelbaum

View Articletitled, Karyng about karyotyping in adult ALL

CLINICAL TRIALS AND OBSERVATIONS

Unraveling CML phase by phase
Clinical Trials & Observations

John Goldman

View Articletitled, Unraveling CML phase by phase

HEMOSTASIS

Inside-out, outside-in: what's the difference?

Edward F. Plow,Yan-Qing Ma

View Articletitled, Inside-out, outside-in: what's the difference?

HEMATOPOIESIS

MEGAprofiles provide big insightsinto platelet function

Wadie F. Bahou

View Articletitled, MEGAprofiles provide big insightsinto platelet function

IMMUNOBIOLOGY

Serotonin: a real blast for T cells

John Gordon,Nicholas M. Barnes

View Articletitled, Serotonin: a real blast for T cells

NEOPLASIA

The CBFB-MYH11 butterfly effect in hematopoiesis

Andre J. van Wijnen,Gary S. Stein

View Articletitled, The CBFB-MYH11 butterfly effect in hematopoiesis

NEOPLASIA

Multiple myeloma and FISH (but no CHIPS)

Rafael Fonseca

View Articletitled, Multiple myeloma and FISH (but no CHIPS)

RED CELLS

Spectrin unfolding mutations: kinks in the links

Luanne L. Peters

View Articletitled, Spectrin unfolding mutations: kinks in the links

TRANSPLANTATION

Nonmyeloablative allotransplantation for myeloma: light and shade

Michele Cavo

View Articletitled, Nonmyeloablative allotransplantation for myeloma: light and shade

NEOPLASIA

Win-WNT pathway in ALL

Gertjan J. L. Kaspers

View Articletitled, Win-WNT pathway in ALL

PHAGOCYTES

Blood orchestrates a leukocyte integrin trio

Joel S. Bennett

View Articletitled, Blood orchestrates a leukocyte integrin trio

PLENARY PAPERS

Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT₇ receptor

Matilde León-Ponte,,Gerard P. Ahern,Peta J. O'Connell

View Articletitled, Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor

Supplemental data

PERSPECTIVE

Clinical trials with adult stem/progenitor cells for tissue repair: let's not overlook some essential precautions
Clinical Trials & Observations

Darwin J. Prockop,Scott D. Olson

View Articletitled, Clinical trials with adult stem/progenitor cells for tissue repair: let's not overlook some essential precautions

REVIEW ARTICLES

Diamond-Blackfan anemia: erythropoiesis lost in translation

Johan Flygare,Stefan Karlsson

View Articletitled, Diamond-Blackfan anemia: erythropoiesis lost in translation

REVIEW IN TRANSLATIONAL HEMATOLOGY

The cytoprotective protein C pathway

Laurent O. Mosnier,Berislav V. Zlokovic,John H. Griffin

View Articletitled, The cytoprotective protein C pathway

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Influence of ERK activation on decreased chemotaxis of mature human cord blood monocyte–derived dendritic cells to CCL19 and CXCL12
Brief Report

Geling Li,Sunanda Basu,Myung-Kwan Han,Young-June Kim,Hal E. Broxmeyer

View Articletitled, Influence of ERK activation on decreased chemotaxis of mature human cord blood monocyte–derived dendritic cells to CCL19 and CXCL12

CLINICAL TRIALS AND OBSERVATIONS

Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib
Clinical Trials & Observations

George Mulligan,Constantine Mitsiades,Barb Bryant,Fenghuang Zhan,Wee J. Chng,Steven Roels,Erik Koenig,Andrew Fergus,Yongsheng Huang,Paul Richardson,William L. Trepicchio,Annemiek Broyl,Pieter Sonneveld,John D. Shaughnessy, Jr,P. Leif Bergsagel,David Schenkein,Dixie-Lee Esseltine,Anthony Boral,Kenneth C. Anderson

View Articletitled, Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib

Supplemental data

Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial
Clinical Trials & Observations

Anthony V. Moorman,Christine J. Harrison,Georgina A. N. Buck,Sue M. Richards,Lorna M. Secker-Walker,Mary Martineau,Gail H. Vance,Athena M. Cherry,Rodney R. Higgins,Adele K. Fielding,Letizia Foroni,Elisabeth Paietta,Martin S. Tallman,Mark R. Litzow,Peter H. Wiernik,Jacob M. Rowe,Anthony H. Goldstone,Gordon W. Dewald,on behalf of the Medical Research Council (MRC)/National Cancer Research Institute (NCRI) Adult Leukaemia Working Party of the United Kingdom and the Eastern Cooperative Oncology Group

View Articletitled, Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial

Supplemental data

T⁻B⁺NK⁺ severe combined immunodeficiency caused by complete deficiency of the CD3ζ subunit of the T-cell antigen receptor complex
Clinical Trials & Observations

Joseph L. Roberts,Jens Peter H. Lauritsen,Myriah Cooney,Roberta E. Parrott,Elisa O. Sajaroff,Chan M. Win,Michael D. Keller,Jeffery H. Carpenter,Juan Carabana,Michael S. Krangel,Marcella Sarzotti,Xiao-Ping Zhong,David L. Wiest,Rebecca H. Buckley

View Articletitled, T−B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3ζ subunit of the T-cell antigen receptor complex

Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis
Clinical Trials & Observations

Jorge Cortes,Philippe Rousselot,Dong-Wook Kim,Ellen Ritchie,Nelson Hamerschlak,Steven Coutre,Andreas Hochhaus,Francois Guilhot,Giuseppe Saglio,Jane Apperley,Oliver Ottmann,Neil Shah,Philipp Erben,Susan Branford,Prasheen Agarwal,Ashwin Gollerkeri,Michele Baccarani

View Articletitled, Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis

Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia
Clinical Trials & Observations

Elias Jabbour,Susan O'Brien,Hagop Kantarjian,Guillermo Garcia-Manero,Alessandra Ferrajoli,Farhad Ravandi,Maria Cabanillas,Deborah A. Thomas

View Articletitled, Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia

Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia
Clinical Trials & Observations

Phillip Scheinberg,Steven H. Fischer,Li Li,Olga Nunez,Colin O. Wu,Elaine M. Sloand,Jeffrey I. Cohen,Neal S. Young,A. John Barrett

View Articletitled, Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia

HEMATOPOIESIS

Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach

Hana Raslova,Audrey Kauffmann,Dalila Sekkaï,Hugues Ripoche,Fréderic Larbret,Thomas Robert,Diana Tronik Le Roux,Guido Kroemer,Najet Debili,Philippe Dessen,Vladimir Lazar,William Vainchenker

View Articletitled, Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach

Supplemental data

Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection

Alyssa D. Gregory,Lisa A. Hogue,Thomas W. Ferkol,Daniel C. Link

View Articletitled, Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection

Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis

Marc J. Heikens,Thai M. Cao,Chikako Morita,Sarah L. DeHart,Schickwann Tsai

View Articletitled, Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis

MafB negatively regulates RANKL-mediated osteoclast differentiation

Kabsun Kim,Jung Ha Kim,Junwon Lee,Hye Mi Jin,Hyun Kook,Kyung Keun Kim,Soo Young Lee,Nacksung Kim

View Articletitled, MafB negatively regulates RANKL-mediated osteoclast differentiation

Supplemental data

ERRATUM

Erratum in Schmidt et al., Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemia

View Articletitled, Erratum in Schmidt et al., Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemia

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins

Iain C. Macaulay,Marloes R. Tijssen,Daphne C. Thijssen-Timmer,Arief Gusnanto,Michael Steward,Philippa Burns,Cordelia F. Langford,Peter D. Ellis,Frank Dudbridge,Jaap-Jan Zwaginga,Nicholas A. Watkins,C. Ellen van der Schoot,Willem H. Ouwehand

View Articletitled, Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins

Supplemental data

Tissue-type plasminogen activator–mediated shedding of astrocytic low-density lipoprotein receptor–related protein increases the permeability of the neurovascular unit

Rohini Polavarapu,Maria Carolina Gongora,Hong Yi,Sripriya Ranganthan,Daniel A. Lawrence,Dudley Strickland,Manuel Yepes

View Articletitled, Tissue-type plasminogen activator–mediated shedding of astrocytic low-density lipoprotein receptor–related protein increases the permeability of the neurovascular unit

Vitamin K–containing dietary supplements: comparison of synthetic vitamin K₁ and natto-derived menaquinone-7
Clinical Trials & Observations

Leon J. Schurgers,Kirsten J. F. Teunissen,Karly Hamulyák,Marjo H. J. Knapen,Hogne Vik,Cees Vermeer

View Articletitled, Vitamin K–containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7

Structure-function analysis reveals discrete β3 integrin inside-out and outside-in signaling pathways in platelets

Zhiying Zou,Hong Chen,Alec A. Schmaier,Richard O. Hynes,Mark L. Kahn

View Articletitled, Structure-function analysis reveals discrete β3 integrin inside-out and outside-in signaling pathways in platelets

Supplemental data

Thromboxane receptor blockade improves the antiatherogenic effect of thromboxane A₂ suppression in LDLR KO mice

Tillmann Cyrus,Yuemang Yao,Tao Ding,Jean Michel Dogné,Domenico Praticò

View Articletitled, Thromboxane receptor blockade improves the antiatherogenic effect of thromboxane A2 suppression in LDLR KO mice

X-linked gray platelet syndrome due to a GATA1 Arg216Gln mutation
Clinical Trials & Observations Brief Report

Venée N. Tubman,Jason E. Levine,Dean R. Campagna,Rita Monahan-Earley,Ann M. Dvorak,Ellis J. Neufeld,Mark D. Fleming

View Articletitled, X-linked gray platelet syndrome due to a GATA1 Arg216Gln mutation

Supplemental data

IMMUNOBIOLOGY

Selective deletion of antigen-specific CD8⁺ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin

Paul R. Hess,Carie Barnes,Matthew D. Woolard,Michael D. L. Johnson,John M. Cullen,Edward J. Collins,Jeffrey A. Frelinger

View Articletitled, Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin

TLR agonists induce regulatory dendritic cells to recruit Th1 cells via preferential IP-10 secretion and inhibit Th1 proliferation

Cheng Qian,Huazhang An,Yizhi Yu,Shuxun Liu,Xuetao Cao

View Articletitled, TLR agonists induce regulatory dendritic cells to recruit Th1 cells via preferential IP-10 secretion and inhibit Th1 proliferation

The Pten/PI3K pathway governs the homeostasis of Vα14iNKT cells

Hiroyuki Kishimoto,Toshiaki Ohteki,Nobuyuki Yajima,Koichi Kawahara,Miyuki Natsui,Satoru Kawarasaki,Koichi Hamada,Yasuo Horie,Yoshiaki Kubo,Seiji Arase,Masaru Taniguchi,Bart Vanhaesebroeck,Tak Wah Mak,Toru Nakano,Shigeo Koyasu,Takehiko Sasaki,Akira Suzuki

View Articletitled, The Pten/PI3K pathway governs the homeostasis of Vα14iNKT cells

Supplemental data

Nonmalignant T cells stimulate growth of T-cell lymphoma cells in the presence of bacterial toxins

Anders Woetmann,Paola Lovato,Karsten W. Eriksen,Thorbjørn Krejsgaard,Tord Labuda,Qian Zhang,Anne-Merethe Mathiesen,Carsten Geisler,Arne Svejgaard,Mariusz A. Wasik,Niels Ødum

View Articletitled, Nonmalignant T cells stimulate growth of T-cell lymphoma cells in the presence of bacterial toxins

Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell–natural killer cell crosstalk

Jun Xu,Ayan K. Chakrabarti,Jennifer L. Tan,Lisheng Ge,Andrea Gambotto,Nikola L. Vujanovic

View Articletitled, Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell–natural killer cell crosstalk

Supplemental data

Notch activity synergizes with B-cell–receptor and CD40 signaling to enhance B-cell activation

Matthew Thomas,Marco Calamito,Bhaskar Srivastava,Ivan Maillard,Warren S. Pear,David Allman

View Articletitled, Notch activity synergizes with B-cell–receptor and CD40 signaling to enhance B-cell activation

Supplemental data

HIV inhibits CD4⁺ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells

Adriano Boasso,Jean-Philippe Herbeuval,Andrew W. Hardy,Stephanie A. Anderson,Matthew J. Dolan,Dietmar Fuchs,Gene M. Shearer

View Articletitled, HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells

Supplemental data

Vav proteins control MyD88-dependent oxidative burst

Ana V. Miletic,Daniel B. Graham,Vivianne Montgrain,Keiko Fujikawa,Tracie Kloeppel,Karry Brim,Brian Weaver,Robert Schreiber,Ramnik Xavier,Wojciech Swat

View Articletitled, Vav proteins control MyD88-dependent oxidative burst

Supplemental data

Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cells

Espen O. Kvale,Yngvar Fløisand,Fridtjof Lund-Johansen,Halvor Rollag,Lorant Farkas,Smita Ghanekar,Per Brandtzaeg,Frode L. Jahnsen,Johanna Olweus

View Articletitled, Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cells

Combined deficiencies in Bruton tyrosine kinase and phospholipase Cγ2 arrest B-cell development at a pre-BCR⁺ stage

Shengli Xu,Koon-Guan Lee,Jianxin Huo,Tomohiro Kurosaki,Kong-Peng Lam

View Articletitled, Combined deficiencies in Bruton tyrosine kinase and phospholipase Cγ2 arrest B-cell development at a pre-BCR+ stage

Synaptotagmin (Syt) IX is an essential determinant for protein sorting to secretory granules in mast cells

Yael Haberman,Idit Ziv,Yaara Gorzalczany,Koret Hirschberg,Leonide Mittleman,Mitsunori Fukuda,Ronit Sagi-Eisenberg

View Articletitled, Synaptotagmin (Syt) IX is an essential determinant for protein sorting to secretory granules in mast cells

Supplemental data

Cell-free production of scFv fusion proteins: an efficient approach for personalized lymphoma vaccines

Gregory Kanter,Junhao Yang,Alexei Voloshin,Shoshana Levy,James R. Swartz,Ronald Levy

View Articletitled, Cell-free production of scFv fusion proteins: an efficient approach for personalized lymphoma vaccines

NEOPLASIA

ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia

View Articletitled, ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia

Supplemental data

Members of the glutathione and ABC-transporter families are associated with clinical outcome in patients with diffuse large B-cell lymphoma
Clinical Trials & Observations

Charalambos Andreadis,Phyllis A. Gimotty,Peter Wahl,Rachel Hammond,Jane Houldsworth,Stephen J. Schuster,Timothy R. Rebbeck

View Articletitled, Members of the glutathione and ABC-transporter families are associated with clinical outcome in patients with diffuse large B-cell lymphoma

A novel PAX5-ELN fusion protein identified in B-cell acute lymphoblastic leukemia acts as a dominant negative on wild-type PAX5

Marina Bousquet,Cyril Broccardo,Cathy Quelen,Fabienne Meggetto,Emilienne Kuhlein,Georges Delsol,Nicole Dastugue,Pierre Brousset

View Articletitled, A novel PAX5-ELN fusion protein identified in B-cell acute lymphoblastic leukemia acts as a dominant negative on wild-type PAX5

Supplemental data

Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner

Angela C. Hirbe,Özge Uluçkan,Elizabeth A. Morgan,Mark C. Eagleton,Julie L. Prior,David Piwnica-Worms,Kathryn Trinkaus,Anthony Apicelli,Katherine Weilbaecher

View Articletitled, Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner

Supplemental data

CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus

Ling Zhao,Jennifer L. Cannons,Stacie Anderson,Martha Kirby,Liping Xu,Lucio H. Castilla,Pamela L. Schwartzberg,Rémy Bosselut,P. Paul Liu

View Articletitled, CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus

Supplemental data

Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo

Guang-Biao Zhou,Hui Kang,Lan Wang,Li Gao,Ping Liu,Jun Xie,Feng-Xiang Zhang,Xiang-Qin Weng,Zhi-Xiang Shen,Jue Chen,Long-Jun Gu,Ming Yan,Dong-Er Zhang,Sai-Juan Chen,Zhen-Yi Wang,Zhu Chen

View Articletitled, Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo

Supplemental data

Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)

View Articletitled, Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)

Supplemental data

Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia

José Román-Gómez,Lucia Cordeu,Xabier Agirre,Antonio Jiménez-Velasco,Edurne San José-Eneriz,Leire Garate,María José Calasanz,Anabel Heiniger,Antonio Torres,Felipe Prosper

View Articletitled, Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia

Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells

Geoffrey A. Bartholomeusz,Moshe Talpaz,Vaibhav Kapuria,Ling Yuan Kong,Shimei Wang,Zeev Estrov,Waldemar Priebe,Ji Wu,Nicholas J. Donato

View Articletitled, Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells

Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph)
Clinical Trials & Observations

View Articletitled, Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph)

Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myélome
Clinical Trials & Observations

View Articletitled, Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myélome

Supplemental data

Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia
Clinical Trials & Observations Brief Report

Stephane Picard,Karine Titier,Gabriel Etienne,Emmanuelle Teilhet,Dominique Ducint,Marie-Agnes Bernard,Regis Lassalle,Gerald Marit,Josy Reiffers,Bernard Begaud,Nicholas Moore,Mathieu Molimard,Francois-Xavier Mahon

View Articletitled, Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia

MALT lymphoma and extranodal diffuse large B-cell lymphoma are targeted by aberrant somatic hypermutation
Brief Report

Alexander J. A. Deutsch,Ariane Aigelsreiter,Philipp B. Staber,Alfred Beham,Werner Linkesch,Christian Guelly,Ruth I. Brezinschek,Margareta Fruhwirth,Werner Emberger,Maike Buettner,Christine Beham-Schmid,Peter Neumeister

View Articletitled, MALT lymphoma and extranodal diffuse large B-cell lymphoma are targeted by aberrant somatic hypermutation

Supplemental data

Chemotherapy exposure increases leukemia cell stiffness
Brief Report

Wilbur A. Lam,Michael J. Rosenbluth,Daniel A. Fletcher

View Articletitled, Chemotherapy exposure increases leukemia cell stiffness

Supplemental data

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
Brief Report

Zhihong Zeng,Dos D. Sarbassov,Ismael J. Samudio,Karen W. L. Yee,Mark F. Munsell,C. Ellen Jackson,Francis J. Giles,David M. Sabatini,Michael Andreeff,Marina Konopleva

View Articletitled, Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML

Supplemental data

PHAGOCYTES

The β-tail domain (βTD) regulates physiologic ligand binding to integrin CD11b/CD18

Vineet Gupta,Annette Gylling,José Luis Alonso,Takashi Sugimori,Petre Ianakiev,Jiang-Ping Xiong,M. Amin Arnaout

View Articletitled, The β-tail domain (βTD) regulates physiologic ligand binding to integrin CD11b/CD18

Generation of activation-specific human anti-α_Mβ₂ single-chain antibodies as potential diagnostic tools and therapeutic agents

Steffen U. Eisenhardt,Meike Schwarz,Nils Schallner,Juliana Soosairajah,Nicole Bassler,Dexing Huang,Christoph Bode,Karlheinz Peter

View Articletitled, Generation of activation-specific human anti-αMβ2 single-chain antibodies as potential diagnostic tools and therapeutic agents

Supplemental data

Natural history and early diagnosis of LAD-1/variant syndrome
Clinical Trials & Observations

Taco W. Kuijpers,Robin van Bruggen,Nanne Kamerbeek,Anton T. J. Tool,Gonul Hicsonmez,Aytemiz Gurgey,Axel Karow,Arthur J. Verhoeven,Karl Seeger,Özden Sanal,Charlotte Niemeyer,Dirk Roos

View Articletitled, Natural history and early diagnosis of LAD-1/variant syndrome

Supplemental data

RED CELLS

Pathogenic proline mutation in the linker between spectrin repeats: disease caused by spectrin unfolding

Colin P. Johnson,Massimiliano Gaetani,Vanessa Ortiz,Nishant Bhasin,Sandy Harper,Patrick G. Gallagher,David W. Speicher,Dennis E. Discher

View Articletitled, Pathogenic proline mutation in the linker between spectrin repeats: disease caused by spectrin unfolding

Supplemental data

Endothelial Lu/BCAM glycoproteins are novel ligands for red blood cell α₄β₁integrin: role in adhesion of sickle red blood cells to endothelial cells

Wassim El Nemer,Marie-Paule Wautier,Cécile Rahuel,Pierre Gane,Patricia Hermand,Frédéric Galactéros,Jean-Luc Wautier,Jean-Pierre Cartron,Yves Colin,Caroline Le Van Kim

View Articletitled, Endothelial Lu/BCAM glycoproteins are novel ligands for red blood cell α4β1integrin: role in adhesion of sickle red blood cells to endothelial cells

RNA silencing of the mitochondrial ABCB7 transporter in HeLa cells causes an iron-deficient phenotype with mitochondrial iron overload

Patrizia Cavadini,Giorgio Biasiotto,Maura Poli,Sonia Levi,Rosanna Verardi,Isabella Zanella,Manuela Derosas,Rosaria Ingrassia,Marcella Corrado,Paolo Arosio

View Articletitled, RNA silencing of the mitochondrial ABCB7 transporter in HeLa cells causes an iron-deficient phenotype with mitochondrial iron overload

Molecular basis of glutathione reductase deficiency in human blood cells

Nanne M. Kamerbeek,Rob van Zwieten,Martin de Boer,Gert Morren,Herma Vuil,Natalja Bannink,Carsten Lincke,Koert M. Dolman,Katja Becker,R. Heiner Schirmer,Stephan Gromer,Dirk Roos

View Articletitled, Molecular basis of glutathione reductase deficiency in human blood cells

Supplemental data

Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis
Brief Report

Corinne Pondarre,Dean R. Campagna,Brendan Antiochos,Lindsay Sikorski,Howard Mulhern,Mark D. Fleming

View Articletitled, Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis

Supplemental data

STEM CELLS IN HEMATOLOGY

Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potential

Hiroto Araki,Kazumi Yoshinaga,Piernicola Boccuni,Yan Zhao,Ronald Hoffman,Nadim Mahmud

View Articletitled, Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potential

TRANSPLANTATION

Enhanced T-cell reconstitution by hematopoietic progenitors expanded ex vivo using the Notch ligand Delta1

Mari H. Dallas,Barbara Varnum-Finney,Paul J. Martin,Irwin D. Bernstein

View Articletitled, Enhanced T-cell reconstitution by hematopoietic progenitors expanded ex vivo using the Notch ligand Delta1

Reduced-intensity conditioning for myeloma: lower nonrelapse mortality but higher relapse rates compared with myeloablative conditioning
Clinical Trials & Observations

Charles Crawley,Simona Iacobelli,Bo Björkstrand,Jane F. Apperley,Dietger Niederwieser,Gösta Gahrton,for the Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)

View Articletitled, Reduced-intensity conditioning for myeloma: lower nonrelapse mortality but higher relapse rates compared with myeloablative conditioning

Supplemental data

Patients with adenosine deaminase deficiency surviving after hematopoietic stem cell transplantation are at high risk of CNS complications
Clinical Trials & Observations

Manfred Hönig,Michael H. Albert,Ansgar Schulz,Monika Sparber-Sauer,Catharina Schütz,Bernd Belohradsky,Tayfun Güngör,Markus T. Rojewski,Harald Bode,Ulrich Pannicke,Dominique Lippold,Klaus Schwarz,Klaus-Michael Debatin,Michael S. Hershfield,Wilhelm Friedrich

View Articletitled, Patients with adenosine deaminase deficiency surviving after hematopoietic stem cell transplantation are at high risk of CNS complications

Reduction of GVHD and enhanced antitumor effects after adoptive infusion of alloreactive Ly49-mismatched NK cells from MHC-matched donors
Brief Report

Andreas Lundqvist,J. Philip McCoy,Leigh Samsel,Richard Childs

View Articletitled, Reduction of GVHD and enhanced antitumor effects after adoptive infusion of alloreactive Ly49-mismatched NK cells from MHC-matched donors

CORRESPONDENCE

Vitamin K supplementation during oral anticoagulation: cautions
Brief Report

Darrel W. Stafford,Harold R. Roberts,Cees Vermeer

View Articletitled, Vitamin K supplementation during oral anticoagulation: cautions

Response: vitamin K supplementation during oral anticoagulation: no real cause for concern

Elizabeth Sconce,Hilary Wynne,Farhad Kamali

View Articletitled, Response: vitamin K supplementation during oral anticoagulation: no real cause for concern

Acute thrombocytopenia caused by sensitivity to the glucuronide conjugate of acetaminophen

Daniel W. Bougie,Ana I. Benito,Luis I. Sanchez-Abarca,Ricardo Torres,Jessica Birenbaum,Richard H. Aster

View Articletitled, Acute thrombocytopenia caused by sensitivity to the glucuronide conjugate of acetaminophen

Imatinib increases the intracellular concentration of nilotinib, which may explain the observed synergy between these drugs

Deborah L. White,Verity A. Saunders,Steven R. Quinn,Paul W. Manley,Timothy P. Hughes

View Articletitled, Imatinib increases the intracellular concentration of nilotinib, which may explain the observed synergy between these drugs

Survival of genetic subtypes of relapsed myeloma may be modulated by secondary events

Wee J. Chng,George Mulligan,Barbara Bryant,Leif Bergsagel

View Articletitled, Survival of genetic subtypes of relapsed myeloma may be modulated by secondary events

The serum-free light chain assay cannot replace 24-hour urine protein estimation in patients with plasma cell dyscrasias

Seema Singhal,Regina Stein,Eric Vickrey,Jayesh Mehta

View Articletitled, The serum-free light chain assay cannot replace 24-hour urine protein estimation in patients with plasma cell dyscrasias

Issue Archive

Table of Contents

INSIDE BLOOD

Genomics in myeloma: the philosopher's stone? Clinical Trials & Observations

Karyng about karyotyping in adult ALL Clinical Trials & Observations

Unraveling CML phase by phase Clinical Trials & Observations

PLENARY PAPERS

PERSPECTIVE

Clinical trials with adult stem/progenitor cells for tissue repair: let's not overlook some essential precautions Clinical Trials & Observations

REVIEW ARTICLES

REVIEW IN TRANSLATIONAL HEMATOLOGY

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Influence of ERK activation on decreased chemotaxis of mature human cord blood monocyte–derived dendritic cells to CCL19 and CXCL12 Brief Report

CLINICAL TRIALS AND OBSERVATIONS

Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib Clinical Trials & Observations

Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial Clinical Trials & Observations

T−B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3ζ subunit of the T-cell antigen receptor complex Clinical Trials & Observations

Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis Clinical Trials & Observations

Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia Clinical Trials & Observations

Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia Clinical Trials & Observations

HEMATOPOIESIS

ERRATUM

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Vitamin K–containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7 Clinical Trials & Observations

X-linked gray platelet syndrome due to a GATA1 Arg216Gln mutation Clinical Trials & Observations Brief Report

IMMUNOBIOLOGY

NEOPLASIA

Members of the glutathione and ABC-transporter families are associated with clinical outcome in patients with diffuse large B-cell lymphoma Clinical Trials & Observations

Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph) Clinical Trials & Observations

Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myélome Clinical Trials & Observations

Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia Clinical Trials & Observations Brief Report

MALT lymphoma and extranodal diffuse large B-cell lymphoma are targeted by aberrant somatic hypermutation Brief Report

Chemotherapy exposure increases leukemia cell stiffness Brief Report

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML Brief Report

PHAGOCYTES

Natural history and early diagnosis of LAD-1/variant syndrome Clinical Trials & Observations

RED CELLS

Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis Brief Report

STEM CELLS IN HEMATOLOGY

TRANSPLANTATION

Reduced-intensity conditioning for myeloma: lower nonrelapse mortality but higher relapse rates compared with myeloablative conditioning Clinical Trials & Observations

Patients with adenosine deaminase deficiency surviving after hematopoietic stem cell transplantation are at high risk of CNS complications Clinical Trials & Observations

Reduction of GVHD and enhanced antitumor effects after adoptive infusion of alloreactive Ly49-mismatched NK cells from MHC-matched donors Brief Report

CORRESPONDENCE

Vitamin K supplementation during oral anticoagulation: cautions Brief Report

Cover Image

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

Genomics in myeloma: the philosopher's stone?
Clinical Trials & Observations

Karyng about karyotyping in adult ALL
Clinical Trials & Observations

Unraveling CML phase by phase
Clinical Trials & Observations

Clinical trials with adult stem/progenitor cells for tissue repair: let's not overlook some essential precautions
Clinical Trials & Observations

Influence of ERK activation on decreased chemotaxis of mature human cord blood monocyte–derived dendritic cells to CCL19 and CXCL12
Brief Report

Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib
Clinical Trials & Observations

Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial
Clinical Trials & Observations

T⁻B⁺NK⁺ severe combined immunodeficiency caused by complete deficiency of the CD3ζ subunit of the T-cell antigen receptor complex
Clinical Trials & Observations

Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis
Clinical Trials & Observations

Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia
Clinical Trials & Observations

Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia
Clinical Trials & Observations

Vitamin K–containing dietary supplements: comparison of synthetic vitamin K₁ and natto-derived menaquinone-7
Clinical Trials & Observations

X-linked gray platelet syndrome due to a GATA1 Arg216Gln mutation
Clinical Trials & Observations Brief Report

Members of the glutathione and ABC-transporter families are associated with clinical outcome in patients with diffuse large B-cell lymphoma
Clinical Trials & Observations

Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph)
Clinical Trials & Observations

Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myélome
Clinical Trials & Observations

Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia
Clinical Trials & Observations Brief Report

MALT lymphoma and extranodal diffuse large B-cell lymphoma are targeted by aberrant somatic hypermutation
Brief Report

Chemotherapy exposure increases leukemia cell stiffness
Brief Report

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
Brief Report

Natural history and early diagnosis of LAD-1/variant syndrome
Clinical Trials & Observations

Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis
Brief Report

Reduced-intensity conditioning for myeloma: lower nonrelapse mortality but higher relapse rates compared with myeloablative conditioning
Clinical Trials & Observations

Patients with adenosine deaminase deficiency surviving after hematopoietic stem cell transplantation are at high risk of CNS complications
Clinical Trials & Observations

Reduction of GVHD and enhanced antitumor effects after adoptive infusion of alloreactive Ly49-mismatched NK cells from MHC-matched donors
Brief Report

Vitamin K supplementation during oral anticoagulation: cautions
Brief Report