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Issue Archive

Volume 109, Issue 6
March 15 2007
Issue Cover

Table of Contents

INSIDE BLOOD

IMMUNOBIOLOGY
Memory T cells: death by acquisition
Ralph A. Reisfeld
View Articletitled, Memory T cells: death by acquisition
CLINICAL OBSERVATIONS
The granulocyte connection in MPD-associated thrombosis
Ayalew Tefferi
View Articletitled, The granulocyte connection in MPD-associated thrombosis
CLINICAL TRIALS AND OBSERVATIONS
Closing the gap in CML
Clinical Trials & Observations
Jacob M. Rowe
View Articletitled, Closing the gap in CML
HEMATOPOIESIS
Endothelial cell–based therapy for hematopoiesis
Dan G. Duda
View Articletitled, Endothelial cell–based therapy for hematopoiesis
IMMUNOBIOLOGY
Bruton tyrosine kinase (Btk): key for signaling via Toll-like receptor 8
Ofer Levy
View Articletitled, Bruton tyrosine kinase (Btk): key for signaling via Toll-like receptor 8

EDITORIALS

A digital exam for hematologists
Sanford J. Shattil
View Articletitled, A digital exam for hematologists

PLENARY PAPERS

A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1
John D. Shaughnessy, Jr,Fenghuang Zhan,Bart E. Burington,Yongsheng Huang,Simona Colla,Ichiro Hanamura,James P. Stewart,Bob Kordsmeier,Christopher Randolph,David R. Williams,Yan Xiao,Hongwei Xu,Joshua Epstein,Elias Anaissie,Somashekar G. Krishna,Michele Cottler-Fox,Klaus Hollmig,Abid Mohiuddin,Mauricio Pineda-Roman,Guido Tricot,Frits van Rhee,Jeffrey Sawyer,Yazan Alsayed,Ronald Walker,Maurizio Zangari,John Crowley,Bart Barlogie
View Articletitled, A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1

REVIEW ARTICLES

Antithrombotic properties of aspirin and resistance to aspirin: beyond strictly antiplatelet actions
Anetta Undas,Kathleen E. Brummel-Ziedins,Kenneth G. Mann
View Articletitled, Antithrombotic properties of aspirin and resistance to aspirin: beyond strictly antiplatelet actions

ERRATUM

Erratum in Winter et al. Prognostic significance of Bcl-6 protein expression in DLBCL treated with CHOP or R-CHOP: a prospective correlative study
View Articletitled, Erratum in Winter et al. Prognostic significance of Bcl-6 protein expression in DLBCL treated with CHOP or R-CHOP: a prospective correlative study

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-κB–regulated antiapoptotic and cell survival gene products in human multiple myeloma cells
Anjana Bhardwaj,Gautam Sethi,Saroj Vadhan-Raj,,Carlos Bueso-Ramos,Yasunari Takada,Upasna Gaur,Asha S. Nair,Shishir Shishodia,Bharat B. Aggarwal
View Articletitled, Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-κB–regulated antiapoptotic and cell survival gene products in human multiple myeloma cells

CLINICAL TRIALS AND OBSERVATIONS

Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy
Clinical Trials & Observations
Andreas Hochhaus,Hagop M. Kantarjian,Michele Baccarani,Jeffrey H. Lipton,Jane F. Apperley,Brian J. Druker,Thierry Facon,Stuart L. Goldberg,Francisco Cervantes,Dietger Niederwieser,Richard T. Silver,Richard M. Stone,Timothy P. Hughes,Martin C. Muller,Rana Ezzeddine,Athena M. Countouriotis,Neil P. Shah
View Articletitled, Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy
Leukocytosis is a risk factor for thrombosis in essential thrombocythemia: interaction with treatment, standard risk factors, and Jak2 mutation status
Clinical Trials & Observations
Alessandra Carobbio,Guido Finazzi,Vittoria Guerini,Orietta Spinelli,Federica Delaini,Roberto Marchioli,Giovanna Borrelli,Alessandro Rambaldi,Tiziano Barbui
View Articletitled, Leukocytosis is a risk factor for thrombosis in essential thrombocythemia: interaction with treatment, standard risk factors, and Jak2 mutation status
Minimally differentiated acute myeloid leukemia (FAB AML-M0) is associated with an adverse outcome in children: a report from the Children's Oncology Group, studies CCG-2891 and CCG-2961
Clinical Trials & Observations
Draga Barbaric,Todd A. Alonzo,Robert B. Gerbing,Soheil Meshinchi,Nyla A. Heerema,Dorothy R. Barnard,Beverly J. Lange,William G. Woods,Robert J. Arceci,Franklin O. Smith
View Articletitled, Minimally differentiated acute myeloid leukemia (FAB AML-M0) is associated with an adverse outcome in children: a report from the Children's Oncology Group, studies CCG-2891 and CCG-2961
Supplemental data
Pneumococcal conjugate vaccine provides early protective antibody responses in children after related and unrelated allogeneic hematopoietic stem cell transplantation
Clinical Trials & Observations Brief Report
Roland Meisel,Lisa Kuypers,Uta Dirksen,Ralf Schubert,Bernd Gruhn,Gabriele Strauss,Karin Beutel,Andreas H. Groll,Ulrich Duffner,Renate Blütters-Sawatzki,Wolfgang Holter,Tobias Feuchtinger,Hans-Peter Grüttner,Horst Schroten,Stefan Zielen,Christian Ohmann,Hans-Jürgen Laws,Dagmar Dilloo,for the Impfung von Kindern nach allogener Stammzelltransplantation (IKAST) Study Group
View Articletitled, Pneumococcal conjugate vaccine provides early protective antibody responses in children after related and unrelated allogeneic hematopoietic stem cell transplantation
Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21)
Clinical Trials & Observations Brief Report
Anthony V. Moorman,Susan M. Richards,Hazel M. Robinson,Jon C. Strefford,Brenda E. S. Gibson,Sally E. Kinsey,Tim O. B. Eden,Ajay J. Vora,Christopher D. Mitchell,Christine J. Harrison,on behalf of the UK Medical Research Council (MRC)/National Cancer Research Institute (NCRI) Childhood Leukaemia Working Party (CLWP)
View Articletitled, Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21)
Supplemental data

GENE THERAPY

Facilitating matched pairing and expression of TCR chains introduced into human T cells
Jürgen Kuball,Michelle L. Dossett,Matthias Wolfl,William Y. Ho,Ralf-Holger Voss,Carla Fowler,Philip D. Greenberg
View Articletitled, Facilitating matched pairing and expression of TCR chains introduced into human T cells
Supplemental data

HEMATOPOIESIS

Naive recirculating B cells mature simultaneously in the spleen and bone marrow
Annaiah Cariappa,Catharine Chase,Haoyuan Liu,Paul Russell,Shiv Pillai
View Articletitled, Naive recirculating B cells mature simultaneously in the spleen and bone marrow
RhoH is important for positive thymocyte selection and T-cell receptor signaling
Tatjana Dorn,Ursula Kuhn,Gerd Bungartz,Sebastian Stiller,Martina Bauer,Joachim Ellwart,Thorsten Peters,Karin Scharffetter-Kochanek,Monika Semmrich,Melanie Laschinger,Bernhard Holzmann,Wolfgang E. F. Klinkert,Per Thor Straten,Tania Køllgaard,Michael Sixt,Cord Brakebusch
View Articletitled, RhoH is important for positive thymocyte selection and T-cell receptor signaling
Supplemental data
Gfi1b:green fluorescent protein knock-in mice reveal a dynamic expression pattern of Gfi1b during hematopoiesis that is largely complementary to Gfi1
Lothar Vassen,Taro Okayama,Tarik Möröy
View Articletitled, Gfi1b:green fluorescent protein knock-in mice reveal a dynamic expression pattern of Gfi1b during hematopoiesis that is largely complementary to Gfi1
Supplemental data
Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice
John P. Chute,Garrett G. Muramoto,Alice B. Salter,Sarah K. Meadows,Dennis W. Rickman,Benny Chen,Heather A. Himburg,Nelson J. Chao
View Articletitled, Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice
Cytokine and integrin stimulation synergize to promote higher levels of GATA-2, c-myb, and CD34 protein in primary human hematopoietic progenitors from bone marrow
Mo A. Dao,Jan A. Nolta
View Articletitled, Cytokine and integrin stimulation synergize to promote higher levels of GATA-2, c-myb, and CD34 protein in primary human hematopoietic progenitors from bone marrow
Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis
Brendan J. Jenkins,Andrew W. Roberts,Claire J. Greenhill,Meri Najdovska,Therese Lundgren-May,Lorraine Robb,Dianne Grail,Matthias Ernst
View Articletitled, Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis
Supplemental data
The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish
Lucy J. Patterson,Martin Gering,Craig E. Eckfeldt,Anthony R. Green,Catherine M. Verfaillie,Stephen C. Ekker,Roger Patient
View Articletitled, The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish
CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) express early apoptotic markers but avoid programmed cell death by up-regulation of antiapoptotic proteins
Elaine M. Sloand,Loretta Pfannes,Gubin Chen,Simant Shah,Elena E. Solomou,John Barrett,Neal S. Young
View Articletitled, CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) express early apoptotic markers but avoid programmed cell death by up-regulation of antiapoptotic proteins
α4-Integrin+ endothelium derived from primate embryonic stem cells generates primitive and definitive hematopoietic cells
Gen Shinoda,Katsutsugu Umeda,Toshio Heike,Masato Arai,Akira Niwa,Feng Ma,Hirofumi Suemori,Hong Yuan Luo,David H. K. Chui,Ryuzo Torii,Masabumi Shibuya,Norio Nakatsuji,Tatsutoshi Nakahata
View Articletitled, α4-Integrin<sup>+</sup> endothelium derived from primate embryonic stem cells generates primitive and definitive hematopoietic cells
Supplemental data
Defective apoptosis of peripheral-blood lymphocytes in hyper-IgD and periodic fever syndrome
Brief Report
Evelien J. Bodar,Jeroen C.H. van der Hilst,Waander van Heerde,Jos W. M. van der Meer,Joost P. H. Drenth,Anna Simon
View Articletitled, Defective apoptosis of peripheral-blood lymphocytes in hyper-IgD and periodic fever syndrome

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Vitamin K supplementation can improve stability of anticoagulation for patients with unexplained variability in response to warfarin
Clinical Trials & Observations
Elizabeth Sconce,Peter Avery,Hilary Wynne,Farhad Kamali
View Articletitled, Vitamin K supplementation can improve stability of anticoagulation for patients with unexplained variability in response to warfarin
von Willebrand factor and factor VIII are independently required to form stable occlusive thrombi in injured veins
Anil K. Chauhan,Janka Kisucka,Colin B. Lamb,Wolfgang Bergmeier,Denisa D. Wagner
View Articletitled, von Willebrand factor and factor VIII are independently required to form stable occlusive thrombi in injured veins
Variations in glycosylation of von Willebrand factor with O-linked sialylated T antigen are associated with its plasma levels
Carina J. M. van Schooten,Cécile V. Denis,Ton Lisman,Jeroen C. J. Eikenboom,Frank W. Leebeek,Jenny Goudemand,Edith Fressinaud,H. Marijke van den Berg,Philip G. de Groot,Peter J. Lenting
View Articletitled, Variations in glycosylation of von Willebrand factor with <em>O</em>-linked sialylated T antigen are associated with its plasma levels
Involvement of the fractalkine pathway in the pathogenesis of childhood hemolytic uremic syndrome
María Victoria Ramos,Gabriela C. Fernández,Natasha Patey,Pablo Schierloh,Ramón Exeni,Irene Grimoldi,Graciela Vallejo,Christian Elías-Costa,Maria del Carmen Sasiain,Howard Trachtman,Christophe Combadière,François Proulx,Marina S. Palermo
View Articletitled, Involvement of the fractalkine pathway in the pathogenesis of childhood hemolytic uremic syndrome
Leukocytosis as a major thrombotic risk factor in patients with polycythemia vera
Clinical Trials & Observations
Raffaele Landolfi,Leonardo Di Gennaro,Tiziano Barbui,Valerio De Stefano,Guido Finazzi,RosaMaria Marfisi,Gianni Tognoni,Roberto Marchioli,for the European Collaboration on Low-Dose Aspirin in Polycythemia Vera (ECLAP)
View Articletitled, Leukocytosis as a major thrombotic risk factor in patients with polycythemia vera
Supplemental data
MRP8/MRP14 impairs endothelial integrity and induces a caspase-dependent and -independent cell death program
Dorothee Viemann,Katarzyna Barczyk,Thomas Vogl,Ute Fischer,Cord Sunderkötter,Klaus Schulze-Osthoff,Johannes Roth
View Articletitled, MRP8/MRP14 impairs endothelial integrity and induces a caspase-dependent and -independent cell death program
Src family kinases mediate neutrophil adhesion to adherent platelets
Virgilio Evangelista,Zehra Pamuklar,Antonio Piccoli,Stefano Manarini,Giuseppe Dell'Elba,Romina Pecce,Nicola Martelli,Lorenzo Federico,Mauricio Rojas,Giorgio Berton,Clifford A. Lowell,Licia Totani,Susan S. Smyth
View Articletitled, Src family kinases mediate neutrophil adhesion to adherent platelets
Comparison of the effects of antibody-coated liposomes, IVIG, and anti-RBC immunotherapy in a murine model of passive chronic immune thrombocytopenia
Brief Report
Rong Deng,Joseph P. Balthasar
View Articletitled, Comparison of the effects of antibody-coated liposomes, IVIG, and anti-RBC immunotherapy in a murine model of passive chronic immune thrombocytopenia
A coding VKORC1 Asp36Tyr polymorphism predisposes to warfarin resistance
Clinical Trials & Observations Brief Report
Ronen Loebstein,Ilana Dvoskin,Hillel Halkin,Manuela Vecsler,Aharon Lubetsky,Gideon Rechavi,Ninette Amariglio,Yoram Cohen,Gie Ken-Dror,Shlomo Almog,Eva Gak
View Articletitled, A coding VKORC1 Asp36Tyr polymorphism predisposes to warfarin resistance

IMMUNOBIOLOGY

Hlx homeobox transcription factor negatively regulates interferon-γ production in monokine-activated natural killer cells
Brian Becknell,Tiffany L. Hughes,Aharon G. Freud,Bradley W. Blaser,Jianhua Yu,Rossana Trotta,Hsiaoyin C. Mao,Marie L. Caligiuri de Jesús,Mohamad Alghothani,Don M. Benson, Jr,Amy Lehman,David Jarjoura,Danilo Perrotti,Michael D. Bates,Michael A. Caligiuri
View Articletitled, Hlx homeobox transcription factor negatively regulates interferon-γ production in monokine-activated natural killer cells
Acquisition of antigen presentasome (APS), an MHC/costimulatory complex, is a checkpoint of memory T-cell homeostasis
Sven Mostböck,Marta Catalfamo,Yutaka Tagaya,Jeffrey Schlom,Helen Sabzevari
View Articletitled, Acquisition of antigen presentasome (APS), an MHC/costimulatory complex, is a checkpoint of memory T-cell homeostasis
In the absence of IGF-1 signaling, IFN-γ suppresses human malignant T-cell growth
Laura Conti,Gabriella Regis,Angela Longo,Paola Bernabei,Roberto Chiarle,Mirella Giovarelli,Francesco Novelli
View Articletitled, In the absence of IGF-1 signaling, IFN-γ suppresses human malignant T-cell growth
Increased mitochondrial mass characterizes the survival defect of HIV-specific CD8+ T cells
Constantinos Petrovas,Yvonne M. Mueller,Ioannis D. Dimitriou,Susan R. Altork,Anupam Banerjee,Peter Sklar,Karam C. Mounzer,John D. Altman,Peter D. Katsikis
View Articletitled, Increased mitochondrial mass characterizes the survival defect of HIV-specific CD8<sup>+</sup> T cells
Supplemental data
Specific antibodies to moesin, a membrane-cytoskeleton linker protein, are frequently detected in patients with acquired aplastic anemia
Hiroyuki Takamatsu,Xingmin Feng,Tatsuya Chuhjo,Xuzhang Lu,Chiharu Sugimori,Katsuya Okawa,Miyuki Yamamoto,Shoichi Iseki,Shinji Nakao
View Articletitled, Specific antibodies to moesin, a membrane-cytoskeleton linker protein, are frequently detected in patients with acquired aplastic anemia
Generation of peripheral B cells occurs via two spatially and temporally distinct pathways
Robert Coleman Lindsley,Matthew Thomas,Bhaskar Srivastava,David Allman
View Articletitled, Generation of peripheral B cells occurs via two spatially and temporally distinct pathways
Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging
Dullei Min,Angela Panoskaltsis-Mortari,Makoto Kuro-o,Georg A. Holländer,Bruce R. Blazar,Kenneth I. Weinberg
View Articletitled, Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging
Vaccine-delivered HIV envelope inhibits CD4+ T-cell activation, a mechanism for poor HIV vaccine responses
Kathy Fernando,Haitao Hu,Houping Ni,James A. Hoxie,Drew Weissman
View Articletitled, Vaccine-delivered HIV envelope inhibits CD4<sup>+</sup> T-cell activation, a mechanism for poor HIV vaccine responses
A novel human B cell subpopulation representing the initial germinal center population to express AID
Grant R. Kolar,Darshna Mehta,Rosana Pelayo,J. Donald Capra
View Articletitled, A novel human B cell subpopulation representing the initial germinal center population to express AID
Impaired Toll-like receptor 8–mediated IL-6 and TNF-α production in antigen-presenting cells from patients with X-linked agammaglobulinemia
Clinical Trials & Observations Brief Report
Klára Sochorová,Rudolf Horváth,Daniela Rožková,Jiří Litzman,Jiřina Bartůňková,Anna Šedivá,Radek Špíšek
View Articletitled, Impaired Toll-like receptor 8–mediated IL-6 and TNF-α production in antigen-presenting cells from patients with X-linked agammaglobulinemia
Supplemental data

NEOPLASIA

The growth factor fusion construct containing B-lymphocyte stimulator (BLyS) and the toxin rGel induces apoptosis specifically in BAFF-R–positive CLL cells
Ramadevi Nimmanapalli,Mi-Ae Lyu,Min Du,Michael J. Keating,Michael G. Rosenblum,Varsha Gandhi
View Articletitled, The growth factor fusion construct containing B-lymphocyte stimulator (BLyS) and the toxin rGel induces apoptosis specifically in BAFF-R–positive CLL cells
Hypoxia-inducible transcription factor–1 alpha determines sensitivity of endothelial cells to the proteosome inhibitor bortezomib
Lorenzo Veschini,Daniela Belloni,Chiara Foglieni,Maria Giulia Cangi,Marina Ferrarini,Federico Caligaris-Cappio,Elisabetta Ferrero
View Articletitled, Hypoxia-inducible transcription factor–1 alpha determines sensitivity of endothelial cells to the proteosome inhibitor bortezomib
Supplemental data
A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus–associated lymphoid malignancies
Clinical Trials & Observations
Susan P. Perrine,Olivier Hermine,Trudy Small,Felipe Suarez,Richard O'Reilly,Farid Boulad,Joyce Fingeroth,Melissa Askin,Arthur Levy,Steven J. Mentzer,Massimo Di Nicola,Alessandro M. Gianni,Christoph Klein,Steven Horwitz,Douglas V. Faller
View Articletitled, A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus–associated lymphoid malignancies
Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress
Crescent R. Isham,Jennifer D. Tibodeau,Wendy Jin,Ruifang Xu,Michael M. Timm,Keith C. Bible
View Articletitled, Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress
Supplemental data
Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53
Jonathan M. Irish,Nina Ånensen,Randi Hovland,Jørn Skavland,Anne-Lise Børresen-Dale,Øystein Bruserud,Garry P. Nolan,Bjørn T. Gjertsen
View Articletitled, Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53
Supplemental data
Bmi-1 is induced by the Epstein-Barr virus oncogene LMP1 and regulates the expression of viral target genes in Hodgkin lymphoma cells
Amanda Dutton,Ciaran B. Woodman,Marilyn B. Chukwuma,James I. K. Last,Wenbin Wei,Martina Vockerodt,Karl R. N. Baumforth,Joanne R. Flavell,Martin Rowe,A. Malcolm R. Taylor,Lawrence S. Young,Paul G. Murray
View Articletitled, Bmi-1 is induced by the Epstein-Barr virus oncogene LMP1 and regulates the expression of viral target genes in Hodgkin lymphoma cells
Supplemental data
Activity and safety of bortezomib in multiple myeloma patients with advanced renal failure: a multicenter retrospective study
Clinical Trials & Observations Brief Report
Asher A. Chanan-Khan,Jonathan L. Kaufman,Jayesh Mehta,Paul G. Richardson,Kena C. Miller,Sagar Lonial,Nikhil C. Munshi,Robert Schlossman,Joseph Tariman,Seema Singhal
View Articletitled, Activity and safety of bortezomib in multiple myeloma patients with advanced renal failure: a multicenter retrospective study
Supplemental data
RNAi-mediated silencing of TEL/AML1 reveals a heat-shock protein– and survivin-dependent mechanism for survival
Brief Report
Christofer Diakos,Gerd Krapf,Christopher Gerner,Andrea Inthal,Christof Lemberger,Jozef Ban,Alexander M. Dohnal,E. Renate Panzer-Grümayer
View Articletitled, RNAi-mediated silencing of <em>TEL/AML1</em> reveals a heat-shock protein– and survivin-dependent mechanism for survival
Supplemental data

RED CELLS

Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte
Felicia M. Low,Mark B. Hampton,Alexander V. Peskin,Christine C. Winterbourn
View Articletitled, Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte
Congenital erythropoietic porphyria due to a mutation in GATA1: the first trans-acting mutation causative for a human porphyria
Clinical Trials & Observations
John D. Phillips,David P. Steensma,Michael A. Pulsipher,Gerald J. Spangrude,James P. Kushner
View Articletitled, Congenital erythropoietic porphyria due to a mutation in <em>GATA1</em>: the first <em>trans</em>-acting mutation causative for a human porphyria
The effect of deoxygenation on whole-cell conductance of red blood cells from healthy individuals and patients with sickle cell disease
Joseph A. Browning,Henry M. Staines,Hannah C. Robinson,Trevor Powell,J. Clive Ellory,John S. Gibson
View Articletitled, The effect of deoxygenation on whole-cell conductance of red blood cells from healthy individuals and patients with sickle cell disease
Distinct roles of Mdm2 and Mdm4 in red cell production
Brief Report
Marion Maetens,Gilles Doumont,Sarah De Clercq,Sarah Francoz,Pascal Froment,Eric Bellefroid,Ursula Klingmuller,Guillermina Lozano,Jean-Christophe Marine
View Articletitled, Distinct roles of Mdm2 and Mdm4 in red cell production
Supplemental data

STEM CELLS IN HEMATOLOGY

In vitro and in vivo arterial differentiation of human multipotent adult progenitor cells
Xabier L. Aranguren,Aernout Luttun,Carlos Clavel,Cristina Moreno,Gloria Abizanda,Miguel A. Barajas,Beatriz Pelacho,Maialen Uriz,Miriam Araña,Ana Echavarri,Mario Soriano,Enrique J. Andreu,Juana Merino,Jose Manuel Garcia-Verdugo,Catherine M. Verfaillie,Felipe Prósper
View Articletitled, In vitro and in vivo arterial differentiation of human multipotent adult progenitor cells
Supplemental data

TRANSPLANTATION

Development of a secondary autoimmune disorder after hematopoietic stem cell transplantation for autoimmune diseases: role of conditioning regimen used
Yvonne Loh,Yu Oyama,Laisvyde Statkute,Kathleen Quigley,Kimberly Yaung,Elizabeth Gonda,Walter Barr,Borko Jovanovic,Robert Craig,Dusan Stefoski,Bruce Cohen,Richard K. Burt
View Articletitled, Development of a secondary autoimmune disorder after hematopoietic stem cell transplantation for autoimmune diseases: role of conditioning regimen used
In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation
Vu H. Nguyen,Robert Zeiser,Daniel L. daSilva,Daisy S. Chang,Andreas Beilhack,Christopher H. Contag,Robert S. Negrin
View Articletitled, In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation
Supplemental data
A phase 2/3 multicenter randomized clinical trial of ABX-CBL versus ATG as secondary therapy for steroid-resistant acute graft-versus-host disease
Clinical Trials & Observations
Margaret L. MacMillan,Daniel Couriel,Daniel J. Weisdorf,Gisela Schwab,Nancy Havrilla,Thomas R. Fleming,Saling Huang,Lorin Roskos,Shimon Slavin,Richard K. Shadduck,John DiPersio,Mary Territo,Steve Pavletic,Charles Linker,Helen E. Heslop,H. Joachim Deeg,Bruce R. Blazar
View Articletitled, A phase 2/3 multicenter randomized clinical trial of ABX-CBL versus ATG as secondary therapy for steroid-resistant acute graft-versus-host disease
Donor-derived cells and human graft-versus-host disease of the skin
Brief Report
Hideyuki Murata,Anne Janin,Christophe Leboeuf,Jean Soulier,Eliane Gluckman,Veronique Meignin,Gerard Socie
View Articletitled, Donor-derived cells and human graft-versus-host disease of the skin

CORRESPONDENCE

Stubby elliptocytes are an invariable feature of leukoerythroblastosis
Michael Quigley,Ronald L. Linfesty,Kelly Bethel,Robert Sharpe
View Articletitled, Stubby elliptocytes are an invariable feature of leukoerythroblastosis
All Issues

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