Jean-Luc Harousseau,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group,Jeffrey E. Lancet,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group,Josy Reiffers,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group,Bob Lowenberg,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group,Xavier Thomas,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group,Francoise Huguet,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group,Pierre Fenaux,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group,Steven Zhang,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group,Wayne Rackoff,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group,Peter De Porre,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group,Richard Stone,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group

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Fatal agranulocytosis after deferiprone therapy in a child with Diamond-Blackfan anemia
Brief Report

Jan-Inge Henter,Jonas Karlén

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A novel proteoliposomal vaccine induces antitumor immunity against follicular lymphoma
Brief Report

Sattva S. Neelapu,Barry L. Gause,Linda Harvey,Seung-Tae Lee,Andrea Robin Frye,Jessie Horton,Richard J. Robb,Mircea C. Popescu,Larry W. Kwak

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Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: a Cancer and Leukemia Group B study
Brief Report

Susan P. Whitman,Amy S. Ruppert,Guido Marcucci,Krzysztof Mrózek,Peter Paschka,Christian Langer,Claudia D. Baldus,Jing Wen,Tamara Vukosavljevic,Bayard L. Powell,Andrew J. Carroll,Jonathan E. Kolitz,Richard A. Larson,Michael A. Caligiuri,Clara D. Bloomfield

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Supplemental data

GENE THERAPY

Cytokine-independent growth and clonal expansion of a primary human CD8⁺ T-cell clone following retroviral transduction with the IL-15 gene

Cary Hsu,Stephanie A. Jones,Cyrille J. Cohen,Zhili Zheng,Keith Kerstann,Juhua Zhou,Paul F. Robbins,Peter D. Peng,Xinglei Shen,Theotonius J. Gomes,Cynthia E. Dunbar,David J. Munroe,Claudia Stewart,Kenneth Cornetta,Danny Wangsa,Thomas Ried,Steven A. Rosenberg,Richard A. Morgan

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Hematopoietic stem cell–targeted neonatal gene therapy reverses lethally progressive osteopetrosis in oc/oc mice

Maria K. Johansson,Teun J. de Vries,Ton Schoenmaker,Mats Ehinger,Ann C. M. Brun,Anders Fasth,Stefan Karlsson,Vincent Everts,Johan Richter

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HEMATOPOIESIS

Studies of c-Mpl function distinguish the replication of hematopoietic stem cells from the expansion of differentiating clones

Janis L. Abkowitz,Jing Chen

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EGO, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression

Lori A. Wagner,Clarissa J. Christensen,Diane M. Dunn,Gerald J. Spangrude,Ann Georgelas,Linda Kelley,M. Sean Esplin,Robert B. Weiss,Gerald J. Gleich

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Supplemental data

Cyclin D–Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization

Andrew G. Muntean,Liyan Pang,Mortimer Poncz,Steven F. Dowdy,Gerd A. Blobel,John D. Crispino

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Supplemental data

Friend of GATA-1–independent transcriptional repression: a novel mode of GATA-1 function
Brief Report

Kirby D. Johnson,Meghan E. Boyer,Jeong-Ah Kang,Amittha Wickrema,Alan B. Cantor,Emery H. Bresnick

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Supplemental data

Perforin gene mutations in patients with acquired aplastic anemia
Brief Report

Elena E. Solomou,Federica Gibellini,Brian Stewart,Daniela Malide,Maria Berg,Valeria Visconte,Spencer Green,Richard Childs,Stephen J. Chanock,Neal S. Young

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Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways
Brief Report

Jing Zhang,Yangang Liu,Caroline Beard,David A. Tuveson,Rudolf Jaenisch,Tyler E. Jacks,Harvey F. Lodish

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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Human platelets synthesize and express functional tissue factor

Olga Panes,Valeria Matus,Claudia G. Sáez,Teresa Quiroga,Jaime Pereira,Diego Mezzano

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Supplemental data

Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia

Jasimuddin Ahamed,Frank Niessen,Toru Kurokawa,Young Kyung Lee,Gourab Bhattacharjee,James H. Morrissey,Wolfram Ruf

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Ligand density dramatically affects integrin αIIbβ3-mediated platelet signaling and spreading

Markéta Jiroušková,Jyoti K. Jaiswal,Barry S. Coller

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Supplemental data

Fatal hemorrhage in mice lacking γ-glutamyl carboxylase

Aihua Zhu,Hongmin Sun,Richard M. Raymond, Jr,Barbara C. Furie,Bruce Furie,Mila Bronstein,Randal J. Kaufman,Randal Westrick,David Ginsburg

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Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer

Mary Anna Venneri,Michele De Palma,Maurilio Ponzoni,Ferdinando Pucci,Cristina Scielzo,Erika Zonari,Roberta Mazzieri,Claudio Doglioni,Luigi Naldini

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Supplemental data

The effect of a single nucleotide polymorphism on human α₂-antiplasmin activity

Victoria J. Christiansen,Kenneth W. Jackson,Kyung N. Lee,Patrick A. McKee

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Supplemental data

TLR3 ligand stimulates fully functional memory CD8⁺ T cells in the absence of CD4⁺ T-cell help

Sandra Hervas-Stubbs,Aurélie Olivier,Florence Boisgerault,Nathalie Thieblemont,Claude Leclerc

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Supplemental data

A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo

M. Gabriele Bixel,Björn Petri,Alexander G. Khandoga,Andrej Khandoga,Karen Wolburg-Buchholz,Hartwig Wolburg,Sigrid März,Fritz Krombach,Dietmar Vestweber

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Supplemental data

The DC-SIGN–related lectin LSECtin mediates antigen capture and pathogen binding by human myeloid cells

Angeles Dominguez-Soto,Laura Aragoneses-Fenoll,Enrique Martin-Gayo,Lorena Martinez-Prats,Maria Colmenares,Marisa Naranjo-Gomez,Francesc E. Borras,Pilar Munoz,Mercedes Zubiaur,Maria L. Toribio,Rafael Delgado,Angel L. Corbi

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CD4 cells can be more efficient at tumor rejection than CD8 cells

Ainhoa Perez-Diez,Nathalie T. Joncker,Kyungho Choi,William F. N. Chan,Colin C. Anderson,Olivier Lantz,Polly Matzinger

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Supplemental data

IgM and IgA anti-erythrocyte autoantibodies induce anemia in a mouse model through multivalency-dependent hemagglutination but not through complement activation

Lucie Baudino,Liliane Fossati-Jimack,Christelle Chevalley,Eduardo Martinez-Soria,Marc J. Shulman,Shozo Izui

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Direct inhibition of CD40L expression can contribute to the clinical efficacy of daclizumab independently of its effects on cell division and Th1/Th2 cytokine production

James T. Snyder,Jijia Shen,Hooman Azmi,Jeannie Hou,Daniel H. Fowler,Jack A. Ragheb

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A novel proteoliposomal vaccine elicits potent antitumor immunity in mice
Brief Report

Mircea C. Popescu,Richard J. Robb,Michael M. Batenjany,Lawrence T. Boni,Mary E. Neville,Robin W. Pennington,Sattva S. Neelapu,Larry W. Kwak

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NEOPLASIA

Role of BCR/ABL gene-expression levels in determining the phenotype and imatinib sensitivity of transformed human hematopoietic cells

Hardik Modi,Tinisha McDonald,Su Chu,Jiing-Kuan Yee,Stephen J. Forman,Ravi Bhatia

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Inactivation of RB1 in mantle-cell lymphoma detected by nonsense-mediated mRNA decay pathway inhibition and microarray analysis

Magda Pinyol,Silvia Bea,Laura Plà,Vincent Ribrag,Jacques Bosq,Andreas Rosenwald,Elias Campo,Pedro Jares

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Supplemental data

Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma

Suzanne Trudel,Zhi Hua Li,Jennifer Rauw,Rodger E. Tiedemann,Xiao Yan Wen,A. Keith Stewart

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Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival

James R. Cerhan,Sophia Wang,Matthew J. Maurer,Stephen M. Ansell,Susan M. Geyer,Wendy Cozen,Lindsay M. Morton,Scott Davis,Richard K. Severson,Nathaniel Rothman,Charles F. Lynch,Sholom Wacholder,Stephen J. Chanock,Thomas M. Habermann,Patricia Hartge

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Supplemental data

Hsp72 up-regulates Epstein-Barr virus EBNALP coactivation with EBNA2

Chih-Wen Peng,Bo Zhao,Hong-Chi Chen,Min-Luen Chou,Chiou-Yan Lai,Shinn-Zong Lin,Hsue-Yin Hsu,Elliott Kieff

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Atiprimod inhibits the growth of mantle cell lymphoma in vitro and in vivo and induces apoptosis via activating the mitochondrial pathways

Michael Wang,Liang Zhang,Xiaohong Han,Jing Yang,Jianfei Qian,Sungyoul Hong,Felipe Samaniego,Jorge Romaguera,Qing Yi

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β-Catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation

Zhuyan Guo,Marei Dose,Damian Kovalovsky,Rui Chang,Jennifer O'Neil,A. Thomas Look,Harald von Boehmer,Khashayarsha Khazaie,Fotini Gounari

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Supplemental data

ERK1/2 phosphorylation is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia
Brief Report

Chiara Gregorj,Maria R. Ricciardi,Maria T. Petrucci,Maria C. Scerpa,Fabiana De Cave,Paola Fazi,Marco Vignetti,Antonella Vitale,Marco Mancini,Giuseppe Cimino,Salvatore Palmieri,Francesco Di Raimondo,Giorgina Specchia,Francesco Fabbiano,Nicola Cantore,Federico Mosna,Andrea Camera,Mario Luppi,Luciana Annino,Eustachio Miraglia,Giuseppe Fioritoni,Francesca Ronco,Giovanna Meloni,Franco Mandelli,Michael Andreeff,Michele Milella,Robin Foà,Agostino Tafuri,the GIMEMA Acute Leukemia Working Party, Italy

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Supplemental data

Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations
Brief Report

Kazuyuki Matsuda,Akira Shimada,Nao Yoshida,Atsushi Ogawa,Akihiro Watanabe,Shuhei Yajima,Susumu Iizuka,Kazutoshi Koike,Fumio Yanai,Keiichiro Kawasaki,Masakatsu Yanagimachi,Akira Kikuchi,Yoshitoshi Ohtsuka,Eiko Hidaka,Kazuyoshi Yamauchi,Miyuki Tanaka,Ryu Yanagisawa,Yozo Nakazawa,Masaaki Shiohara,Atsushi Manabe,Seiji Kojima,Kenichi Koike

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RED CELLS

Dynamic regulation of Gata factor levels is more important than their identity

Rita Ferreira,Albert Wai,Ritsuko Shimizu,Nynke Gillemans,Robbert Rottier,Marieke von Lindern,Kinuko Ohneda,Frank Grosveld,Masayuki Yamamoto,Sjaak Philipsen

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Supplemental data

A complex splicing defect associated with homozygous ankyrin-deficient hereditary spherocytosis
Brief Report

E. Jennifer Edelman,Yelena Maksimova,Feride Duru,Cigdem Altay,Patrick G. Gallagher

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Supplemental data

STEM CELLS IN HEMATOLOGY

Asymmetric cell division within the human hematopoietic stem and progenitor cell compartment: identification of asymmetrically segregating proteins

Julia Beckmann,Sebastian Scheitza,Peter Wernet,Johannes C. Fischer,Bernd Giebel

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Supplemental data

TRANSPLANTATION

Homeostatic expansion and repertoire regeneration of donor T cells during graft versus host disease is constrained by the host environment

Jack Gorski,Xiao Chen,Mariya Gendelman,Maryam Yassai,Ashley Krueger,Elizabeth Tivol,Brent Logan,Richard Komorowski,Sanja Vodanovic-Jankovic,William R. Drobyski

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Proteomic patterns predict acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

Eva M. Weissinger,Eric Schiffer,Bernd Hertenstein,James L. Ferrara,Ernst Holler,Michael Stadler,Hans-Jochem Kolb,Axel Zander,Petra Zürbig,Markus Kellmann,Arnold Ganser

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Supplemental data

Targeting host B-cell immune responses by persistent donor NK-cell alloreactivity following nonmyeloablative allogeneic stem cell transplantation

Roelof Flierman,Geert Westerhuis,Marjolijn Hameetman,Leonie M. van Duivenvoorde,Thorbald van Hall,Jacob M. van Laar,Willem E. Fibbe,René E. M. Toes

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Effect of the new HJV-L165X mutation on penetrance of HFE

Boukje A. C. van Dijk,Erwin H. J. M. Kemna,Harold Tjalsma,Siem M. Klaver,Erwin T. G. Wiegerinck,Jan-Pieter Goossens,Peter H. Th. J. Slee,Martijn H. Breuning,Dorine W. Swinkels

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A closer look at intravascular hemolysis (IVH) following intravenous anti-D for immune thrombocytopenic purpura (ITP)

Michael D. Tarantino,James B. Bussel,Douglas B. Cines,Keith R. McCrae,Terry Gernsheimer,Howard A. Liebman,Wing-Yen Wong,Roshni Kulkarni,Eric Grabowski,Robert McMillan

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Response: Further examination of intravascular hemolysis (IVH) following intravenous anti-D for immune thrombocytopenic purpura (ITP)

Ann Reed Gaines

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Cover Image

Cover Image

"Water" by Giuseppe Arcimboldo (Italy, 1527-1593). Reproduced with the permission of the Kunsthistorisches Museum, Vienna, Austria. See the commentary by Migliaccio, page 5077, and the related article by Ferreira et al, page 5481.
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Table of Contents

INSIDE BLOOD

PLENARY PAPERS

ERRATUM

REVIEW ARTICLES

REVIEW IN TRANSLATIONAL HEMATOLOGY

HOW I TREAT

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

CLINICAL TRIALS AND OBSERVATIONS

Postremission treatment of elderly patients with acute myeloid leukemia in first complete remission after intensive induction chemotherapy:results of the multicenter randomized Acute Leukemia French Association (ALFA) 9803 trial Clinical Trials & Observations

Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801 Clinical Trials & Observations

Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized phase 2 trial Clinical Trials & Observations

A phase 2 study of the oral farnesyltransferase inhibitor tipifarnib in patients with refractory or relapsed acute myeloid leukemia Clinical Trials & Observations

Fatal agranulocytosis after deferiprone therapy in a child with Diamond-Blackfan anemia Brief Report

A novel proteoliposomal vaccine induces antitumor immunity against follicular lymphoma Brief Report

Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: a Cancer and Leukemia Group B study Brief Report

GENE THERAPY

HEMATOPOIESIS

Friend of GATA-1–independent transcriptional repression: a novel mode of GATA-1 function Brief Report

Perforin gene mutations in patients with acquired aplastic anemia Brief Report

Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways Brief Report

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IMMUNOBIOLOGY

A novel proteoliposomal vaccine elicits potent antitumor immunity in mice Brief Report

NEOPLASIA

ERK1/2 phosphorylation is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia Brief Report

Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations Brief Report

RED CELLS

A complex splicing defect associated with homozygous ankyrin-deficient hereditary spherocytosis Brief Report

STEM CELLS IN HEMATOLOGY

TRANSPLANTATION

CORRESPONDENCE

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ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

Postremission treatment of elderly patients with acute myeloid leukemia in first complete remission after intensive induction chemotherapy:results of the multicenter randomized Acute Leukemia French Association (ALFA) 9803 trial
Clinical Trials & Observations

Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801
Clinical Trials & Observations

Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized phase 2 trial
Clinical Trials & Observations

A phase 2 study of the oral farnesyltransferase inhibitor tipifarnib in patients with refractory or relapsed acute myeloid leukemia
Clinical Trials & Observations

Fatal agranulocytosis after deferiprone therapy in a child with Diamond-Blackfan anemia
Brief Report

A novel proteoliposomal vaccine induces antitumor immunity against follicular lymphoma
Brief Report

Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: a Cancer and Leukemia Group B study
Brief Report

Friend of GATA-1–independent transcriptional repression: a novel mode of GATA-1 function
Brief Report

Perforin gene mutations in patients with acquired aplastic anemia
Brief Report

Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways
Brief Report

A novel proteoliposomal vaccine elicits potent antitumor immunity in mice
Brief Report

ERK1/2 phosphorylation is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia
Brief Report

Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations
Brief Report

A complex splicing defect associated with homozygous ankyrin-deficient hereditary spherocytosis
Brief Report