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Issue Archive

Volume 109, Issue 12
June 15 2007
Issue Cover

Table of Contents

INSIDE BLOOD

GENE THERAPY
Gene therapy sculpts the bone
Luigi D. Notarangelo
View Articletitled, Gene therapy sculpts the bone
CLINICAL OBSERVATIONS
What if conventional-dose imatinib fails?
Charles A. Schiffer
View Articletitled, What if conventional-dose imatinib fails?
HEMOSTASIS
Platelet tissue factor comes of age
Andrew S. Weyrich,Hansjörg Schwertz,Nigel Mackman
View Articletitled, Platelet tissue factor comes of age
IMMUNOBIOLOGY
Antitumor T-cell wars: do CD4s outwit CD8s?
Ignacio Melero
View Articletitled, Antitumor T-cell wars: do CD4s outwit CD8s?
NEOPLASIA
MicroRNAs play a role in neoplasia
Thomas J. Kipps
View Articletitled, MicroRNAs play a role in neoplasia
IMMUNOBIOLOGY
To transmigrate or not to transmigrate
Klaus Ley
View Articletitled, To transmigrate or not to transmigrate
NEOPLASIA
Uncontrolled Wnt signaling causes leukemia
Frank J. T. Staal
View Articletitled, Uncontrolled Wnt signaling causes leukemia
HEMATOPOIESIS
Scavenger receptor helps erythroblasts stay on island
Mark J. Koury
View Articletitled, Scavenger receptor helps erythroblasts stay on island
TRANSPLANTATION
Clinical proteomics: towards diagnostics and prognostics
Visith Thongboonkerd
View Articletitled, Clinical proteomics: towards diagnostics and prognostics
HEMOSTASIS
Monocytes TIE(2)d up in murky business
George Coukos
View Articletitled, Monocytes TIE(2)d up in murky business
RED CELLS
To code or not to code
Anna Rita Migliaccio
View Articletitled, To code or not to code

PLENARY PAPERS

Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice
Elizabeth S. Raveche,Erica Salerno,Brian J. Scaglione,Vijaya Manohar,Fatima Abbasi,Yi-Chu Lin,Torgny Fredrickson,Pablo Landgraf,Sumant Ramachandra,Konrad Huppi,Jorge R. Toro,Vincent E. Zenger,Robert A. Metcalf,Gerald E. Marti
View Articletitled, Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice

ERRATUM

Erratum for Duvic et al., Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
View Articletitled, Erratum for Duvic et al., Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)

REVIEW ARTICLES

The growing complexity of platelet aggregation
Shaun P. Jackson
View Articletitled, The growing complexity of platelet aggregation

REVIEW IN TRANSLATIONAL HEMATOLOGY

Waldenström macroglobulinemia
Arun Vijay,Morie A. Gertz
View Articletitled, Waldenström macroglobulinemia

HOW I TREAT

How I treat patients with polycythemia vera
Guido Finazzi,Tiziano Barbui
View Articletitled, How I treat patients with polycythemia vera

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-κB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis
Ajaikumar B. Kunnumakkara,Asha S. Nair,Kwang Seok Ahn,Manoj K. Pandey,Zhengfang Yi,Mingyao Liu,Bharat B. Aggarwal
View Articletitled, Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-κB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis
The adaptor protein Lad associates with the G protein β subunit and mediates chemokine-dependent T-cell migration
Dongsu Park,Inyoung Park,Deogwon Lee,Young Bong Choi,Hyunsook Lee,Yungdae Yun
View Articletitled, The adaptor protein Lad associates with the G protein β subunit and mediates chemokine-dependent T-cell migration

CLINICAL TRIALS AND OBSERVATIONS

Postremission treatment of elderly patients with acute myeloid leukemia in first complete remission after intensive induction chemotherapy:results of the multicenter randomized Acute Leukemia French Association (ALFA) 9803 trial
Clinical Trials & Observations
Claude Gardin,Pascal Turlure,Thierry Fagot,Xavier Thomas,Christine Terre,Nathalie Contentin,Emmanuel Raffoux,Stephane de Botton,Cecile Pautas,Oumedaly Reman,Jean-Henri Bourhis,Pierre Fenaux,Sylvie Castaigne,Mauricette Michallet,Claude Preudhomme,Thierry de Revel,Dominique Bordessoule,Herve Dombret,for the Acute Leukemia French Association (ALFA)
View Articletitled, Postremission treatment of elderly patients with acute myeloid leukemia in first complete remission after intensive induction chemotherapy:results of the multicenter randomized Acute Leukemia French Association (ALFA) 9803 trial
Supplemental data
Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801
Clinical Trials & Observations
Daniel J. DeAngelo,Daohai Yu,Jeffrey L. Johnson,Steven E. Coutre,Richard M. Stone,Alison T. Stopeck,Jon P. Gockerman,Beverly S. Mitchell,Frederick R. Appelbaum,Richard A. Larson
View Articletitled, Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801
Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized phase 2 trial
Clinical Trials & Observations
Hagop Kantarjian,Ricardo Pasquini,Nelson Hamerschlak,Philippe Rousselot,Jerzy Holowiecki,Saengsuree Jootar,Tadeusz Robak,Nina Khoroshko,Tamas Masszi,Aleksander Skotnicki,Andrzej Hellmann,Andrey Zaritsky,Anatoly Golenkov,Jerald Radich,Timothy Hughes,Athena Countouriotis,Neil Shah
View Articletitled, Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized phase 2 trial
A phase 2 study of the oral farnesyltransferase inhibitor tipifarnib in patients with refractory or relapsed acute myeloid leukemia
Clinical Trials & Observations
Jean-Luc Harousseau,Jeffrey E. Lancet,Josy Reiffers,Bob Lowenberg,Xavier Thomas,Francoise Huguet,Pierre Fenaux,Steven Zhang,Wayne Rackoff,Peter De Porre,Richard Stone,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group,for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group
View Articletitled, A phase 2 study of the oral farnesyltransferase inhibitor tipifarnib in patients with refractory or relapsed acute myeloid leukemia
Fatal agranulocytosis after deferiprone therapy in a child with Diamond-Blackfan anemia
Brief Report
Jan-Inge Henter,Jonas Karlén
View Articletitled, Fatal agranulocytosis after deferiprone therapy in a child with Diamond-Blackfan anemia
A novel proteoliposomal vaccine induces antitumor immunity against follicular lymphoma
Brief Report
Sattva S. Neelapu,Barry L. Gause,Linda Harvey,Seung-Tae Lee,Andrea Robin Frye,Jessie Horton,Richard J. Robb,Mircea C. Popescu,Larry W. Kwak
View Articletitled, A novel proteoliposomal vaccine induces antitumor immunity against follicular lymphoma
Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: a Cancer and Leukemia Group B study
Brief Report
Susan P. Whitman,Amy S. Ruppert,Guido Marcucci,Krzysztof Mrózek,Peter Paschka,Christian Langer,Claudia D. Baldus,Jing Wen,Tamara Vukosavljevic,Bayard L. Powell,Andrew J. Carroll,Jonathan E. Kolitz,Richard A. Larson,Michael A. Caligiuri,Clara D. Bloomfield
View Articletitled, Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and <em>MLL</em> partial tandem duplication: a Cancer and Leukemia Group B study
Supplemental data

GENE THERAPY

Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene
Cary Hsu,Stephanie A. Jones,Cyrille J. Cohen,Zhili Zheng,Keith Kerstann,Juhua Zhou,Paul F. Robbins,Peter D. Peng,Xinglei Shen,Theotonius J. Gomes,Cynthia E. Dunbar,David J. Munroe,Claudia Stewart,Kenneth Cornetta,Danny Wangsa,Thomas Ried,Steven A. Rosenberg,Richard A. Morgan
View Articletitled, Cytokine-independent growth and clonal expansion of a primary human CD8<sup>+</sup> T-cell clone following retroviral transduction with the IL-15 gene
Hematopoietic stem cell–targeted neonatal gene therapy reverses lethally progressive osteopetrosis in oc/oc mice
Maria K. Johansson,Teun J. de Vries,Ton Schoenmaker,Mats Ehinger,Ann C. M. Brun,Anders Fasth,Stefan Karlsson,Vincent Everts,Johan Richter
View Articletitled, Hematopoietic stem cell–targeted neonatal gene therapy reverses lethally progressive osteopetrosis in oc/oc mice

HEMATOPOIESIS

Studies of c-Mpl function distinguish the replication of hematopoietic stem cells from the expansion of differentiating clones
Janis L. Abkowitz,Jing Chen
View Articletitled, Studies of c-Mpl function distinguish the replication of hematopoietic stem cells from the expansion of differentiating clones
EGO, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression
Lori A. Wagner,Clarissa J. Christensen,Diane M. Dunn,Gerald J. Spangrude,Ann Georgelas,Linda Kelley,M. Sean Esplin,Robert B. Weiss,Gerald J. Gleich
View Articletitled, <em>EGO</em>, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression
Supplemental data
Cyclin D–Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization
Andrew G. Muntean,Liyan Pang,Mortimer Poncz,Steven F. Dowdy,Gerd A. Blobel,John D. Crispino
View Articletitled, Cyclin D–Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization
Supplemental data
Migratory path of definitive hematopoietic stem/progenitor cells during zebrafish development
Hao Jin,Jin Xu,Zilong Wen
View Articletitled, Migratory path of definitive hematopoietic stem/progenitor cells during zebrafish development
β-Trcp mediates ubiquitination and degradation of the erythropoietin receptor and controls cell proliferation
Laure Meyer,Bénédicte Deau,Hana Forejtníková,Dominique Duménil,Florence Margottin-Goguet,Catherine Lacombe,Patrick Mayeux,Frédérique Verdier
View Articletitled, β-Trcp mediates ubiquitination and degradation of the erythropoietin receptor and controls cell proliferation
The macrophage CD163 surface glycoprotein is an erythroblast adhesion receptor
Babs O. Fabriek,Machteld M. J. Polfliet,Rianka P. M. Vloet,Roel C. van der Schors,Antoon J. M. Ligtenberg,Lehn K. Weaver,Christiaan Geest,Kenjiro Matsuno,Søren K. Moestrup,Christien D. Dijkstra,Timo K. van den Berg
View Articletitled, The macrophage CD163 surface glycoprotein is an erythroblast adhesion receptor
Supplemental data
Friend of GATA-1–independent transcriptional repression: a novel mode of GATA-1 function
Brief Report
Kirby D. Johnson,Meghan E. Boyer,Jeong-Ah Kang,Amittha Wickrema,Alan B. Cantor,Emery H. Bresnick
View Articletitled, Friend of GATA-1–independent transcriptional repression: a novel mode of GATA-1 function
Supplemental data
Perforin gene mutations in patients with acquired aplastic anemia
Brief Report
Elena E. Solomou,Federica Gibellini,Brian Stewart,Daniela Malide,Maria Berg,Valeria Visconte,Spencer Green,Richard Childs,Stephen J. Chanock,Neal S. Young
View Articletitled, Perforin gene mutations in patients with acquired aplastic anemia
Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways
Brief Report
Jing Zhang,Yangang Liu,Caroline Beard,David A. Tuveson,Rudolf Jaenisch,Tyler E. Jacks,Harvey F. Lodish
View Articletitled, Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Human platelets synthesize and express functional tissue factor
Olga Panes,Valeria Matus,Claudia G. Sáez,Teresa Quiroga,Jaime Pereira,Diego Mezzano
View Articletitled, Human platelets synthesize and express functional tissue factor
Supplemental data
Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia
Jasimuddin Ahamed,Frank Niessen,Toru Kurokawa,Young Kyung Lee,Gourab Bhattacharjee,James H. Morrissey,Wolfram Ruf
View Articletitled, Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia
Ligand density dramatically affects integrin αIIbβ3-mediated platelet signaling and spreading
Markéta Jiroušková,Jyoti K. Jaiswal,Barry S. Coller
View Articletitled, Ligand density dramatically affects integrin αIIbβ3-mediated platelet signaling and spreading
Supplemental data
Fatal hemorrhage in mice lacking γ-glutamyl carboxylase
Aihua Zhu,Hongmin Sun,Richard M. Raymond, Jr,Barbara C. Furie,Bruce Furie,Mila Bronstein,Randal J. Kaufman,Randal Westrick,David Ginsburg
View Articletitled, Fatal hemorrhage in mice lacking γ-glutamyl carboxylase
Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer
Mary Anna Venneri,Michele De Palma,Maurilio Ponzoni,Ferdinando Pucci,Cristina Scielzo,Erika Zonari,Roberta Mazzieri,Claudio Doglioni,Luigi Naldini
View Articletitled, Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer
Supplemental data
The effect of a single nucleotide polymorphism on human α2-antiplasmin activity
Victoria J. Christiansen,Kenneth W. Jackson,Kyung N. Lee,Patrick A. McKee
View Articletitled, The effect of a single nucleotide polymorphism on human α<sub>2</sub>-antiplasmin activity

IMMUNOBIOLOGY

Human tissue mast cells are an inducible reservoir of persistent HIV infection
J. Bruce Sundstrom,Jane E. Ellis,Gregory A. Hair,Arnold S. Kirshenbaum,Dean D. Metcalfe,Hong Yi,Adriana C. Cardona,Michael K. Lindsay,Aftab A. Ansari
View Articletitled, Human tissue mast cells are an inducible reservoir of persistent HIV infection
Resistance to TGF-β1 correlates with aberrant expression of TGF-β receptor II in human B-cell lymphoma cell lines
Gang Chen,Paritosh Ghosh,Hiroshi Osawa,Carl Y. Sasaki,Louis Rezanka,Jiandong Yang,Thomas J. O'Farrell,Dan L. Longo
View Articletitled, Resistance to TGF-β1 correlates with aberrant expression of TGF-β receptor II in human B-cell lymphoma cell lines
Roles of RabGEF1/Rabex-5 domains in regulating FcϵRI surface expression and FcϵRI-dependent responses in mast cells
Janet Kalesnikoff,Eon J. Rios,Ching-Cheng Chen,M. Alejandro Barbieri,Mindy Tsai,See-Ying Tam,Stephen J. Galli
View Articletitled, Roles of RabGEF1/Rabex-5 domains in regulating FcϵRI surface expression and FcϵRI-dependent responses in mast cells
Supplemental data
TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help
Sandra Hervas-Stubbs,Aurélie Olivier,Florence Boisgerault,Nathalie Thieblemont,Claude Leclerc
View Articletitled, TLR3 ligand stimulates fully functional memory CD8<sup>+</sup> T cells in the absence of CD4<sup>+</sup> T-cell help
Supplemental data
A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo
M. Gabriele Bixel,Björn Petri,Alexander G. Khandoga,Andrej Khandoga,Karen Wolburg-Buchholz,Hartwig Wolburg,Sigrid März,Fritz Krombach,Dietmar Vestweber
View Articletitled, A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo
Supplemental data
The DC-SIGN–related lectin LSECtin mediates antigen capture and pathogen binding by human myeloid cells
Angeles Dominguez-Soto,Laura Aragoneses-Fenoll,Enrique Martin-Gayo,Lorena Martinez-Prats,Maria Colmenares,Marisa Naranjo-Gomez,Francesc E. Borras,Pilar Munoz,Mercedes Zubiaur,Maria L. Toribio,Rafael Delgado,Angel L. Corbi
View Articletitled, The DC-SIGN–related lectin LSECtin mediates antigen capture and pathogen binding by human myeloid cells
CD4 cells can be more efficient at tumor rejection than CD8 cells
Ainhoa Perez-Diez,Nathalie T. Joncker,Kyungho Choi,William F. N. Chan,Colin C. Anderson,Olivier Lantz,Polly Matzinger
View Articletitled, CD4 cells can be more efficient at tumor rejection than CD8 cells
Supplemental data
IgM and IgA anti-erythrocyte autoantibodies induce anemia in a mouse model through multivalency-dependent hemagglutination but not through complement activation
Lucie Baudino,Liliane Fossati-Jimack,Christelle Chevalley,Eduardo Martinez-Soria,Marc J. Shulman,Shozo Izui
View Articletitled, IgM and IgA anti-erythrocyte autoantibodies induce anemia in a mouse model through multivalency-dependent hemagglutination but not through complement activation
Kit is essential for PMA-inflammation–induced mast-cell accumulation in the skin
Claudia Waskow,Susanne Bartels,Susan M. Schlenner,Celine Costa,Hans-Reimer Rodewald
View Articletitled, Kit is essential for PMA-inflammation–induced mast-cell accumulation in the skin
Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets
Diego Piccioli,Simona Tavarini,Erica Borgogni,Veronica Steri,Sandra Nuti,Chiara Sammicheli,Monia Bardelli,Daniela Montagna,Franco Locatelli,Andreas Wack
View Articletitled, Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets
Naturally occurring C-terminally truncated STAT5 is a negative regulator of HIV-1 expression
Andrea Crotti,Marina Lusic,Rossella Lupo,Patricia M. J. Lievens,Elio Liboi,Giulia Della Chiara,Marco Tinelli,Adriano Lazzarin,Bruce K. Patterson,Mauro Giacca,Chiara Bovolenta,Guido Poli
View Articletitled, Naturally occurring C-terminally truncated STAT5 is a negative regulator of HIV-1 expression
CD38/CD19: a lipid raft–dependent signaling complex in human B cells
Silvia Deaglio,Tiziana Vaisitti,Richard Billington,Luciana Bergui,Paola Omede',Armando A. Genazzani,Fabio Malavasi
View Articletitled, CD38/CD19: a lipid raft–dependent signaling complex in human B cells
Direct inhibition of CD40L expression can contribute to the clinical efficacy of daclizumab independently of its effects on cell division and Th1/Th2 cytokine production
James T. Snyder,Jijia Shen,Hooman Azmi,Jeannie Hou,Daniel H. Fowler,Jack A. Ragheb
View Articletitled, Direct inhibition of CD40L expression can contribute to the clinical efficacy of daclizumab independently of its effects on cell division and Th1/Th2 cytokine production
A novel proteoliposomal vaccine elicits potent antitumor immunity in mice
Brief Report
Mircea C. Popescu,Richard J. Robb,Michael M. Batenjany,Lawrence T. Boni,Mary E. Neville,Robin W. Pennington,Sattva S. Neelapu,Larry W. Kwak
View Articletitled, A novel proteoliposomal vaccine elicits potent antitumor immunity in mice

NEOPLASIA

Role of BCR/ABL gene-expression levels in determining the phenotype and imatinib sensitivity of transformed human hematopoietic cells
Hardik Modi,Tinisha McDonald,Su Chu,Jiing-Kuan Yee,Stephen J. Forman,Ravi Bhatia
View Articletitled, Role of <em>BCR/ABL</em> gene-expression levels in determining the phenotype and imatinib sensitivity of transformed human hematopoietic cells
Inactivation of RB1 in mantle-cell lymphoma detected by nonsense-mediated mRNA decay pathway inhibition and microarray analysis
Magda Pinyol,Silvia Bea,Laura Plà,Vincent Ribrag,Jacques Bosq,Andreas Rosenwald,Elias Campo,Pedro Jares
View Articletitled, Inactivation of <em>RB1</em> in mantle-cell lymphoma detected by nonsense-mediated mRNA decay pathway inhibition and microarray analysis
Supplemental data
Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma
Suzanne Trudel,Zhi Hua Li,Jennifer Rauw,Rodger E. Tiedemann,Xiao Yan Wen,A. Keith Stewart
View Articletitled, Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma
Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival
James R. Cerhan,Sophia Wang,Matthew J. Maurer,Stephen M. Ansell,Susan M. Geyer,Wendy Cozen,Lindsay M. Morton,Scott Davis,Richard K. Severson,Nathaniel Rothman,Charles F. Lynch,Sholom Wacholder,Stephen J. Chanock,Thomas M. Habermann,Patricia Hartge
View Articletitled, Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival
Supplemental data
Hsp72 up-regulates Epstein-Barr virus EBNALP coactivation with EBNA2
Chih-Wen Peng,Bo Zhao,Hong-Chi Chen,Min-Luen Chou,Chiou-Yan Lai,Shinn-Zong Lin,Hsue-Yin Hsu,Elliott Kieff
View Articletitled, Hsp72 up-regulates Epstein-Barr virus EBNALP coactivation with EBNA2
Atiprimod inhibits the growth of mantle cell lymphoma in vitro and in vivo and induces apoptosis via activating the mitochondrial pathways
Michael Wang,Liang Zhang,Xiaohong Han,Jing Yang,Jianfei Qian,Sungyoul Hong,Felipe Samaniego,Jorge Romaguera,Qing Yi
View Articletitled, Atiprimod inhibits the growth of mantle cell lymphoma in vitro and in vivo and induces apoptosis via activating the mitochondrial pathways
β-Catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation
Zhuyan Guo,Marei Dose,Damian Kovalovsky,Rui Chang,Jennifer O'Neil,A. Thomas Look,Harald von Boehmer,Khashayarsha Khazaie,Fotini Gounari
View Articletitled, β-Catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation
Supplemental data
ERK1/2 phosphorylation is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia
Brief Report
Chiara Gregorj,Maria R. Ricciardi,Maria T. Petrucci,Maria C. Scerpa,Fabiana De Cave,Paola Fazi,Marco Vignetti,Antonella Vitale,Marco Mancini,Giuseppe Cimino,Salvatore Palmieri,Francesco Di Raimondo,Giorgina Specchia,Francesco Fabbiano,Nicola Cantore,Federico Mosna,Andrea Camera,Mario Luppi,Luciana Annino,Eustachio Miraglia,Giuseppe Fioritoni,Francesca Ronco,Giovanna Meloni,Franco Mandelli,Michael Andreeff,Michele Milella,Robin Foà,Agostino Tafuri,the GIMEMA Acute Leukemia Working Party, Italy
View Articletitled, ERK1/2 phosphorylation is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia
Supplemental data
Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations
Brief Report
Kazuyuki Matsuda,Akira Shimada,Nao Yoshida,Atsushi Ogawa,Akihiro Watanabe,Shuhei Yajima,Susumu Iizuka,Kazutoshi Koike,Fumio Yanai,Keiichiro Kawasaki,Masakatsu Yanagimachi,Akira Kikuchi,Yoshitoshi Ohtsuka,Eiko Hidaka,Kazuyoshi Yamauchi,Miyuki Tanaka,Ryu Yanagisawa,Yozo Nakazawa,Masaaki Shiohara,Atsushi Manabe,Seiji Kojima,Kenichi Koike
View Articletitled, Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific <em>RAS</em> mutations

RED CELLS

Dynamic regulation of Gata factor levels is more important than their identity
Rita Ferreira,Albert Wai,Ritsuko Shimizu,Nynke Gillemans,Robbert Rottier,Marieke von Lindern,Kinuko Ohneda,Frank Grosveld,Masayuki Yamamoto,Sjaak Philipsen
View Articletitled, Dynamic regulation of Gata factor levels is more important than their identity
Supplemental data
A complex splicing defect associated with homozygous ankyrin-deficient hereditary spherocytosis
Brief Report
E. Jennifer Edelman,Yelena Maksimova,Feride Duru,Cigdem Altay,Patrick G. Gallagher
View Articletitled, A complex splicing defect associated with homozygous ankyrin-deficient hereditary spherocytosis
Supplemental data

STEM CELLS IN HEMATOLOGY

Asymmetric cell division within the human hematopoietic stem and progenitor cell compartment: identification of asymmetrically segregating proteins
Julia Beckmann,Sebastian Scheitza,Peter Wernet,Johannes C. Fischer,Bernd Giebel
View Articletitled, Asymmetric cell division within the human hematopoietic stem and progenitor cell compartment: identification of asymmetrically segregating proteins
Supplemental data

TRANSPLANTATION

Homeostatic expansion and repertoire regeneration of donor T cells during graft versus host disease is constrained by the host environment
Jack Gorski,Xiao Chen,Mariya Gendelman,Maryam Yassai,Ashley Krueger,Elizabeth Tivol,Brent Logan,Richard Komorowski,Sanja Vodanovic-Jankovic,William R. Drobyski
View Articletitled, Homeostatic expansion and repertoire regeneration of donor T cells during graft versus host disease is constrained by the host environment
Proteomic patterns predict acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
Eva M. Weissinger,Eric Schiffer,Bernd Hertenstein,James L. Ferrara,Ernst Holler,Michael Stadler,Hans-Jochem Kolb,Axel Zander,Petra Zürbig,Markus Kellmann,Arnold Ganser
View Articletitled, Proteomic patterns predict acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
Supplemental data

CORRESPONDENCE

Vitamin supplementation in the secondary prevention of venous thromboembolism: about the VITRO study
Rossella Marcucci,Francesco Sofi,Anna Maria Gori,Gian Franco Gensini,Rosanna Abbate
View Articletitled, Vitamin supplementation in the secondary prevention of venous thromboembolism: about the VITRO study
Vitamins and Thrombosis (VITRO) study—homocysteine lowering with B vitamins
Antonis Georg Tsamaloukas
View Articletitled, Vitamins and Thrombosis (VITRO) study—homocysteine lowering with B vitamins
Response: Homocysteine lowering and recurrent venous thrombosis: the VITRO trial
Martin den Heijer,Henk J. Blom,Frits R. Rosendaal,Gerard M. J. Bos
View Articletitled, Response: Homocysteine lowering and recurrent venous thrombosis: the VITRO trial
RAG1 and BRCA2 polymorphisms in non-Hodgkin lymphoma
Kathryn Scott,Peter J. Adamson,Sharon L. Barrans,Lisa J. Worrillow,Eleanor V. Willett,James M. Allan
View Articletitled, <em>RAG1</em> and <em>BRCA2</em> polymorphisms in non-Hodgkin lymphoma
NHL and genomic variability in RAG1 and BRCA2
Deirdre A. Hill,Sophia Wang,Patricia Hartge,Nathaniel Rothman
View Articletitled, NHL and genomic variability in <em>RAG1</em> and <em>BRCA2</em>
Targeting host B-cell immune responses by persistent donor NK-cell alloreactivity following nonmyeloablative allogeneic stem cell transplantation
Roelof Flierman,Geert Westerhuis,Marjolijn Hameetman,Leonie M. van Duivenvoorde,Thorbald van Hall,Jacob M. van Laar,Willem E. Fibbe,René E. M. Toes
View Articletitled, Targeting host B-cell immune responses by persistent donor NK-cell alloreactivity following nonmyeloablative allogeneic stem cell transplantation
Effect of the new HJV-L165X mutation on penetrance of HFE
Boukje A. C. van Dijk,Erwin H. J. M. Kemna,Harold Tjalsma,Siem M. Klaver,Erwin T. G. Wiegerinck,Jan-Pieter Goossens,Peter H. Th. J. Slee,Martijn H. Breuning,Dorine W. Swinkels
View Articletitled, Effect of the new HJV-L165X mutation on penetrance of HFE
A closer look at intravascular hemolysis (IVH) following intravenous anti-D for immune thrombocytopenic purpura (ITP)
Michael D. Tarantino,James B. Bussel,Douglas B. Cines,Keith R. McCrae,Terry Gernsheimer,Howard A. Liebman,Wing-Yen Wong,Roshni Kulkarni,Eric Grabowski,Robert McMillan
View Articletitled, A closer look at intravascular hemolysis (IVH) following intravenous anti-D for immune thrombocytopenic purpura (ITP)
Response: Further examination of intravascular hemolysis (IVH) following intravenous anti-D for immune thrombocytopenic purpura (ITP)
Ann Reed Gaines
View Articletitled, Response: Further examination of intravascular hemolysis (IVH) following intravenous anti-D for immune thrombocytopenic purpura (ITP)
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