Rüdiger Hehlmann,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Ute Berger,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Markus Pfirrmann,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Hermann Heimpel,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Andreas Hochhaus,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Joerg Hasford,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Hans-Jochem Kolb,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Tanja Lahaye,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Ole Maywald,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Andreas Reiter,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Dieter K. Hossfeld,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Christoph Huber,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Helmut Löffler,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Hans Pralle,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Wolfgang Queisser,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Andreas Tobler,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Christoph Nerl,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Max Solenthaler,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Mariele E. Goebeler,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Martin Griesshammer,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Thomas Fischer,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Stephan Kremers,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Hartmut Eimermacher,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Michael Pfreundschuh,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Wolf-Dietrich Hirschmann,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Klaus Lechner,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Barbara Wassmann,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Christiane Falge,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Hartmut H. Kirchner,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group,Alois Gratwohl,for the Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group

View Articletitled, Drug treatment is superior to allografting as first-line therapy in chronic myeloid leukemia

Supplemental data

Recombinant versus plasma-derived factor VIII products and the development of inhibitors in previously untreated patients with severe hemophilia A: the CANAL cohort study
Clinical Trials & Observations

Samantha C. Gouw,for the CANAL Study group,Johanna G. van der Bom,for the CANAL Study group,Günter Auerswald,for the CANAL Study group,Carmen Escuriola Ettinghausen,for the CANAL Study group,Ulf Tedgård,for the CANAL Study group,H. Marijke van den Berg,for the CANAL Study group

View Articletitled, Recombinant versus plasma-derived factor VIII products and the development of inhibitors in previously untreated patients with severe hemophilia A: the CANAL cohort study

Supplemental data

GENE THERAPY

Antitumor effects of HSV-TK–engineered donor lymphocytes after allogeneic stem-cell transplantation

Fabio Ciceri,Chiara Bonini,Sarah Marktel,Elisabetta Zappone,Paolo Servida,Massimo Bernardi,Alessandra Pescarollo,Attilio Bondanza,Jacopo Peccatori,Silvano Rossini,Zulma Magnani,Monica Salomoni,Claudia Benati,Maurilio Ponzoni,Luciano Callegaro,Paolo Corradini,Marco Bregni,Catia Traversari,Claudio Bordignon

View Articletitled, Antitumor effects of HSV-TK–engineered donor lymphocytes after allogeneic stem-cell transplantation

The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies

Catia Traversari,Sarah Marktel,Zulma Magnani,Patrizia Mangia,Vincenzo Russo,Fabio Ciceri,Chiara Bonini,Claudio Bordignon

View Articletitled, The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies

HEMATOPOIESIS

G-CSF treatment of severe congenital neutropenia reverses neutropenia but does not correct the underlying functional deficiency of the neutrophil in defending against microorganisms

Marta Donini,Stefania Fontana,Gianfranco Savoldi,William Vermi,Laura Tassone,Francesca Gentili,Elena Zenaro,Daniela Ferrari,Lucia D. Notarangelo,Fulvio Porta,Fabio Facchetti,Luigi D. Notarangelo,Stefano Dusi,Raffaele Badolato

View Articletitled, G-CSF treatment of severe congenital neutropenia reverses neutropenia but does not correct the underlying functional deficiency of the neutrophil in defending against microorganisms

Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle

Paul Robach,Gaetano Cairo,Cecilia Gelfi,Francesca Bernuzzi,Henriette Pilegaard,Agnese Viganò,Paolo Santambrogio,Paolo Cerretelli,José A. L. Calbet,Stéphane Moutereau,Carsten Lundby

View Articletitled, Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle

Evidence that the Pim1 kinase gene is a direct target of HOXA9

Yu-Long Hu,Emmanuelle Passegué,Stephen Fong,Corey Largman,Hugh Jeffrey Lawrence

View Articletitled, Evidence that the Pim1 kinase gene is a direct target of HOXA9

Supplemental data

Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist
Brief Report

Julian M. Jenkins,Daphne Williams,Yanli Deng,Joanne Uhl,Valerie Kitchen,David Collins,Connie L. Erickson-Miller

View Articletitled, Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure

Femke Zwerts,Florea Lupu,Astrid De Vriese,Saskia Pollefeyt,Lieve Moons,Rachel A. Altura,Yuying Jiang,Patrick H. Maxwell,Peter Hill,Hideyasu Oh,Claus Rieker,Désiré Collen,Simon J. Conway,Edward M. Conway

View Articletitled, Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure

Supplemental data

Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion

Jeffrey S. Scehnet,Weidong Jiang,S. Ram Kumar,Valery Krasnoperov,Alexandre Trindade,Rui Benedito,Dusan Djokovic,Cristina Borges,Eric J. Ley,Antonio Duarte,Parkash S. Gill

View Articletitled, Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion

Supplemental data

In vivo vasculogenic potential of human blood-derived endothelial progenitor cells

Juan M. Melero-Martin,Zia A. Khan,Arnaud Picard,Xiao Wu,Sailaja Paruchuri,Joyce Bischoff

View Articletitled, In vivo vasculogenic potential of human blood-derived endothelial progenitor cells

Supplemental data

Regulation of protein C inhibitor (PCI) activity by specific oxidized and negatively charged phospholipids

Julia M. Malleier,Olga Oskolkova,Valery Bochkov,Ingrid Jerabek,Barbora Sokolikova,Thomas Perkmann,Johannes Breuss,Bernd R. Binder,Margarethe Geiger

View Articletitled, Regulation of protein C inhibitor (PCI) activity by specific oxidized and negatively charged phospholipids

Supplemental data

Blood and lymphatic endothelial cell-specific differentiation programs are stringently controlled by the tissue environment

Stefan Amatschek,Ernst Kriehuber,Wolfgang Bauer,Barbel Reininger,Paul Meraner,Alois Wolpl,Norbert Schweifer,Christian Haslinger,Georg Stingl,Dieter Maurer

View Articletitled, Blood and lymphatic endothelial cell-specific differentiation programs are stringently controlled by the tissue environment

Supplemental data

Moderation of the platelet releasate response by aspirin

Judith A. Coppinger,Roisin O'Connor,Kieran Wynne,Michelle Flanagan,Matthew Sullivan,Patricia B. Maguire,Desmond J. Fitzgerald,Gerard Cagney

View Articletitled, Moderation of the platelet releasate response by aspirin

Supplemental data

Kringle 5 of human plasminogen, an angiogenesis inhibitor, induces both autophagy and apoptotic death in endothelial cells

Tri Minh Bui Nguyen,Indira V. Subramanian,Ameeta Kelekar,Sundaram Ramakrishnan

View Articletitled, Kringle 5 of human plasminogen, an angiogenesis inhibitor, induces both autophagy and apoptotic death in endothelial cells

Supplemental data

Platelet-bound lipopolysaccharide enhances Fc receptor–mediated phagocytosis of IgG-opsonized platelets
Brief Report

John W. Semple,Rukhsana Aslam,Michael Kim,Edwin R. Speck,John Freedman

View Articletitled, Platelet-bound lipopolysaccharide enhances Fc receptor–mediated phagocytosis of IgG-opsonized platelets

The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro
Brief Report

Stephen A. Newland,Iain C. Macaulay,Andres R. Floto,Edwin C. de Vet,Willem H. Ouwehand,Nicholas A. Watkins,Paul A. Lyons,Duncan R. Campbell

View Articletitled, The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro

Supplemental data

IMMUNOBIOLOGY

Eradication of lymphoma by CD8 T cells following anti-CD40 monoclonal antibody therapy is critically dependent on CD27 costimulation

Ruth R. French,Vadim Y. Taraban,Graham R. Crowther,Tania F. Rowley,Juliet C. Gray,Peter W. Johnson,Alison L. Tutt,Aymen Al-Shamkhani,Martin J. Glennie

View Articletitled, Eradication of lymphoma by CD8 T cells following anti-CD40 monoclonal antibody therapy is critically dependent on CD27 costimulation

Supplemental data

Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors

Pearlie K. Epling-Burnette,Fanqi Bai,Jeffrey S. Painter,Dana E. Rollison,Helmut R. Salih,Matthias Krusch,JianXiang Zou,Edna Ku,Bin Zhong,David Boulware,Lynn Moscinski,Sheng Wei,Julie Y. Djeu,Alan F. List

View Articletitled, Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors

Supplemental data

Interferon-producing killer dendritic cells (IKDCs) arise via a unique differentiation pathway from primitive c-kit^HiCD62L⁺ lymphoid progenitors

Robert S. Welner,Rosana Pelayo,Karla P. Garrett,Xinrong Chen,S. Scott Perry,Xiao-Hong Sun,Barbara L. Kee,Paul W. Kincade

View Articletitled, Interferon-producing killer dendritic cells (IKDCs) arise via a unique differentiation pathway from primitive c-kitHiCD62L+ lymphoid progenitors

Supplemental data

HIV-1–specific CTLs effectively suppress replication of HIV-1 in HIV-1–infected macrophages

Mamoru Fujiwara,Masafumi Takiguchi

View Articletitled, HIV-1–specific CTLs effectively suppress replication of HIV-1 in HIV-1–infected macrophages

Bortezomib enhances dendritic cell (DC)–mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications

Radek Spisek,Anna Charalambous,Amitabha Mazumder,David H. Vesole,Sundar Jagannath,Madhav V. Dhodapkar

View Articletitled, Bortezomib enhances dendritic cell (DC)–mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications

Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections

Nobuhiro Nakano,Chiharu Nishiyama,Shunsuke Kanada,Yusuke Niwa,Naomi Shimokawa,Hiroko Ushio,Makoto Nishiyama,Ko Okumura,Hideoki Ogawa

View Articletitled, Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections

T cell–dependent survival of CD20⁺ and CD20⁻ plasma cells in human secondary lymphoid tissue

David R. Withers,Claudia Fiorini,Randy T. Fischer,Rachel Ettinger,Peter E. Lipsky,Amrie C. Grammer

View Articletitled, T cell–dependent survival of CD20+ and CD20− plasma cells in human secondary lymphoid tissue

Supplemental data

Adoptive transfer of tumor-primed, in vitro–activated, CD4⁺ T effector cells (T_Es) combined with CD8⁺ T_Es provides intratumoral T_E proliferation and synergistic antitumor response

Li-Xin Wang,Suyu Shu,Mary L. Disis,Gregory E. Plautz

View Articletitled, Adoptive transfer of tumor-primed, in vitro–activated, CD4+ T effector cells (TEs) combined with CD8+ TEs provides intratumoral TE proliferation and synergistic antitumor response

Functional characterization of natural killer cells in type I leukocyte adhesion deficiency

Roberta Castriconi,Alessandra Dondero,Claudia Cantoni,Mariella Della Chiesa,Carola Prato,Marina Nanni,Maurilia Fiorini,Lucia Notarangelo,Silvia Parolini,Lorenzo Moretta,Luigi Notarangelo,Alessandro Moretta,Cristina Bottino

View Articletitled, Functional characterization of natural killer cells in type I leukocyte adhesion deficiency

CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype

Yuwen Zhu,Gefeng Zhu,Liqun Luo,Andrew S. Flies,Lieping Chen

View Articletitled, CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype

NEOPLASIA

Monoclonal TCR-Vβ13.1⁺/CD4⁺/NKa⁺/CD8^−/+dim T-LGL lymphocytosis: evidence for an antigen-driven chronic T-cell stimulation origin

Pilar Garrido,Francisco Ruiz-Cabello,Paloma Bárcena,Yorick Sandberg,Julia Cantón,Margarida Lima,Ana Balanzategui,Marcos González,Miguel Angel López-Nevot,Anton W. Langerak,Andrés C. García-Montero,Julia Almeida,Alberto Orfao

View Articletitled, Monoclonal TCR-Vβ13.1+/CD4+/NKa+/CD8−/+dim T-LGL lymphocytosis: evidence for an antigen-driven chronic T-cell stimulation origin

Development of a murine model for blastoid variant mantle-cell lymphoma

Richard J. Ford,Long Shen,Yen Chiu Lin-Lee,Lan V. Pham,Asha Multani,Hai-Jun Zhou,Archito T. Tamayo,ChongJie Zhang,Lesleyann Hawthorn,John K. Cowell,Julian L. Ambrus, Jr

View Articletitled, Development of a murine model for blastoid variant mantle-cell lymphoma

Supplemental data

Endogenous bcl-2 is not required for the development of Eμ-myc–induced B-cell lymphoma

Priscilla N. Kelly,Hamsa Puthalakath,Jerry M. Adams,Andreas Strasser

View Articletitled, Endogenous bcl-2 is not required for the development of Eμ-myc–induced B-cell lymphoma

Supplemental data

Heparanase influences expression and shedding of syndecan-1, and its expression by the bone marrow environment is a bad prognostic factor in multiple myeloma

Karène Mahtouk,Dirk Hose,Pierre Raynaud,Michael Hundemer,Michel Jourdan,Eric Jourdan,Veronique Pantesco,Marion Baudard,John De Vos,Marion Larroque,Thomas Moehler,Jean-Francois Rossi,Thierry Rème,Hartmut Goldschmidt,Bernard Klein

View Articletitled, Heparanase influences expression and shedding of syndecan-1, and its expression by the bone marrow environment is a bad prognostic factor in multiple myeloma

The myeloproliferative disorder–associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3

Michelle B. Hookham,Joanne Elliott,Yvonne Suessmuth,Judith Staerk,Alister C. Ward,William Vainchenker,Melanie J. Percy,Mary Frances McMullin,Stefan N. Constantinescu,James A. Johnston

View Articletitled, The myeloproliferative disorder–associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3

Supplemental data

Prognostic impact of immunohistochemically defined germinal center phenotype in diffuse large B-cell lymphoma patients treated with immunochemotherapy

Heidi Nyman,Magdalena Adde,Marja-Liisa Karjalainen-Lindsberg,Minna Taskinen,Mattias Berglund,Rose-Marie Amini,Carl Blomqvist,Gunilla Enblad,Sirpa Leppä

View Articletitled, Prognostic impact of immunohistochemically defined germinal center phenotype in diffuse large B-cell lymphoma patients treated with immunochemotherapy

Supplemental data

p53 status dictates responses of B lymphomas to monotherapy with proteasome inhibitors

Duonan Yu,Martin Carroll,Andrei Thomas-Tikhonenko

View Articletitled, p53 status dictates responses of B lymphomas to monotherapy with proteasome inhibitors

Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia

View Articletitled, Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia

Supplemental data

The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (T_FH) cells

Laurence de Leval,David S. Rickman,Caroline Thielen,Aurélien de Reynies,Yen-Lin Huang,Georges Delsol,Laurence Lamant,Karen Leroy,Josette Brière,Thierry Molina,Françoise Berger,Christian Gisselbrecht,Luc Xerri,Philippe Gaulard

View Articletitled, The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells

Supplemental data

Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenström macroglobulinemia

Anne-Sophie Moreau,Xiaoying Jia,Hai T. Ngo,Xavier Leleu,Garrett O'Sullivan,Yazan Alsayed,Alexey Leontovich,Klaus Podar,Jeffrey Kutok,John Daley,Suzan Lazo-Kallanian,Evdoxia Hatjiharissi,Marc S. Raab,Lian Xu,Steven P. Treon,Teru Hideshima,Kenneth C. Anderson,Irene M. Ghobrial

View Articletitled, Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenström macroglobulinemia

CLLU1 expression analysis adds prognostic information to risk prediction in chronic lymphocytic leukemia

Pär Josefsson,Christian H. Geisler,Henrik Leffers,Jørgen H. Petersen,Mette K. Andersen,Jesper Jurlander,Anne Mette Buhl

View Articletitled, CLLU1 expression analysis adds prognostic information to risk prediction in chronic lymphocytic leukemia

Comparative biodistributions of pretargeted radioimmunoconjugates targeting CD20, CD22, and DR molecules on human B-cell lymphomas

Anastasia Pantelias,John M. Pagel,Nathan Hedin,Laura Saganic,Shani Wilbur,Donald K. Hamlin,D. Scott Wilbur,Yukang Lin,Diane Stone,Don Axworthy,Ajay K. Gopal,Oliver W. Press

View Articletitled, Comparative biodistributions of pretargeted radioimmunoconjugates targeting CD20, CD22, and DR molecules on human B-cell lymphomas

The mitochondrial effects of novel apoptogenic molecules generated by psoralen photolysis as a crucial mechanism in PUVA therapy

Sergio Caffieri,Fabio Di Lisa,Federico Bolesani,Monica Facco,Gianpietro Semenzato,Francesco Dall'Acqua,Marcella Canton

View Articletitled, The mitochondrial effects of novel apoptogenic molecules generated by psoralen photolysis as a crucial mechanism in PUVA therapy

CKS1B, overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27^Kip1-dependent and -independent mechanisms

Fenghuang Zhan,Simona Colla,Xiaosong Wu,Bangzheng Chen,James P. Stewart,W. Michael Kuehl,Bart Barlogie,John D. Shaughnessy, Jr

View Articletitled, CKS1B, overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and -independent mechanisms

CD28-mediated regulation of multiple myeloma cell proliferation and survival

Nizar J. Bahlis,Anne M. King,Despina Kolonias,Louise M. Carlson,Hong Yu Liu,Mohamad A. Hussein,Howard R. Terebelo,Gerald E. Byrne, Jr,Bruce L. Levine,Lawrence H. Boise,Kelvin P. Lee

View Articletitled, CD28-mediated regulation of multiple myeloma cell proliferation and survival

Identification of BCR-ABL point mutations conferring resistance to the Abl kinase inhibitor AMN107 (nilotinib) by a random mutagenesis study

Arghya Ray,Sandra W. Cowan-Jacob,Paul W. Manley,Jürgen Mestan,James D. Griffin

View Articletitled, Identification of BCR-ABL point mutations conferring resistance to the Abl kinase inhibitor AMN107 (nilotinib) by a random mutagenesis study

Supplemental data

Hsp90 regulates the Fanconi anemia DNA damage response pathway

Tsukasa Oda,Toshiya Hayano,Hidenobu Miyaso,Nobuhiro Takahashi,Takayuki Yamashita

View Articletitled, Hsp90 regulates the Fanconi anemia DNA damage response pathway

RED CELLS

Ineffective erythropoiesis in β-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

Sara Gardenghi,Maria F. Marongiu,Pedro Ramos,Ella Guy,Laura Breda,Amy Chadburn,YiFang Liu,Ninette Amariglio,Gideon Rechavi,Eliezer A. Rachmilewitz,William Breuer,Z. Ioav Cabantchik,Diedra M. Wrighting,Nancy C. Andrews,Maria de Sousa,Patricia J. Giardina,Robert W. Grady,Stefano Rivella

View Articletitled, Ineffective erythropoiesis in β-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

Supplemental data

Highly homologous T-cell receptor beta sequences support a common target for autoreactive T cells in most patients with paroxysmal nocturnal hemoglobinuria

Lucia Gargiulo,Sonia Lastraioli,Giannamaria Cerruti,Martina Serra,Fabrizio Loiacono,Simona Zupo,Lucio Luzzatto,Rosario Notaro

View Articletitled, Highly homologous T-cell receptor beta sequences support a common target for autoreactive T cells in most patients with paroxysmal nocturnal hemoglobinuria

STEM CELLS IN HEMATOLOGY

Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells

Michelle B. Bowie,David G. Kent,Michael R. Copley,Connie J. Eaves

View Articletitled, Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells

TRANSPLANTATION

Effector and regulatory T-cell function is differentially regulated by RelB within antigen-presenting cells during GVHD

Kelli P. A. MacDonald,Rachel D. Kuns,Vanessa Rowe,Edward S. Morris,Tatjana Banovic,Helen Bofinger,Brendan O'Sullivan,Kate A. Markey,Alistair L. Don,Ranjeny Thomas,Geoffrey R. Hill

View Articletitled, Effector and regulatory T-cell function is differentially regulated by RelB within antigen-presenting cells during GVHD

Supplemental data

Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCT
Brief Report

Jeffery S. Miller,Sarah Cooley,Peter Parham,Sherif S. Farag,Michael R. Verneris,Karina L. McQueen,Lisbeth A. Guethlein,Elizabeth A. Trachtenberg,Michael Haagenson,Mary M. Horowitz,John P. Klein,Daniel J. Weisdorf

View Articletitled, Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCT

CORRESPONDENCE

Isolated high-molecular-weight kininogen deficiency: a novel frameshift mutation in exon 10

Toshio Shigekiyo,Junko Miyagi,Atsuhisa Shirakami,Hironobu Shibata,Kazuo Tsukai,Ken-ichi Aihara

View Articletitled, Isolated high-molecular-weight kininogen deficiency: a novel frameshift mutation in exon 10

Donor lymphocyte infusions for the treatment of minimal residual disease in acute leukemia

Alida Dominietto,Sarah Pozzi,Maurizio Miglino,Flavio Albarracin,Giovanna Piaggio,Francesca Bertolotti,Raffaella Grasso,Simona Zupo,Anna Maria Raiola,Marco Gobbi,Francesco Frassoni,Andrea Bacigalupo

View Articletitled, Donor lymphocyte infusions for the treatment of minimal residual disease in acute leukemia

Killer cell Ig-like receptors CD158a and CD158b display a coactivatory function, involving the c-Jun NH₂-terminal protein kinase signaling pathway, when expressed on malignant CD4⁺ T cells from a patient with Sézary syndrome

Anne Marie-Cardine,Delphine Huet,Nicolas Ortonne,Natacha Remtoula,Sabine Le Gouvello,Martine Bagot,Armand Bensussan

View Articletitled, Killer cell Ig-like receptors CD158a and CD158b display a coactivatory function, involving the c-Jun NH2-terminal protein kinase signaling pathway, when expressed on malignant CD4+ T cells from a patient with Sézary syndrome

Cover Image

Cover Image

Bcr/Abl point mutations identified by random mutagenesis that confer resistance to the Abl kinase inhibitor nilotinib. See the related article by Ray et al, beginning on page 5011.
Front Matter
Table of Contents
Advertising
Editorial Board

Issue Archive

Table of Contents

INSIDE BLOOD

No more transplantation in CML? Clinical Trials & Observations

PD-1+ T cells: exhausted and premature? Clinical Trials & Observations

How low can you go: quality effects of an anti-CD4 antibody Clinical Trials & Observations

Inhibitors in hemophilia: nature or nurture? Clinical Trials & Observations

BLOOD WORK

PLENARY PAPERS

ERRATUM

REVIEW ARTICLES

HOW I TREAT

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

CLINICAL TRIALS AND OBSERVATIONS

Low-dose imatinib mesylate leads to rapid induction of major molecular responses and achievement of complete molecular remission in FIP1L1-PDGFRA–positive chronic eosinophilic leukemia Clinical Trials & Observations

Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: an international retrospective study Clinical Trials & Observations

Treatment-related risk factors of inhibitor development in previously untreated patients with hemophilia A: the CANAL cohort study Clinical Trials & Observations

Clinical efficacy of zanolimumab (HuMax-CD4): two phase 2 studies in refractory cutaneous T-cell lymphoma Clinical Trials & Observations

Racial variation in the relationship of anemia with mortality and mobility disability among older adults Clinical Trials & Observations

PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors Clinical Trials & Observations

Prognostic nomogram and index for overall survival in previously untreated patients with chronic lymphocytic leukemia Clinical Trials & Observations

Drug treatment is superior to allografting as first-line therapy in chronic myeloid leukemia Clinical Trials & Observations

Recombinant versus plasma-derived factor VIII products and the development of inhibitors in previously untreated patients with severe hemophilia A: the CANAL cohort study Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist Brief Report

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Platelet-bound lipopolysaccharide enhances Fc receptor–mediated phagocytosis of IgG-opsonized platelets Brief Report

The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro Brief Report

IMMUNOBIOLOGY

NEOPLASIA

RED CELLS

STEM CELLS IN HEMATOLOGY

TRANSPLANTATION

Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCT Brief Report

CORRESPONDENCE

Cover Image

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

No more transplantation in CML?
Clinical Trials & Observations

PD-1⁺ T cells: exhausted and premature?
Clinical Trials & Observations

How low can you go: quality effects of an anti-CD4 antibody
Clinical Trials & Observations

Inhibitors in hemophilia: nature or nurture?
Clinical Trials & Observations

Low-dose imatinib mesylate leads to rapid induction of major molecular responses and achievement of complete molecular remission in FIP1L1-PDGFRA–positive chronic eosinophilic leukemia
Clinical Trials & Observations

Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: an international retrospective study
Clinical Trials & Observations

Treatment-related risk factors of inhibitor development in previously untreated patients with hemophilia A: the CANAL cohort study
Clinical Trials & Observations

Clinical efficacy of zanolimumab (HuMax-CD4): two phase 2 studies in refractory cutaneous T-cell lymphoma
Clinical Trials & Observations

Racial variation in the relationship of anemia with mortality and mobility disability among older adults
Clinical Trials & Observations

PD-1 up-regulation is correlated with HIV-specific memory CD8⁺ T-cell exhaustion in typical progressors but not in long-term nonprogressors
Clinical Trials & Observations

Prognostic nomogram and index for overall survival in previously untreated patients with chronic lymphocytic leukemia
Clinical Trials & Observations

Drug treatment is superior to allografting as first-line therapy in chronic myeloid leukemia
Clinical Trials & Observations

Recombinant versus plasma-derived factor VIII products and the development of inhibitors in previously untreated patients with severe hemophilia A: the CANAL cohort study
Clinical Trials & Observations

Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist
Brief Report

Platelet-bound lipopolysaccharide enhances Fc receptor–mediated phagocytosis of IgG-opsonized platelets
Brief Report

The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro
Brief Report

Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCT
Brief Report