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INSIDE BLOOD

NEOPLASIA

AML1/ETO, a promiscuous fusion oncoprotein

Kevin Petrie,Arthur Zelent

View Articletitled, AML1/ETO, a promiscuous fusion oncoprotein

CLINICAL TRIALS AND OBSERVATIONS

Dasatinib in accelerated phase
Clinical Trials & Observations

Stephen O'Brien

View Articletitled, Dasatinib in accelerated phase

HEMOSTASIS

Flow beats inflammation, but not always

Bernd R. Binder

View Articletitled, Flow beats inflammation, but not always

IMMUNOBIOLOGY

“Stimulate the phagocytes!” Fascin-ating! Are DCs actin' up?

Philip L. McCarthy

View Articletitled, “Stimulate the phagocytes!” Fascin-ating! Are DCs actin' up?

HEMATOPOIESIS

PECAMigration

Peter J. Newman

View Articletitled, PECAMigration

RED CELLS

Crypt cell hypothesis: technical knock-out

Robert E. Fleming

View Articletitled, Crypt cell hypothesis: technical knock-out

HEMATOPOIESIS

Of mice and iron: ferroportin disease

Nancy C. Andrews

View Articletitled, Of mice and iron: ferroportin disease

IMMUNOBIOLOGY

Looking at HIV-infected lymph nodes

Zvi Grossman

View Articletitled, Looking at HIV-infected lymph nodes

TRANSPLANTATION

At last, an “ointment” for gastrointestinal GVHD?

Alois Gratwohl

View Articletitled, At last, an “ointment” for gastrointestinal GVHD?

HEMOSTASIS

Inflamed endothelium: an EPC adhesion kit

Elaine W. Raines

View Articletitled, Inflamed endothelium: an EPC adhesion kit

HOW I TREAT

How I treat refractory acute GVHD
Clinical Trials & Observations

H. Joachim Deeg

View Articletitled, How I treat refractory acute GVHD

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion

Laura Lasagni,Renaud Grepin,Benedetta Mazzinghi,Elena Lazzeri,Claudia Meini,Costanza Sagrinati,Francesco Liotta,Francesca Frosali,Elisa Ronconi,Nathalie Alain-Courtois,Lara Ballerini,Giuseppe Stefano Netti,Enrico Maggi,Francesco Annunziato,Mario Serio,Sergio Romagnani,Andreas Bikfalvi,Paola Romagnani

View Articletitled, PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion

Supplemental data

The molecular basis of IL-21–mediated proliferation

Rong Zeng,Rosanne Spolski,Esther Casas,Wei Zhu,David E. Levy,Warren J. Leonard

View Articletitled, The molecular basis of IL-21–mediated proliferation

CLINICAL TRIALS AND OBSERVATIONS

Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase
Clinical Trials & Observations

Francois Guilhot,Jane Apperley,Dong-Wook Kim,Eduardo O. Bullorsky,Michele Baccarani,Gail J. Roboz,Sergio Amadori,Carmino A. de Souza,Jeffrey H. Lipton,Andreas Hochhaus,Dominik Heim,Richard A. Larson,Susan Branford,Martin C. Muller,Prasheen Agarwal,Ashwin Gollerkeri,Moshe Talpaz

View Articletitled, Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase

Ancestry and pharmacogenetics of antileukemic drug toxicity
Clinical Trials & Observations

Shinji Kishi,Cheng Cheng,Deborah French,Deqing Pei,Soma Das,Edwin H. Cook,Nobuko Hijiya,Carmelo Rizzari,Gary L. Rosner,Tony Frudakis,Ching-Hon Pui,William E. Evans,Mary V. Relling

View Articletitled, Ancestry and pharmacogenetics of antileukemic drug toxicity

Supplemental data

A multicenter phase 2 study of the farnesyltransferase inhibitor tipifarnib in intermediate- to high-risk myelodysplastic syndrome
Clinical Trials & Observations

Pierre Fenaux,Azra Raza,Ghulam J. Mufti,Carlo Aul,Ulrich Germing,Hagop Kantarjian,Larry Cripe,René Kerstens,Peter De Porre,Razelle Kurzrock

View Articletitled, A multicenter phase 2 study of the farnesyltransferase inhibitor tipifarnib in intermediate- to high-risk myelodysplastic syndrome

Supplemental data

Effective asparagine depletion with pegylated asparaginase results in improved outcomes in adult acute lymphoblastic leukemia: Cancer and Leukemia Group B Study 9511
Clinical Trials & Observations Brief Report

Meir Wetzler,Ben L. Sanford,Joanne Kurtzberg,Divino DeOliveira,Stanley R. Frankel,Bayard L. Powell,Jonathan E. Kolitz,Clara D. Bloomfield,Richard A. Larson

View Articletitled, Effective asparagine depletion with pegylated asparaginase results in improved outcomes in adult acute lymphoblastic leukemia: Cancer and Leukemia Group B Study 9511

Supplemental data

CD33 expression and P-glycoprotein–mediated drug efflux inversely correlate and predict clinical outcome in patients with acute myeloid leukemia treated with gemtuzumab ozogamicin monotherapy
Clinical Trials & Observations Brief Report

Roland B. Walter,Ted A. Gooley,Vincent H. J. van der Velden,Michael R. Loken,Jacques J. M. van Dongen,David A. Flowers,Irwin D. Bernstein,Frederick R. Appelbaum

View Articletitled, CD33 expression and P-glycoprotein–mediated drug efflux inversely correlate and predict clinical outcome in patients with acute myeloid leukemia treated with gemtuzumab ozogamicin monotherapy

Rapid infusion rituximab in combination with corticosteroid-containing chemotherapy or as maintenance therapy is well tolerated and can safely be delivered in the community setting
Brief Report

Laurie H. Sehn,Jane Donaldson,Allison Filewich,Catherine Fitzgerald,Karamjit K. Gill,Nancy Runzer,Barb Searle,Sheila Souliere,John J. Spinelli,Judy Sutherland,Joseph M. Connors

View Articletitled, Rapid infusion rituximab in combination with corticosteroid-containing chemotherapy or as maintenance therapy is well tolerated and can safely be delivered in the community setting

HEMATOPOIESIS

The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease

Irene E. Zohn,Ivana De Domenico,Andrew Pollock,Diane McVey Ward,Jessica F. Goodman,Xiayun Liang,Amaru J. Sanchez,Lee Niswander,Jerry Kaplan

View Articletitled, The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease

Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPϵ gene
Clinical Trials & Observations

Arati Khanna-Gupta,Hong Sun,Theresa Zibello,Han Myung Lee,Richard Dahl,Laurence A. Boxer,Nancy Berliner

View Articletitled, Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPϵ gene

Supplemental data

B-cell development fails in the absence of the Pbx1 proto-oncogene

Mrinmoy Sanyal,James W. Tung,Holger Karsunky,Hong Zeng,Licia Selleri,Irving L. Weissman,Leonore A. Herzenberg,Michael L. Cleary

View Articletitled, B-cell development fails in the absence of the Pbx1 proto-oncogene

Supplemental data

Cell-cycle–dependent oscillation of GATA2 expression in hematopoietic cells

Shinichiro Koga,Nobuhiro Yamaguchi,Tomoko Abe,Masayoshi Minegishi,Shigeru Tsuchiya,Masayuki Yamamoto,Naoko Minegishi

View Articletitled, Cell-cycle–dependent oscillation of GATA2 expression in hematopoietic cells

Modulation of DNA binding properties of CCAAT/enhancer binding protein epsilon by heterodimer formation and interactions with NFkappaB pathway

Alexey M. Chumakov,Agnes Silla,Elizabeth A. Williamson,H. Phillip Koeffler

View Articletitled, Modulation of DNA binding properties of CCAAT/enhancer binding protein epsilon by heterodimer formation and interactions with NFkappaB pathway

TC-PTP–deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-γ

Annie Bourdeau,Nadia Dubé,Krista M. Heinonen,Jean-François Théberge,Karen M. Doody,Michel L. Tremblay

View Articletitled, TC-PTP–deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-γ

Supplemental data

Proplatelet formation is regulated by the Rho/ROCK pathway

Yunhua Chang,Frédéric Auradé,Frédéric Larbret,Yanyan Zhang,Jean-Pierre Le Couedic,Laurence Momeux,Jerôme Larghero,Jacques Bertoglio,Fawzia Louache,Elisabeth Cramer,William Vainchenker,Najet Debili

View Articletitled, Proplatelet formation is regulated by the Rho/ROCK pathway

A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice

Tarvinder S. Dhanjal,Caroline Pendaries,Ewan A. Ross,Mark K. Larson,Majd B. Protty,Chris D. Buckley,Steve P. Watson

View Articletitled, A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice

Supplemental data

Human bone marrow mesenchymal stromal cells express the neural ganglioside GD2: a novel surface marker for the identification of MSCs
Brief Report

Caridad Martinez,Ted J. Hofmann,Roberta Marino,Massimo Dominici,Edwin M. Horwitz

View Articletitled, Human bone marrow mesenchymal stromal cells express the neural ganglioside GD2: a novel surface marker for the identification of MSCs

ERRATUM

Erratum for Papadaki et al., entitled Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alpha-mediated effect

View Articletitled, Erratum for Papadaki et al., entitled Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alpha-mediated effect

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2

Joost O. Fledderus,Johannes V. van Thienen,Reinier A. Boon,Rob J. Dekker,Jakub Rohlena,Oscar L. Volger,Ann-Pascale J. J. Bijnens,Mat J. A. P. Daemen,Johan Kuiper,Theo J. C. van Berkel,Hans Pannekoek,Anton J. G. Horrevoets

View Articletitled, Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2

Supplemental data

Antithrombin Cambridge II (A384S): an underestimated genetic risk factor for venous thrombosis
Clinical Trials & Observations

Javier Corral,David Hernandez-Espinosa,Jose Manual Soria,Rocio Gonzalez-Conejero,Adriana Ordonez,Jose Ramon Gonzalez-Porras,Elena Perez-Ceballos,Ramon Lecumberri,Ignacio Sanchez,Vanessa Roldan,Jose Mateo,Antonia Minano,Marcos Gonzalez,Ignacio Alberca,Jordi Fontcuberta,Vicente Vicente

View Articletitled, Antithrombin Cambridge II (A384S): an underestimated genetic risk factor for venous thrombosis

C-KIT, by interacting with the membrane-bound ligand, recruits endothelial progenitor cells to inflamed endothelium

Patrizia Dentelli,Arturo Rosso,Antonina Balsamo,Sofia Colmenares Benedetto,Annarita Zeoli,Marco Pegoraro,Giovanni Camussi,Luigi Pegoraro,Maria Felice Brizzi

View Articletitled, C-KIT, by interacting with the membrane-bound ligand, recruits endothelial progenitor cells to inflamed endothelium

Supplemental data

IMMUNOBIOLOGY

Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1
Clinical Trials & Observations

Angélique Biancotto,Jean-Charles Grivel,Sarah J. Iglehart,Christophe Vanpouille,Andrea Lisco,Scott F. Sieg,Robert Debernardo,Kristen Garate,Benigno Rodriguez,Leonid B. Margolis,Michael M. Lederman

View Articletitled, Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1

Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils

Mai Zhang,Takashi Angata,Jae Youn Cho,Marina Miller,David H. Broide,Ajit Varki

View Articletitled, Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils

Supplemental data

Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin

René Geyeregger,Maximilian Zeyda,Wolfgang Bauer,Ernst Kriehuber,Marcus D. Säemann,Gerhard J. Zlabinger,Dieter Maurer,Thomas M. Stulnig

View Articletitled, Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin

Supplemental data

Distinctive NK-cell receptor repertoires sustain high-level constitutive NK-cell activation in HIV-exposed uninfected individuals
Clinical Trials & Observations

Sophie Ravet,Daniel Scott-Algara,Elodie Bonnet,Hung Khiem Tran,Ton Tran,Ngai Nguyen,Lien Xuan Truong,Ioannis Theodorou,Françoise Barré-Sinoussi,Gianfranco Pancino,Pascale Paul

View Articletitled, Distinctive NK-cell receptor repertoires sustain high-level constitutive NK-cell activation in HIV-exposed uninfected individuals

NK cytotoxicity mediated by CD16 but not by NKp30 is functional in Griscelli syndrome
Clinical Trials & Observations

Roi Gazit,Memet Aker,Moran Elboim,Hagit Achdout,Gil Katz,Dana G. Wolf,Shulamit Katzav,Ofer Mandelboim

View Articletitled, NK cytotoxicity mediated by CD16 but not by NKp30 is functional in Griscelli syndrome

Macrophage glucocorticoid receptors regulate Toll-like receptor 4–mediated inflammatory responses by selective inhibition of p38 MAP kinase

Sandip Bhattacharyya,Diane E. Brown,Judson A. Brewer,Sherri K. Vogt,Louis J. Muglia

View Articletitled, Macrophage glucocorticoid receptors regulate Toll-like receptor 4–mediated inflammatory responses by selective inhibition of p38 MAP kinase

Supplemental data

DC-HIL is a negative regulator of T lymphocyte activation

Jin-Sung Chung,Kota Sato,Irene I. Dougherty,Ponciano D. Cruz, Jr,Kiyoshi Ariizumi

View Articletitled, DC-HIL is a negative regulator of T lymphocyte activation

Supplemental data

TCRζ^dimlymphocytes define populations of circulating effector cells that migrate to inflamed tissues

Zhuoli Zhang,Claire L. Gorman,Anna-Chiara Vermi,Claudia Monaco,Andrew Foey,Sally Owen,Parisa Amjadi,Alena Vallance,Catherine McClinton,Federica Marelli-Berg,Pia Isomäki,Andrew Russell,Francesco Dazzi,Timothy J. Vyse,Fionula M. Brennan,Andrew P. Cope

View Articletitled, TCRζdimlymphocytes define populations of circulating effector cells that migrate to inflamed tissues

Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host

Cunren Liu,Shaohua Yu,John Kappes,Jianhua Wang,William E. Grizzle,Kurt R. Zinn,Huang-Ge Zhang

View Articletitled, Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host

GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells

Umberto De Fanis,Francesca Mori,Rebecca J. Kurnat,Won Kyung Lee,Maria Bova,N. Franklin Adkinson,Vincenzo Casolaro

View Articletitled, GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells

Supplemental data

Activation of MAP kinase p38 is critical for the cell-cycle–controlled suppressor function of regulatory T cells

Henric S. Adler,Sebastian Kubsch,Edith Graulich,Stephan Ludwig,Juergen Knop,Kerstin Steinbrink

View Articletitled, Activation of MAP kinase p38 is critical for the cell-cycle–controlled suppressor function of regulatory T cells

Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity

Min Chen,Li Huang,Jin Wang

View Articletitled, Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity

Supplemental data

Nonredundant roles for Stat5a/b in directly regulating Foxp3

Zhengju Yao,Yuka Kanno,Marc Kerenyi,Geoffrey Stephens,Lydia Durant,Wendy T. Watford,Arian Laurence,Gertraud W. Robinson,Ethan M. Shevach,Richard Moriggl,Lothar Hennighausen,Changyou Wu,John J. O'Shea

View Articletitled, Nonredundant roles for Stat5a/b in directly regulating Foxp3

Supplemental data

Intravenous immunoglobulins contain naturally occurring antibodies that mimic antineutrophil cytoplasmic antibodies and activate neutrophils in a TNFα-dependent and Fc-receptor–independent way

Sven Jarius,Peter Eichhorn,Michael H. Albert,Stefan Wagenpfeil,Manfred Wick,Bernd H. Belohradsky,Reinhard Hohlfeld,Dieter E. Jenne,Raymond Voltz

View Articletitled, Intravenous immunoglobulins contain naturally occurring antibodies that mimic antineutrophil cytoplasmic antibodies and activate neutrophils in a TNFα-dependent and Fc-receptor–independent way

The thymic theme of acetylcholinesterase splice variants in myasthenia gravis

Adi Gilboa-Geffen,Paul P. Lacoste,Lilach Soreq,Geraldine Cizeron-Clairac,Rozen Le Panse,Frederique Truffault,Iftach Shaked,Hermona Soreq,Sonia Berrih-Aknin

View Articletitled, The thymic theme of acetylcholinesterase splice variants in myasthenia gravis

Supplemental data

NEOPLASIA

The p21^Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO

Luke F. Peterson,Ming Yan,Dong-Er Zhang

View Articletitled, The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO

Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34⁺ cells

Letizia Venturini,Karin Battmer,Mirco Castoldi,Beate Schultheis,Andreas Hochhaus,Martina U. Muckenthaler,Arnold Ganser,Matthias Eder,Michaela Scherr

View Articletitled, Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+ cells

Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas

Wei Xu,Barbara L. Kee

View Articletitled, Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas

Supplemental data

Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation

Yun Dai,Payal Khanna,Shuang Chen,Xin-Yan Pei,Paul Dent,Steven Grant

View Articletitled, Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation

Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by V_H-gene mutational status

C. Ian Mockridge,Kathleen N. Potter,Isla Wheatley,Louise A. Neville,Graham Packham,Freda K. Stevenson

View Articletitled, Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status

Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia

Francesco Fazi,Giuseppe Zardo,Vania Gelmetti,Lorena Travaglini,Alberto Ciolfi,Luciano Di Croce,Alessandro Rosa,Irene Bozzoni,Francesco Grignani,Francesco Lo-Coco,Pier Giuseppe Pelicci,Clara Nervi

View Articletitled, Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia

The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak

Patricia Pérez-Galán,Gaël Roué,Neus Villamor,Elias Campo,Dolors Colomer

View Articletitled, The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak

Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity

Ronan Quere,Aurelie Baudet,Bruno Cassinat,Gerald Bertrand,Jacques Marti,Laurent Manchon,David Piquemal,Christine Chomienne,Therese Commes

View Articletitled, Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity

Supplemental data

The role of PKC and PDK1 in monocyte lineage specification by Ras

Lorna Pearn,Janet Fisher,Alan K. Burnett,Richard L. Darley

View Articletitled, The role of PKC and PDK1 in monocyte lineage specification by Ras

The oxidative stress response regulates DKK1 expression through the JNK signaling cascade in multiple myeloma plasma cells

Simona Colla,Fenghuang Zhan,Wei Xiong,Xiaosong Wu,Hongwei Xu,Owen Stephens,Shmuel Yaccoby,Joshua Epstein,Bart Barlogie,John D. Shaughnessy, Jr

View Articletitled, The oxidative stress response regulates DKK1 expression through the JNK signaling cascade in multiple myeloma plasma cells

PHAGOCYTES

Neutrophil elastase depends on serglycin proteoglycan for localization in granules

Carsten U. Niemann,Magnus Åbrink,Gunnar Pejler,Rikke L. Fischer,Erik I. Christensen,Stefan D. Knight,Niels Borregaard

View Articletitled, Neutrophil elastase depends on serglycin proteoglycan for localization in granules

NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils

Sibylle von Vietinghoff,Gisela Tunnemann,Claudia Eulenberg,Maren Wellner,M. Cristina Cardoso,Friedrich C. Luft,Ralph Kettritz

View Articletitled, NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils

Supplemental data

RED CELLS

BMP4, SCF, and hypoxia cooperatively regulate the expansion of murine stress erythroid progenitors

John M. Perry,Omid F. Harandi,Robert F. Paulson

View Articletitled, BMP4, SCF, and hypoxia cooperatively regulate the expansion of murine stress erythroid progenitors

Supplemental data

Defective targeting of hemojuvelin to plasma membrane is a common pathogenetic mechanism in juvenile hemochromatosis

Laura Silvestri,Alessia Pagani,Claudia Fazi,Gianmario Gerardi,Sonia Levi,Paolo Arosio,Clara Camaschella

View Articletitled, Defective targeting of hemojuvelin to plasma membrane is a common pathogenetic mechanism in juvenile hemochromatosis

Supplemental data

Physiologic systemic iron metabolism in mice deficient for duodenal Hfe

Maja Vujic Spasic,Judit Kiss,Thomas Herrmann,Regina Kessler,Jens Stolte,Bruno Galy,Birgit Rathkolb,Eckhard Wolf,Wolfgang Stremmel,Matthias W. Hentze,Martina U. Muckenthaler

View Articletitled, Physiologic systemic iron metabolism in mice deficient for duodenal Hfe

STEM CELLS IN HEMATOLOGY

Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability

Charlie Mantel,Ying Guo,Man Ryul Lee,Min-Kyoung Kim,Myung-Kwan Han,Hirohiko Shibayama,Seiji Fukuda,Mervin C. Yoder,Louis M. Pelus,Kye-Seong Kim,Hal E. Broxmeyer

View Articletitled, Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability

Supplemental data

TRANSFUSION MEDICINE

Mapping helper T-cell epitopes on platelet membrane glycoprotein IIIa in chronic autoimmune thrombocytopenic purpura

Hosea Sukati,Henry G. Watson,Stanislaw J. Urbaniak,Robert N. Barker

View Articletitled, Mapping helper T-cell epitopes on platelet membrane glycoprotein IIIa in chronic autoimmune thrombocytopenic purpura

TRANSPLANTATION

Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants
Clinical Trials & Observations

M. Louise Markert,Blythe H. Devlin,Marilyn J. Alexieff,Jie Li,Elizabeth A. McCarthy,Stephanie E. Gupton,Ivan K. Chinn,Laura P. Hale,Thomas B. Kepler,Min He,Marcella Sarzotti,Michael A. Skinner,Henry E. Rice,Jeffrey C. Hoehner

View Articletitled, Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants

Chronic GvHD decreases antiviral immune responses in allogeneic BMT

Mohammad S. Hossain,John D. Roback,Brian P. Pollack,David L. Jaye,Amelia Langston,Edmund K. Waller

View Articletitled, Chronic GvHD decreases antiviral immune responses in allogeneic BMT

A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease
Clinical Trials & Observations

David M. Hockenbery,Scott Cruickshank,Timothy C. Rodell,Ted Gooley,Friedrich Schuening,Scott Rowley,Donald David,Mark Brunvand,Brian Berryman,Sunil Abhyankar,Michelle Bouvier,George B. McDonald,for the orBec GVHD Study Group

View Articletitled, A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease

Supplemental data

Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse

Nadira Durakovic,Vedran Radojcic,Mario Skarica,Karl B. Bezak,Jonathan D. Powell,Ephraim J. Fuchs,Leo Luznik

View Articletitled, Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse

Supplemental data

Long-term T-cell reconstitution after hematopoietic stem-cell transplantation in primary T-cell–immunodeficient patients is associated with myeloid chimerism and possibly the primary disease phenotype

Marina Cavazzana-Calvo,Frédérique Carlier,Françoise Le Deist,Estelle Morillon,Pierre Taupin,David Gautier,Isabelle Radford-Weiss,Sophie Caillat-Zucman,Bénédicte Neven,Stephane Blanche,Rémi Cheynier,Alain Fischer,Salima Hacein-Bey-Abina

View Articletitled, Long-term T-cell reconstitution after hematopoietic stem-cell transplantation in primary T-cell–immunodeficient patients is associated with myeloid chimerism and possibly the primary disease phenotype

Bone marrow transplantation for severe aplastic anemia: a randomized controlled study of conditioning regimens
Clinical Trials & Observations Brief Report

Richard E. Champlin,Waleska S. Perez,Jakob R. Passweg,John P. Klein,Bruce M. Camitta,Eliane Gluckman,Christopher N. Bredeson,Mary Eapen,Mary M. Horowitz

View Articletitled, Bone marrow transplantation for severe aplastic anemia: a randomized controlled study of conditioning regimens

Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem cell transplantation
Clinical Trials & Observations Brief Report

Philippe Armand,Haesook T. Kim,Corey S. Cutler,Vincent T. Ho,John Koreth,Edwin P. Alyea,Robert J. Soiffer,Joseph H. Antin

View Articletitled, Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem cell transplantation

CORRESPONDENCE

Granulocyte colony-stimulating factor and severe aplastic anemia

Blanche P. Alter,Philip S. Rosenberg

View Articletitled, Granulocyte colony-stimulating factor and severe aplastic anemia

Response: G-CSF and aplastic anemia

Gerard Socie,on behalf of the Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation

View Articletitled, Response: G-CSF and aplastic anemia

Apparent nonhemolytic alloantibody-induced red-cell antigen loss from transfused erythrocytes

Amy Powers,Monique Mohammed,Lynne Uhl,Richard L. Haspel

View Articletitled, Apparent nonhemolytic alloantibody-induced red-cell antigen loss from transfused erythrocytes

Issue Archive

Table of Contents

INSIDE BLOOD

Dasatinib in accelerated phase Clinical Trials & Observations

HOW I TREAT

How I treat refractory acute GVHD Clinical Trials & Observations

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

CLINICAL TRIALS AND OBSERVATIONS

Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase Clinical Trials & Observations

Ancestry and pharmacogenetics of antileukemic drug toxicity Clinical Trials & Observations

A multicenter phase 2 study of the farnesyltransferase inhibitor tipifarnib in intermediate- to high-risk myelodysplastic syndrome Clinical Trials & Observations

Effective asparagine depletion with pegylated asparaginase results in improved outcomes in adult acute lymphoblastic leukemia: Cancer and Leukemia Group B Study 9511 Clinical Trials & Observations Brief Report

CD33 expression and P-glycoprotein–mediated drug efflux inversely correlate and predict clinical outcome in patients with acute myeloid leukemia treated with gemtuzumab ozogamicin monotherapy Clinical Trials & Observations Brief Report

Rapid infusion rituximab in combination with corticosteroid-containing chemotherapy or as maintenance therapy is well tolerated and can safely be delivered in the community setting Brief Report

HEMATOPOIESIS

Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPϵ gene Clinical Trials & Observations

Human bone marrow mesenchymal stromal cells express the neural ganglioside GD2: a novel surface marker for the identification of MSCs Brief Report

ERRATUM

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Antithrombin Cambridge II (A384S): an underestimated genetic risk factor for venous thrombosis Clinical Trials & Observations

IMMUNOBIOLOGY

Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1 Clinical Trials & Observations

Distinctive NK-cell receptor repertoires sustain high-level constitutive NK-cell activation in HIV-exposed uninfected individuals Clinical Trials & Observations

NK cytotoxicity mediated by CD16 but not by NKp30 is functional in Griscelli syndrome Clinical Trials & Observations

NEOPLASIA

PHAGOCYTES

RED CELLS

STEM CELLS IN HEMATOLOGY

TRANSFUSION MEDICINE

TRANSPLANTATION

Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants Clinical Trials & Observations

A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease Clinical Trials & Observations

Bone marrow transplantation for severe aplastic anemia: a randomized controlled study of conditioning regimens Clinical Trials & Observations Brief Report

Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem cell transplantation Clinical Trials & Observations Brief Report

CORRESPONDENCE

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ASH Publications

American Society of Hematology

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Dasatinib in accelerated phase
Clinical Trials & Observations

How I treat refractory acute GVHD
Clinical Trials & Observations

Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase
Clinical Trials & Observations

Ancestry and pharmacogenetics of antileukemic drug toxicity
Clinical Trials & Observations

A multicenter phase 2 study of the farnesyltransferase inhibitor tipifarnib in intermediate- to high-risk myelodysplastic syndrome
Clinical Trials & Observations

Effective asparagine depletion with pegylated asparaginase results in improved outcomes in adult acute lymphoblastic leukemia: Cancer and Leukemia Group B Study 9511
Clinical Trials & Observations Brief Report

CD33 expression and P-glycoprotein–mediated drug efflux inversely correlate and predict clinical outcome in patients with acute myeloid leukemia treated with gemtuzumab ozogamicin monotherapy
Clinical Trials & Observations Brief Report

Rapid infusion rituximab in combination with corticosteroid-containing chemotherapy or as maintenance therapy is well tolerated and can safely be delivered in the community setting
Brief Report

Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPϵ gene
Clinical Trials & Observations

Human bone marrow mesenchymal stromal cells express the neural ganglioside GD2: a novel surface marker for the identification of MSCs
Brief Report

Antithrombin Cambridge II (A384S): an underestimated genetic risk factor for venous thrombosis
Clinical Trials & Observations

Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1
Clinical Trials & Observations

Distinctive NK-cell receptor repertoires sustain high-level constitutive NK-cell activation in HIV-exposed uninfected individuals
Clinical Trials & Observations

NK cytotoxicity mediated by CD16 but not by NKp30 is functional in Griscelli syndrome
Clinical Trials & Observations

Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants
Clinical Trials & Observations

A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease
Clinical Trials & Observations

Bone marrow transplantation for severe aplastic anemia: a randomized controlled study of conditioning regimens
Clinical Trials & Observations Brief Report

Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem cell transplantation
Clinical Trials & Observations Brief Report