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INSIDE BLOOD

IMMUNOBIOLOGY

FcαRI: a case of multiple personality disorder?

Marjolein van Egmond

View Articletitled, FcαRI: a case of multiple personality disorder?

HEMOSTASIS

VEGF therapy: risky business for established plaques?

Alexandra Kadl,Norbert Leitinger

View Articletitled, VEGF therapy: risky business for established plaques?

HEMOSTASIS

VWD data worth 10 000 words

J. Evan Sadler

View Articletitled, VWD data worth 10 000 words

HEMATOPOIESIS

What is WHIM syndrome?

David C. Dale

View Articletitled, What is WHIM syndrome?

HEMOSTASIS

IVIg in ITP: no role for cytokines?

Bethan Psaila,James B. Bussel

View Articletitled, IVIg in ITP: no role for cytokines?

IMMUNOBIOLOGY

Monogamy and polygamy in T-cell receptor (TCR) chain association

Terrence L. Geiger

View Articletitled, Monogamy and polygamy in T-cell receptor (TCR) chain association

NEOPLASIA

Genomic loss is our gain

Jeremy S. Abramson

View Articletitled, Genomic loss is our gain

HEMATOPOIESIS

Drifting precariously due to lost tyrosines

Peter D. Emanuel

View Articletitled, Drifting precariously due to lost tyrosines

NEOPLASIA

JAK2^V617F and phenotype: questions galore

Animesh Pardanani

View Articletitled, JAK2V617F and phenotype: questions galore

BLOOD WORK

Chest mass and anemia

View Articletitled, Chest mass and anemia

ERRATA

Erratum in Catley et al. Aggresome induction by proteasome inhibitor bortezomib and α-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells

View Articletitled, Erratum in Catley et al. Aggresome induction by proteasome inhibitor bortezomib and α-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells

Erratum in Merlini. Exciting new agents in multiple myeloma

View Articletitled, Erratum in Merlini. Exciting new agents in multiple myeloma

PLENARY PAPERS

T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFβ dosage.

Laleh Talebian,Zhe Li,Yalin Guo,Justin Gaudet,Maren E. Speck,Daisuke Sugiyama,Prabhjot Kaur,Warren S. Pear,Ivan Maillard,Nancy A. Speck

View Articletitled, T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFβ dosage.

CLINICAL TRIALS AND OBSERVATIONS

Discoidin domain receptor 1 contributes to eosinophil survival in an NF-κB–dependent manner in Churg-Strauss syndrome
Clinical Trials & Observations

Wataru Matsuyama,Hideo Mitsuyama,Mikiko Ono,Yuko Shirahama,Ikkou Higashimoto,Mituhiro Osame,Kimiyoshi Arimura

View Articletitled, Discoidin domain receptor 1 contributes to eosinophil survival in an NF-κB–dependent manner in Churg-Strauss syndrome

Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
Clinical Trials & Observations

Madeleine Duvic,Rakshandra Talpur,Xiao Ni,Chunlei Zhang,Parul Hazarika,Cecilia Kelly,Judy H. Chiao,John F. Reilly,Justin L. Ricker,Victoria M. Richon,Stanley R. Frankel

View Articletitled, Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)

Prognostic significance of early vaso-occlusive complications in children with sickle cell anemia
Clinical Trials & Observations

Charles T. Quinn,Elizabeth P. Shull,Naveed Ahmad,Nancy J. Lee,Zora R. Rogers,George R. Buchanan

View Articletitled, Prognostic significance of early vaso-occlusive complications in children with sickle cell anemia

Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: a report from the Children's Oncology Group
Clinical Trials & Observations

Smita Bhatia,Mark D. Krailo,Zhengjia Chen,Laura Burden,Frederic B. Askin,Paul S. Dickman,Holcombe E. Grier,Michael P. Link,Paul A. Meyers,Elizabeth J. Perlman,Aaron R. Rausen,Leslie L. Robison,Teresa J. Vietti,James S. Miser

View Articletitled, Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: a report from the Children's Oncology Group

Supplemental data

Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia
Clinical Trials & Observations

Hagop Kantarjian,Yasuhiro Oki,Guillermo Garcia-Manero,Xuelin Huang,Susan O'Brien,Jorge Cortes,Stefan Faderl,Carlos Bueso-Ramos,Farhad Ravandi,Zeev Estrov,Alessandra Ferrajoli,William Wierda,Jianqin Shan,Jan Davis,Francis Giles,Hussain I. Saba,Jean-Pierre J. Issa

View Articletitled, Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia

Imatinib mesylate discontinuation in patients with chronic myelogenous leukemia in complete molecular remission for more than 2 years
Clinical Trials & Observations Brief Report

Philippe Rousselot,Francoise Huguet,Delphine Rea,Laurence Legros,Jean Michel Cayuela,Odile Maarek,Odile Blanchet,Gerald Marit,Eliane Gluckman,Josy Reiffers,Martine Gardembas,François-Xavier Mahon,The Intergroupe Français des Leucémies Myéloïdes Chronique (FIφLMC)

View Articletitled, Imatinib mesylate discontinuation in patients with chronic myelogenous leukemia in complete molecular remission for more than 2 years

Durable responses to imatinib in patients with PDGFRB fusion gene–positive and BCR-ABL–negative chronic myeloproliferative disorders
Clinical Trials & Observations Brief Report

View Articletitled, Durable responses to imatinib in patients with PDGFRB fusion gene–positive and BCR-ABL–negative chronic myeloproliferative disorders

GENE THERAPY

Foamy virus–mediated gene transfer to canine repopulating cells

Hans-Peter Kiem,James Allen,Grant Trobridge,Erik Olson,Kirsten Keyser,Laura Peterson,David W. Russell

View Articletitled, Foamy virus–mediated gene transfer to canine repopulating cells

HEMATOPOIESIS

Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis

François Delhommeau,Sabrina Dupont,Carole Tonetti,Aline Massé,Isabelle Godin,Jean-Pierre Le Couedic,Najet Debili,Patrick Saulnier,Nicole Casadevall,William Vainchenker,Stéphane Giraudier

View Articletitled, Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis

Supplemental data

WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus–truncated CXCR4

Toshinao Kawai,Uimook Choi,Lanise Cardwell,Suk See DeRavin,Nora Naumann,Narda L. Whiting-Theobald,Gilda F. Linton,Jaehyun Moon,Philip M. Murphy,Harry L. Malech

View Articletitled, WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus–truncated CXCR4

Reduced expression of inducible gelatinase B/matrix metalloproteinase-9 in monocytes from patients with myelodysplastic syndrome: correlation of inducible levels with the percentage of cytogenetically marked cells and with marrow cellularity

Mineo Iwata,Manoj Pillai,Aravind Ramakrishnan,Robert C. Hackman,H. Joachim Deeg,Ghislain Opdenakker,Beverly Torok-Storb

View Articletitled, Reduced expression of inducible gelatinase B/matrix metalloproteinase-9 in monocytes from patients with myelodysplastic syndrome: correlation of inducible levels with the percentage of cytogenetically marked cells and with marrow cellularity

Supplemental data

Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: results of a long-term survey
Clinical Trials & Observations

Manuela Germeshausen,Matthias Ballmaier,Karl Welte

View Articletitled, Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: results of a long-term survey

Supplemental data

Diminished proteasomal degradation results in accumulation of Gfi1 protein in monocytes

Jurgen A. F. Marteijn,Laurens T. van der Meer,Liesbeth Van Emst,Theo de Witte,Joop H. Jansen,Bert A. van der Reijden

View Articletitled, Diminished proteasomal degradation results in accumulation of Gfi1 protein in monocytes

Sustained alterations in biodistribution of stem/progenitor cells in Tie2Cre+α4^f/f mice are hematopoietic cell autonomous
Brief Report

Gregory V. Priestley,Tatiana Ulyanova,Thalia Papayannopoulou

View Articletitled, Sustained alterations in biodistribution of stem/progenitor cells in Tie2Cre+α4f/f mice are hematopoietic cell autonomous

Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Phenotype and genotype of a cohort of families historically diagnosed with type 1 von Willebrand disease in the European study, Molecular and Clinical Markers for the Diagnosis and Management of Type 1 von Willebrand Disease (MCMDM-1VWD)
Clinical Trials & Observations

View Articletitled, Phenotype and genotype of a cohort of families historically diagnosed with type 1 von Willebrand disease in the European study, Molecular and Clinical Markers for the Diagnosis and Management of Type 1 von Willebrand Disease (MCMDM-1VWD)

Supplemental data

Vascular endothelial growth factor-A induces plaque expansion in ApoE knock-out mice by promoting de novo leukocyte recruitment

Markus Lucerna,Alma Zernecke,Ramon de Nooijer,Saskia C. de Jager,Ilze Bot,Christian van der Lans,Ivana Kholova,Elisa A. Liehn,Theo J. C. van Berkel,Seppo Yla-Herttuala,Christian Weber,Eric A. L. Biessen

View Articletitled, Vascular endothelial growth factor-A induces plaque expansion in ApoE knock-out mice by promoting de novo leukocyte recruitment

Polymerization of fibrin: direct observation and quantification of individual B:b knob-hole interactions

Rustem I. Litvinov,Oleg V. Gorkun,Dennis K. Galanakis,Sergiy Yakovlev,Leonid Medved,Henry Shuman,John W. Weisel

View Articletitled, Polymerization of fibrin: direct observation and quantification of individual B:b knob-hole interactions

Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: a randomized, placebo-controlled, double-blind trial
Clinical Trials & Observations

Martin den Heijer,Huub P. J. Willems,Henk J. Blom,Wim B. J. Gerrits,Marco Cattaneo,Sabine Eichinger,Frits R. Rosendaal,Gerard M. J. Bos

View Articletitled, Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: a randomized, placebo-controlled, double-blind trial

The mutational spectrum of type 1 von Willebrand disease: results from a Canadian cohort study

Paula D. James,Colleen Notley,Carol Hegadorn,Jayne Leggo,Angie Tuttle,Shawn Tinlin,Christine Brown,Chandler Andrews,Andrea Labelle,Yvette Chirinian,Lee O'Brien,Maha Othman,Georges Rivard,Dilys Rapson,Christine Hough,David Lillicrap,for the Association of Hemophilia Clinic Directors of Canada

View Articletitled, The mutational spectrum of type 1 von Willebrand disease: results from a Canadian cohort study

A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg?
Brief Report

Andrew R. Crow,Seng Song,John W. Semple,John Freedman,Alan H. Lazarus

View Articletitled, A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg?

Supplemental data

IMMUNOBIOLOGY

Regulation of ϵ germline transcription and switch region mutations by IgH locus 3′ enhancers in transgenic mice

Jurga Laurencikiene,Vytas Tamosiunas,Eva Severinson

View Articletitled, Regulation of ϵ germline transcription and switch region mutations by IgH locus 3′ enhancers in transgenic mice

Supplemental data

The actin cloud induced by LFA-1–mediated outside-in signals lowers the threshold for T-cell activation

Jun-ichiro Suzuki,Sho Yamasaki,Jennifer Wu,Gary A. Koretzky,Takashi Saito

View Articletitled, The actin cloud induced by LFA-1–mediated outside-in signals lowers the threshold for T-cell activation

Supplemental data

Phospholipase C, calcium, and calmodulin are critical for α4β1 integrin affinity up-regulation and monocyte arrest triggered by chemoattractants

Sharon J. Hyduk,Jason R. Chan,,Stewart T. Duffy,Mian Chen,Mark D. Peterson,Thomas K. Waddell,Genevieve C. Digby,Katalin Szaszi,Andras Kapus,Myron I. Cybulsky

View Articletitled, Phospholipase C, calcium, and calmodulin are critical for α4β1 integrin affinity up-regulation and monocyte arrest triggered by chemoattractants

Supplemental data

Human Langerhans-cell activation triggered in vitro by conditionally expressed MKK6 is counterregulated by the downstream effector RelB

Almut Jörgl,Barbara Platzer,Sabine Taschner,Leonhard X. Heinz,Bernhard Höcher,Peter M. Reisner,Florian Göbel,Herbert Strobl

View Articletitled, Human Langerhans-cell activation triggered in vitro by conditionally expressed MKK6 is counterregulated by the downstream effector RelB

IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin

Rachael A. Clark,Thomas S. Kupper

View Articletitled, IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin

Supplemental data

IgA Fc receptor I signals apoptosis through the FcRγ ITAM and affects tumor growth

Yutaka Kanamaru,Houda Tamouza,Séverine Pfirsch,Delphine El Mehdi,Claudine Guérin-Marchand,Marina Pretolani,Ulrich Blank,Renato C. Monteiro

View Articletitled, IgA Fc receptor I signals apoptosis through the FcRγ ITAM and affects tumor growth

Hematopoietic stem cell–engrafted NOD/SCID/IL2Rγ^null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses

Satoru Watanabe,Kazuo Terashima,Shinrai Ohta,Shigeo Horibata,Misako Yajima,Yoko Shiozawa,M. Zahidunnabi Dewan,Zhong Yu,Mamoru Ito,Tomohiro Morio,Norio Shimizu,Mitsuo Honda,Naoki Yamamoto

View Articletitled, Hematopoietic stem cell–engrafted NOD/SCID/IL2Rγnull mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses

Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells

Sean R. Stowell,Sougata Karmakar,Caleb J. Stowell,Marcelo Dias-Baruffi,Rodger P. McEver,Richard D. Cummings

View Articletitled, Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells

Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells

Kazuya Sato,Katsutoshi Ozaki,Iekuni Oh,Akiko Meguro,Keiko Hatanaka,Tadashi Nagai,Kazuo Muroi,Keiya Ozawa

View Articletitled, Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells

Supplemental data

Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex

Mirjam H. M. Heemskerk,Renate S. Hagedoorn,Menno A. W. G. van der Hoorn,Lars T. van der Veken,Manja Hoogeboom,Michel G. D. Kester,Roel Willemze,J. H. Frederik Falkenburg

View Articletitled, Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex

The immunosuppressive drug FK778 induces regulatory activity in stimulated human CD4⁺CD25⁻ T cells

Ellen Kreijveld,Hans J. P. M. Koenen,Luuk B. Hilbrands,Hans J. P. van Hooff,Irma Joosten

View Articletitled, The immunosuppressive drug FK778 induces regulatory activity in stimulated human CD4+CD25− T cells

Immune competence of cancer-reactive T cells generated de novo in adult tumor-bearing mice

Kenneth F. May, Jr,Kenneth Lute,Ergun Kocak,Shahab Abdessalam,Lijie Yin,Ou Li,Zhen Guan,Gary Philips,Pan Zheng,Yang Liu

View Articletitled, Immune competence of cancer-reactive T cells generated de novo in adult tumor-bearing mice

NEOPLASIA

Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations
Clinical Trials & Observations

View Articletitled, Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations

Supplemental data

Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas

View Articletitled, Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas

Supplemental data

Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus

Abdallah Souabni,Wolfram Jochum,Meinrad Busslinger

View Articletitled, Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus

Supplemental data

Association of a novel regulatory polymorphism (−938C>A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia
Clinical Trials & Observations

Holger Nückel,Ulrich H. Frey,Maja Bau,Ludger Sellmann,Jens Stanelle,Jan Dürig,Karl-Heinz Jöckel,Ulrich Dührsen,Winfried Siffert

View Articletitled, Association of a novel regulatory polymorphism (−938C>A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia

Expression of the human germinal center–associated lymphoma (HGAL) protein identifies a subset of classic Hodgkin lymphoma of germinal center derivation and improved survival
Clinical Trials & Observations

Yasodha Natkunam,Eric D. Hsi,Patricia Aoun,Shuchun Zhao,Paul Elson,Brad Pohlman,Hina Naushad,Martin Bast,Ronald Levy,Izidore S. Lossos

View Articletitled, Expression of the human germinal center–associated lymphoma (HGAL) protein identifies a subset of classic Hodgkin lymphoma of germinal center derivation and improved survival

INNO-406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph⁺ leukemia cells in the central nervous system, and cyclosporine A augments its in vivo activity

Asumi Yokota,Shinya Kimura,Satohiro Masuda,Eishi Ashihara,Junya Kuroda,Kiyoshi Sato,Yuri Kamitsuji,Eri Kawata,Yasuyuki Deguchi,Yoshimasa Urasaki,Yasuhito Terui,Martin Ruthardt,Takanori Ueda,Kiyohiko Hatake,Ken-ichi Inui,Taira Maekawa

View Articletitled, INNO-406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+ leukemia cells in the central nervous system, and cyclosporine A augments its in vivo activity

Supplemental data

EXEL-0862, a novel tyrosine kinase inhibitor, induces apoptosis in vitro and ex vivo in human mast cells expressing the KIT D816V mutation

Jingxuan Pan,Alfonso Quintás-Cardama,Hagop M. Kantarjian,Cem Akin,Taghi Manshouri,Peter Lamb,Jorge E. Cortes,Ayalew Tefferi,Francis J. Giles,Srdan Verstovsek

View Articletitled, EXEL-0862, a novel tyrosine kinase inhibitor, induces apoptosis in vitro and ex vivo in human mast cells expressing the KIT D816V mutation

Deficient expression of NCR in NK cells from acute myeloid leukemia: evolution during leukemia treatment and impact of leukemia cells in NCR^dull phenotype induction

Cyril Fauriat,Sylvaine Just-Landi,Françoise Mallet,Christine Arnoulet,Danielle Sainty,Daniel Olive,Regis T. Costello

View Articletitled, Deficient expression of NCR in NK cells from acute myeloid leukemia: evolution during leukemia treatment and impact of leukemia cells in NCRdull phenotype induction

Neutrophil-derived APRIL concentrated in tumor lesions by proteoglycans correlates with human B-cell lymphoma aggressiveness
Clinical Trials & Observations

Juerg Schwaller,Pascal Schneider,Paulette Mhawech-Fauceglia,Thomas McKee,Samir Myit,Thomas Matthes,Jurg Tschopp,Olivier Donze,Frederique-Anne Le Gal,Bertrand Huard

View Articletitled, Neutrophil-derived APRIL concentrated in tumor lesions by proteoglycans correlates with human B-cell lymphoma aggressiveness

Supplemental data

JAK2^V617F: prevalence in a large Chinese hospital population
Clinical Trials & Observations Brief Report

Xuesong Xu,Qi Zhang,Jian Luo,Shu Xing,Qingshan Li,Sanford B. Krantz,Xueqi Fu,Zhizhuang Joe Zhao

View Articletitled, JAK2V617F: prevalence in a large Chinese hospital population

Supplemental data

RED CELLS

Maturation and enucleation of primitive erythroblasts during mouse embryogenesis is accompanied by changes in cell-surface antigen expression

Stuart T. Fraser,Joan Isern,Margaret H. Baron

View Articletitled, Maturation and enucleation of primitive erythroblasts during mouse embryogenesis is accompanied by changes in cell-surface antigen expression

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

Maria Vittoria Verga Falzacappa,Maja Vujic Spasic,Regina Kessler,Jens Stolte,Matthias W. Hentze,Martina U. Muckenthaler

View Articletitled, STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

Monoclonal immunoglobulin with antitransferrin activity: a rare cause of hypersideremia with increased transferrin saturation
Clinical Trials & Observations Brief Report

Marie-Alexandra Alyanakian,Youri Taes,Mimouna Bensaïd,Berta Segovia,Pierre Aucouturier,Jean-Didier Rain,Joris Delanghe,Bruno Varet,Carole Beaumont

View Articletitled, Monoclonal immunoglobulin with antitransferrin activity: a rare cause of hypersideremia with increased transferrin saturation

Supplemental data

Reversal of cardiac complications by deferiprone and deferoxamine combination therapy in a patient affected by a severe type of juvenile hemochromatosis (JH)
Clinical Trials & Observations Brief Report

Giovanna Fabio,Francesca Minonzio,Paola Delbini,Annamaria Bianchi,Maria Domenica Cappellini

View Articletitled, Reversal of cardiac complications by deferiprone and deferoxamine combination therapy in a patient affected by a severe type of juvenile hemochromatosis (JH)

TRANSPLANTATION

Targeting the activation-induced antigen CD137 can selectively deplete alloreactive T cells from antileukemic and antitumor donor T-cell lines

Thomas C. Wehler,Marion Nonn,Britta Brandt,Cedrik M. Britten,Mark Gröne,Mariya Todorova,Irina Link,Shamsul A. Khan,Ralf G. Meyer,Christoph Huber,Udo F. Hartwig,Wolfgang Herr

View Articletitled, Targeting the activation-induced antigen CD137 can selectively deplete alloreactive T cells from antileukemic and antitumor donor T-cell lines

Prophylactic transfer of CD8-depleted donor lymphocytes after T-cell–depleted reduced-intensity transplantation

Ralf G. Meyer,Cedrik M. Britten,Daniela Wehler,Klaus Bender,Georg Hess,Abdo Konur,Udo F. Hartwig,Thomas C. Wehler,Andrew J. Ullmann,Chiara Gentilini,Lutz Uharek,Christoph Huber,Karin Kolbe,Wolfgang Herr

View Articletitled, Prophylactic transfer of CD8-depleted donor lymphocytes after T-cell–depleted reduced-intensity transplantation

Successful bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning
Clinical Trials & Observations Brief Report

Aarati Rao,Naynesh Kamani,Alexandra Filipovich,Susan Molleran Lee,Stella M. Davies,Jignesh Dalal,Shalini Shenoy

View Articletitled, Successful bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning

CORRESPONDENCE

Cellular origin and lineage specificity of the JAK2^V617F allele in polycythemia vera

Carolyn M. Butcher,Jonathon F. Hutton,Uwe Hahn,L. Bik To,Peter Bardy,Ian Lewis,Richard J. D'Andrea

View Articletitled, Cellular origin and lineage specificity of the JAK2V617F allele in polycythemia vera

Low-dose versus high-dose therapy for Gaucher disease: goals and markers

Carla E. M. Hollak,Maaike de Fost,Johannes M. F. G. Aerts,Stephan vom Dahl

View Articletitled, Low-dose versus high-dose therapy for Gaucher disease: goals and markers

Response: Correlation between Gaucher disease clinical severity and surrogate markers is weak

Ari Zimran,Deborah Elstein,Ernest Beutler

View Articletitled, Response: Correlation between Gaucher disease clinical severity and surrogate markers is weak

Platelet transfusion in neonatal alloimmune thrombocytopenia

David Allen,Salim Verjee,Sarah Rees,Michael F. Murphy,David J. Roberts

View Articletitled, Platelet transfusion in neonatal alloimmune thrombocytopenia

A recurrent in-frame insertion in a CEBPA transactivation domain is a polymorphism rather than a mutation that does not affect gene expression profiling–based clustering of AML

Bas J. Wouters,Irene Louwers,Peter J. M. Valk,Bob Löwenberg,Ruud Delwel

View Articletitled, A recurrent in-frame insertion in a CEBPA transactivation domain is a polymorphism rather than a mutation that does not affect gene expression profiling–based clustering of AML

Issue Archive

Table of Contents

INSIDE BLOOD

BLOOD WORK

ERRATA

PLENARY PAPERS

CLINICAL TRIALS AND OBSERVATIONS

Discoidin domain receptor 1 contributes to eosinophil survival in an NF-κB–dependent manner in Churg-Strauss syndrome Clinical Trials & Observations

Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL) Clinical Trials & Observations

Prognostic significance of early vaso-occlusive complications in children with sickle cell anemia Clinical Trials & Observations

Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: a report from the Children's Oncology Group Clinical Trials & Observations

Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia Clinical Trials & Observations

Imatinib mesylate discontinuation in patients with chronic myelogenous leukemia in complete molecular remission for more than 2 years Clinical Trials & Observations Brief Report

Durable responses to imatinib in patients with PDGFRB fusion gene–positive and BCR-ABL–negative chronic myeloproliferative disorders Clinical Trials & Observations Brief Report

GENE THERAPY

HEMATOPOIESIS

Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: results of a long-term survey Clinical Trials & Observations

Sustained alterations in biodistribution of stem/progenitor cells in Tie2Cre+α4f/f mice are hematopoietic cell autonomous Brief Report

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Phenotype and genotype of a cohort of families historically diagnosed with type 1 von Willebrand disease in the European study, Molecular and Clinical Markers for the Diagnosis and Management of Type 1 von Willebrand Disease (MCMDM-1VWD) Clinical Trials & Observations

Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: a randomized, placebo-controlled, double-blind trial Clinical Trials & Observations

A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg? Brief Report

IMMUNOBIOLOGY

NEOPLASIA

Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations Clinical Trials & Observations

Association of a novel regulatory polymorphism (−938C>A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia Clinical Trials & Observations

Expression of the human germinal center–associated lymphoma (HGAL) protein identifies a subset of classic Hodgkin lymphoma of germinal center derivation and improved survival Clinical Trials & Observations

Neutrophil-derived APRIL concentrated in tumor lesions by proteoglycans correlates with human B-cell lymphoma aggressiveness Clinical Trials & Observations

JAK2V617F: prevalence in a large Chinese hospital population Clinical Trials & Observations Brief Report

RED CELLS

Monoclonal immunoglobulin with antitransferrin activity: a rare cause of hypersideremia with increased transferrin saturation Clinical Trials & Observations Brief Report

Reversal of cardiac complications by deferiprone and deferoxamine combination therapy in a patient affected by a severe type of juvenile hemochromatosis (JH) Clinical Trials & Observations Brief Report

TRANSPLANTATION

Successful bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning Clinical Trials & Observations Brief Report

CORRESPONDENCE

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ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

Discoidin domain receptor 1 contributes to eosinophil survival in an NF-κB–dependent manner in Churg-Strauss syndrome
Clinical Trials & Observations

Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
Clinical Trials & Observations

Prognostic significance of early vaso-occlusive complications in children with sickle cell anemia
Clinical Trials & Observations

Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: a report from the Children's Oncology Group
Clinical Trials & Observations

Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia
Clinical Trials & Observations

Imatinib mesylate discontinuation in patients with chronic myelogenous leukemia in complete molecular remission for more than 2 years
Clinical Trials & Observations Brief Report

Durable responses to imatinib in patients with PDGFRB fusion gene–positive and BCR-ABL–negative chronic myeloproliferative disorders
Clinical Trials & Observations Brief Report

Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: results of a long-term survey
Clinical Trials & Observations

Sustained alterations in biodistribution of stem/progenitor cells in Tie2Cre+α4^f/f mice are hematopoietic cell autonomous
Brief Report

Phenotype and genotype of a cohort of families historically diagnosed with type 1 von Willebrand disease in the European study, Molecular and Clinical Markers for the Diagnosis and Management of Type 1 von Willebrand Disease (MCMDM-1VWD)
Clinical Trials & Observations

Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: a randomized, placebo-controlled, double-blind trial
Clinical Trials & Observations

A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg?
Brief Report

Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations
Clinical Trials & Observations

Association of a novel regulatory polymorphism (−938C>A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia
Clinical Trials & Observations

Expression of the human germinal center–associated lymphoma (HGAL) protein identifies a subset of classic Hodgkin lymphoma of germinal center derivation and improved survival
Clinical Trials & Observations

Neutrophil-derived APRIL concentrated in tumor lesions by proteoglycans correlates with human B-cell lymphoma aggressiveness
Clinical Trials & Observations

JAK2^V617F: prevalence in a large Chinese hospital population
Clinical Trials & Observations Brief Report

Monoclonal immunoglobulin with antitransferrin activity: a rare cause of hypersideremia with increased transferrin saturation
Clinical Trials & Observations Brief Report

Reversal of cardiac complications by deferiprone and deferoxamine combination therapy in a patient affected by a severe type of juvenile hemochromatosis (JH)
Clinical Trials & Observations Brief Report

Successful bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning
Clinical Trials & Observations Brief Report