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Volume 108, Issue 7

October 1 2006

In this Issue

INSIDE BLOOD
BLOOD WORK
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
CLINICAL TRIALS AND OBSERVATIONS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
STEM CELLS IN HEMATOLOGY
TRANSFUSION MEDICINE
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

NEOPLASIA

Leukemia does not live by 1 lesion alone

Judith E. Karp

View Articletitled, Leukemia does not live by 1 lesion alone

CLINICAL TRIALS AND OBSERVATIONS

Complete response in myeloma: a Trojan horse?
Clinical Trials & Observations

Bart Barlogie,Guido Tricot

View Articletitled, Complete response in myeloma: a Trojan horse?

IMMUNOBIOLOGY

That fish (NEMO) again?

Gulbu Uzel

View Articletitled, That fish (NEMO) again?

TRANSPLANTATION

Trans-presentation of IL-15

Jerome Ritz

View Articletitled, Trans-presentation of IL-15

TRANSFUSION MEDICINE

Hot on the trail of TRALI

David F. Stroncek

View Articletitled, Hot on the trail of TRALI

HEMOSTASIS

Hyperhomocysteinemia: the protein C pathway to thrombosis

Diane E. Handy

View Articletitled, Hyperhomocysteinemia: the protein C pathway to thrombosis

HEMOSTASIS

ADAMTS13 cleavage of ULVWF: put the action where it is needed

Jing-fei Dong

View Articletitled, ADAMTS13 cleavage of ULVWF: put the action where it is needed

HEMATOPOIESIS

Ets and megakaryocytes: maturation matters

Katya Ravid

View Articletitled, Ets and megakaryocytes: maturation matters

RED CELLS

“Iron mining” to inhibit tumor growth

Des R. Richardson,David B. Lovejoy

View Articletitled, “Iron mining” to inhibit tumor growth

RED CELLS

From 1 to 2 mutated JAK2: the road from ET to PV

Stéphane Giraudier,William Vainchenker

View Articletitled, From 1 to 2 mutated JAK2: the road from ET to PV

BLOOD WORK

Osteoclast

View Articletitled, Osteoclast

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Differentially methylated alleles in a distinct region of the human interleukin-1α promoter are associated with allele-specific expression of IL-1α in CD4⁺ T cells

Johanna G. I. van Rietschoten,Kitty F. Verzijlbergen,Sonja I. Gringhuis,Tineke C. T. M. van der Pouw Kraan,Jean-Pierre Bayley,Eddy A. Wierenga,Peter A. Jones,Jan M. Kooter,Cor L. Verweij

View Articletitled, Differentially methylated alleles in a distinct region of the human interleukin-1α promoter are associated with allele-specific expression of IL-1α in CD4+ T cells

DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not transendothelial migration

Ziv Shulman,Ronit Pasvolsky,Eilon Woolf,Valentin Grabovsky,Sara W. Feigelson,Noam Erez,Yoshinori Fukui,Ronen Alon

View Articletitled, DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not transendothelial migration

Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Thalidomide, dexamethasone, and pegylated liposomal doxorubicin (ThaDD) for patients older than 65 years with newly diagnosed multiple myeloma
Clinical Trials & Observations

Massimo Offidani,Laura Corvatta,Maria-Novella Piersantelli,Giuseppe Visani,Francesco Alesiani,Marino Brunori,Piero Galieni,Massimo Catarini,Maurizio Burattini,Riccardo Centurioni,Mario Ferranti,Serena Rupoli,Anna Rita Scortechini,Luciano Giuliodori,Marco Candela,Debora Capelli,Mauro Montanari,Attilio Olivieri,Antonella Poloni,Claudia Polloni,Monica Marconi,Pietro Leoni

View Articletitled, Thalidomide, dexamethasone, and pegylated liposomal doxorubicin (ThaDD) for patients older than 65 years with newly diagnosed multiple myeloma

Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: results of a multicenter phase 1/2 study
Clinical Trials & Observations

María-Victoria Mateos,José-M. Hernández,Miguel-T. Hernández,Norma-C. Gutiérrez,Luis Palomera,Marta Fuertes,Joaquín Díaz-Mediavilla,Juan-J. Lahuerta,Javier de la Rubia,María-José Terol,Ana Sureda,Joan Bargay,Paz Ribas,Felipe de Arriba,Adrian Alegre,Albert Oriol,Dolores Carrera,José García-Laraña,Ramón García-Sanz,Joan Bladé,Felipe Prósper,Gemma Mateo,Dixie-Lee Esseltine,Helgi van de Velde,Jesús-F. San Miguel

View Articletitled, Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: results of a multicenter phase 1/2 study

Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation
Clinical Trials & Observations

Hadrian Szpurka,Ramon Tiu,Gurunathan Murugesan,Samer Aboudola,Eric D. Hsi,Karl S. Theil,Mikkael A. Sekeres,Jaroslaw P. Maciejewski

View Articletitled, Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation

HEMATOPOIESIS

Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia

Phil J. Ancliff,Michael P. Blundell,Giles O. Cory,Yolanda Calle,Austen Worth,Helena Kempski,Siobhan Burns,Gareth E. Jones,Jo Sinclair,Christine Kinnon,Ian M. Hann,Rosemary E. Gale,David C. Linch,Adrian J. Thrasher

View Articletitled, Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia

Supplemental data

Increased hematopoietic stem cell mobilization in aged mice

Zhenlan Xing,Marnie A. Ryan,Deidre Daria,Kalpana J. Nattamai,Gary Van Zant,Lei Wang,Yi Zheng,Hartmut Geiger

View Articletitled, Increased hematopoietic stem cell mobilization in aged mice

Maturation stage–specific regulation of megakaryopoiesis by pointed-domain Ets proteins

Liyan Pang,Hai-Hui Xue,Gabor Szalai,Xun Wang,Yuhuan Wang,Dennis K. Watson,Warren J. Leonard,Gerd A. Blobel,Mortimer Poncz

View Articletitled, Maturation stage–specific regulation of megakaryopoiesis by pointed-domain Ets proteins

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Apical sorting of ADAMTS13 in vascular endothelial cells and Madin-Darby canine kidney cells depends on the CUB domains and their association with lipid rafts

Dezhi Shang,X. Wu Zheng,Masami Niiya,X. Long Zheng

View Articletitled, Apical sorting of ADAMTS13 in vascular endothelial cells and Madin-Darby canine kidney cells depends on the CUB domains and their association with lipid rafts

Thrombotic complications in childhood acute lymphoblastic leukemia: a meta-analysis of 17 prospective studies comprising 1752 pediatric patients
Clinical Trials & Observations

Vanesa Caruso,Licia Iacoviello,Augusto Di Castelnuovo,Sergio Storti,Guglielmo Mariani,Giovanni de Gaetano,Maria Benedetta Donati

View Articletitled, Thrombotic complications in childhood acute lymphoblastic leukemia: a meta-analysis of 17 prospective studies comprising 1752 pediatric patients

Reversible inhibition of the platelet procoagulant response through manipulation of the Gardos channel

Jef L. Wolfs,Simone J. Wielders,Paul Comfurius,Theo Lindhout,John C. Giddings,Robert F. Zwaal,Edouard M. Bevers

View Articletitled, Reversible inhibition of the platelet procoagulant response through manipulation of the Gardos channel

Impact of fibronectin assembly on platelet thrombus formation in response to type I collagen and von Willebrand factor

Jaehyung Cho,Deane F. Mosher

View Articletitled, Impact of fibronectin assembly on platelet thrombus formation in response to type I collagen and von Willebrand factor

Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia

Sanjana Dayal,Katina M. Wilson,Lorie Leo,Erland Arning,Teodoro Bottiglieri,Steven R. Lentz

View Articletitled, Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia

Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
Clinical Trials & Observations

Jean-Sébastien Hulot,Alessandra Bura,Eric Villard,Michel Azizi,Véronique Remones,Catherine Goyenvalle,Martine Aiach,Philippe Lechat,Pascale Gaussem

View Articletitled, Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects

A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis

Matthew P. McCormack,Mark A. Hall,Simone M. Schoenwaelder,Quan Zhao,Sarah Ellis,Julia A. Prentice,Ashleigh J. Clarke,Nicholas J. Slater,Jessica M. Salmon,Shaun P. Jackson,Stephen M. Jane,David J. Curtis

View Articletitled, A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis

IMMUNOBIOLOGY

CD8⁺ T-cell–mediated killing of donor dendritic cells prevents alloreactive T helper type-2 responses in vivo

Sophie Laffont,Jérôme D. Coudert,Lucile Garidou,Laurent Delpy,Aurélie Wiedemann,Cécile Demur,Christiane Coureau,Jean-Charles Guéry

View Articletitled, CD8+ T-cell–mediated killing of donor dendritic cells prevents alloreactive T helper type-2 responses in vivo

Thymosin α1 activates dendritic cell tryptophan catabolism and establishes a regulatory environment for balance of inflammation and tolerance

Luigina Romani,Francesco Bistoni,Katia Perruccio,Claudia Montagnoli,Roberta Gaziano,Silvia Bozza,Pierluigi Bonifazi,Giovanni Bistoni,Guido Rasi,Andrea Velardi,Francesca Fallarino,Enrico Garaci,Paolo Puccetti

View Articletitled, Thymosin α1 activates dendritic cell tryptophan catabolism and establishes a regulatory environment for balance of inflammation and tolerance

ADAM17 deficiency by mature neutrophils has differential effects on L-selectin shedding

Ying Li,Jennifer Brazzell,Amy Herrera,Bruce Walcheck

View Articletitled, ADAM17 deficiency by mature neutrophils has differential effects on L-selectin shedding

Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen–specific CD8⁺ T-cell function in Hodgkin lymphoma patients

Maher K. Gandhi,Eleanore Lambley,Jaikumar Duraiswamy,Ujjwal Dua,Corey Smith,Suzanne Elliott,Devinder Gill,Paula Marlton,John Seymour,Rajiv Khanna

View Articletitled, Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen–specific CD8+ T-cell function in Hodgkin lymphoma patients

Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma

Cornelia M. Tschopp,Nicole Spiegl,Svetlana Didichenko,Werner Lutmann,Peter Julius,J. Christian Virchow,C. Erik Hack,Clemens A. Dahinden

View Articletitled, Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma

Supplemental data

Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7

Régis Peffault de Latour,Hélène C. Dujardin,Florence Mishellany,Odile Burlen-Defranoux,Julien Zuber,Rute Marques,James Di Santo,Ana Cumano,Paulo Vieira,Antonio Bandeira

View Articletitled, Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7

TLR agonists promote ERK-mediated preferential IL-10 production of regulatory dendritic cells (diffDCs), leading to NK-cell activation

Cheng Qian,Xiaodong Jiang,Huazhang An,Yizhi Yu,Zhenhong Guo,Shuxun Liu,Hongmei Xu,Xuetao Cao

View Articletitled, TLR agonists promote ERK-mediated preferential IL-10 production of regulatory dendritic cells (diffDCs), leading to NK-cell activation

Analysis of natural killer–cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease
Clinical Trials & Observations

Stefania Marcenaro,Federico Gallo,Stefania Martini,Alessandra Santoro,Gillian M. Griffiths,Maurizio Aricó,Lorenzo Moretta,Daniela Pende

View Articletitled, Analysis of natural killer–cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease

Impaired dendritic-cell function in ectodermal dysplasia with immune deficiency is linked to defective NEMO ubiquitination
Clinical Trials & Observations

Stephane T. Temmerman,Chi A. Ma,Louis Borges,Marek Kubin,Shuying Liu,Jonathan M. J. Derry,Ashish Jain

View Articletitled, Impaired dendritic-cell function in ectodermal dysplasia with immune deficiency is linked to defective NEMO ubiquitination

NEOPLASIA

Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)–based mutagenesis screen: high efficacy of drug combinations

Heather A. Bradeen,Christopher A. Eide,Thomas O'Hare,Kara J. Johnson,Stephanie G. Willis,Francis Y. Lee,Brian J. Druker,Michael W. Deininger

View Articletitled, Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)–based mutagenesis screen: high efficacy of drug combinations

Supplemental data

Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature

Judy R. van Beijnum,Ruud P. Dings,Edith van der Linden,Bernadette M. M. Zwaans,Frans C. S. Ramaekers,Kevin H. Mayo,Arjan W. Griffioen

View Articletitled, Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature

Supplemental data

Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice

Chaitali Parikh,Ramesh Subrahmanyam,Ruibao Ren

View Articletitled, Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice

Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia
Clinical Trials & Observations

Steven M. Kornblau,Matthew Womble,Yi Hua Qiu,C. Ellen Jackson,Wenjing Chen,Marina Konopleva,Elihu H. Estey,Michael Andreeff

View Articletitled, Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia

Supplemental data

KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients

Andres C. Garcia-Montero,Maria Jara-Acevedo,Cristina Teodosio,Maria Luz Sanchez,Rosa Nunez,Aranzazu Prados,Isabel Aldanondo,Laura Sanchez,Mercedes Dominguez,Luis M. Botana,Francisca Sanchez-Jimenez,Karl Sotlar,Julia Almeida,Luis Escribano,Alberto Orfao

View Articletitled, KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients

High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6-deregulating mutations, in gastric lymphoma
Clinical Trials & Observations

Yun-Wen Chen,Xiao-Tong Hu,Anthony C. Liang,Wing-Yan Au,Chi-Chiu So,Michelle L. Wong,Lijun Shen,Qian Tao,Kent-Man Chu,Yok-Lam Kwong,Raymond H. Liang,Gopesh Srivastava

View Articletitled, High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6-deregulating mutations, in gastric lymphoma

Supplemental data

CD32B, the human inhibitory Fc-γ receptor IIB, as a target for monoclonal antibody therapy of B-cell lymphoma

Christopher T. Rankin,Maria-Concetta Veri,Sergey Gorlatov,Nadine Tuaillon,Steve Burke,Ling Huang,H. David Inzunza,Hua Li,Shannon Thomas,Syd Johnson,Jeffrey Stavenhagen,Scott Koenig,Ezio Bonvini

View Articletitled, CD32B, the human inhibitory Fc-γ receptor IIB, as a target for monoclonal antibody therapy of B-cell lymphoma

Supplemental data

Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells

Kumudha Balakrishnan,Ramadevi Nimmanapalli,Farhad Ravandi,Michael J. Keating,Varsha Gandhi

View Articletitled, Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells

Haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death

Paula V. Cabrera,Maho Amano,Junya Mitoma,Jessica Chan,Jonathan Said,Minoru Fukuda,Linda G. Baum

View Articletitled, Haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death

Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK⁺ anaplastic large-cell lymphoma cells

Lin Qiu,Raymond Lai,Quan Lin,Esther Lau,David M. Thomazy,Daniel Calame,Richard J. Ford,Larry W. Kwak,Robert A. Kirken,Hesham M. Amin

View Articletitled, Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK+ anaplastic large-cell lymphoma cells

CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities
Brief Report

Young-Jin Lee,Letetia C. Jones,Nikolai A. Timchenko,Danilo Perrotti,Daniel G. Tenen,Scott C. Kogan

View Articletitled, CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities

PHAGOCYTES

Schistosoma mansoni infection in eosinophil lineage–ablated mice

Jonathan M. Swartz,Kimberly D. Dyer,Allen W. Cheever,Thirumalai Ramalingam,Lesley Pesnicak,Joseph B. Domachowske,James J. Lee,Nancy A. Lee,Paul S. Foster,Thomas A. Wynn,Helene F. Rosenberg

View Articletitled, Schistosoma mansoni infection in eosinophil lineage–ablated mice

Supplemental data

RED CELLS

In vivo tumor growth is inhibited by cytosolic iron deprivation caused by the expression of mitochondrial ferritin

Guangjun Nie,Guohua Chen,Alex D. Sheftel,Kostas Pantopoulos,Prem Ponka

View Articletitled, In vivo tumor growth is inhibited by cytosolic iron deprivation caused by the expression of mitochondrial ferritin

Progenitors homozygous for the V617F mutation occur in most patients with polycythemia vera, but not essential thrombocythemia
Brief Report

Linda M. Scott,Mike A. Scott,Peter J. Campbell,Anthony R. Green

View Articletitled, Progenitors homozygous for the V617F mutation occur in most patients with polycythemia vera, but not essential thrombocythemia

Supplemental data

STEM CELLS IN HEMATOLOGY

G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a paracrine mechanism

Benjamin J. Capoccia,Rebecca M. Shepherd,Daniel C. Link

View Articletitled, G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a paracrine mechanism

Clonal analysis of thymus-repopulating cells presents direct evidence for self-renewal division of human hematopoietic stem cells

Takashi Yahata,Shizu Yumino,Yin Seng,Hiroko Miyatake,Tomoko Uno,Yukari Muguruma,Mamoru Ito,Hiroyuki Miyoshi,Shunichi Kato,Tomomitsu Hotta,Kiyoshi Ando

View Articletitled, Clonal analysis of thymus-repopulating cells presents direct evidence for self-renewal division of human hematopoietic stem cells

Supplemental data

TRANSFUSION MEDICINE

Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury

Samina Yasmin Khan,Marguerite R. Kelher,Joanna M. Heal,Neil Blumberg,Lynn K. Boshkov,Richard Phipps,Kelly F. Gettings,Nathan J. McLaughlin,Christopher C. Silliman

View Articletitled, Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury

TRANSPLANTATION

Trans-presentation of donor-derived interleukin 15 is necessary for the rapid onset of acute graft-versus-host disease but not for graft-versus-tumor activity

Bradley W. Blaser,Noah R. Schwind,Seth Karol,Dennis Chang,Samuel Shin,Sameek Roychowdhury,Brian Becknell,Amy K. Ferketich,Donna F. Kusewitt,Bruce R. Blazar,Michael A. Caligiuri

View Articletitled, Trans-presentation of donor-derived interleukin 15 is necessary for the rapid onset of acute graft-versus-host disease but not for graft-versus-tumor activity

Supplemental data

Immunogenicity of recombinant hepatitis B vaccine (rHBV) in recipients of unrelated or related allogeneic hematopoietic cell (HC) transplants
Clinical Trials & Observations

Dana Jaffe,Esperanza B. Papadopoulos,James W. Young,Richard J. O'Reilly,Susan Prockop,Nancy A. Kernan,Ann Jakubowski,Farid Boulad,Miguel-Angel Perales,Hugo Castro-Malaspina,Trudy N. Small

View Articletitled, Immunogenicity of recombinant hepatitis B vaccine (rHBV) in recipients of unrelated or related allogeneic hematopoietic cell (HC) transplants

The metastasis-associated 67-kDa laminin receptor is involved in G-CSF–induced hematopoietic stem cell mobilization

Carmine Selleri,Pia Ragno,Patrizia Ricci,Valeria Visconte,Nicola Scarpato,Maria Vincenza Carriero,Bruno Rotoli,Guido Rossi,Nunzia Montuori

View Articletitled, The metastasis-associated 67-kDa laminin receptor is involved in G-CSF–induced hematopoietic stem cell mobilization

Host B cells produce IL-10 following TBI and attenuate acute GVHD after allogeneic bone marrow transplantation

Vanessa Rowe,Tatjana Banovic,Kelli P. MacDonald,Rachel Kuns,Alistair L. Don,Edward S. Morris,Angela C. Burman,Helen M. Bofinger,Andrew D. Clouston,Geoffrey R. Hill

View Articletitled, Host B cells produce IL-10 following TBI and attenuate acute GVHD after allogeneic bone marrow transplantation

CORRESPONDENCE

Management of extreme thrombocytosis in otherwise low-risk essential thrombocythemia; does number matter?

Ayalew Tefferi,Naseema Gangat,Alexandra P. Wolanskyj

View Articletitled, Management of extreme thrombocytosis in otherwise low-risk essential thrombocythemia; does number matter?

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Issue Archive

Table of Contents

INSIDE BLOOD

Complete response in myeloma: a Trojan horse? Clinical Trials & Observations

BLOOD WORK

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

CLINICAL TRIALS AND OBSERVATIONS

Thalidomide, dexamethasone, and pegylated liposomal doxorubicin (ThaDD) for patients older than 65 years with newly diagnosed multiple myeloma Clinical Trials & Observations

Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: results of a multicenter phase 1/2 study Clinical Trials & Observations

Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation Clinical Trials & Observations

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Thrombotic complications in childhood acute lymphoblastic leukemia: a meta-analysis of 17 prospective studies comprising 1752 pediatric patients Clinical Trials & Observations

Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects Clinical Trials & Observations

IMMUNOBIOLOGY

Analysis of natural killer–cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease Clinical Trials & Observations

Impaired dendritic-cell function in ectodermal dysplasia with immune deficiency is linked to defective NEMO ubiquitination Clinical Trials & Observations

NEOPLASIA

Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia Clinical Trials & Observations

High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6-deregulating mutations, in gastric lymphoma Clinical Trials & Observations

CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities Brief Report

PHAGOCYTES

RED CELLS

Progenitors homozygous for the V617F mutation occur in most patients with polycythemia vera, but not essential thrombocythemia Brief Report

STEM CELLS IN HEMATOLOGY

TRANSFUSION MEDICINE

TRANSPLANTATION

Immunogenicity of recombinant hepatitis B vaccine (rHBV) in recipients of unrelated or related allogeneic hematopoietic cell (HC) transplants Clinical Trials & Observations

CORRESPONDENCE

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ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

Complete response in myeloma: a Trojan horse?
Clinical Trials & Observations

Thalidomide, dexamethasone, and pegylated liposomal doxorubicin (ThaDD) for patients older than 65 years with newly diagnosed multiple myeloma
Clinical Trials & Observations

Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: results of a multicenter phase 1/2 study
Clinical Trials & Observations

Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation
Clinical Trials & Observations

Thrombotic complications in childhood acute lymphoblastic leukemia: a meta-analysis of 17 prospective studies comprising 1752 pediatric patients
Clinical Trials & Observations

Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
Clinical Trials & Observations

Analysis of natural killer–cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease
Clinical Trials & Observations

Impaired dendritic-cell function in ectodermal dysplasia with immune deficiency is linked to defective NEMO ubiquitination
Clinical Trials & Observations

Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia
Clinical Trials & Observations

High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6-deregulating mutations, in gastric lymphoma
Clinical Trials & Observations

CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities
Brief Report

Progenitors homozygous for the V617F mutation occur in most patients with polycythemia vera, but not essential thrombocythemia
Brief Report

Immunogenicity of recombinant hepatitis B vaccine (rHBV) in recipients of unrelated or related allogeneic hematopoietic cell (HC) transplants
Clinical Trials & Observations