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Volume 108, Issue 6

September 15 2006

In this Issue

INSIDE BLOOD
PLENARY PAPERS
REVIEW ARTICLES
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
CLINICAL TRIALS AND OBSERVATIONS
ERRATA
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
STEM CELLS IN HEMATOLOGY
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

IMMUNOBIOLOGY

Opposing roles of dendritic cell subsets in HIV-1 infection

Justin Stebbing,Mark Bower

View Articletitled, Opposing roles of dendritic cell subsets in HIV-1 infection

TRANSPLANTATION

Weeding out dangerous alloresponses by graft engineering

John Barrett

View Articletitled, Weeding out dangerous alloresponses by graft engineering

STEM CELLS IN HEMATOLOGY

34 + 43 = early human blood lineage

Eric E. Bouhassira

View Articletitled, 34 + 43 = early human blood lineage

HEMOSTASIS

PDGFRβ: a multifaceted player in vascular and hematopoietic development

Zhenping Zhu

View Articletitled, PDGFRβ: a multifaceted player in vascular and hematopoietic development

HEMOSTASIS

Change erythrocytes into thrombolytic agents

Soichi Kojima

View Articletitled, Change erythrocytes into thrombolytic agents

IMMUNOBIOLOGY

KSHV wages a 2-front war on PECAM/CD31

Robert Yarchoan,Muzammel Haque

View Articletitled, KSHV wages a 2-front war on PECAM/CD31

NEOPLASIA

TCL1-induced germinal center B lymphomas in mice

Siegfried Janz

View Articletitled, TCL1-induced germinal center B lymphomas in mice

NEOPLASIA

Searching for polycythemia vera's Holy Grail

Ronald Hoffman

View Articletitled, Searching for polycythemia vera's Holy Grail

RED CELLS

ICAM-4 lands on the erythroblast island

James Palis

View Articletitled, ICAM-4 lands on the erythroblast island

IMMUNOBIOLOGY

Small mimotopes are big in identifying B-cell epitopes

Erika Jensen-Jarolim,Angelika B. Riemer

View Articletitled, Small mimotopes are big in identifying B-cell epitopes

HEMOSTASIS

γ-glutamyl carboxylation: squaring the vitamin K cycle

Martin J. Shearer

View Articletitled, γ-glutamyl carboxylation: squaring the vitamin K cycle

PLENARY PAPERS

Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation
Clinical Trials & Observations

Persis J. Amrolia,Giada Muccioli-Casadei,Helen Huls,Stuart Adams,April Durett,Adrian Gee,Eric Yvon,Heidi Weiss,Mark Cobbold,H. Bobby Gaspar,Cliona Rooney,Ingrid Kuehnle,Victor Ghetie,John Schindler,Robert Krance,Helen E. Heslop,Paul Veys,Ellen Vitetta,Malcolm K. Brenner

View Articletitled, Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation

REVIEW ARTICLES

Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet
Clinical Trials & Observations

Michele Baccarani,Giuseppe Saglio,John Goldman,Andreas Hochhaus,Bengt Simonsson,Frederick Appelbaum,Jane Apperley,Francisco Cervantes,Jorge Cortes,Michael Deininger,Alois Gratwohl,François Guilhot,Mary Horowitz,Timothy Hughes,Hagop Kantarjian,Richard Larson,Dietger Niederwieser,Richard Silver,Rudiger Hehlmann

View Articletitled, Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Transforming growth factor-β1 regulates macrophage migration via RhoA

Jun-Sub Kim,Jae-Gyu Kim,Mi-Young Moon,Chan-Young Jeon,Ha-Young Won,Hee-Jun Kim,Yee-Jin Jeon,Ji-Yeon Seo,Jong-Il Kim,Jaebong Kim,Jae-Yong Lee,Pyeung-Hyeun Kim,Jae-Bong Park

View Articletitled, Transforming growth factor-β1 regulates macrophage migration via RhoA

Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Evaluation of the safety and pharmacodynamics of Hematide, a novel erythropoietic agent, in a phase 1, double-blind, placebo-controlled, dose-escalation study in healthy volunteers
Clinical Trials & Observations

Richard B. Stead,John Lambert,Dawie Wessels,Julie S. Iwashita,Kerstin K. Leuther,Kathryn W. Woodburn,Peter J. Schatz,Douglas M. Okamoto,Robert Naso,Anne-Marie Duliege

View Articletitled, Evaluation of the safety and pharmacodynamics of Hematide, a novel erythropoietic agent, in a phase 1, double-blind, placebo-controlled, dose-escalation study in healthy volunteers

Survival benefit with imatinib mesylate versus interferon-α–based regimens in newly diagnosed chronic-phase chronic myelogenous leukemia
Clinical Trials & Observations

Hagop M. Kantarjian,Moshe Talpaz,Susan O'Brien,Daniel Jones,Francis Giles,Guillermo Garcia-Manero,Stefan Faderl,Farhad Ravandi,Mary Beth Rios,Jianqin Shan,Jorge Cortes

View Articletitled, Survival benefit with imatinib mesylate versus interferon-α–based regimens in newly diagnosed chronic-phase chronic myelogenous leukemia

ERRATA

Erratum for vol. 108, p. 407

View Articletitled, Erratum for vol. 108, p. 407

GENE THERAPY

Simple conditioning with monospecific CD4⁺CD25⁺ regulatory T cells for bone marrow engraftment and tolerance to multiple gene products

David-Alexandre Gross,Pascal Chappert,Marylene Leboeuf,Virginie Monteilhet,Laetitia Van Wittenberghe,Olivier Danos,Jean Davoust

View Articletitled, Simple conditioning with monospecific CD4+CD25+ regulatory T cells for bone marrow engraftment and tolerance to multiple gene products

HEMATOPOIESIS

Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophages

Masato Murakami,Shinobu Iwai,Sachie Hiratsuka,Mai Yamauchi,Kazuhide Nakamura,Yoichiro Iwakura,Masabumi Shibuya

View Articletitled, Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophages

Supplemental data

Adult murine hematopoiesis can proceed without β1 and β7 integrins

Gerd Bungartz,Sebastian Stiller,Martina Bauer,Werner Müller,Angela Schippers,Norbert Wagner,Reinhard Fässler,Cord Brakebusch

View Articletitled, Adult murine hematopoiesis can proceed without β1 and β7 integrins

Supplemental data

The JAK2-V617F mutation is frequently present at diagnosis in patients with essential thrombocythemia and polycythemia vera
Clinical Trials & Observations Brief Report

Eric Lippert,Marjorie Boissinot,Robert Kralovics,François Girodon,Irène Dobo,Vincent Praloran,Nathalie Boiret-Dupré,Radek C. Skoda,Sylvie Hermouet

View Articletitled, The JAK2-V617F mutation is frequently present at diagnosis in patients with essential thrombocythemia and polycythemia vera

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2

Cédric Sapet,Stéphanie Simoncini,Béatrice Loriod,Denis Puthier,José Sampol,Catherine Nguyen,Françoise Dignat-George,Francine Anfosso

View Articletitled, Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2

Supplemental data

Platelet-derived growth factor receptor-β promotes early endothelial cell differentiation

Charlotte Rolny,Ingrid Nilsson,Peetra Magnusson,Annika Armulik,Lars Jakobsson,Parri Wentzel,Per Lindblom,Jenny Norlin,Christer Betsholtz,Rainer Heuchel,Michael Welsh,Lena Claesson-Welsh

View Articletitled, Platelet-derived growth factor receptor-β promotes early endothelial cell differentiation

Analysis of fibrinogen variants at γ387Ile shows that the side chain of γ387 and the tertiary structure of the γC-terminal tail are important not only for assembly and secretion of fibrinogen but also for lateral aggregation of protofibrils and XIIIa-catalyzed γ-γ dimer formation

Satomi Kani,Fumiko Terasawa,Kazuyoshi Yamauchi,Minoru Tozuka,Nobuo Okumura

View Articletitled, Analysis of fibrinogen variants at γ387Ile shows that the side chain of γ387 and the tertiary structure of the γC-terminal tail are important not only for assembly and secretion of fibrinogen but also for lateral aggregation of protofibrils and XIIIa-catalyzed γ-γ dimer formation

Supplemental data

Human complement receptor type 1–directed loading of tissue plasminogen activator on circulating erythrocytes for prophylactic fibrinolysis

Sergei Zaitsev,Kristina Danielyan,Juan-Carlos Murciano,Kumkum Ganguly,Tatiana Krasik,Ronald P. Taylor,Steven Pincus,Steven Jones,Douglas B. Cines,Vladimir R. Muzykantov

View Articletitled, Human complement receptor type 1–directed loading of tissue plasminogen activator on circulating erythrocytes for prophylactic fibrinolysis

Activation-independent platelet adhesion and aggregation under elevated shear stress

Zaverio M. Ruggeri,Jennifer N. Orje,Rolf Habermann,Augusto B. Federici,Armin J. Reininger

View Articletitled, Activation-independent platelet adhesion and aggregation under elevated shear stress

Supplemental data

Impaired “outside-in” integrin α_IIbβ₃ signaling and thrombus stability in TSSC6-deficient mice

Matt W. Goschnick,Lai-Man Lau,Janet L. Wee,Yong S. Liu,P. Mark Hogarth,Lorraine M. Robb,Michael J. Hickey,Mark D. Wright,Denise E. Jackson

View Articletitled, Impaired “outside-in” integrin αIIbβ3 signaling and thrombus stability in TSSC6-deficient mice

A novel fibrinogen variant (fibrinogen Seoul II; AαGln328Pro) characterized by impaired fibrin α-chain cross-linking
Clinical Trials & Observations

Rojin Park,Hyun-Ju Doh,Seong-Soo A. An,Jong-Rak Choi,Kwang-Hoe Chung,Kyung-Soon Song

View Articletitled, A novel fibrinogen variant (fibrinogen Seoul II; AαGln328Pro) characterized by impaired fibrin α-chain cross-linking

Compound heterozygosity of novel missense mutations in the gamma-glutamyl-carboxylase gene causes hereditary combined vitamin K–dependent coagulation factor deficiency
Clinical Trials & Observations

Dhouha Darghouth,Kevin W. Hallgren,Rebecca L. Shtofman,Amel Mrad,Youssef Gharbi,Ahmed Maherzi,Radhia Kastally,Sophie LeRicousse,Kathleen L. Berkner,Jean-Philippe Rosa

View Articletitled, Compound heterozygosity of novel missense mutations in the gamma-glutamyl-carboxylase gene causes hereditary combined vitamin K–dependent coagulation factor deficiency

Supplemental data

IMMUNOBIOLOGY

Kaposi sarcoma herpesvirus K5 removes CD31/PECAM from endothelial cells

Mandana Mansouri,Janet Douglas,Patrick P. Rose,Kristine Gouveia,Gary Thomas,Robert E. Means,Ashlee V. Moses,Klaus Früh

View Articletitled, Kaposi sarcoma herpesvirus K5 removes CD31/PECAM from endothelial cells

Aire-deficient mice develop hematopoetic irregularities and marginal zone B-cell lymphoma

Signe Hässler,Chris Ramsey,Mikael C. Karlsson,Disa Larsson,Björn Herrmann,Björn Rozell,Magnus Backheden,Leena Peltonen,Olle Kämpe,Ola Winqvist

View Articletitled, Aire-deficient mice develop hematopoetic irregularities and marginal zone B-cell lymphoma

Supplemental data

Do CD8 effector cells need IL-7R expression to become resting memory cells?

Eva Buentke,Anne Mathiot,Mauro Tolaini,James Di Santo,Rose Zamoyska,Benedict Seddon

View Articletitled, Do CD8 effector cells need IL-7R expression to become resting memory cells?

Supplemental data

Opposing roles of blood myeloid and plasmacytoid dendritic cells in HIV-1 infection of T cells: transmission facilitation versus replication inhibition

Fedde Groot,Toni M. M. van Capel,Martien L. Kapsenberg,Ben Berkhout,Esther C. de Jong

View Articletitled, Opposing roles of blood myeloid and plasmacytoid dendritic cells in HIV-1 infection of T cells: transmission facilitation versus replication inhibition

Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)

David T. Teachey,Dana A. Obzut,Kelly Axsom,John K. Choi,Kelly C. Goldsmith,Junior Hall,Jessica Hulitt,Catherine S. Manno,John M. Maris,Nicholas Rhodin,Kathleen E. Sullivan,Valerie I. Brown,Stephan A. Grupp

View Articletitled, Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)

Supplemental data

Frequent antibody production against RARα in both APL mice and patients
Brief Report

Marie Robin,Juliette Andreu-Gallien,Marie-Helene Schlageter,Djaouida Bengoufa,Isabelle Guillemot,Katerina Pokorna,Carine Robert,Jerome Larghero,Philippe Rousselot,Emmanuel Raffoux,Herve Dombret,Pierre Fenaux,Marika Pla,Dominique Charron,Rose-Ann Padua,Christine Chomienne

View Articletitled, Frequent antibody production against RARα in both APL mice and patients

The epitope recognized by rituximab
Brief Report

Mascha Binder,Florian Otto,Roland Mertelsmann,Hendrik Veelken,Martin Trepel

View Articletitled, The epitope recognized by rituximab

NEOPLASIA

Immunoglobulin free light chains and solitary plasmacytoma of bone

David Dingli,Robert A. Kyle,S. Vincent Rajkumar,Grzegorz S. Nowakowski,Dirk R. Larson,John P. Bida,Morie A. Gertz,Terry M. Therneau,L. Joseph Melton, III,Angela Dispenzieri,Jerry A. Katzmann

View Articletitled, Immunoglobulin free light chains and solitary plasmacytoma of bone

Expression of the outcome predictor in acute leukemia 1 (OPAL1) gene is not an independent prognostic factor in patients treated according to COALL or St Jude protocols
Clinical Trials & Observations

Amy Holleman,Monique L. den Boer,Meyling H. Cheok,Karin M. Kazemier,Deqing Pei,James R. Downing,Gritta E. Janka-Schaub,Ulrich Göbel,Ulrike B. Graubner,Ching-Hon Pui,William E. Evans,Rob Pieters

View Articletitled, Expression of the outcome predictor in acute leukemia 1 (OPAL1) gene is not an independent prognostic factor in patients treated according to COALL or St Jude protocols

Dysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformation

Rhine R. Shen,David O. Ferguson,Mathilde Renard,Katrina K. Hoyer,Unkyu Kim,Xingpei Hao,Frederick W. Alt,Robert G. Roeder,Herbert C. Morse, III,Michael A. Teitell

View Articletitled, Dysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformation

Supplemental data

Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia
Clinical Trials & Observations

Brunangelo Falini,Maria Paola Martelli,Niccolò Bolli,Rossella Bonasso,Emanuela Ghia,Maria Teresa Pallotta,Daniela Diverio,Ildo Nicoletti,Roberta Pacini,Alessia Tabarrini,Barbara Verducci Galletti,Roberta Mannucci,Giovanni Roti,Roberto Rosati,Giorgina Specchia,Arcangelo Liso,Enrico Tiacci,Myriam Alcalay,Lucilla Luzi,Sara Volorio,Loris Bernard,Anna Guarini,Sergio Amadori,Franco Mandelli,Fabrizio Pane,Francesco Lo-Coco,Giuseppe Saglio,Pier-Giuseppe Pelicci,Massimo F. Martelli,Cristina Mecucci,for the GIMEMA Acute Leukemia Working Party

View Articletitled, Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia

Association of Ig/BCL6 translocations with germinal center B lymphocytes in human lymphoid tissues: implications for malignant transformation

Xuwei Yang,Koutetsu Lee,Jonathan Said,Xun Gong,Ke Zhang

View Articletitled, Association of Ig/BCL6 translocations with germinal center B lymphocytes in human lymphoid tissues: implications for malignant transformation

Supplemental data

Effects of paraprotein heavy and light chain types and free light chain load on survival in myeloma: an analysis of patients receiving conventional-dose chemotherapy in Medical Research Council UK multiple myeloma trials
Clinical Trials & Observations

Mark Drayson,Gulnaz Begum,Supratik Basu,Sudhaker Makkuni,Janet Dunn,Nicola Barth,J. Anthony Child

View Articletitled, Effects of paraprotein heavy and light chain types and free light chain load on survival in myeloma: an analysis of patients receiving conventional-dose chemotherapy in Medical Research Council UK multiple myeloma trials

The molecular classification of multiple myeloma
Clinical Trials & Observations

Fenghuang Zhan,Yongsheng Huang,Simona Colla,James P. Stewart,Ichiro Hanamura,Sushil Gupta,Joshua Epstein,Shmuel Yaccoby,Jeffrey Sawyer,Bart Burington,Elias Anaissie,Klaus Hollmig,Mauricio Pineda-Roman,Guido Tricot,Frits van Rhee,Ronald Walker,Maurizio Zangari,John Crowley,Bart Barlogie,John D. Shaughnessy, Jr

View Articletitled, The molecular classification of multiple myeloma

Supplemental data

NPM-ALK–dependent expression of the transcription factor CCAAT/enhancer binding protein β in ALK-positive anaplastic large cell lymphoma

Leticia Quintanilla-Martinez,Stefania Pittaluga,Cornelius Miething,Margit Klier,Martina Rudelius,Theresa Davies-Hill,Natasa Anastasov,Antonio Martinez,Angelica Vivero,Justus Duyster,Elaine S. Jaffe,Falko Fend,Mark Raffeld

View Articletitled, NPM-ALK–dependent expression of the transcription factor CCAAT/enhancer binding protein β in ALK-positive anaplastic large cell lymphoma

High molecular response rate of polycythemia vera patients treated with pegylated interferon α–2a
Clinical Trials & Observations Brief Report

Jean-Jacques Kiladjian,Bruno Cassinat,Pascal Turlure,Nathalie Cambier,Murielle Roussel,Sylvia Bellucci,Marie-Laurence Menot,Gerald Massonnet,Jean-Luc Dutel,Kamel Ghomari,Philippe Rousselot,Marie-Jose Grange,Yasmina Chait,William Vainchenker,Nathalie Parquet,Lina Abdelkader-Aljassem,Jean-François Bernard,Jean-Didier Rain,Sylvie Chevret,Christine Chomienne,Pierre Fenaux

View Articletitled, High molecular response rate of polycythemia vera patients treated with pegylated interferon α–2a

Somatic activation of a conditional Kras^G12D allele causes ineffective erythropoiesis in vivo
Brief Report

Benjamin S. Braun,Joehleen A. Archard,Jessica A. G. Van Ziffle,David A. Tuveson,Tyler E. Jacks,Kevin Shannon

View Articletitled, Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo

Supplemental data

PHAGOCYTES

Tissue-transglutaminase contributes to neutrophil granulocyte differentiation and functions

Zoltán Balajthy,Krisztián Csomós,György Vámosi,Attila Szántó,Michel Lanotte,László Fésüs

View Articletitled, Tissue-transglutaminase contributes to neutrophil granulocyte differentiation and functions

Kinin receptor expression during Staphylococcus aureus infection

Sara H. Bengtson,Stephen B. Phagoo,Anna Norrby-Teglund,Lisa Påhlman,Matthias Mörgelin,Bruce L. Zuraw,L. M. Fredrik Leeb-Lundberg,Heiko Herwald

View Articletitled, Kinin receptor expression during Staphylococcus aureus infection

RED CELLS

Targeted gene deletion demonstrates that the cell adhesion molecule ICAM-4 is critical for erythroblastic island formation

Gloria Lee,Annie Lo,Sarah A. Short,Tosti J. Mankelow,Frances Spring,Stephen F. Parsons,Karina Yazdanbakhsh,Narla Mohandas,David J. Anstee,Joel Anne Chasis

View Articletitled, Targeted gene deletion demonstrates that the cell adhesion molecule ICAM-4 is critical for erythroblastic island formation

Evidence for subcomplexes in the Fanconi anemia pathway

Annette L. Medhurst,El Houari Laghmani,Jurgen Steltenpool,Miriam Ferrer,Chantal Fontaine,Jan de Groot,Martin A. Rooimans,Rik J. Scheper,Amom Ruhikanta Meetei,Weidong Wang,Hans Joenje,Johan P. de Winter

View Articletitled, Evidence for subcomplexes in the Fanconi anemia pathway

Fetal hemoglobin silencing in humans

Patricia A. Oneal,Nicole M. Gantt,Joseph D. Schwartz,Natarajan V. Bhanu,Y. Terry Lee,John W. Moroney,Christopher H. Reed,Alan N. Schechter,Naomi L. C. Luban,Jeffery L. Miller

View Articletitled, Fetal hemoglobin silencing in humans

Supplemental data

STEM CELLS IN HEMATOLOGY

Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment

Gabriel Ghiaur,Andrew Lee,Jeff Bailey,Jose A. Cancelas,Yi Zheng,David A. Williams

View Articletitled, Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment

Supplemental data

Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation cultures

Maxim A. Vodyanik,James A. Thomson,Igor I. Slukvin

View Articletitled, Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation cultures

Supplemental data

TRANSPLANTATION

Host MHC class II⁺ antigen-presenting cells and CD4 cells are required for CD8-mediated graft-versus-leukemia responses following delayed donor leukocyte infusions

Ronjon Chakraverty,Hyeon-Seok Eom,Jessica Sachs,Jennifer Buchli,Pete Cotter,Richard Hsu,Guiling Zhao,Megan Sykes

View Articletitled, Host MHC class II+ antigen-presenting cells and CD4 cells are required for CD8-mediated graft-versus-leukemia responses following delayed donor leukocyte infusions

Supplemental data

Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting

Alma J. Nauta,Geert Westerhuis,Alwine B. Kruisselbrink,Ellie G. A. Lurvink,Roel Willemze,Willem E. Fibbe

View Articletitled, Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting

Short-term repopulating cells with myeloid potential in human mobilized peripheral blood do not have a side population (SP) phenotype
Brief Report

Marlene Fischer,Manfred Schmidt,Silke Klingenberg,Connie J. Eaves,Christof von Kalle,Hanno Glimm

View Articletitled, Short-term repopulating cells with myeloid potential in human mobilized peripheral blood do not have a side population (SP) phenotype

Serial transplantation of mismatched donor hematopoietic cells between HLA-identical sibling pairs with congenital immunodeficiency: in vivo tolerance permits rapid immune reconstitution following T-replete transplantation without GVHD in the secondary recipient
Clinical Trials & Observations Brief Report

Jonathan M. Cohen,Valerie Rogers,H. Bobby Gaspar,Alison Jones,E. Graham Davies,Kanchan Rao,Daniel J. McCloskey,Kimberley Gilmour,Robert Wynn,Persis J. Amrolia,Paul Veys

View Articletitled, Serial transplantation of mismatched donor hematopoietic cells between HLA-identical sibling pairs with congenital immunodeficiency: in vivo tolerance permits rapid immune reconstitution following T-replete transplantation without GVHD in the secondary recipient

Autologous graft-versus-host disease–like syndrome after an alemtuzumab-containing conditioning regimen and autologous stem cell transplantation for chronic lymphocytic leukemia
Brief Report

Thorsten Zenz,Matthias Ritgen,Peter Dreger,Alexander Kröber,Thomas F. Barth,Richard Schlenk,Sebastian Böttcher,Michael J. Hallek,Michael Kneba,Donald Bunjes,Hartmut Döhner,Stephan Stilgenbauer

View Articletitled, Autologous graft-versus-host disease–like syndrome after an alemtuzumab-containing conditioning regimen and autologous stem cell transplantation for chronic lymphocytic leukemia

Supplemental data

CORRESPONDENCE

Altitude above sea level as a variable for definition of anemia

Guillermo J. Ruíz-Argüelles

View Articletitled, Altitude above sea level as a variable for definition of anemia

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Issue Archive

Table of Contents

INSIDE BLOOD

PLENARY PAPERS

Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation Clinical Trials & Observations

REVIEW ARTICLES

Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet Clinical Trials & Observations

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

CLINICAL TRIALS AND OBSERVATIONS

Evaluation of the safety and pharmacodynamics of Hematide, a novel erythropoietic agent, in a phase 1, double-blind, placebo-controlled, dose-escalation study in healthy volunteers Clinical Trials & Observations

Survival benefit with imatinib mesylate versus interferon-α–based regimens in newly diagnosed chronic-phase chronic myelogenous leukemia Clinical Trials & Observations

ERRATA

GENE THERAPY

HEMATOPOIESIS

The JAK2-V617F mutation is frequently present at diagnosis in patients with essential thrombocythemia and polycythemia vera Clinical Trials & Observations Brief Report

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

A novel fibrinogen variant (fibrinogen Seoul II; AαGln328Pro) characterized by impaired fibrin α-chain cross-linking Clinical Trials & Observations

Compound heterozygosity of novel missense mutations in the gamma-glutamyl-carboxylase gene causes hereditary combined vitamin K–dependent coagulation factor deficiency Clinical Trials & Observations

IMMUNOBIOLOGY

Frequent antibody production against RARα in both APL mice and patients Brief Report

The epitope recognized by rituximab Brief Report

NEOPLASIA

Expression of the outcome predictor in acute leukemia 1 (OPAL1) gene is not an independent prognostic factor in patients treated according to COALL or St Jude protocols Clinical Trials & Observations

Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia Clinical Trials & Observations

Effects of paraprotein heavy and light chain types and free light chain load on survival in myeloma: an analysis of patients receiving conventional-dose chemotherapy in Medical Research Council UK multiple myeloma trials Clinical Trials & Observations

The molecular classification of multiple myeloma Clinical Trials & Observations

High molecular response rate of polycythemia vera patients treated with pegylated interferon α–2a Clinical Trials & Observations Brief Report

Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo Brief Report

PHAGOCYTES

RED CELLS

STEM CELLS IN HEMATOLOGY

TRANSPLANTATION

Short-term repopulating cells with myeloid potential in human mobilized peripheral blood do not have a side population (SP) phenotype Brief Report

Autologous graft-versus-host disease–like syndrome after an alemtuzumab-containing conditioning regimen and autologous stem cell transplantation for chronic lymphocytic leukemia Brief Report

CORRESPONDENCE

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Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation
Clinical Trials & Observations

Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet
Clinical Trials & Observations

Evaluation of the safety and pharmacodynamics of Hematide, a novel erythropoietic agent, in a phase 1, double-blind, placebo-controlled, dose-escalation study in healthy volunteers
Clinical Trials & Observations

Survival benefit with imatinib mesylate versus interferon-α–based regimens in newly diagnosed chronic-phase chronic myelogenous leukemia
Clinical Trials & Observations

The JAK2-V617F mutation is frequently present at diagnosis in patients with essential thrombocythemia and polycythemia vera
Clinical Trials & Observations Brief Report

A novel fibrinogen variant (fibrinogen Seoul II; AαGln328Pro) characterized by impaired fibrin α-chain cross-linking
Clinical Trials & Observations

Compound heterozygosity of novel missense mutations in the gamma-glutamyl-carboxylase gene causes hereditary combined vitamin K–dependent coagulation factor deficiency
Clinical Trials & Observations

Frequent antibody production against RARα in both APL mice and patients
Brief Report

The epitope recognized by rituximab
Brief Report

Expression of the outcome predictor in acute leukemia 1 (OPAL1) gene is not an independent prognostic factor in patients treated according to COALL or St Jude protocols
Clinical Trials & Observations

Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia
Clinical Trials & Observations

Effects of paraprotein heavy and light chain types and free light chain load on survival in myeloma: an analysis of patients receiving conventional-dose chemotherapy in Medical Research Council UK multiple myeloma trials
Clinical Trials & Observations

The molecular classification of multiple myeloma
Clinical Trials & Observations

High molecular response rate of polycythemia vera patients treated with pegylated interferon α–2a
Clinical Trials & Observations Brief Report

Somatic activation of a conditional Kras^G12D allele causes ineffective erythropoiesis in vivo
Brief Report

Short-term repopulating cells with myeloid potential in human mobilized peripheral blood do not have a side population (SP) phenotype
Brief Report

Autologous graft-versus-host disease–like syndrome after an alemtuzumab-containing conditioning regimen and autologous stem cell transplantation for chronic lymphocytic leukemia
Brief Report