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Volume 108, Issue 4

August 15 2006

In this Issue

INSIDE BLOOD
PLENARY PAPERS
ERRATA
REVIEW ARTICLES
REVIEW IN TRANSLATIONAL HEMATOLOGY
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
CLINICAL TRIALS AND OBSERVATIONS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
RED CELLS
TRANSPLANTATION

INSIDE BLOOD

NEOPLASIA

Of mice and men...

John G. Gribben

View Articletitled, Of mice and men...

NEOPLASIA

Imatinib and ABCG2: who controls whom?

Junia V. Melo

View Articletitled, Imatinib and ABCG2: who controls whom?

CLINICAL TRIALS AND OBSERVATIONS

NOTCH1: prognostic factor or molecular target?
Clinical Trials & Observations

Stephen P. Hunger

View Articletitled, NOTCH1: prognostic factor or molecular target?

CLINICAL TRIALS AND OBSERVATIONS

Lenalidomide and the 3 Ms: déjà vu all over again?
Clinical Trials & Observations

Jerry L. Spivak

View Articletitled, Lenalidomide and the 3 Ms: déjà vu all over again?

HEMATOPOIESIS

Knocking the Sox off EPO signaling

Kevin D. Bunting

View Articletitled, Knocking the Sox off EPO signaling

HEMATOPOIESIS

Battling bone marrow B-lineage cells

Tucker W. LeBien

View Articletitled, Battling bone marrow B-lineage cells

RED CELLS

A lack of border guards?

William G. Wood,Douglas R. Higgs

View Articletitled, A lack of border guards?

IMMUNOBIOLOGY

Donor Foxp3-positive T cells: the missing link

Allan D. Hess

View Articletitled, Donor Foxp3-positive T cells: the missing link

PLENARY PAPERS

Competition within the early B-cell compartment conditions B-cell reconstitution after hematopoietic stem cell transplantation in nonirradiated recipients

Allen Liu,Christian A. J. Vosshenrich,Chantal Lagresle-Peyrou,Michele Malassis-Seris,Christophe Hue,Alain Fischer,James P. Di Santo,Marina Cavazzana-Calvo

View Articletitled, Competition within the early B-cell compartment conditions B-cell reconstitution after hematopoietic stem cell transplantation in nonirradiated recipients

ERRATA

Erratum for vol. 108, p. 337

View Articletitled, Erratum for vol. 108, p. 337

REVIEW ARTICLES

Natural history of cerebral vein thrombosis: a systematic review
Clinical Trials & Observations

Francesco Dentali,Monica Gianni,Mark A. Crowther,Walter Ageno

View Articletitled, Natural history of cerebral vein thrombosis: a systematic review

REVIEW IN TRANSLATIONAL HEMATOLOGY

In-tandem insight from basic science combined with clinical research: CD38 as both marker and key component of the pathogenetic network underlying chronic lymphocytic leukemia
Clinical Trials & Observations

Silvia Deaglio,Tiziana Vaisitti,Semra Aydin,Enza Ferrero,Fabio Malavasi

View Articletitled, In-tandem insight from basic science combined with clinical research: CD38 as both marker and key component of the pathogenetic network underlying chronic lymphocytic leukemia

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

The Src kinase Lyn is required for CCR5 signaling in response to MIP-1β and R5 HIV-1 gp120 in human macrophages

Brian Tomkowicz,Chuhee Lee,Vipa Ravyn,Ricky Cheung,Andrzej Ptasznik,Ronald G. Collman

View Articletitled, The Src kinase Lyn is required for CCR5 signaling in response to MIP-1β and R5 HIV-1 gp120 in human macrophages

CLINICAL TRIALS AND OBSERVATIONS

Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia
Clinical Trials & Observations

Stephen Breit,Martin Stanulla,Thomas Flohr,Martin Schrappe,Wolf-Dieter Ludwig,Gabriele Tolle,Margit Happich,Martina U. Muckenthaler,Andreas E. Kulozik

View Articletitled, Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia

Supplemental data

Lenalidomide therapy in myelofibrosis with myeloid metaplasia
Clinical Trials & Observations

Ayalew Tefferi,Jorge Cortes,Srdan Verstovsek,Ruben A. Mesa,Deborah Thomas,Terra L. Lasho,William J. Hogan,Mark R. Litzow,Jacob B. Allred,Dan Jones,Catriona Byrne,Jerome B. Zeldis,Rhett P. Ketterling,Rebecca F. McClure,Francis Giles,Hagop M. Kantarjian

View Articletitled, Lenalidomide therapy in myelofibrosis with myeloid metaplasia

Intrathecal triple therapy decreases central nervous system relapse but fails to improve event-free survival when compared with intrathecal methotrexate: results of the Children's Cancer Group (CCG) 1952 study for standard-risk acute lymphoblastic leukemia, reported by the Children's Oncology Group
Clinical Trials & Observations

Yousif Matloub,Susan Lindemulder,Paul S. Gaynon,Harland Sather,Mei La,Emmett Broxson,Rochelle Yanofsky,Raymond Hutchinson,Nyla A. Heerema,James Nachman,Marilyn Blake,Linda M. Wells,April D. Sorrell,Margaret Masterson,John F. Kelleher,Linda C. Stork

View Articletitled, Intrathecal triple therapy decreases central nervous system relapse but fails to improve event-free survival when compared with intrathecal methotrexate: results of the Children's Cancer Group (CCG) 1952 study for standard-risk acute lymphoblastic leukemia, reported by the Children's Oncology Group

Antileukemia activity of the combination of an anthracycline with a histone deacetylase inhibitor
Clinical Trials & Observations

Blanca Sanchez-Gonzalez,Hui Yang,Carlos Bueso-Ramos,Koyu Hoshino,Alfonso Quintas-Cardama,Victoria M. Richon,Guillermo Garcia-Manero

View Articletitled, Antileukemia activity of the combination of an anthracycline with a histone deacetylase inhibitor

Supplemental data

GENE THERAPY

Correction of sickle cell disease by homologous recombination in embryonic stem cells

Li-Chen Wu,Chiao-Wang Sun,Thomas M. Ryan,Kevin M. Pawlik,Jinxiang Ren,Tim M. Townes

View Articletitled, Correction of sickle cell disease by homologous recombination in embryonic stem cells

HEMATOPOIESIS

Endothelial stroma programs hematopoietic stem cells to differentiate into regulatory dendritic cells through IL-10

Hua Tang,Zhenhong Guo,Minghui Zhang,Jianli Wang,Guoyou Chen,Xuetao Cao

View Articletitled, Endothelial stroma programs hematopoietic stem cells to differentiate into regulatory dendritic cells through IL-10

Supplemental data

Sox6 cell-autonomously stimulates erythroid cell survival, proliferation, and terminal maturation and is thereby an important enhancer of definitive erythropoiesis during mouse development

Bogdan Dumitriu,Michael R. Patrick,Jane P. Petschek,Srujana Cherukuri,Ursula Klingmuller,Paul L. Fox,Véronique Lefebvre

View Articletitled, Sox6 cell-autonomously stimulates erythroid cell survival, proliferation, and terminal maturation and is thereby an important enhancer of definitive erythropoiesis during mouse development

Unique effects of Stat3 on the early phase of hematopoietic stem cell regeneration

Yang-Jo Chung,Bo-Bae Park,Young-Ju Kang,Tae-min Kim,Connie J. Eaves,Il-Hoan Oh

View Articletitled, Unique effects of Stat3 on the early phase of hematopoietic stem cell regeneration

Supplemental data

Increasing Flt3L availability alters composition of a novel bone marrow lymphoid progenitor compartment

Rhodri Ceredig,Melanie Rauch,Gina Balciunaite,Antonius G. Rolink

View Articletitled, Increasing Flt3L availability alters composition of a novel bone marrow lymphoid progenitor compartment

C/EBPα directs monocytic commitment of primary myeloid progenitors

Dehua Wang,Jenice D'Costa,Curt I. Civin,Alan D. Friedman

View Articletitled, C/EBPα directs monocytic commitment of primary myeloid progenitors

The p67 laminin receptor identifies human erythroid progenitor and precursor cells and is functionally important for their bone marrow lodgment
Brief Report

Halvard Bonig,Kai-Hsin Chang,Betty Nakamoto,Thalia Papayannopoulou

View Articletitled, The p67 laminin receptor identifies human erythroid progenitor and precursor cells and is functionally important for their bone marrow lodgment

Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

A monoclonal antibody against CD148, a receptor-like tyrosine phosphatase, inhibits endothelial-cell growth and angiogenesis

Takamune Takahashi,Keiko Takahashi,Raymond L. Mernaugh,Nobuo Tsuboi,Hua Liu,Thomas O. Daniel

View Articletitled, A monoclonal antibody against CD148, a receptor-like tyrosine phosphatase, inhibits endothelial-cell growth and angiogenesis

Supplemental data

Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration

Benoit Favier,Antoine Alam,Pauline Barron,Jacques Bonnin,Patricia Laboudie,Pierre Fons,Marie Mandron,Jean-Pascal Herault,Gera Neufeld,Pierre Savi,Jean-Marc Herbert,Françoise Bono

View Articletitled, Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration

Supplemental data

Role of a 5′-enhancer in the transcriptional regulation of the human endothelial cell protein C receptor gene

Luigina R. Mollica,James T. B. Crawley,Ke Liu,James B. Rance,Peter N. Cockerill,George A. Follows,Josette-Renee Landry,Dominic J. Wells,David A. Lane

View Articletitled, Role of a 5′-enhancer in the transcriptional regulation of the human endothelial cell protein C receptor gene

Supplemental data

Hepatocyte growth factor mediates angiopoietin-induced smooth muscle cell recruitment

Hanako Kobayashi,Laura M. DeBusk,Yael O. Babichev,Daniel J. Dumont,Pengnian Charles Lin

View Articletitled, Hepatocyte growth factor mediates angiopoietin-induced smooth muscle cell recruitment

Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome
Clinical Trials & Observations

Jessica Caprioli,Marina Noris,Simona Brioschi,Gaia Pianetti,Federica Castelletti,Paola Bettinaglio,Caterina Mele,Elena Bresin,Linda Cassis,Sara Gamba,Francesca Porrati,Sara Bucchioni,Giuseppe Monteferrante,Celia J. Fang,M. K. Liszewski,David Kavanagh,John P. Atkinson,Giuseppe Remuzzi,for the International Registry of Recurrent and Familial HUS/TTP

View Articletitled, Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome

The thrombospondin-1 N700S polymorphism is associated with early myocardial infarction without altering von Willebrand factor multimer size
Clinical Trials & Observations

Jeffrey I. Zwicker,Flora Peyvandi,Roberta Palla,Rossana Lombardi,Maria Teresa Canciani,Andrea Cairo,Diego Ardissino,Luisa Bernardinelli,Kenneth A. Bauer,Jack Lawler,Pier Mannucci

View Articletitled, The thrombospondin-1 N700S polymorphism is associated with early myocardial infarction without altering von Willebrand factor multimer size

IMMUNOBIOLOGY

Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells

Ofer Levy,Eugénie E. Suter,Richard L. Miller,Michael R. Wessels

View Articletitled, Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells

Supplemental data

High donor FOXP3-positive regulatory T-cell (T_reg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT

Katayoun Rezvani,Stephan Mielke,Mojgan Ahmadzadeh,Yasemin Kilical,Bipin N. Savani,Josette Zeilah,Keyvan Keyvanfar,Aldemar Montero,Nancy Hensel,Roger Kurlander,A. John Barrett

View Articletitled, High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT

Antigen targeting to endosomal pathway in dendritic cell vaccination activates regulatory T cells and attenuates tumor immunity

Mikael Maksimow,Mari Miiluniemi,Fumiko Marttila-Ichihara,Sirpa Jalkanen,Arno Hänninen

View Articletitled, Antigen targeting to endosomal pathway in dendritic cell vaccination activates regulatory T cells and attenuates tumor immunity

A homozygous Fas ligand gene mutation in a patient causes a new type of autoimmune lymphoproliferative syndrome
Clinical Trials & Observations

Manuel Del-Rey,Jesus Ruiz-Contreras,Alberto Bosque,Sara Calleja,Jose Gomez-Rial,Ernesto Roldan,Pablo Morales,Antonio Serrano,Alberto Anel,Estela Paz-Artal,Luis M. Allende

View Articletitled, A homozygous Fas ligand gene mutation in a patient causes a new type of autoimmune lymphoproliferative syndrome

ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15

Claire L. Sutherland,Brian Rabinovich,N. Jan Chalupny,Pierre Brawand,Robert Miller,David Cosman

View Articletitled, ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15

Abnormal disulfide-linked oligomerization results in ER retention and altered signaling by TNFR1 mutants in TNFR1-associated periodic fever syndrome (TRAPS)

Adrian A. Lobito,Fiona C. Kimberley,Jagan R. Muppidi,Hirsh Komarow,Adrianna J. Jackson,Keith M. Hull,Daniel L. Kastner,Gavin R. Screaton,Richard M. Siegel

View Articletitled, Abnormal disulfide-linked oligomerization results in ER retention and altered signaling by TNFR1 mutants in TNFR1-associated periodic fever syndrome (TRAPS)

Supplemental data

NEOPLASIA

Bcr-Abl resistance screening predicts a limited spectrum of point mutations to be associated with clinical resistance to the Abl kinase inhibitor nilotinib (AMN107)

Nikolas von Bubnoff,Paul W. Manley,Jurgen Mestan,Jana Sanger,Christian Peschel,Justus Duyster

View Articletitled, Bcr-Abl resistance screening predicts a limited spectrum of point mutations to be associated with clinical resistance to the Abl kinase inhibitor nilotinib (AMN107)

Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia

Amy J. Johnson,David M. Lucas,Natarajan Muthusamy,Lisa L. Smith,Ryan B. Edwards,Michael D. De Lay,Carlo M. Croce,Michael R. Grever,John C. Byrd

View Articletitled, Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia

Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD

Jennifer L. Rocnik,Rachel Okabe,Jin-Chen Yu,Benjamin H. Lee,Neill Giese,David P. Schenkein,D. Gary Gilliland

View Articletitled, Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD

Supplemental data

Mcl-1L cleavage is involved in TRAIL-R1– and TRAIL-R2–mediated apoptosis induced by HGS-ETR1 and HGS-ETR2 human mAbs in myeloma cells

Emmanuelle Menoret,Patricia Gomez-Bougie,Alexandrine Geffroy-Luseau,Sylvanne Daniels,Philippe Moreau,Steven Le Gouill,Jean-Luc Harousseau,Regis Bataille,Martine Amiot,Catherine Pellat-Deceunynck

View Articletitled, Mcl-1L cleavage is involved in TRAIL-R1– and TRAIL-R2–mediated apoptosis induced by HGS-ETR1 and HGS-ETR2 human mAbs in myeloma cells

Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBPα

Giovanna Ferrari-Amorotti,Karen Keeshan,Michela Zattoni,Clara Guerzoni,Giorgio Iotti,Sara Cattelani,Nick J. Donato,Bruno Calabretta

View Articletitled, Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBPα

Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma
Clinical Trials & Observations

Brian C.-H. Chiu,Bhavana J. Dave,Aaron Blair,Susan M. Gapstur,Shelia Hoar Zahm,Dennis D. Weisenburger

View Articletitled, Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma

Functional ABCG2 is overexpressed on primary CML CD34⁺ cells and is inhibited by imatinib mesylate
Brief Report

Niove E. Jordanides,Heather G. Jorgensen,Tessa L. Holyoake,Joanne C. Mountford

View Articletitled, Functional ABCG2 is overexpressed on primary CML CD34+ cells and is inhibited by imatinib mesylate

Sorafenib is a potent inhibitor of FIP1L1-PDGFRα and the imatinib-resistant FIP1L1-PDGFRα T674I mutant
Brief Report

Els Lierman,Cedric Folens,Elizabeth H. Stover,Nicole Mentens,Helen Van Miegroet,Werner Scheers,Marc Boogaerts,Peter Vandenberghe,Peter Marynen,Jan Cools

View Articletitled, Sorafenib is a potent inhibitor of FIP1L1-PDGFRα and the imatinib-resistant FIP1L1-PDGFRα T674I mutant

Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders
Brief Report

Robert Kralovics,Soon-Siong Teo,Sai Li,Alexandre Theocharides,Andreas S. Buser,Andre Tichelli,Radek C. Skoda

View Articletitled, Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders

Supplemental data

RED CELLS

Detection of serum hepcidin in renal failure and inflammation by using ProteinChip System

Naohisa Tomosugi,Hiroshi Kawabata,Rumi Wakatabe,Masato Higuchi,Hideki Yamaya,Hisanori Umehara,Isao Ishikawa

View Articletitled, Detection of serum hepcidin in renal failure and inflammation by using ProteinChip System

Supplemental data

The Steap proteins are metalloreductases

Robert S. Ohgami,Dean R. Campagna,Alice McDonald,Mark D. Fleming

View Articletitled, The Steap proteins are metalloreductases

Supplemental data

Flanking HS-62.5 and 3′ HS1, and regions upstream of the LCR, are not required for β-globin transcription

M. A. Bender,Rachel Byron,Tobias Ragoczy,Agnes Telling,Michael Bulger,Mark Groudine

View Articletitled, Flanking HS-62.5 and 3′ HS1, and regions upstream of the LCR, are not required for β-globin transcription

Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis

Jeanne-Claire Lesbordes-Brion,Lydie Viatte,Myriam Bennoun,Dan-Qing Lou,Guillemette Ramey,Christophe Houbron,Ghislaine Hamard,Axel Kahn,Sophie Vaulont

View Articletitled, Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis

TRANSPLANTATION

Prospective simultaneous quantification of human cytomegalovirus-specific CD4⁺ and CD8⁺ T-cell reconstitution in young recipients of allogeneic hematopoietic stem cell transplants
Clinical Trials & Observations

Daniele Lilleri,Giuseppe Gerna,Chiara Fornara,Laura Lozza,Rita Maccario,Franco Locatelli

View Articletitled, Prospective simultaneous quantification of human cytomegalovirus-specific CD4+ and CD8+ T-cell reconstitution in young recipients of allogeneic hematopoietic stem cell transplants

Simultaneous bone marrow and intestine transplantation promotes marrow-derived hematopoietic stem cell engraftment and chimerism

Atsunori Nakao,Hideyoshi Toyokawa,Kei Kimizuka,Michael A. Nalesnik,Isao Nozaki,Robert J. Bailey,Anthony J. Demetris,Thomas E. Starzl,Noriko Murase

View Articletitled, Simultaneous bone marrow and intestine transplantation promotes marrow-derived hematopoietic stem cell engraftment and chimerism

Allogeneic stem cell transplantation for patients with chronic myeloid leukemia and acute lymphocytic leukemia after Bcr-Abl kinase mutation–related imatinib failure
Clinical Trials & Observations Brief Report

Elias Jabbour,Jorge Cortes,Hagop M. Kantarjian,Sergio Giralt,Dan Jones,Roy Jones,Francis Giles,Borje S. Andersson,Richard Champlin,Marcos de Lima

View Articletitled, Allogeneic stem cell transplantation for patients with chronic myeloid leukemia and acute lymphocytic leukemia after Bcr-Abl kinase mutation–related imatinib failure

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Table of Contents
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Issue Archive

Table of Contents

INSIDE BLOOD

NOTCH1: prognostic factor or molecular target? Clinical Trials & Observations

Lenalidomide and the 3 Ms: déjà vu all over again? Clinical Trials & Observations

PLENARY PAPERS

ERRATA

REVIEW ARTICLES

Natural history of cerebral vein thrombosis: a systematic review Clinical Trials & Observations

REVIEW IN TRANSLATIONAL HEMATOLOGY

In-tandem insight from basic science combined with clinical research: CD38 as both marker and key component of the pathogenetic network underlying chronic lymphocytic leukemia Clinical Trials & Observations

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

CLINICAL TRIALS AND OBSERVATIONS

Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia Clinical Trials & Observations

Lenalidomide therapy in myelofibrosis with myeloid metaplasia Clinical Trials & Observations

Antileukemia activity of the combination of an anthracycline with a histone deacetylase inhibitor Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

The p67 laminin receptor identifies human erythroid progenitor and precursor cells and is functionally important for their bone marrow lodgment Brief Report

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome Clinical Trials & Observations

The thrombospondin-1 N700S polymorphism is associated with early myocardial infarction without altering von Willebrand factor multimer size Clinical Trials & Observations

IMMUNOBIOLOGY

A homozygous Fas ligand gene mutation in a patient causes a new type of autoimmune lymphoproliferative syndrome Clinical Trials & Observations

NEOPLASIA

Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma Clinical Trials & Observations

Functional ABCG2 is overexpressed on primary CML CD34+ cells and is inhibited by imatinib mesylate Brief Report

Sorafenib is a potent inhibitor of FIP1L1-PDGFRα and the imatinib-resistant FIP1L1-PDGFRα T674I mutant Brief Report

Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders Brief Report

RED CELLS

TRANSPLANTATION

Prospective simultaneous quantification of human cytomegalovirus-specific CD4+ and CD8+ T-cell reconstitution in young recipients of allogeneic hematopoietic stem cell transplants Clinical Trials & Observations

Allogeneic stem cell transplantation for patients with chronic myeloid leukemia and acute lymphocytic leukemia after Bcr-Abl kinase mutation–related imatinib failure Clinical Trials & Observations Brief Report

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NOTCH1: prognostic factor or molecular target?
Clinical Trials & Observations

Lenalidomide and the 3 Ms: déjà vu all over again?
Clinical Trials & Observations

Natural history of cerebral vein thrombosis: a systematic review
Clinical Trials & Observations

In-tandem insight from basic science combined with clinical research: CD38 as both marker and key component of the pathogenetic network underlying chronic lymphocytic leukemia
Clinical Trials & Observations

Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia
Clinical Trials & Observations

Lenalidomide therapy in myelofibrosis with myeloid metaplasia
Clinical Trials & Observations

Antileukemia activity of the combination of an anthracycline with a histone deacetylase inhibitor
Clinical Trials & Observations

The p67 laminin receptor identifies human erythroid progenitor and precursor cells and is functionally important for their bone marrow lodgment
Brief Report

Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome
Clinical Trials & Observations

The thrombospondin-1 N700S polymorphism is associated with early myocardial infarction without altering von Willebrand factor multimer size
Clinical Trials & Observations

A homozygous Fas ligand gene mutation in a patient causes a new type of autoimmune lymphoproliferative syndrome
Clinical Trials & Observations

Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma
Clinical Trials & Observations

Functional ABCG2 is overexpressed on primary CML CD34⁺ cells and is inhibited by imatinib mesylate
Brief Report

Sorafenib is a potent inhibitor of FIP1L1-PDGFRα and the imatinib-resistant FIP1L1-PDGFRα T674I mutant
Brief Report

Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders
Brief Report

Prospective simultaneous quantification of human cytomegalovirus-specific CD4⁺ and CD8⁺ T-cell reconstitution in young recipients of allogeneic hematopoietic stem cell transplants
Clinical Trials & Observations

Allogeneic stem cell transplantation for patients with chronic myeloid leukemia and acute lymphocytic leukemia after Bcr-Abl kinase mutation–related imatinib failure
Clinical Trials & Observations Brief Report