Issue Archive

INSIDE BLOOD

CLINICAL TRIALS AND OBSERVATIONS

An endothelial metronome breast cancer?

Clinical Trials & Observations

Karen L. MacKenzie,Richard B. Lock

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IMMUNOBIOLOGY

Macrophage diversity and polarization: in vivo veritas

Alberto Mantovani

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IMMUNOBIOLOGY

Time to restore individual rights for IL-2 and IL-15?

Yutaka Tagaya

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IMMUNOBIOLOGY

Per aspera ad astra: from early T-cell development to accelerating late T-cell apoptosis

Henning Walczak

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HEMATOPOIESIS

Boosting functional hematolymphopoiesis in humanized mice

Tao Cheng

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TRANSPLANTATION

aGVHDAI: escape from the silo

Steven Pavletic

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NEOPLASIA

Distinct MYC thresholds in hematopoietic neoplasia

Siegfried Janz

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IMMUNOBIOLOGY

Animal models: a pot of gold

Guillermo A. Herrera

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HEMOSTASIS

Factor VIII biosynthesis: new inspirations?

Jay Lozier

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NEOPLASIA

Chips, candidate genes, and CLL

Neil Caporaso

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NEOPLASIA

Alert and sniffy-nosed about Mll-AF4?

Mel Greaves,C. W. Eric So

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PERSPECTIVES

Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia

Clinical Trials & Observations

Bruce D. Cheson,Peter L. Greenberg,John M. Bennett,Bob Lowenberg,Pierre W. Wijermans,Stephen D. Nimer,Antonio Pinto,Miloslav Beran,Theo M. de Witte,Richard M. Stone,Moshe Mittelman,Guillermo F. Sanz,Steven D. Gore,Charles A. Schiffer,Hagop Kantarjian

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REVIEW ARTICLES

Regulatory T-cell compartmentalization and trafficking

Shuang Wei,Ilona Kryczek,Weiping Zou

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CHEMOKINES, CYTOKINES, AND INTERLEUKINS

The chemokine CXCL13 is a key molecule in autoimmune myasthenia gravis

Amel Meraouna,Geraldine Cizeron-Clairac,Rozen Le Panse,Jacky Bismuth,Frederique Truffault,Chantal Tallaksen,Sonia Berrih-Aknin

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Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Analysis of prognostic factors of acute lymphoblastic leukemia in infants: report on CCG 1953 from the Children's Oncology Group

Clinical Trials & Observations

Joanne M. Hilden,Patricia A. Dinndorf,Sharon O. Meerbaum,Harland Sather,Doojduen Villaluna,Nyla A. Heerema,Ron McGlennen,Franklin O. Smith,William G. Woods,Wanda L. Salzer,Helen S. Johnstone,Zoann Dreyer,Gregory H. Reaman

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Circulating endothelial-cell kinetics and viability predict survival in breast cancer patients receiving metronomic chemotherapy

Clinical Trials & Observations

Patrizia Mancuso,Marco Colleoni,Angelica Calleri,Laura Orlando,Patrick Maisonneuve,Giancarlo Pruneri,Alice Agliano,Aron Goldhirsch,Yuval Shaked,Robert S. Kerbel,Francesco Bertolini

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Mortality rates and causes of death among all HIV-positive individuals with hemophilia in Canada over 21 years of follow-up

Clinical Trials & Observations

Donald M. Arnold,Jim A. Julian,Irwin R. Walker,for the Association of Hemophilia Clinic Directors of Canada

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Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis: results from the international ALL trial MRC UKALL XII/ECOG E2993

Clinical Trials & Observations

Hillard M. Lazarus,Susan M. Richards,Raj Chopra,Mark R. Litzow,Alan K. Burnett,Peter H. Wiernik,Ian M. Franklin,Martin S. Tallman,Lucy Cook,Georgina Buck,I. Jill Durrant,Jacob M. Rowe,Anthony H. Goldstone,for the Medical Research Council (MRC)/National Cancer Research Institute (NCRI) Adult Leukaemia Working Party of the United Kingdom and the Eastern Cooperative Oncology Group

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Cladribine alone and in combination with cyclophosphamide or cyclophosphamide plus mitoxantrone in the treatment of progressive chronic lymphocytic leukemia: report of a prospective, multicenter, randomized trial of the Polish Adult Leukemia Group (PALG CLL2)

Clinical Trials & Observations

Tadeusz Robak,Jerzy Z. Blonski,Joanna Gora-Tybor,Krzysztof Jamroziak,Jadwiga Dwilewicz-Trojaczek,Agnieszka Tomaszewska,Lech Konopka,Bernadetta Ceglarek,Anna Dmoszynska,Malgorzata Kowal,Janusz Kloczko,Beata Stella-Holowiecka,Kazimierz Sulek,Malgorzata Calbecka,Krystyna Zawilska,Kazimierz Kuliczkowski,Aleksander B. Skotnicki,Krzysztof Warzocha,Marek Kasznicki,the Polish Leukemia Group (PALG CLL2)

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GENE THERAPY

Immune deviation by mucosal antigen administration suppresses gene-transfer–induced inhibitor formation to factor IX

Ou Cao,Elina Armstrong,Alexander Schlachterman,Lixin Wang,David K. Okita,Bianca Conti-Fine,Katherine A. High,Roland W. Herzog

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HEMATOPOIESIS

Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34⁺ cell transplantation

Ping Lan,Noriko Tonomura,Akira Shimizu,Shumei Wang,Yong-Guang Yang

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Mutations in neutrophil elastase causing congenital neutropenia lead to cytoplasmic protein accumulation and induction of the unfolded protein response

Inga Köllner,Beate Sodeik,Sabine Schreek,Holger Heyn,Nils von Neuhoff,Manuela Germeshausen,Cornelia Zeidler,Martin Krüger,Brigitte Schlegelberger,Karl Welte,Carmela Beger

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Supplemental data

The differentiation program of embryonic definitive hematopoietic stem cells is largely α4 integrin independent

Ruby Gribi,Lilian Hook,Janice Ure,Alexander Medvinsky

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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Reduced thrombus stability in mice lacking the α_2A-adrenergic receptor

Miroslava Požgajová,Ulrich J. H. Sachs,Lutz Hein,Bernhard Nieswandt

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FVIII production by human lung microvascular endothelial cells

Brief Report

Marc Jacquemin,Arne Neyrinck,Maria Iris Hermanns,Renaud Lavend'homme,Filip Rega,Jean-Marie Saint-Remy,Kathelijne Peerlinck,Dirk Van Raemdonck,Charles James Kirkpatrick

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IMMUNOBIOLOGY

Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding

Wu-Guo Deng,Shao-Tzu Tang,Hui-Ping Tseng,Kenneth K. Wu

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Peroxisome proliferator-activated receptor γ (PPARγ) ligands reverse CTL suppression by alternatively activated (M2) macrophages in cancer

Jo A. Van Ginderachter,Sofie Meerschaut,Yuanqing Liu,Lea Brys,Kurt De Groeve,Gholamreza Hassanzadeh Ghassabeh,Geert Raes,Patrick De Baetselier

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Role of the monoclonal κ chain V domain and reversibility of renal damage in a transgenic model of acquired Fanconi syndrome

Christophe Sirac,Frank Bridoux,Claire Carrion,Olivier Devuyst,Béatrice Fernandez,Jean-Michel Goujon,Chahrazed El Hamel,Jean-Claude Aldigier,Guy Touchard,Michel Cogné

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Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo

Tobias Warger,Philipp Osterloh,Gerd Rechtsteiner,Melanie Fassbender,Valeska Heib,Beate Schmid,Edgar Schmitt,Hansjörg Schild,Markus P. Radsak

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Proteasome inhibitor bortezomib modulates TLR4-induced dendritic cell activation

Alessio Nencioni,Karin Schwarzenberg,Katharina M. Brauer,Susanne M. Schmidt,Alberto Ballestrero,Frank Grünebach,Peter Brossart

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Caspase-2 is activated at the CD95 death-inducing signaling complex in the course of CD95-induced apoptosis

Inna N. Lavrik,Alexander Golks,Simone Baumann,Peter H. Krammer

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Proteasome-dependent down-regulation of activated Stat5A in the nucleus

Yuhong Chen,Xuezhi Dai,Arthur L. Haas,Renren Wen,Demin Wang

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Identification of a common gene signature for type II cytokine–associated myeloid cells elicited in vivo in different pathologic conditions

Gholamreza Hassanzadeh Ghassabeh,Patrick De Baetselier,Lea Brys,Wim Noël,Jo A. Van Ginderachter,Sofie Meerschaut,Alain Beschin,Frank Brombacher,Geert Raes

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Neutrophil responsiveness to IgG, as determined by fixed ratios of mRNA levels for activating and inhibitory FcγRII (CD32), is stable over time and unaffected by cytokines

Edwin van Mirre,Willemijn B. Breunis,Judy Geissler,C. Erik Hack,Martin de Boer,Dirk Roos,Taco W. Kuijpers

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Gimap4 accelerates T-cell death

Silke Schnell,Corinne Démollière,Paul van den Berk,Heinz Jacobs

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Supplemental data

Differential regulation of T-cell growth by IL-2 and IL-15

Georgina H. Cornish,Linda V. Sinclair,Doreen A. Cantrell

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ICSBP/IRF-8 differentially regulates antigen uptake during dendritic-cell development and affects antigen presentation to CD4⁺ T cells

Fabrizio Mattei,Giovanna Schiavoni,Paola Borghi,Massimo Venditti,Irene Canini,Paola Sestili,Immacolata Pietraforte,Herbert C. Morse, III,Carlo Ramoni,Filippo Belardelli,Lucia Gabriele

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Supplemental data

Enhancement of ligand-dependent activation of human natural killer T cells by lenalidomide: therapeutic implications

Brief Report

David H. Chang,Nancy Liu,Virginia Klimek,Hani Hassoun,Amitabha Mazumder,Stephen D. Nimer,Sundar Jagannath,Madhav V. Dhodapkar

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NEOPLASIA

Molecular dissection of Meis1 reveals 2 domains required for leukemia induction and a key role for Hoxa gene activation

Aline Mamo,Jana Krosl,Evert Kroon,Janet Bijl,Alexander Thompson,Nadine Mayotte,Simon Girard,Richard Bisaillon,Nathalie Beslu,Mark Featherstone,Guy Sauvageau

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Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells

Bing Z. Carter,Duncan H. Mak,Wendy D. Schober,Teresa McQueen,David Harris,Zeev Estrov,Randall L. Evans,Michael Andreeff

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Variants in the ATM-BRCA2-CHEK2 axis predispose to chronic lymphocytic leukemia

Matthew F. Rudd,Gabrielle S. Sellick,Emily L. Webb,Daniel Catovsky,Richard S. Houlston

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Combined effects of novel tyrosine kinase inhibitor AMN107 and histone deacetylase inhibitor LBH589 against Bcr-Abl–expressing human leukemia cells

Warren Fiskus,Michael Pranpat,Purva Bali,Maria Balasis,Sandhya Kumaraswamy,Sandhya Boyapalle,Kathy Rocha,Jie Wu,Francis Giles,Paul W. Manley,Peter Atadja,Kapil Bhalla

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MYC levels govern hematopoietic tumor type and latency in transgenic mice

Darrin P. Smith,Mary L. Bath,Donald Metcalf,Alan W. Harris,Suzanne Cory

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Tumor microenvironment and mitotic checkpoint are key factors in the outcome of classic Hodgkin lymphoma

Abel Sánchez-Aguilera,Carlos Montalbán,Paloma de la Cueva,Lydia Sánchez-Verde,Manuel M. Morente,Mónica García-Cosío,José García-Laraña,Carmen Bellas,Mariano Provencio,Vicens Romagosa,Alberto Fernández de Sevilla,Javier Menárguez,Pilar Sabín,María J. Mestre,Miguel Méndez,Manuel F. Fresno,Concepción Nicolás,Miguel A. Piris,Juan F. García,for the Spanish Hodgkin Lymphoma Study Group

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A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy

Weili Chen,Quanzhi Li,Wendy A. Hudson,Ashish Kumar,Nicole Kirchhof,John H. Kersey

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Complex interaction of BCRP/ABCG2 and imatinib in BCR-ABL–expressing cells: BCRP-mediated resistance to imatinib is attenuated by imatinib-induced reduction of BCRP expression

Takeo Nakanishi,Ken Shiozawa,Bret A. Hassel,Douglas D. Ross

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Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction

Clinical Trials & Observations

Carla S. Wilson,George S. Davidson,Shawn B. Martin,Erik Andries,Jeffrey Potter,Richard Harvey,Kerem Ar,Yuexian Xu,Kenneth J. Kopecky,Donna P. Ankerst,Holly Gundacker,Marilyn L. Slovak,Monica Mosquera-Caro,I-Ming Chen,Derek L. Stirewalt,Maurice Murphy,Frederick A. Schultz,Huining Kang,Xuefei Wang,Jerald P. Radich,Frederick R. Appelbaum,Susan R. Atlas,John Godwin,Cheryl L. Willman

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OCT-1–mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib

Deborah L. White,Verity A. Saunders,Phuong Dang,Jane Engler,Andrew C. W. Zannettino,Antony C. Cambareri,Steven R. Quinn,Paul W. Manley,Timothy P. Hughes

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Effective therapy for a murine model of human anaplastic large-cell lymphoma with the anti-CD30 monoclonal antibody, HeFi-1, does not require activating Fc receptors

Meili Zhang,Zhengsheng Yao,Zhuo Zhang,Kayhan Garmestani,Carolyn K. Goldman,Jeffrey V. Ravetch,John Janik,Martin W. Brechbiel,Thomas A. Waldmann

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Biologic pathways associated with relapse in childhood acute lymphoblastic leukemia: a Children's Oncology Group study

Deepa Bhojwani,Huining Kang,Naomi P. Moskowitz,Dong-Joon Min,Hokyung Lee,Jeffrey W. Potter,George Davidson,Cheryl L. Willman,Michael J. Borowitz,Ilana Belitskaya-Levy,Stephen P. Hunger,Elizabeth A. Raetz,William L. Carroll

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PHAGOCYTES

FcγR-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways

Latha P. Ganesan,Trupti Joshi,Huiqing Fang,Vijay Kumar Kutala,Julie Roda,Rossana Trotta,Amy Lehman,Periannan Kuppusamy,John C. Byrd,William E. Carson,Michael A. Caligiuri,Susheela Tridandapani

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RED CELLS

Real-time monitoring of stress erythropoiesis in vivo using Gata1 and β-globin LCR luciferase transgenic mice

Mikiko Suzuki,Kinuko Ohneda,Sakie Hosoya-Ohmura,Saho Tsukamoto,Osamu Ohneda,Sjaak Philipsen,Masayuki Yamamoto

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Supplemental data

The mutation rate in PIG-A is normal in patients with paroxysmal nocturnal hemoglobinuria (PNH)

Brief Report

David J. Araten,Lucio Luzzatto

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STEM CELLS IN HEMATOLOGY

Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors

Injune Kim,Shenghui He,Ömer H. Yilmaz,Mark J. Kiel,Sean J. Morrison

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TRANSFUSION MEDICINE

The neuropathologic phenotype of experimental ovine BSE is maintained after blood transfusion

Sílvia Sisó,Lorenzo González,Fiona Houston,Nora Hunter,Stuart Martin,Martin Jeffrey

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TRANSPLANTATION

An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens

Clinical Trials & Observations

Wendy M. Leisenring,Paul J. Martin,Effie W. Petersdorf,Anne E. Regan,Nada Aboulhosn,Jean M. Stern,Saundra N. Aker,Raymond C. Salazar,George B. McDonald

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Rituximab for steroid-refractory chronic graft-versus-host disease

Clinical Trials & Observations

Corey Cutler,David Miklos,Haesook T. Kim,Nathaniel Treister,Sook-Bin Woo,Don Bienfang,Lloyd B. Klickstein,Jesse Levin,Katherine Miller,Carol Reynolds,Rebecca Macdonell,Mildred Pasek,Stephanie J. Lee,Vincent Ho,Robert Soiffer,Joseph H. Antin,Jerome Ritz,Edwin Alyea

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Early determinants of long-term T-cell reconstitution after hematopoietic stem cell transplantation for severe combined immunodeficiency

Clinical Trials & Observations

José A. Borghans,Robbert G. Bredius,Mette D. Hazenberg,Helene Roelofs,Els C. Jol-van der Zijde,Jeroen Heidt,Sigrid A. Otto,Taco W. Kuijpers,Willem E. Fibbe,Jaak M. Vossen,Frank Miedema,Maarten J. van Tol

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CORRESPONDENCE

The IL-17 cytokine family members are inhibitors of human hematopoietic progenitor proliferation

Hal E. Broxmeyer,Trevor Starnes,Heather Ramsey,Scott Cooper,Richard Dahl,Elizabeth Williamson,Robert Hromas

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Expansion of SCID repopulating cells does not prove expansion of hematopoietic stem cells

Peter A. Horn,Hans-Peter Kiem

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The stromal component of the marrow microenvironment is not derived from the malignant clone in MDS

Aravind Ramakrishnan,Norihiro Awaya,Eileen Bryant,Beverly Torok-Storb

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Steady remission of scleromyxedema 3 years after autologous stem cell transplantation: an in vivo and in vitro study

Isabel Illa,Carolina de la Torre,Ricardo Rojas-Garcia,Antoni Altes,Rafael Blesa,Jordi Sierra,Eduard Gallardo

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Deferasirox versus deferoxamine

Mike G. Martin,Murat O. Arcasoy

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Misclassification of amyloidosis is unwarranted

Alan Solomon,Charles L. Murphy,Per Westermark

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The quest for the normal hemoglobin concentration

Peter A. Boehringer,Ivy L. Darden

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Does liver biopsy overestimate liver iron concentration?

Roland Fischer,Paul Harmatz,Peter Nielsen

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