Issue Archive

INSIDE BLOOD

NEOPLASIA

Syk-driven mTOR in lymphoma-complimentary targets?

Francis J. Giles, M. D.

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NEOPLASIA

No tumor-CD200 expression, please!

Reginald Gorczynski

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IMMUNOBIOLOGY

Career choices of monocytes in dangerous times

James L. M. Ferrara

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HEMOSTASIS

Uncovering the dark side of PKCδ

Ulhas P. Naik

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RED CELLS

How many mutations does it take to get PNH?

Wendell F. Rosse

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PHAGOCYTES

Fluorescent neutrophils throw the spotlight on inflammation

Graham J. Lieschke

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HEMATOPOIESIS

Plasmacytoid DCs fail to soar without Ikaros

Marco Colonna

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TRANSPLANTATION

Treg-cell expansion: better to be “naive”

Benny J. Chen

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IMMUNOBIOLOGY

Poisoning autoimmunity

Vito Pistoia

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NEOPLASIA

NPM1 mutation in AML: WHO and why?

David Grimwade

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TRANSPLANTATION

Going home: inhibiting stem cell CD26

Hal E. Broxmeyer

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PLENARY PAPERS

Arsenic trioxide: a promising novel therapeutic agent for lymphoproliferative and autoimmune syndromes in MRL/lpr mice

Pierre Bobé,Danielle Bonardelle,Karim Benihoud,Paule Opolon,Mounira K. Chelbi-Alix

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A transgenic zebrafish model of neutrophilic inflammation

Stephen A. Renshaw,Catherine A. Loynes,Daniel M.I. Trushell,Stone Elworthy,Philip W. Ingham,Moira K.B. Whyte

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ERRATA

Erratum for vol. 108, p. 3234

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PERSPECTIVES

HBZ, a new important player in the mystery of adult T-cell leukemia

Jean-Michel Mesnard,Benoît Barbeau,Christian Devaux

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REVIEW ARTICLES

Proteomic approaches to dissect platelet function: half the story

Dmitri V. Gnatenko,Peter L. Perrotta,Wadie F. Bahou

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REVIEW IN TRANSLATIONAL HEMATOLOGY

Multiple myeloma bone disease: pathophysiology of osteoblast inhibition

Nicola Giuliani,Vittorio Rizzoli,G. David Roodman

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CLINICAL TRIALS AND OBSERVATIONS

Body mass index does not influence pharmacokinetics or outcome of treatment in children with acute lymphoblastic leukemia

Clinical Trials & Observations

Nobuko Hijiya,John C. Panetta,Yinmei Zhou,Emily P. Kyzer,Scott C. Howard,Sima Jeha,Bassem I. Razzouk,Raul C. Ribeiro,Jeffrey E. Rubnitz,Melissa M. Hudson,John T. Sandlund,Ching-Hon Pui,Mary V. Relling

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Maintenance therapy with rituximab leads to a significant prolongation of response duration after salvage therapy with a combination of rituximab, fludarabine, cyclophosphamide, and mitoxantrone (R-FCM) in patients with recurring and refractory follicular and mantle cell lymphomas: results of a prospective randomized study of the German Low Grade Lymphoma Study Group (GLSG)

Clinical Trials & Observations

Roswitha Forstpointner,Michael Unterhalt,Martin Dreyling,Hans-Peter Böck,Roland Repp,Hannes Wandt,Christiane Pott,John F. Seymour,Bernd Metzner,Annette Hänel,Tanja Lehmann,Frank Hartmann,Hermann Einsele,Wolfgang Hiddemann

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GENE THERAPY

Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells

Silke Holtkamp,Sebastian Kreiter,Abderraouf Selmi,Petra Simon,Michael Koslowski,Christoph Huber,Özlem Türeci,Ugur Sahin

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HEMATOPOIESIS

Primitive erythropoiesis from mesodermal precursors expressing VE-cadherin, PECAM-1, Tie2, endoglin, and CD34 in the mouse embryo

Masatsugu Ema,Tomomasa Yokomizo,Asami Wakamatsu,Tsumoru Terunuma,Masayuki Yamamoto,Satoru Takahashi

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Ikaros is required for plasmacytoid dendritic cell differentiation

David Allman,Marc Dalod,Carine Asselin-Paturel,Thomas Delale,Scott H. Robbins,Giorgio Trinchieri,Christine A. Biron,Philippe Kastner,Susan Chan

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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

PKCδ regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation

Giordano Pula,Kai Schuh,Keiko Nakayama,Keiichi I. Nakayama,Ulrich Walter,Alastair W. Poole

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Levels of intrinsic coagulation factors and the risk of myocardial infarction among men: opposite and synergistic effects of factors XI and XII

Clinical Trials & Observations

Carine J. M. Doggen,Frits R. Rosendaal,Joost C. M. Meijers

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The risk of dialysis access thrombosis is related to the transforming growth factor–β1 production haplotype and is modified by polymorphisms in the plasminogen activator inhibitor–type 1 gene

Clinical Trials & Observations

Alejandro Lazo-Langner,Greg A. Knoll,Philip S. Wells,Nancy Carson,Marc A. Rodger

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Nitric oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors

Peter B. Anning,Barbara Coles,Jonathan Morton,Haibin Wang,Jashim Uddin,Jason D. Morrow,Sudhansu K. Dey,Lawrence J. Marnett,Valerie B. O'Donnell

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IMMUNOBIOLOGY

Most human thymic and peripheral-blood CD4⁺CD25⁺ regulatory T cells express 2 T-cell receptors

Heli Tuovinen,Jukka T. Salminen,T. Petteri Arstila

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Optimizing immunotherapy in multiple myeloma: restoring the function of patients' monocyte-derived dendritic cells by inhibiting p38 or activating MEK/ERK MAPK and neutralizing interleukin-6 in progenitor cells

Siqing Wang,Sungyoul Hong,Jing Yang,Jianfei Qian,Xiang Zhang,Elizabeth Shpall,Larry W. Kwak,Qing Yi

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Analysis of natural killer cells isolated from human decidua: evidence that 2B4 (CD244) functions as an inhibitory receptor and blocks NK-cell function

Paola Vacca,Gabriella Pietra,Michela Falco,Elisa Romeo,Cristina Bottino,Francesca Bellora,Federico Prefumo,Ezio Fulcheri,Pier Luigi Venturini,Mauro Costa,Alessandro Moretta,Lorenzo Moretta,Maria Cristina Mingari

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BCR ubiquitination controls BCR-mediated antigen processing and presentation

Lisa Drake,Erica M. McGovern-Brindisi,James R. Drake

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Antigen recognition induces phosphatidylserine exposure on the cell surface of human CD8⁺ T cells

Karin Fischer,Simon Voelkl,Jana Berger,Reinhard Andreesen,Thomas Pomorski,Andreas Mackensen

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Involvement of suppressors of cytokine signaling in toll-like receptor–mediated block of dendritic cell differentiation

Holger Bartz,Nicole M. Avalos,Andrea Baetz,Klaus Heeg,Alexander H. Dalpke

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Expression of tumor-associated antigens in acute myeloid leukemia: implications for specific immunotherapeutic approaches

Jochen Greiner,Michael Schmitt,Li Li,Krzysztof Giannopoulos,Katrin Bosch,Anita Schmitt,Konstanze Dohner,Richard F. Schlenk,Jonathan R. Pollack,Hartmut Dohner,Lars Bullinger

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The tryptophan catabolite l-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function

Mariella Della Chiesa,Simona Carlomagno,Guido Frumento,Mirna Balsamo,Claudia Cantoni,Romana Conte,Lorenzo Moretta,Alessandro Moretta,Massimo Vitale

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NEOPLASIA

Selective leukemic-cell killing by a novel functional class of thalidomide analogs

Yun Ge,Idalia Montano,Gabriella Rustici,Wendy J. Freebern,Cynthia M. Haggerty,Wenwu Cui,Damaris Ponciano-Jackson,G. V. R. Chandramouli,Erin R. Gardner,William D. Figg,Mones Abu-Asab,Maria Tsokos,Sharon H. Jackson,Kevin Gardner

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JAZ mediates G₁ cell-cycle arrest and apoptosis by positively regulating p53 transcriptional activity

Mingli Yang,Song Wu,Xuekun Su,W. Stratford May

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Mutated nucleophosmin detects clonal multilineage involvement in acute myeloid leukemia: impact on WHO classification

Clinical Trials & Observations

Laura Pasqualucci,Arcangelo Liso,Maria Paola Martelli,Niccolò Bolli,Roberta Pacini,Alessia Tabarrini,Manola Carini,Barbara Bigerna,Alessandra Pucciarini,Roberta Mannucci,Ildo Nicoletti,Enrico Tiacci,Giovanna Meloni,Giorgina Specchia,Nicola Cantore,Francesco Di Raimondo,Stefano Pileri,Cristina Mecucci,Franco Mandelli,Massimo Fabrizio Martelli,Brunangelo Falini

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Syk-dependent mTOR activation in follicular lymphoma cells

Ludivine Leseux,Safouane M. Hamdi,Talal al Saati,Florence Capilla,Christian Recher,Guy Laurent,Christine Bezombes

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Prognostic significance of Epstein-Barr virus in nodal peripheral T-cell lymphoma, unspecified: a Groupe d'Etude des Lymphomes de l'Adulte (GELA) study

Clinical Trials & Observations

Jehan Dupuis,Jean-François Emile,Nicolas Mounier,Christian Gisselbrecht,Nadine Martin-Garcia,Tony Petrella,Reda Bouabdallah,Françoise Berger,Alain Delmer,Bertrand Coiffier,Félix Reyes,Philippe Gaulard

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Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors

Tony A. Navas,Mani Mohindru,Myka Estes,Jing Ying Ma,Lubomir Sokol,Perry Pahanish,Simrit Parmar,Edwin Haghnazari,Li Zhou,Robert Collins,Irene Kerr,Aaron N. Nguyen,Yin Xu,Leonidas C. Platanias,Alan A. List,Linda S. Higgins,Amit Verma

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Role of phosphatidylinositol 3′-kinase/AKT pathway in diffuse large B-cell lymphoma survival

Shahab Uddin,Azhar R. Hussain,Abdul K. Siraj,Pulicat S. Manogaran,Naif A. Al-Jomah,Azadali Moorji,Valerie Atizado,Fouad Al-Dayel,Asim Belgaumi,Hassan El-Solh,Adnan Ezzat,Prashant Bavi,Khawla S. Al-Kuraya

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Fludarabine increases oxaliplatin cytotoxicity in normal and chronic lymphocytic leukemia lymphocytes by suppressing interstrand DNA crosslink removal

Mazin A. Moufarij,Deepa Sampath,Michael J. Keating,William Plunkett

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CD200 is a new prognostic factor in multiple myeloma

Clinical Trials & Observations

Jerome Moreaux,Dirk Hose,Thierry Reme,Eric Jourdan,Michael Hundemer,Eric Legouffe,Philippe Moine,Philippe Bourin,Marion Moos,Jill Corre,Thomas Möhler,John De Vos,Jean Francois Rossi,Hartmut Goldschmidt,Bernard Klein

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HOX11L2/TLX3 is transcriptionally activated through T-cell regulatory elements downstream of BCL11B as a result of the t(5;14)(q35;q32)

Xin-Ying Su,Véronique Della-Valle,Isabelle Andre-Schmutz,Claudie Lemercier,Isabelle Radford-Weiss,Paola Ballerini,Michel Lessard,Marina Lafage-Pochitaloff,Francine Mugneret,Roland Berger,Serge P. Romana,Olivier A. Bernard,Virginie Penard-Lacronique

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Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia

Ting-Lei Gu,Valerie L. Goss,Cynthia Reeves,Lana Popova,Julie Nardone,Joan MacNeill,Denise K. Walters,Yi Wang,John Rush,Michael J. Comb,Brian J. Druker,Roberto D. Polakiewicz

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PHAGOCYTES

Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils

Kathleen Szczur,Haiming Xu,Simon Atkinson,Yi Zheng,Marie-Dominique Filippi

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CD157 plays a pivotal role in neutrophil transendothelial migration

Erika Ortolan,Elena V. Tibaldi,Bruna Ferranti,Luisa Lavagno,Giovanni Garbarino,Rosario Notaro,Lucio Luzzatto,Fabio Malavasi,Ada Funaro

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Receptor-type protein tyrosine phosphatase gamma (PTPγ), a new identifier for myeloid dendritic cells and specialized macrophages

Daniele Lissandrini,William Vermi,Marzia Vezzalini,Silvano Sozzani,Fabio Facchetti,Graziella Bellone,Andrea Mafficini,Francesca Gentili,Maria Grazia Ennas,Cristina Tecchio,Claudio Sorio

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RED CELLS

Molecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH)

Norimitsu Inoue,Tomohisa Izui-Sarumaru,Yoshiko Murakami,Yuichi Endo,Jun-Ichi Nishimura,Ken Kurokawa,Maki Kuwayama,Hiroaki Shime,Takashi Machii,Yuzuru Kanakura,Gabrielle Meyers,Carl Wittwer,Zhong Chen,William Babcock,Debra Frei-Lahr,Charles J. Parker,Taroh Kinoshita

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Cis and trans regulation of hepcidin expression by upstream stimulatory factor

Henry K. Bayele,Harry McArdle,Surjit K.S. Srai

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STEM CELLS IN HEMATOLOGY

Smad7 promotes self-renewal of hematopoietic stem cells

Ulrika Blank,Goran Karlsson,Jennifer L. Moody,Taiju Utsugisawa,Mattias Magnusson,Sofie Singbrant,Jonas Larsson,Stefan Karlsson

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TRANSFUSION MEDICINE

Immunologic and functional evidence for anti–Siglec-9 autoantibodies in intravenous immunoglobulin preparations

Stephan von Gunten,Alexander Schaub,Monique Vogel,Beda M. Stadler,Sylvia Miescher,Hans-Uwe Simon

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TRANSPLANTATION

Only the CD45RA⁺ subpopulation of CD4⁺CD25^high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion

Petra Hoffmann,Ruediger Eder,Tina J. Boeld,Kristina Doser,Biserka Piseshka,Reinhard Andreesen,Matthias Edinger

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CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation

William H. Peranteau,Masayuki Endo,Obinna O. Adibe,Aziz Merchant,Philip W. Zoltick,Alan W. Flake

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Umbilical cord blood transplantation and cytomegalovirus: posttransplantation infection and donor screening

Maria S. Albano,Patricia Taylor,Robert F. Pass,Andromachi Scaradavou,Rodica Ciubotariu,Carmelita Carrier,Ludy Dobrila,Pablo Rubinstein,Cladd E. Stevens

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Continuous in vivo infusion of interferon-gamma (IFN-γ) enhances engraftment of syngeneic wild-type cells in Fanca^–/– and Fancg^–/– mice

Yue Si,Samantha Ciccone,Feng-Chun Yang,Jin Yuan,Daisy Zeng,Shi Chen,Henri J. van de Vrugt,John Critser,Fre Arwert,Laura S. Haneline,D. Wade Clapp

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Long-term outcome of patients given transplants of mobilized blood or bone marrow: a report from the International Bone Marrow Transplant Registry and the European Group for Blood and Marrow Transplantation

Clinical Trials & Observations

Norbert Schmitz,Mary Eapen,Mary M. Horowitz,Mei-Jie Zhang,John P. Klein,J. Douglas Rizzo,Fausto R. Loberiza,Alois Gratwohl,Richard E. Champlin

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CORRESPONDENCE

Low-dose decitabine and high-risk MDS

Azra Raza,Fatima Zehra Raza,Naomi Galili

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Recovery of spermatogenesis after total-body irradiation

Bipin N. Savani,Eleftheria Kozanas,Aarthi Shenoy,A. John Barrett

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