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Issue Archive

Volume 108, Issue 12
December 1 2006
Issue Cover

Table of Contents

INSIDE BLOOD

CLINICAL TRIALS AND OBSERVATIONS
“Quick” fix to add to the mix?
Clinical Trials & Observations
Mervin C. Yoder
View Articletitled, “Quick” fix to add to the mix?
TRANSPLANTATION
MSCs roll into the mainstream
Darwin J. Prockop
View Articletitled, MSCs roll into the mainstream
HEMOSTASIS
Sticky business: von Willebrand factor in inflammation
José A. López
View Articletitled, Sticky business: von Willebrand factor in inflammation
HEMOSTASIS
When collagen meets VWF
Hans Deckmyn,Karen Vanhoorelbeke
View Articletitled, When collagen meets VWF
IMMUNOBIOLOGY
The thymus: a house dividing
Geoffrey O. Gillard,Andrew G. Farr
View Articletitled, The thymus: a house dividing
IMMUNOBIOLOGY
Hodgkin lymphoma: to the HAART of the matter
Alexandra M. Levine
View Articletitled, Hodgkin lymphoma: to the HAART of the matter
HEMATOPOIESIS
It's hepcidin again, but is it the only master?
Prem Ponka,Alex D. Sheftel
View Articletitled, It's hepcidin again, but is it the only master?
TRANSPLANTATION
Refining therapy for AL amyloidosis
Giampaolo Merlini
View Articletitled, Refining therapy for AL amyloidosis
RED CELLS
A new Rac-ket in red cells
Velia M. Fowler,Robert S. Fischer
View Articletitled, A new Rac-ket in red cells
HEMATOPOIESIS
A TRAIL to Chinese herbal medicine
Peter T. Daniel
View Articletitled, A TRAIL to Chinese herbal medicine

BLOOD WORK

Anemia and splenomegaly
View Articletitled, Anemia and splenomegaly

PLENARY PAPERS

Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton
Theodosia A. Kalfa,Suvarnamala Pushkaran,Narla Mohandas,John H. Hartwig,Velia M. Fowler,James F. Johnson,Clinton H. Joiner,David A. Williams,Yi Zheng
View Articletitled, Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton

REVIEW IN TRANSLATIONAL HEMATOLOGY

MicroRNAs: regulators of gene expression and cell differentiation
Ramesh A. Shivdasani
View Articletitled, MicroRNAs: regulators of gene expression and cell differentiation

CLINICAL TRIALS AND OBSERVATIONS

Clinical implications of FLT3 mutations in pediatric AML
Clinical Trials & Observations
Soheil Meshinchi,Todd A. Alonzo,Derek L. Stirewalt,Michel Zwaan,Martin Zimmerman,Dirk Reinhardt,Gertjan J. L. Kaspers,Nyla A. Heerema,Robert Gerbing,Beverly J. Lange,Jerald P. Radich
View Articletitled, Clinical implications of <em>FLT3</em> mutations in pediatric AML
Angiogenic cells can be rapidly mobilized and efficiently harvested from the blood following treatment with AMD3100
Clinical Trials & Observations
Rebecca M. Shepherd,Benjamin J. Capoccia,Steven M. Devine,John DiPersio,Kathryn M. Trinkaus,David Ingram,Daniel C. Link
View Articletitled, Angiogenic cells can be rapidly mobilized and efficiently harvested from the blood following treatment with AMD3100
Prolonged bleeding-free period following prophylactic infusion of recombinant factor VIII reconstituted with pegylated liposomes
Clinical Trials & Observations
Jack Spira,Olga P. Plyushch,Tatyana A. Andreeva,Yury Andreev
View Articletitled, Prolonged bleeding-free period following prophylactic infusion of recombinant factor VIII reconstituted with pegylated liposomes
Phase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamics
Clinical Trials & Observations
Daniel J. DeAngelo,Richard M. Stone,Mark L. Heaney,Stephen D. Nimer,Ronald L. Paquette,Rebecca B. Klisovic,Michael A. Caligiuri,Michael R. Cooper,Jean-Michel Lecerf,Michael D. Karol,Shihong Sheng,Nick Holford,Peter T. Curtin,Brian J. Druker,Michael C. Heinrich
View Articletitled, Phase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamics

HEMATOPOIESIS

STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils
Athanasia D. Panopoulos,Ling Zhang,Jonathan W. Snow,Daniel M. Jones,Amber M. Smith,Karim C. El Kasmi,Fulu Liu,Mark A. Goldsmith,Daniel C. Link,Peter J. Murray,Stephanie S. Watowich
View Articletitled, STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils
Viral gene expression during the establishment of human cytomegalovirus latent infection in myeloid progenitor cells
Allen K. L. Cheung,Allison Abendroth,Anthony L. Cunningham,Barry Slobedman
View Articletitled, Viral gene expression during the establishment of human cytomegalovirus latent infection in myeloid progenitor cells
Supplemental data
Wogonin sensitizes resistant malignant cells to TNFα- and TRAIL-induced apoptosis
Stefanie C. Fas,Sven Baumann,Jia Yun Zhu,Marco Giaisi,Monika K. Treiber,Ulrich Mahlknecht,Peter H. Krammer,Min Li-Weber
View Articletitled, Wogonin sensitizes resistant malignant cells to TNFα- and TRAIL-induced apoptosis
Smad5 is dispensable for adult murine hematopoiesis
Sofie Singbrant,Jennifer L. Moody,Ulrika Blank,Goran Karlsson,Lieve Umans,An Zwijsen,Stefan Karlsson
View Articletitled, Smad5 is dispensable for adult murine hematopoiesis
Growth factor receptors as regulators of hematopoiesis
Michael A. Weinreich,Ingrid Lintmaer,Linlin Wang,H. Denny Liggitt,Michael A. Harkey,C. Anthony Blau
View Articletitled, Growth factor receptors as regulators of hematopoiesis
CCL18/PARC stimulates hematopoiesis in long-term bone marrow cultures indirectly through its effect on monocytes
Antonia Wimmer,Sophia K. Khaldoyanidi,Martin Judex,Naira Serobyan,Richard G. DiScipio,Ingrid U. Schraufstatter
View Articletitled, CCL18/PARC stimulates hematopoiesis in long-term bone marrow cultures indirectly through its effect on monocytes
Supplemental data
Suppression of hepcidin during anemia requires erythropoietic activity
Mihwa Pak,Miguel A. Lopez,Victroia Gabayan,Tomas Ganz,Seth Rivera
View Articletitled, Suppression of hepcidin during anemia requires erythropoietic activity
Acetylation of GATA-1 is required for chromatin occupancy
Brief Report
Janine M. Lamonica,Christopher R. Vakoc,Gerd A. Blobel
View Articletitled, Acetylation of GATA-1 is required for chromatin occupancy
Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Polymorphisms in the TNFA gene and the risk of inhibitor development in patients with hemophilia A
Jan Astermark,Johannes Oldenburg,Joyce Carlson,Anna Pavlova,Kaan Kavakli,Erik Berntorp,Ann-Kari Lefvert,for the MIBS Study Group
View Articletitled, Polymorphisms in the <em>TNFA</em> gene and the risk of inhibitor development in patients with hemophilia A
P-selectin glycoprotein ligand 1 and β2-integrins cooperate in the adhesion of leukocytes to von Willebrand factor
Ronan Pendu,Virginie Terraube,Olivier D. Christophe,Carl G. Gahmberg,Philip G. de Groot,Peter J. Lenting,Cecile V. Denis
View Articletitled, P-selectin glycoprotein ligand 1 and β2-integrins cooperate in the adhesion of leukocytes to von Willebrand factor
Supplemental data
A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides
Ton Lisman,Nicolas Raynal,Dafna Groeneveld,Ben Maddox,Anthony R. Peachey,Eric G. Huizinga,Philip G. de Groot,Richard W. Farndale
View Articletitled, A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides
Supplemental data
siRNA silencing of calumenin enhances functional factor IX production
Nadeem Wajih,Susan M. Hutson,Reidar Wallin
View Articletitled, siRNA silencing of calumenin enhances functional factor IX production

IMMUNOBIOLOGY

Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes
Annika Grabbe,Jürgen Wienands
View Articletitled, Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes
c-Rel plays a key role in deficient activation of B cells from a non–X-linked hyper-IgM patient
Clinical Trials & Observations
Kristina T. Lu,Frank L. Sinquett,Rebecca L. Dryer,Charles Song,Lori R. Covey
View Articletitled, c-Rel plays a key role in deficient activation of B cells from a non–X-linked hyper-IgM patient
Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells
Daniel H. D. Gray,Natalie Seach,Tomoo Ueno,Morag K. Milton,Adrian Liston,Andrew M. Lew,Christopher C. Goodnow,Richard L. Boyd
View Articletitled, Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells
Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS
Clinical Trials & Observations
Robert J. Biggar,Elaine S. Jaffe,James J. Goedert,Anil Chaturvedi,Ruth Pfeiffer,Eric A. Engels,for the HIV/AIDS Cancer Match Study
View Articletitled, Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS
Stimulated plasmacytoid dendritic cells impair human T-cell development
Heike Schmidlin,Wendy Dontje,Fedde Groot,Suzanne J. Ligthart,Arnaud D. Colantonio,Monique E. Oud,Esther J. Schilder-Tol,Marcel Spaargaren,Hergen Spits,Christel H. Uittenbogaart,Bianca Blom
View Articletitled, Stimulated plasmacytoid dendritic cells impair human T-cell development
Supplemental data
Histone deacetylase inhibitors increase virus gene expression but decrease CD8+ cell antiviral function in HTLV-1 infection
Angelina Jane Mosley,Kiran N. Meekings,Corinna McCarthy,Dawn Shepherd,Vincenzo Cerundolo,Ralph Mazitschek,Yuetsu Tanaka,Graham P. Taylor,Charles R. Bangham
View Articletitled, Histone deacetylase inhibitors increase virus gene expression but decrease CD8<sup>+</sup> cell antiviral function in HTLV-1 infection
Supplemental data
HIV-1–driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS
Clinical Trials & Observations
Jakob Nilsson,Adriano Boasso,Paula Andrea Velilla,Rui Zhang,Monica Vaccari,Genoveffa Franchini,Gene M. Shearer,Jan Andersson,Claire Chougnet
View Articletitled, HIV-1–driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS
CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent
Luca Gattinoni,Anju Ranganathan,Deborah R. Surman,Douglas C. Palmer,Paul A. Antony,Marc R. Theoret,David M. Heimann,Steven A. Rosenberg,Nicholas P. Restifo
View Articletitled, CTLA-4 dysregulation of self/tumor-reactive CD8<sup>+</sup> T-cell function is CD4<sup>+</sup> T-cell dependent
Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cells
Bartosz Grzywacz,Nandini Kataria,Magdalena Sikora,Robert A. Oostendorp,Elaine A. Dzierzak,Bruce R. Blazar,Jeffrey S. Miller,Michael R. Verneris
View Articletitled, Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cells
CTLA-4 blockade decreases TGF-β, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques
Anna Hryniewicz,Adriano Boasso,Yvette Edghill-Smith,Monica Vaccari,Dietmar Fuchs,David Venzon,Janos Nacsa,Michael R. Betts,Wen-Po Tsai,Jean-Michel Heraud,Brigitte Beer,Diann Blanset,Claire Chougnet,Israel Lowy,Gene M. Shearer,Genoveffa Franchini
View Articletitled, CTLA-4 blockade decreases TGF-β, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques
Emergence of antitumor cytolytic T cells is associated with maintenance of hematologic remission in children with acute myeloid leukemia
Daniela Montagna,Rita Maccario,Franco Locatelli,Enrica Montini,Sara Pagani,Federico Bonetti,Liane Daudt,Ilaria Turin,Daniela Lisini,Claudio Garavaglia,Paolo Dellabona,Giulia Casorati
View Articletitled, Emergence of antitumor cytolytic T cells is associated with maintenance of hematologic remission in children with acute myeloid leukemia
Multidirectional interactions are bridging human NK cells with plasmacytoid and monocyte-derived dendritic cells during innate immune responses
Mariella Della Chiesa,Chiara Romagnani,Andreas Thiel,Lorenzo Moretta,Alessandro Moretta
View Articletitled, Multidirectional interactions are bridging human NK cells with plasmacytoid and monocyte-derived dendritic cells during innate immune responses
Epstein-Barr virus nuclear antigen 2 inhibits AID expression during EBV-driven B-cell growth
Stephanie Tobollik,Linda Meyer,Maike Buettner,Sandra Klemmer,Bettina Kempkes,Elisabeth Kremmer,Gerald Niedobitek,Berit Jungnickel
View Articletitled, Epstein-Barr virus nuclear antigen 2 inhibits AID expression during EBV-driven B-cell growth
Cytotoxic T cells generated against heteroclitic peptides kill primary tumor cells independent of the binding affinity of the native tumor antigen peptide
Katja Mauerer Zirlik,David Zahrieh,Donna Neuberg,John G. Gribben
View Articletitled, Cytotoxic T cells generated against heteroclitic peptides kill primary tumor cells independent of the binding affinity of the native tumor antigen peptide
Differences in the frequency and function of HHV8-specific CD8 T cells between asymptomatic HHV8 infection and Kaposi sarcoma
Clinical Trials & Observations
Marion Lambert,Monique Gannagé,Alexandre Karras,Michal Abel,Christophe Legendre,Delphine Kerob,Felix Agbalika,Pierre-Marie Girard,Celeste Lebbe,Sophie Caillat-Zucman
View Articletitled, Differences in the frequency and function of HHV8-specific CD8 T cells between asymptomatic HHV8 infection and Kaposi sarcoma
Supplemental data

NEOPLASIA

ABCG2 expression, function, and promoter methylation in human multiple myeloma
Joel G. Turner,Jana L. Gump,Chunchun Zhang,James M. Cook,Douglas Marchion,Lori Hazlehurst,Pamela Munster,Michael J. Schell,William S. Dalton,Daniel M. Sullivan
View Articletitled, ABCG2 expression, function, and promoter methylation in human multiple myeloma
T lymphocytes redirected against the κ light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells
Juan Vera,Barbara Savoldo,Stephane Vigouroux,Ettore Biagi,Martin Pule,Claudia Rossig,Jessie Wu,Helen E. Heslop,Cliona M. Rooney,Malcolm K. Brenner,Gianpietro Dotti
View Articletitled, T lymphocytes redirected against the κ light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells
Supplemental data
High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics
Michael Heuser,Gernot Beutel,Juergen Krauter,Konstanze Döhner,Nils von Neuhoff,Brigitte Schlegelberger,Arnold Ganser
View Articletitled, High meningioma 1 <em>(MN1)</em> expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics
Supplemental data
Characterization of stem cell–like cancer cells in immune-competent mice
Jorg A. Kruger,Charles D. Kaplan,Yunping Luo,He Zhou,Dorothy Markowitz,Rong Xiang,Ralph A. Reisfeld
View Articletitled, Characterization of stem cell–like cancer cells in immune-competent mice
Molecular mimicry in the chronic myeloproliferative disorders: reciprocity between quantitative JAK2 V617F and Mpl expression
Alison R. Moliterno,Donna M. Williams,Ophelia Rogers,Jerry L. Spivak
View Articletitled, Molecular mimicry in the chronic myeloproliferative disorders: reciprocity between quantitative JAK2 V617F and Mpl expression
Polymorphisms in human homeobox HLX1 and DNA repair RAD51 genes increase the risk of therapy-related acute myeloid leukemia
Clinical Trials & Observations
Mays Jawad,Claire Helen Seedhouse,Nigel Russell,Mark Plumb
View Articletitled, Polymorphisms in human homeobox <em>HLX1</em> and DNA repair <em>RAD51</em> genes increase the risk of therapy-related acute myeloid leukemia

PHAGOCYTES

The Vav binding site of the non–receptor tyrosine kinase Syk at Tyr 348 is critical for β2 integrin (CD11/CD18)–mediated neutrophil migration
Jurgen Schymeinsky,Anca Sindrilaru,David Frommhold,Markus Sperandio,Ronald Gerstl,Cornelia Then,Attila Mócsai,Karin Scharffetter-Kochanek,Barbara Walzog
View Articletitled, The Vav binding site of the non–receptor tyrosine kinase Syk at Tyr 348 is critical for β<sub>2</sub> integrin (CD11/CD18)–mediated neutrophil migration
Supplemental data

STEM CELLS IN HEMATOLOGY

SOCS up-regulation mobilizes autologous stem cells through CXCR4 blockade
Oscar M. Pello,María del Carmen Moreno-Ortiz,José Miguel Rodríguez-Frade,Laura Martínez-Muñoz,Daniel Lucas,Lucio Gómez,Pilar Lucas,Enrique Samper,Miguel Aracil,Carlos Martínez-A,Antonio Bernad,Mario Mellado
View Articletitled, SOCS up-regulation mobilizes autologous stem cells through CXCR4 blockade
Supplemental data

TRANSPLANTATION

Mesenchymal stem cells display coordinated rolling and adhesion behavior on endothelial cells
Brigitte Rüster,Stephan Göttig,Ralf J. Ludwig,Roxana Bistrian,Stefanie Müller,Erhard Seifried,Jens Gille,Reinhard Henschler
View Articletitled, Mesenchymal stem cells display coordinated rolling and adhesion behavior on endothelial cells
Supplemental data
Successful treatment of AL amyloidosis with high-dose melphalan and autologous stem cell transplantation in patients over age 65
Clinical Trials & Observations
David C. Seldin,Jennifer J. Anderson,Martha Skinner,Karim Malek,Daniel G. Wright,Karen Quillen,Kathleen Finn,Betul Oran,Vaishali Sanchorawala
View Articletitled, Successful treatment of AL amyloidosis with high-dose melphalan and autologous stem cell transplantation in patients over age 65

CORRESPONDENCE

Chromosomal abnormalities in marrow stromal cells from myelodysplastic syndromes (MDS)
Eugenia Flores-Figueroa,Hector Mayani
View Articletitled, Chromosomal abnormalities in marrow stromal cells from myelodysplastic syndromes (MDS)
Discrete stem cells: subsets or a continuum?
Mark A. Kirkland,Peter J. Quesenberry,Ingo Roeder
View Articletitled, Discrete stem cells: subsets or a continuum?
Increased mortality with FLA compared with ADE chemotherapy in high-risk AML
Steven W. Lane,Paula Marlton,Peter N. Mollee
View Articletitled, Increased mortality with FLA compared with ADE chemotherapy in high-risk AML
Osteonecrosis of the jaws in newly diagnosed multiple myeloma patients treated with zoledronic acid and thalidomide-dexamethasone
Patrizia Tosi,Elena Zamagni,Delia Cangini,Paola Tacchetti,Francesco Di Raimondo,Lucio Catalano,Alfonso D'Arco,Sonia Ronconi,Claudia Cellini,Massimo Offidani,Giulia Perrone,Michela Ceccolini,Annamaria Brioli,Sante Tura,Michele Baccarani,Michele Cavo
View Articletitled, Osteonecrosis of the jaws in newly diagnosed multiple myeloma patients treated with zoledronic acid and thalidomide-dexamethasone
Use of the International System for Human Cytogenetic Nomenclature (ISCN)
Juan Ramon Gonzalez Garcia,Juan Pablo Meza-Espinoza
View Articletitled, Use of the International System for Human Cytogenetic Nomenclature (ISCN)
PASD1 is a potential multiple myeloma–associated antigen
Surinder S. Sahota,C. Madusha Goonewardena,Christopher D. O. Cooper,Amanda P. Liggins,Kamal Ait-Tahar,Niklas Zojer,Freda K. Stevenson,Alison H. Banham,Karen Pulford
View Articletitled, <em>PASD1</em> is a potential multiple myeloma–associated antigen
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