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Volume 107, Issue 9

May 1 2006

In this Issue

INSIDE BLOOD
BLOOD WORK
EDITORIALS
PERSPECTIVES
ERRATA
REVIEW ARTICLES
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
CLINICAL TRIALS AND OBSERVATIONS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

IMMUNOBIOLOGY

Shedding of heterodimeric leukocyte integrin

Martin E. Hemler

View Articletitled, Shedding of heterodimeric leukocyte integrin

HEMOSTASIS

“Pulling strings”: shear, platelets, and microparticles

Shaun P. Jackson,Pierre Mangin,Yuping Yuan

View Articletitled, “Pulling strings”: shear, platelets, and microparticles

HEMOSTASIS

Fibronectin comes to the fore in thrombus growth

John W. Weisel

View Articletitled, Fibronectin comes to the fore in thrombus growth

CLINICAL OBSERVATIONS

No RIC in high-risk myeloma?

Henk Lokhorst

View Articletitled, No RIC in high-risk myeloma?

CLINICAL OBSERVATIONS

Is bone marrow fibrosis the real problem?

Ronald Hoffman,Mingjiang Xu

View Articletitled, Is bone marrow fibrosis the real problem?

HEMATOPOIESIS

Polycythemia vera erythroblasts: too tough to die

Henning Walczak

View Articletitled, Polycythemia vera erythroblasts: too tough to die

IMMUNOBIOLOGY

Dendritic cells get VIP treatment

Edmund K. Waller

View Articletitled, Dendritic cells get VIP treatment

HEMOSTASIS

Yet another function for hepatocyte growth factor

Tuomas Tammela,Kari Alitalo

View Articletitled, Yet another function for hepatocyte growth factor

CLINICAL OBSERVATIONS

From rags to riches

Martin S. Tallman

View Articletitled, From rags to riches

RED CELLS

Of mice and men: the voracious spleen

Narla Mohandas

View Articletitled, Of mice and men: the voracious spleen

TRANSFUSION MEDICINE

When are platelets just platelets?

James B. Bussel

View Articletitled, When are platelets just platelets?

BLOOD WORK

Pelger-Huet anomaly and pseudo (acquired) Pelger-Huet

View Articletitled, Pelger-Huet anomaly and pseudo (acquired) Pelger-Huet

EDITORIALS

Scientific integrity: duplicate publication

Finbarr Cotter,Sanford J. Shattil

View Articletitled, Scientific integrity: duplicate publication

PERSPECTIVES

Stem cell mobilization with G-CSF analogs: a rational approach to separate GVHD and GVL?
Clinical Trials & Observations

Edward S. Morris,Kelli P. A. MacDonald,Geoffrey R. Hill

View Articletitled, Stem cell mobilization with G-CSF analogs: a rational approach to separate GVHD and GVL?

Oral chelators deferasirox and deferiprone for transfusional iron overload in thalassemia major: new data, new questions

Ellis J. Neufeld

View Articletitled, Oral chelators deferasirox and deferiprone for transfusional iron overload in thalassemia major: new data, new questions

ERRATA

Erratum for vol. 107, p. 2846

View Articletitled, Erratum for vol. 107, p. 2846

Erratum for vol. 107, p. 1892

View Articletitled, Erratum for vol. 107, p. 1892

REVIEW ARTICLES

Update on treatment recommendations from the Third International Workshop on Waldenström's Macroglobulinemia
Clinical Trials & Observations

Steven P. Treon,Morie A. Gertz,Meletios Dimopoulos,Athanasios Anagnostopoulos,Joan Blade,Andrew R. Branagan,Ramon Garcia-Sanz,Stephen Johnson,Eva Kimby,Veronique LeBlond,Jean-Paul Fermand,David G. Maloney,Giampaolo Merlini,Pierre Morel,Enrica Morra,Gwen Nichols,Enrique M. Ocio,Roger Owen,Marvin J. Stone

View Articletitled, Update on treatment recommendations from the Third International Workshop on Waldenström's Macroglobulinemia

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Gut-associated lymphoid tissue–primed CD4⁺ T cells display CCR9-dependent and -independent homing to the small intestine

Hanna Stenstad,Anna Ericsson,Bengt Johansson-Lindbom,Marcus Svensson,Jan Marsal,Matthias Mack,Dominic Picarella,Dulce Soler,Gabriel Marquez,Mike Briskin,William W. Agace

View Articletitled, Gut-associated lymphoid tissue–primed CD4+ T cells display CCR9-dependent and -independent homing to the small intestine

CLINICAL TRIALS AND OBSERVATIONS

A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with β-thalassemia
Clinical Trials & Observations

Maria Domenica Cappellini,Alan Cohen,Antonio Piga,Mohamed Bejaoui,Silverio Perrotta,Leyla Agaoglu,Yesim Aydinok,Antonis Kattamis,Yurdanur Kilinc,John Porter,Marcello Capra,Renzo Galanello,Slaheddine Fattoum,Guillermo Drelichman,Carmelo Magnano,Monica Verissimo,Miranda Athanassiou-Metaxa,Patricia Giardina,Alexandra Kourakli-Symeonidis,Gritta Janka-Schaub,Thomas Coates,Christiane Vermylen,Nancy Olivieri,Isabelle Thuret,Herbert Opitz,Catherine Ressayre-Djaffer,Peter Marks,Daniele Alberti

View Articletitled, A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with β-thalassemia

Prognostic impact of c-KIT mutations in core binding factor leukemias: an Italian retrospective study
Clinical Trials & Observations

Roberto Cairoli,Alessandro Beghini,Giovanni Grillo,Gianpaolo Nadali,Francesca Elice,Carla Barbara Ripamonti,Patrizia Colapietro,Michele Nichelatti,Laura Pezzetti,Monia Lunghi,Antonio Cuneo,Assunta Viola,Felicetto Ferrara,Mario Lazzarino,Francesco Rodeghiero,Giovanni Pizzolo,Lidia Larizza,Enrica Morra

View Articletitled, Prognostic impact of c-KIT mutations in core binding factor leukemias: an Italian retrospective study

Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia
Clinical Trials & Observations

Elihu Estey,Guillermo Garcia-Manero,Alessandra Ferrajoli,Stefan Faderl,Srdan Verstovsek,Dan Jones,Hagop Kantarjian

View Articletitled, Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia

Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma
Clinical Trials & Observations

Frederic Garban,Michel Attal,Mauricette Michallet,Cyrille Hulin,Jean H. Bourhis,Ibrahim Yakoub-Agha,Thierry Lamy,Gerald Marit,Frederic Maloisel,Christian Berthou,Mamoun Dib,Denis Caillot,Bernard dePrijck,Nicolas Ketterer,Jean-Luc Harousseau,Jean-Jacques Sotto,Philippe Moreau,for the Intergroupe Francophone du Myélome and the Swiss Group for Clinical Cancer Research

View Articletitled, Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma

Age and acute myeloid leukemia
Clinical Trials & Observations

Frederick R. Appelbaum,Holly Gundacker,David R. Head,Marilyn L. Slovak,Cheryl L. Willman,John E. Godwin,Jeanne E. Anderson,Stephen H. Petersdorf

View Articletitled, Age and acute myeloid leukemia

High levels of circulating CD34 cells, dacrocytes, clonal hematopoiesis, and JAK2 mutation differentiate myelofibrosis with myeloid metaplasia from secondary myelofibrosis associated with pulmonary hypertension
Clinical Trials & Observations Brief Report

Uday Popat,Adaani Frost,Enli Liu,Yongli Guan,April Durette,Vishnu Reddy,Josef T. Prchal

View Articletitled, High levels of circulating CD34 cells, dacrocytes, clonal hematopoiesis, and JAK2 mutation differentiate myelofibrosis with myeloid metaplasia from secondary myelofibrosis associated with pulmonary hypertension

Seeking confidence in the diagnosis of systemic AL (Ig light-chain) amyloidosis: patients can have both monoclonal gammopathies and hereditary amyloid proteins
Clinical Trials & Observations Brief Report

Raymond L. Comenzo,Ping Zhou,Martin Fleisher,Bradly Clark,Julie Teruya-Feldstein

View Articletitled, Seeking confidence in the diagnosis of systemic AL (Ig light-chain) amyloidosis: patients can have both monoclonal gammopathies and hereditary amyloid proteins

Severe pulmonary complications in Japanese patients after bortezomib treatment for refractory multiple myeloma
Clinical Trials & Observations Brief Report

Shigesaburo Miyakoshi,Masahiro Kami,Koichiro Yuji,Tomoko Matsumura,Masaaki Takatoku,Makoto Sasaki,Hiroto Narimatsu,Takeshi Fujii,Masateru Kawabata,Shuichi Taniguchi,Keiya Ozawa,Kazuo Oshimi

View Articletitled, Severe pulmonary complications in Japanese patients after bortezomib treatment for refractory multiple myeloma

HEMATOPOIESIS

Increased death receptor resistance and FLIP_short expression in polycythemia vera erythroid precursor cells

Ann Zeuner,Francesca Pedini,Michele Signore,Giusy Ruscio,Carlo Messina,Agostino Tafuri,Gabriella Girelli,Cesare Peschle,Ruggero De Maria

View Articletitled, Increased death receptor resistance and FLIPshort expression in polycythemia vera erythroid precursor cells

Contribution of α6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with α4 integrins

Hong Qian,Karl Tryggvason,Sten Eirik Jacobsen,Marja Ekblom

View Articletitled, Contribution of α6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with α4 integrins

Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation

Ivan Maillard,Benjamin A. Schwarz,Arivazhagan Sambandam,Terry Fang,Olga Shestova,Lanwei Xu,Avinash Bhandoola,Warren S. Pear

View Articletitled, Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation

Monocyte-derived CXCL7 peptides in the marrow microenvironment

Manoj M. Pillai,Mineo Iwata,Norihiro Awaya,Lynn Graf,Beverly Torok-Storb

View Articletitled, Monocyte-derived CXCL7 peptides in the marrow microenvironment

Phosphorylation of Gata1 at serine residues 72, 142, and 310 is not essential for hematopoiesis in vivo

Heather M. Rooke,Stuart H. Orkin

View Articletitled, Phosphorylation of Gata1 at serine residues 72, 142, and 310 is not essential for hematopoiesis in vivo

Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action

Renhai Cao,Meit A. Björndahl,Marta I. Gallego,Shaohua Chen,Piotr Religa,Anker J. Hansen,Yihai Cao

View Articletitled, Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action

Supplemental data

Mechanism of platelet adhesion to von Willebrand factor and microparticle formation under high shear stress

Armin J. Reininger,Harry F. G. Heijnen,Hannah Schumann,Hanno M. Specht,Wolfgang Schramm,Zaverio M. Ruggeri

View Articletitled, Mechanism of platelet adhesion to von Willebrand factor and microparticle formation under high shear stress

Supplemental data

Bone marrow mononuclear cells are recruited to the sites of VEGF-induced neovascularization but are not incorporated into the newly formed vessels

Lorena Zentilin,Sabrina Tafuro,Serena Zacchigna,Nikola Arsic,Lucia Pattarini,Milena Sinigaglia,Mauro Giacca

View Articletitled, Bone marrow mononuclear cells are recruited to the sites of VEGF-induced neovascularization but are not incorporated into the newly formed vessels

Supplemental data

Enhancement of thrombogenesis by plasma fibronectin cross-linked to fibrin and assembled in platelet thrombi

Jaehyung Cho,Deane F. Mosher

View Articletitled, Enhancement of thrombogenesis by plasma fibronectin cross-linked to fibrin and assembled in platelet thrombi

The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin

Yujie Huang,Hubing Shi,Hao Zhou,Xiaomin Song,Shaopeng Yuan,Yongzhang Luo

View Articletitled, The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin

Reduced thromboxane biosynthesis in carriers of toll-like receptor 4 polymorphisms in vivo
Brief Report

Paola Patrignani,Concetta Di Febbo,Stefania Tacconelli,Valeria Moretta,Giovanna Baccante,Maria G. Sciulli,Emanuela Ricciotti,Marta L. Capone,Ivana Antonucci,Maria D. Guglielmi,Liborio Stuppia,Ettore Porreca

View Articletitled, Reduced thromboxane biosynthesis in carriers of toll-like receptor 4 polymorphisms in vivo

IMMUNOBIOLOGY

Bortezomib induces selective depletion of alloreactive T lymphocytes and decreases the production of Th1 cytokines

Belén Blanco,José A. Pérez-Simón,Luis I. Sánchez-Abarca,Xonia Carvajal-Vergara,Juan Mateos,Belén Vidriales,Natalia López-Holgado,Patricia Maiso,Mercedes Alberca,Eva Villarón,David Schenkein,Atanasio Pandiella,Jesús San Miguel

View Articletitled, Bortezomib induces selective depletion of alloreactive T lymphocytes and decreases the production of Th1 cytokines

ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL)

Sarah J. Richardson,Christine Matthews,Mark A. Catherwood,H. Denis Alexander,B. Sean Carey,Joanna Farrugia,Anne Gardiner,Sarah Mould,David Oscier,J. Adrian Copplestone,Archibald G. Prentice

View Articletitled, ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL)

Shedding of lymphocyte function–associated antigen-1 (LFA-1) in a human inflammatory response

Betsy J. Evans,Alison McDowall,Peter C. Taylor,Nancy Hogg,Dorian O. Haskard,R. Clive Landis

View Articletitled, Shedding of lymphocyte function–associated antigen-1 (LFA-1) in a human inflammatory response

Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors

Jiquan Zhang,Anna Raper,Noriko Sugita,Ravi Hingorani,Mariolina Salio,Michael J. Palmowski,Vincenzo Cerundolo,Paul R. Crocker

View Articletitled, Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors

Role of endothelial heparanase in delayed-type hypersensitivity

Evgeny Edovitsky,Immanuel Lerner,Eyal Zcharia,Tamar Peretz,Israel Vlodavsky,Michael Elkin

View Articletitled, Role of endothelial heparanase in delayed-type hypersensitivity

Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL)

Shino Hanabuchi,Norihiko Watanabe,Yi-Hong Wang,Yui-Hsi Wang,Tomoki Ito,Joanne Shaw,Wei Cao,F. Xiao-Feng Qin,Yong-Jun Liu

View Articletitled, Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL)

Expansion of CD94/NKG2C⁺ NK cells in response to human cytomegalovirus-infected fibroblasts

Mónica Gumá,Matthias Budt,Andrea Sáez,Tamara Brckalo,Hartmut Hengel,Ana Angulo,Miguel López-Botet

View Articletitled, Expansion of CD94/NKG2C+ NK cells in response to human cytomegalovirus-infected fibroblasts

Vasoactive intestinal peptide generates human tolerogenic dendritic cells that induce CD4 and CD8 regulatory T cells

Elena Gonzalez-Rey,Alejo Chorny,Amelia Fernandez-Martin,Doina Ganea,Mario Delgado

View Articletitled, Vasoactive intestinal peptide generates human tolerogenic dendritic cells that induce CD4 and CD8 regulatory T cells

Intratumoral CD4⁺CD25⁺ regulatory T-cell-mediated suppression of infiltrating CD4⁺ T cells in B-cell non-Hodgkin lymphoma

Zhi-Zhang Yang,Anne J. Novak,Mary J. Stenson,Thomas E. Witzig,Stephen M. Ansell

View Articletitled, Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma

Dual function for the adaptor MIST in IFN-γ production by NK and CD4⁺NKT cells regulated by the Src kinase Fgr

Hiroki Sasanuma,Akiko Tatsuno,Shinya Hidano,Keiko Ohshima,Yumi Matsuzaki,Katsuhiko Hayashi,Clifford A. Lowell,Daisuke Kitamura,Ryo Goitsuka

View Articletitled, Dual function for the adaptor MIST in IFN-γ production by NK and CD4+NKT cells regulated by the Src kinase Fgr

Regulatory dendritic cells act as regulators of acute lethal systemic inflammatory response

Shigeharu Fujita,Ken-ichiro Seino,Kaori Sato,Yumiko Sato,Kawori Eizumi,Naohide Yamashita,Masaru Taniguchi,Katsuaki Sato

View Articletitled, Regulatory dendritic cells act as regulators of acute lethal systemic inflammatory response

A family with Papillon-Lefèvre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity
Brief Report

Josephine L. Meade,Erika A. de Wynter,Peter Brett,Saghira Malik Sharif,C. Geoffrey Woods,Alexander F. Markham,Graham P. Cook

View Articletitled, A family with Papillon-Lefèvre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity

Supplemental data

NEOPLASIA

Clinical implication of centrosome amplification in plasma cell neoplasm
Clinical Trials & Observations

Wee J. Chng,Greg J. Ahmann,Kim Henderson,Rafael Santana-Davila,Philip R. Greipp,Morie A. Gertz,Martha Q. Lacy,Angela Dispenzieri,Shaji Kumar,S. Vincent Rajkumar,John A. Lust,Robert A. Kyle,Steven R. Zeldenrust,Suzanne R. Hayman,Rafael Fonseca

View Articletitled, Clinical implication of centrosome amplification in plasma cell neoplasm

Relation between JAK2 (V617F) mutation status, granulocyte activation, and constitutive mobilization of CD34⁺ cells into peripheral blood in myeloproliferative disorders

Francesco Passamonti,Elisa Rumi,Daniela Pietra,Matteo G. Della Porta,Emanuela Boveri,Cristiana Pascutto,Laura Vanelli,Luca Arcaini,Sara Burcheri,Luca Malcovati,Mario Lazzarino,Mario Cazzola

View Articletitled, Relation between JAK2 (V617F) mutation status, granulocyte activation, and constitutive mobilization of CD34+ cells into peripheral blood in myeloproliferative disorders

Growth inhibition and apoptosis in human Philadelphia chromosome-positive lymphoblastic leukemia cell lines by treatment with the dual PPARα/γ ligand TZD18

Hongyu Liu,Chuanbing Zang,Martin H. Fenner,Dachuan Liu,Kurt Possinger,H. Phillip Koeffler,Elena Elstner

View Articletitled, Growth inhibition and apoptosis in human Philadelphia chromosome-positive lymphoblastic leukemia cell lines by treatment with the dual PPARα/γ ligand TZD18

Induction of the plasminogen activator inhibitor-2 in cells expressing the ZNF198/FGFR1 fusion kinase that is involved in atypical myeloproliferative disease

Chitta S. Kasyapa,Padmaja Kunapuli,Lesleyann Hawthorn,John K. Cowell

View Articletitled, Induction of the plasminogen activator inhibitor-2 in cells expressing the ZNF198/FGFR1 fusion kinase that is involved in atypical myeloproliferative disease

Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML

Carola Reindl,Ksenia Bagrintseva,Sridhar Vempati,Susanne Schnittger,Joachim W. Ellwart,Katja Wenig,Karl-Peter Hopfner,Wolfgang Hiddemann,Karsten Spiekermann

View Articletitled, Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML

Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells

Daniela de Totero,Raffaella Meazza,Simona Zupo,Giovanna Cutrona,Serena Matis,Monica Colombo,Enrico Balleari,Ivana Pierri,Marina Fabbi,Matteo Capaia,Bruno Azzarone,Marco Gobbi,Manlio Ferrarini,Silvano Ferrini

View Articletitled, Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells

Gene expression and angiotropism in primary CNS lymphoma
Clinical Trials & Observations

James L. Rubenstein,Jane Fridlyand,Arthur Shen,Ken Aldape,David Ginzinger,Tracy Batchelor,Patrick Treseler,Mitchel Berger,Michael McDermott,Michael Prados,Jon Karch,Craig Okada,William Hyun,Seema Parikh,Chris Haqq,Marc Shuman

View Articletitled, Gene expression and angiotropism in primary CNS lymphoma

Supplemental data

Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia
Clinical Trials & Observations Brief Report

Derek L. Stirewalt,Kenneth J. Kopecky,Soheil Meshinchi,Julia H. Engel,Era L. Pogosova-Agadjanyan,Jeremy Linsley,Marilyn L. Slovak,Cheryl L. Willman,Jerald P. Radich

View Articletitled, Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia

Supplemental data

PHAGOCYTES

TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens

Carole Peyssonnaux,Annelies S. Zinkernagel,Vivekanand Datta,Xavier Lauth,Randall S. Johnson,Victor Nizet

View Articletitled, TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens

RED CELLS

Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major
Clinical Trials & Observations

Caterina Borgna-Pignatti,Maria Domenica Cappellini,Piero De Stefano,Giovanni Carlo Del Vecchio,Gian Luca Forni,Maria Rita Gamberini,Roberta Ghilardi,Antonio Piga,Maria Antonietta Romeo,Huaqing Zhao,Avital Cnaan

View Articletitled, Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major

Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis
Clinical Trials & Observations

Dudley J. Pennell,Vasili Berdoukas,Markissia Karagiorga,Vasili Ladis,Antonio Piga,Athanassios Aessopos,Efstathios D. Gotsis,Mark A. Tanner,Gill C. Smith,Mark A. Westwood,Beatrix Wonke,Renzo Galanello

View Articletitled, Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis

Ex vivo perfusion of human spleens maintains clearing and processing functions

Pierre A. Buffet,Geneviève Milon,Valentine Brousse,Jean-Michel Correas,Bertrand Dousset,Anne Couvelard,Reza Kianmanesh,Olivier Farges,Alain Sauvanet,François Paye,Marie-Noëlle Ungeheuer,Catherine Ottone,Huot Khun,Laurence Fiette,Ghislaine Guigon,Michel Huerre,Odile Mercereau-Puijalon,Peter H. David

View Articletitled, Ex vivo perfusion of human spleens maintains clearing and processing functions

TRANSFUSION MEDICINE

Photochemically treated fresh frozen plasma for transfusion of patients with acquired coagulopathy of liver disease

Paul D. Mintz,Nathan M. Bass,Lawrence D. Petz,Randolph Steadman,Michael Streiff,Jeffery McCullough,Sandra Burks,David Wages,Sally Van Doren,Laurence Corash

View Articletitled, Photochemically treated fresh frozen plasma for transfusion of patients with acquired coagulopathy of liver disease

Antigen-positive platelet transfusion in neonatal alloimmune thrombocytopenia (NAIT)
Clinical Trials & Observations Brief Report

Volker Kiefel,Dirk Bassler,Hartmut Kroll,Bosco Paes,Günter Giers,Juliana Ditomasso,Heidemarie Alber,Monika Berns,Bea Wiebe,Ernst-Markus Quenzel,Jochen Hoch,Andreas Greinacher

View Articletitled, Antigen-positive platelet transfusion in neonatal alloimmune thrombocytopenia (NAIT)

TRANSPLANTATION

Mobilization as a preparative regimen for hematopoietic stem cell transplantation

Jing Chen,André Larochelle,Simon Fricker,Gary Bridger,Cynthia E. Dunbar,Janis L. Abkowitz

View Articletitled, Mobilization as a preparative regimen for hematopoietic stem cell transplantation

AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates

André Larochelle,Allen Krouse,Mark Metzger,Donald Orlic,Robert E. Donahue,Simon Fricker,Gary Bridger,Cynthia E. Dunbar,Peiman Hematti

View Articletitled, AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates

The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL

Anthony G. Brickner,Anne M. Evans,Jeffrey K. Mito,Suzanne M. Xuereb,Xin Feng,Tetsuya Nishida,Liane Fairfull,Robert E. Ferrell,Kenneth A. Foon,Donald F. Hunt,Jeffrey Shabanowitz,Victor H. Engelhard,Stanley R. Riddell,Edus H. Warren

View Articletitled, The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL

Vasoactive intestinal peptide induces regulatory dendritic cells that prevent acute graft-versus-host disease while maintaining the graft-versus-tumor response

Alejo Chorny,Elena Gonzalez-Rey,Amelia Fernandez-Martin,Doina Ganea,Mario Delgado

View Articletitled, Vasoactive intestinal peptide induces regulatory dendritic cells that prevent acute graft-versus-host disease while maintaining the graft-versus-tumor response

Allogeneic nonmyeloablative hematopoietic cell transplantation in metastatic colon cancer: tumor-specific T cells directed to a tumor-associated antigen are generated in vivo during GVHD

Fabrizio Carnevale-Schianca,Alessandro Cignetti,Antonio Capaldi,Katiuscia Vitaggio,Antonella Vallario,Alberto Ricchiardi,Elisa Sperti,Renato Ferraris,Marco Gatti,Giovanni Grignani,Delia Rota-Scalabrini,Massimo Geuna,Marco Fizzotti,Dario Sangiolo,Antonino Sottile,Giovanni De Rosa,Anna Rosa Bucci,Giorgio Lambertenghi-Deliliers,Edoardo Benedetti,Richard Nash,Massimo Aglietta

View Articletitled, Allogeneic nonmyeloablative hematopoietic cell transplantation in metastatic colon cancer: tumor-specific T cells directed to a tumor-associated antigen are generated in vivo during GVHD

Comparable results of umbilical cord blood and HLA-matched sibling donor hematopoietic stem cell transplantation after reduced-intensity preparative regimen for advanced Hodgkin lymphoma
Clinical Trials & Observations

Navneet S. Majhail,Daniel J. Weisdorf,John E. Wagner,Todd E. Defor,Claudio G. Brunstein,Linda J. Burns

View Articletitled, Comparable results of umbilical cord blood and HLA-matched sibling donor hematopoietic stem cell transplantation after reduced-intensity preparative regimen for advanced Hodgkin lymphoma

CORRESPONDENCE

Recipient γδ T cells in graft-versus-host disease

Britt E. Anderson,Warren D. Shlomchik,Mark J. Shlomchik

View Articletitled, Recipient γδ T cells in graft-versus-host disease

Assessing the risk of inhibitor formation with different factor VIII products

Pier M. Mannucci

View Articletitled, Assessing the risk of inhibitor formation with different factor VIII products

A novel deletion causing α thalassemia clarifies the importance of the major human alpha globin regulatory element

Vip Viprakasit,Cornelis L. Harteveld,Helena Ayyub,Jackie S. Stanley,Piero C. Giordano,William G. Wood,Douglas R. Higgs

View Articletitled, A novel deletion causing α thalassemia clarifies the importance of the major human alpha globin regulatory element

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Issue Archive

Table of Contents

INSIDE BLOOD

BLOOD WORK

EDITORIALS

PERSPECTIVES

Stem cell mobilization with G-CSF analogs: a rational approach to separate GVHD and GVL? Clinical Trials & Observations

ERRATA

REVIEW ARTICLES

Update on treatment recommendations from the Third International Workshop on Waldenström's Macroglobulinemia Clinical Trials & Observations

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

CLINICAL TRIALS AND OBSERVATIONS

A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with β-thalassemia Clinical Trials & Observations

Prognostic impact of c-KIT mutations in core binding factor leukemias: an Italian retrospective study Clinical Trials & Observations

Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia Clinical Trials & Observations

Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma Clinical Trials & Observations

Age and acute myeloid leukemia Clinical Trials & Observations

High levels of circulating CD34 cells, dacrocytes, clonal hematopoiesis, and JAK2 mutation differentiate myelofibrosis with myeloid metaplasia from secondary myelofibrosis associated with pulmonary hypertension Clinical Trials & Observations Brief Report

Seeking confidence in the diagnosis of systemic AL (Ig light-chain) amyloidosis: patients can have both monoclonal gammopathies and hereditary amyloid proteins Clinical Trials & Observations Brief Report

Severe pulmonary complications in Japanese patients after bortezomib treatment for refractory multiple myeloma Clinical Trials & Observations Brief Report

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Reduced thromboxane biosynthesis in carriers of toll-like receptor 4 polymorphisms in vivo Brief Report

IMMUNOBIOLOGY

A family with Papillon-Lefèvre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity Brief Report

NEOPLASIA

Clinical implication of centrosome amplification in plasma cell neoplasm Clinical Trials & Observations

Gene expression and angiotropism in primary CNS lymphoma Clinical Trials & Observations

Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia Clinical Trials & Observations Brief Report

PHAGOCYTES

RED CELLS

Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major Clinical Trials & Observations

Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis Clinical Trials & Observations

TRANSFUSION MEDICINE

Antigen-positive platelet transfusion in neonatal alloimmune thrombocytopenia (NAIT) Clinical Trials & Observations Brief Report

TRANSPLANTATION

Comparable results of umbilical cord blood and HLA-matched sibling donor hematopoietic stem cell transplantation after reduced-intensity preparative regimen for advanced Hodgkin lymphoma Clinical Trials & Observations

CORRESPONDENCE

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American Society of Hematology

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Stem cell mobilization with G-CSF analogs: a rational approach to separate GVHD and GVL?
Clinical Trials & Observations

Update on treatment recommendations from the Third International Workshop on Waldenström's Macroglobulinemia
Clinical Trials & Observations

A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with β-thalassemia
Clinical Trials & Observations

Prognostic impact of c-KIT mutations in core binding factor leukemias: an Italian retrospective study
Clinical Trials & Observations

Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia
Clinical Trials & Observations

Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma
Clinical Trials & Observations

Age and acute myeloid leukemia
Clinical Trials & Observations

High levels of circulating CD34 cells, dacrocytes, clonal hematopoiesis, and JAK2 mutation differentiate myelofibrosis with myeloid metaplasia from secondary myelofibrosis associated with pulmonary hypertension
Clinical Trials & Observations Brief Report

Seeking confidence in the diagnosis of systemic AL (Ig light-chain) amyloidosis: patients can have both monoclonal gammopathies and hereditary amyloid proteins
Clinical Trials & Observations Brief Report

Severe pulmonary complications in Japanese patients after bortezomib treatment for refractory multiple myeloma
Clinical Trials & Observations Brief Report

Reduced thromboxane biosynthesis in carriers of toll-like receptor 4 polymorphisms in vivo
Brief Report

A family with Papillon-Lefèvre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity
Brief Report

Clinical implication of centrosome amplification in plasma cell neoplasm
Clinical Trials & Observations

Gene expression and angiotropism in primary CNS lymphoma
Clinical Trials & Observations

Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia
Clinical Trials & Observations Brief Report

Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major
Clinical Trials & Observations

Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis
Clinical Trials & Observations

Antigen-positive platelet transfusion in neonatal alloimmune thrombocytopenia (NAIT)
Clinical Trials & Observations Brief Report

Comparable results of umbilical cord blood and HLA-matched sibling donor hematopoietic stem cell transplantation after reduced-intensity preparative regimen for advanced Hodgkin lymphoma
Clinical Trials & Observations