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Volume 107, Issue 6

March 15 2006

In this Issue

INSIDE BLOOD
PERSPECTIVES
REVIEW ARTICLES
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
CLINICAL TRIALS AND OBSERVATIONS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
RED CELLS
TRANSPLANTATION
CORRESPONDENCE
ERRATA

Table of Contents

INSIDE BLOOD

GENE THERAPY

Suicide is painless

Helen E. Heslop

NEOPLASIA

ROS: double-edged sword for leukemic cells

Neil E. Kay

TRANSPLANTATION

Allo attack on amyloidosis

Morie A. Gertz

HEMOSTASIS

HIT without (more) heparin

Theodore E. Warkentin

IMMUNOBIOLOGY

Clues to lymphoma's cellular origin

David Y. Mason

HEMATOPOIESIS

Hematopoietic stem cells, explicitly

Ihor Lemischka

NEOPLASIA

Microtubules, leukemia, and cough syrup

Steven Heidemann

NEOPLASIA

Classical Hodgkin lymphoma: an epigenetically determined disease?

Juan F. García, M.D.

HEMOSTASIS

Could shear stress be the answer?

Miguel A. Cruz

PERSPECTIVES

Nitric oxide generation from hydroxyurea: significance and implications for leukemogenesis in the management of myeloproliferative disorders

Mark J. Burkitt,Alaeddin Raafat

REVIEW ARTICLES

Recent insights into the role of Notch signaling in tumorigenesis

Kevin G. Leong,Aly Karsan

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Mast cells and neutrophils proteolytically activate chemokine precursor CTAP-III and are subject to counterregulation by PF-4 through inhibition of chymase and cathepsin G

Florian Schiemann,Tobias Alexander Grimm,Josef Hoch,Roland Gross,Buko Lindner,Frank Petersen,Silvia Bulfone-Paus,Ernst Brandt

Reduced retention of radioprotective hematopoietic cells within the bone marrow microenvironment in CXCR4^–/– chimeric mice

Adlen Foudi,Peggy Jarrier,Yanyan Zhang,Monika Wittner,Jean-Francois Geay,Yann Lecluse,Takashi Nagasawa,William Vainchenker,Fawzia Louache

Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFκB

M. Asif Amin,Christian S. Haas,Kui Zhu,Pamela J. Mansfield,Michael J. Kim,Nicholas P. Lackowski,Alisa E. Koch

Chemokine and chemokine receptor expression during colony stimulating factor-1–induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1γ) in osteoclastogenesis in vivo and in vitro

Meiheng Yang,Geneviève Mailhot,Carole A. MacKay,April Mason-Savas,Justin Aubin,Paul R. Odgren

CLINICAL TRIALS AND OBSERVATIONS

Quantitative assessment of molecular remission after high-dose therapy with autologous stem cell transplantation predicts long-term remission in mantle cell lymphoma
Clinical Trials & Observations

Christiane Pott,Carsten Schrader,Stefan Gesk,Lana Harder,Markus Tiemann,Thorsten Raff,Monika Brüggemann,Matthias Ritgen,Benedikt Gahn,Michael Unterhalt,Martin Dreyling,Wolfgang Hiddemann,Reiner Siebert,Peter Dreger,Michael Kneba

Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease
Clinical Trials & Observations

Gregory J. Kato,Vicki McGowan,Roberto F. Machado,Jane A. Little,James Taylor, VI,Claudia R. Morris,James S. Nichols,Xunde Wang,Mirjana Poljakovic,Sidney M. Morris, Jr,Mark T. Gladwin

Supplemental data

GENE THERAPY

Tolerance induction by lentiviral gene therapy with a nonmyeloablative regimen

Noboru Mitsuhashi,Jacqueline Fischer-Lougheed,Irina Shulkin,Annette Kleihauer,Donald B. Kohn,Kenneth I. Weinberg,Vaughn A. Starnes,Mary Kearns-Jonker

Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK–modified donor T cells after allogeneic hematopoietic cell transplantation

Carolina Berger,Mary E. Flowers,Edus H. Warren,Stanley R. Riddell

HEMATOPOIESIS

Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation

Hana Raslova,Véronique Baccini,Lamya Loussaief,Béatrice Comba,Jérôme Larghero,Najet Debili,William Vainchenker

The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets

Hans B. Sieburg,Rebecca H. Cho,Brad Dykstra,Naoyuki Uchida,Connie J. Eaves,Christa E. Muller-Sieburg

Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow

Alejandro B. Balazs,Attila J. Fabian,Charles T. Esmon,Richard C. Mulligan

Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1

Mary Yanxia Liu,Melanie Eyries,Chunyan Zhang,Fernando S. Santiago,Levon M. Khachigian

The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth

Nathalie Kertesz,Valery Krasnoperov,Ramachandra Reddy,Lucy Leshanski,S. Ram Kumar,Sergey Zozulya,Parkash S. Gill

Impact of mutations in the von Willebrand factor A2 domain on ADAMTS13-dependent proteolysis

Wolf Achim Hassenpflug,Ulrich Budde,Tobias Obser,Dorothea Angerhaus,Elke Drewke,Sonja Schneppenheim,Reinhard Schneppenheim

Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications

Lubica Rauova,Li Zhai,M. Anna Kowalska,Gowthami M. Arepally,Douglas B. Cines,Mortimer Poncz

IMMUNOBIOLOGY

Down-regulating constitutive activation of the NF-κB canonical pathway overcomes the resistance of cutaneous T-cell lymphoma to apoptosis

Aurore Sors,Francette Jean-Louis,Claire Pellet,Liliane Laroche,Louis Dubertret,Gilles Courtois,Hervé Bachelez,Laurence Michel

Multiplicity and plasticity of natural killer cell signaling pathways

Sabrina Chiesa,Michael Mingueneau,Nicolas Fuseri,Bernard Malissen,David H. Raulet,Marie Malissen,Eric Vivier,Elena Tomasello

Supplemental data

Fluctuations of functionally distinct CD8⁺ T-cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire

Dirk Meyer-Olson,Kristen W. Brady,Melissa T. Bartman,Kristin M. O'Sullivan,Brenna C. Simons,Joseph A. Conrad,Coley B. Duncan,Shelly Lorey,Atif Siddique,Rika Draenert,Marylyn Addo,Marcus Altfeld,Eric Rosenberg,Todd M. Allen,Bruce D. Walker,Spyros A. Kalams

Supplemental data

Fas ligand is localized to membrane rafts, where it displays increased cell death–inducing activity

Nathalie Cahuzac,Wiebke Baum,Vladimir Kirkin,Fabien Conchonaud,Laure Wawrezinieck,Didier Marguet,Ottmar Janssen,Martin Zörnig,Anne-Odile Hueber

CD38 orchestrates migration, survival, and Th1 immune response of human mature dendritic cells

Loredana Frasca,Giorgio Fedele,Silvia Deaglio,Cristina Capuano,Raffaella Palazzo,Tiziana Vaisitti,Fabio Malavasi,Clara Maria Ausiello

Patterns of expression, membrane localization, and effects of ectopic expression suggest a function for MS4a4B, a CD20 homolog in Th1 T cells

Hui Xu,Mark S. Williams,Lisa M. Spain

Supplemental data

IL-2 administration increases CD4⁺CD25^hi Foxp3⁺ regulatory T cells in cancer patients

Mojgan Ahmadzadeh,Steven A. Rosenberg

Essential role of PI3Kδ and PI3Kγ in thymocyte survival

Wojciech Swat,Vivianne Montgrain,Teresa A. Doggett,Jason Douangpanya,Kamal Puri,William Vermi,Thomas G. Diacovo

Supplemental data

Specialization, kinetics, and repertoire of type 1 interferon responses by human plasmacytoid predendritic cells

Tomoki Ito,Holger Kanzler,Omar Duramad,Wei Cao,Yong-Jun Liu

Tumor evasion of the immune system: inhibiting p38 MAPK signaling restores the function of dendritic cells in multiple myeloma

Siqing Wang,Jing Yang,Jianfei Qian,Michele Wezeman,Larry W. Kwak,Qing Yi

Skin-derived interleukin-7 contributes to the proliferation of lymphocytes in cutaneous T-cell lymphoma

Kei-ichi Yamanaka,Rachael Clark,Benjamin Rich,Rebecca Dowgiert,Kazuki Hirahara,Daniel Hurwitz,Michio Shibata,Nina Mirchandani,David A. Jones,Deborah S. Goddard,Sara Eapen,Hitoshi Mizutani,Thomas S. Kupper

Supplemental data

Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B

Wendy Dontje,Remko Schotte,Tom Cupedo,Maho Nagasawa,Ferenc Scheeren,Ramon Gimeno,Hergen Spits,Bianca Blom

Supplemental data

Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration

Önder Alpdogan,Vanessa M. Hubbard,Odette M. Smith,Neel Patel,Sydney Lu,Gabrielle L. Goldberg,Daniel H. Gray,Jared Feinman,Adam A. Kochman,Jeffrey M. Eng,David Suh,Stephanie J. Muriglan,Richard L. Boyd,Marcel R. M. van den Brink

Supplemental data

Macrophages from C3-deficient mice have impaired potency to stimulate alloreactive T cells

Wuding Zhou,Hetal Patel,Ke Li,Qi Peng,Marie-Bernadette Villiers,Steven H. Sacks

Supplemental data

AID expression identifies interfollicular large B cells as putative precursors of mature B-cell malignancies
Brief Report

Gerhard Moldenhauer,Sergey W. Popov,Beate Wotschke,Silke Brüderlein,Petra Riedl,Nicolas Fissolo,Reinhold Schirmbeck,Olga Ritz,Peter Möller,Frank Leithäuser

Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12

Amanda L. Blasius,Marina Cella,Jorge Maldonado,Toshiyuki Takai,Marco Colonna

NEOPLASIA

Array comparative genomic hybridization reveals genomic copy number changes associated with outcome in diffuse large B-cell lymphomas
Clinical Trials & Observations

Weiyi Chen,Jane Houldsworth,Adam B. Olshen,Gouri Nanjangud,Seeta Chaganti,Ennapadem S. Venkatraman,Jeffrey Halaas,Julie Teruya-Feldstein,Andrew D. Zelenetz,R. S. K. Chaganti

Supplemental data

Drug-resistant T-lymphoid tumors undergo apoptosis selectively in response to an antimicrotubule agent, EM011

Ritu Aneja,Jun Zhou,Surya N. Vangapandu,Binfei Zhou,Ramesh Chandra,Harish C. Joshi

Epigenetic processes play a major role in B-cell-specific gene silencing in classical Hodgkin lymphoma

Alexey Ushmorov,Frank Leithäuser,Olena Sakk,Andreas Weinhaüsel,Sergey W. Popov,Peter Möller,Thomas Wirth

Adaphostin-induced oxidative stress overcomes BCR/ABL mutation-dependent and -independent imatinib resistance

Joya Chandra,Jeannette Tracy,David Loegering,Karen Flatten,Srdan Verstovsek,Miloslav Beran,Mercedes Gorre,Zeev Estrov,Nicholas Donato,Moshe Talpaz,Charles Sawyers,Kapil Bhalla,Judith Karp,Edward Sausville,Scott H. Kaufmann

A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation

Mario Notari,Paolo Neviani,Ramasamy Santhanam,Bradley W. Blaser,Ji-Suk Chang,Annamaria Galietta,Anne E. Willis,Denis C. Roy,Michael A. Caligiuri,Guido Marcucci,Danilo Perrotti

Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial
Clinical Trials & Observations

Deepa Sampath,Jorge Cortes,Zeev Estrov,Min Du,Zheng Shi,Michael Andreeff,Varsha Gandhi,William Plunkett

Circulating thrombopoietin as an in vivo growth factor for blast cells in acute myeloid leukemia

Francis Corazza,Christophe Hermans,Stéphanie D'Hondt,Alina Ferster,Alain Kentos,Yves Benoît,Eric Sariban

Neoplastic circulating endothelial cells in multiple myeloma with 13q14 deletion

Gian Matteo Rigolin,Chiara Fraulini,Maria Ciccone,Endri Mauro,Anna Maria Bugli,Cristiano De Angeli,Massimo Negrini,Antonio Cuneo,Gianluigi Castoldi

Supplemental data

Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3), which promotes viability of Hodgkin/Reed-Sternberg cells

Martin Janz,Michael Hummel,Matthias Truss,Brigitte Wollert-Wulf,Stephan Mathas,Korinna Jöhrens,Christian Hagemeier,Kurt Bommert,Harald Stein,Bernd Dörken,Ralf C. Bargou

Supplemental data

Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma

Ying-Wei Lin,Rebecca A. Nichols,John J. Letterio,Peter D. Aplan

Supplemental data

c-FLIP confers resistance to FAS-mediated apoptosis in anaplastic large-cell lymphoma
Brief Report

Mauricio P. Oyarzo,L. Jeffrey Medeiros,Coralyn Atwell,Marianna Feretzaki,Vasiliki Leventaki,Elias Drakos,Hesham M. Amin,George Z. Rassidakis

Supplemental data

RED CELLS

Species- and cell type-specific interactions between CD47 and human SIRPα

Shyamsundar Subramanian,Ranganath Parthasarathy,Shamik Sen,Eric T. Boder,Dennis E. Discher

Supplemental data

High frequency of alternative first exons in erythroid genes suggests a critical role in regulating gene function

Jeff S. Tan,Narla Mohandas,John G. Conboy

Supplemental data

TRANSPLANTATION

Generation of highly purified and functionally active human T_H1 cells against Aspergillus fumigatus

Olaf Beck,Max S. Topp,Ulrike Koehl,Emmanuel Roilides,Maria Simitsopoulou,Mitra Hanisch,Jacqueline Sarfati,Jean Paul Latgé,Thomas Klingebiel,Hermann Einsele,Thomas Lehrnbecher

Interferon-γ-stimulated marrow stromal cells: a new type of nonhematopoietic antigen-presenting cell

John Stagg,Sandra Pommey,Nicoletta Eliopoulos,Jacques Galipeau

Supplemental data

Allogeneic and syngeneic hematopoietic cell transplantation in patients with amyloid light-chain amyloidosis: a report from the European Group for Blood and Marrow Transplantation

Stefan O. Schönland,Henk Lokhorst,Agnes Buzyn,Veronique Leblond,Ute Hegenbart,Giuseppe Bandini,Andrew Campbell,Enric Carreras,Augustin Ferrant,Leanthe Grommisch,Peter Jacobs,Nicolaus Kröger,Giorgio La Nasa,Nigel Russell,Pierre Zachee,Hartmut Goldschmidt,Simona Iacobelli,Dietger Niederwieser,Gösta Gahrton,for the Chronic Leukemia Working Party (CLWP), Myeloma Subcommittee of the European Cooperative Group for Blood and Marrow Transplantation (EBMT)

CORRESPONDENCE

Severe hemolysis following administration of Rh_o(D) immune globulin in an ITP patient associated with anti-C

Joseph Schwartz,Steve Spitalnik,Kathleen M. Grima

ERRATA

Erratum for vol. 105, p. 3956

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