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Volume 107, Issue 5

March 1 2006

In this Issue

INSIDE BLOOD
BLOOD WORK
PERSPECTIVES
ERRATA
REVIEW ARTICLES
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
CLINICAL TRIALS AND OBSERVATIONS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
STEM CELLS IN HEMATOLOGY
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

CHEMOKINES

A fine romance: IL-7 and HGFβ

Crystal L. Mackall

View Articletitled, A fine romance: IL-7 and HGFβ

IMMUNOBIOLOGY

HTLV tax tails

David Derse

View Articletitled, HTLV tax tails

GENE THERAPY

AAV immunity: more than meets the eye

David Lillicrap

View Articletitled, AAV immunity: more than meets the eye

PHAGOCYTES

Putting the brakes on neutrophils

Charles N. Serhan,Nan Chiang

View Articletitled, Putting the brakes on neutrophils

IMMUNOBIOLOGY

HIV creates an immunologic black hole

Richard S. Kornbluth

View Articletitled, HIV creates an immunologic black hole

RED CELLS

Another piece of the globin-switching puzzle

Christopher Lowrey

View Articletitled, Another piece of the globin-switching puzzle

HEMOSTASIS

Filamin A interaction with GPIbα: the platelet shapes up

Michael C. Berndt,Susan L. Cranmer,Robert K. Andrews

View Articletitled, Filamin A interaction with GPIbα: the platelet shapes up

BLOOD WORK

Ring sideroblasts

View Articletitled, Ring sideroblasts

PERSPECTIVES

The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration?
Clinical Trials & Observations

Ernest Beutler,Jill Waalen

View Articletitled, The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration?

ERRATA

Erratum for vol. 101, p. 1359

View Articletitled, Erratum for vol. 101, p. 1359

REVIEW ARTICLES

Survival of the fittest: in vivo selection and stem cell gene therapy

Tobias Neff,Brian C. Beard,Hans-Peter Kiem

View Articletitled, Survival of the fittest: in vivo selection and stem cell gene therapy

CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment

Jan A. Burger,Thomas J. Kipps

View Articletitled, CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Neutrophil adhesion to endothelial cells induced by platelet factor 4 requires sequential activation of Ras, Syk, and JNK MAP kinases

Brigitte Kasper,Ernst Brandt,Martin Ernst,Frank Petersen

View Articletitled, Neutrophil adhesion to endothelial cells induced by platelet factor 4 requires sequential activation of Ras, Syk, and JNK MAP kinases

Supplemental data

A recombinant single-chain IL-7/HGFβ hybrid cytokine induces juxtacrine interactions of the IL-7 and HGF (c-Met) receptors and stimulates the proliferation of CFU-S₁₂, CLPs, and pre-pro-B cells

Laijun Lai,Richard A. Zeff,Irving Goldschneider

View Articletitled, A recombinant single-chain IL-7/HGFβ hybrid cytokine induces juxtacrine interactions of the IL-7 and HGF (c-Met) receptors and stimulates the proliferation of CFU-S12, CLPs, and pre-pro-B cells

Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Evaluation of the efficacy and safety of etoricoxib in the treatment of hemophilic arthropathy
Clinical Trials & Observations

Christos Tsoukas,M. Elaine Eyster,Sumiko Shingo,Saurabh Mukhopadhyay,Karen M. Giallella,Sean P. Curtis,Alise S. Reicin,Agustin Melian

View Articletitled, Evaluation of the efficacy and safety of etoricoxib in the treatment of hemophilic arthropathy

KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival
Clinical Trials & Observations

Susanne Schnittger,Tobias M. Kohl,Torsten Haferlach,Wolfgang Kern,Wolfgang Hiddemann,Karsten Spiekermann,Claudia Schoch

View Articletitled, KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival

Long-term acyclovir for prevention of varicella zoster virus disease after allogeneic hematopoietic cell transplantation—a randomized double-blind placebo-controlled study
Clinical Trials & Observations

Michael Boeckh,Hyung W. Kim,Mary E. D. Flowers,Joel D. Meyers,Raleigh A. Bowden

View Articletitled, Long-term acyclovir for prevention of varicella zoster virus disease after allogeneic hematopoietic cell transplantation—a randomized double-blind placebo-controlled study

KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study Group
Clinical Trials & Observations

Akira Shimada,Tomohiko Taki,Ken Tabuchi,Akio Tawa,Keizo Horibe,Masahiro Tsuchida,Ryoji Hanada,Ichiro Tsukimoto,Yasuhide Hayashi

View Articletitled, KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study Group

Supplemental data

GENE THERAPY

Human immunoglobulin inhibits liver transduction by AAV vectors at low AAV2 neutralizing titers in SCID mice

Ciaran D. Scallan,Haiyan Jiang,Tongyao Liu,Susannah Patarroyo-White,Jurg M. Sommer,Shangzhen Zhou,Linda B. Couto,Glenn F. Pierce

View Articletitled, Human immunoglobulin inhibits liver transduction by AAV vectors at low AAV2 neutralizing titers in SCID mice

Efficient stimulation of HIV-1–specific T cells using dendritic cells electroporated with mRNA encoding autologous HIV-1 Gag and Env proteins

Ellen R. A. Van Gulck,Peter Ponsaerts,Leo Heyndrickx,Katleen Vereecken,Filip Moerman,Ann De Roo,Robert Colebunders,Glenn Van den Bosch,Dirk R. Van Bockstaele,Viggo F. I. Van Tendeloo,Sabine Allard,Bernard Verrier,Concepción Marañón,Guillaume Hoeffel,Anne Hosmalin,Zwi N. Berneman,Guido Vanham

View Articletitled, Efficient stimulation of HIV-1–specific T cells using dendritic cells electroporated with mRNA encoding autologous HIV-1 Gag and Env proteins

Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes

Attilio Bondanza,Veronica Valtolina,Zulma Magnani,Maurilio Ponzoni,Katharina Fleischhauer,Mark Bonyhadi,Catia Traversari,Francesca Sanvito,Salvatore Toma,Marina Radrizzani,Simona La Seta-Catamancio,Fabio Ciceri,Claudio Bordignon,Chiara Bonini

View Articletitled, Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes

HEMATOPOIESIS

Hematopoiesis and stem cell renewal in long-term bone marrow cultures containing catalase

Rashmi Gupta,Simon Karpatkin,Ross S. Basch

View Articletitled, Hematopoiesis and stem cell renewal in long-term bone marrow cultures containing catalase

G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth

Quan-sheng Zhu,Ling Xia,Gordon B. Mills,Clifford A. Lowell,Ivo P. Touw,Seth J. Corey

View Articletitled, G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth

Redirecting differentiation of hematopoietic progenitors by a transcription factor, GATA-2

Kenji Kitajima,Makoto Tanaka,Jie Zheng,Hilo Yen,Ayuko Sato,Daijiro Sugiyama,Hiroki Umehara,Eiko Sakai,Toru Nakano

View Articletitled, Redirecting differentiation of hematopoietic progenitors by a transcription factor, GATA-2

An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor

Judith Staerk,Catherine Lacout,Takeshi Sato,Steven O. Smith,William Vainchenker,Stefan N. Constantinescu

View Articletitled, An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor

Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death

Vanessa S. Marsden,Thomas Kaufmann,Lorraine A. O'Reilly,Jerry M. Adams,Andreas Strasser

View Articletitled, Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death

Supplemental data

Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment

Yukari Muguruma,Takashi Yahata,Hiroko Miyatake,Tadayuki Sato,Tomoko Uno,Jobu Itoh,Shunichi Kato,Mamoru Ito,Tomomitsu Hotta,Kiyoshi Ando

View Articletitled, Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment

AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation

Saghi Ghaffari,Claire Kitidis,Wei Zhao,Dragan Marinkovic,Mark D. Fleming,Biao Luo,Joseph Marszalek,Harvey F. Lodish

View Articletitled, AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation

Anti-Epo receptor antibodies do not predict Epo receptor expression

Steve Elliott,Leigh Busse,Michael B. Bass,Hsieng Lu,Ildiko Sarosi,Angus M. Sinclair,Chris Spahr,Moonkyoung Um,Gwyneth Van,C. Glenn Begley

View Articletitled, Anti-Epo receptor antibodies do not predict Epo receptor expression

Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Heterodimerization of FGF-receptor 1 and PDGF-receptor-α: a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF-2 in human cells

Debora Faraone,Maria S. Aguzzi,Gianluca Ragone,Katia Russo,Maurizio C. Capogrossi,Antonio Facchiano

View Articletitled, Heterodimerization of FGF-receptor 1 and PDGF-receptor-α: a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF-2 in human cells

Supplemental data

Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2
Clinical Trials & Observations

Bin Zhang,Beth McGee,Jennifer S. Yamaoka,Hugo Guglielmone,Katharine A. Downes,Salvador Minoldo,Gustavo Jarchum,Flora Peyvandi,Norma B. de Bosch,Arlette Ruiz-Saez,Bernard Chatelain,Marian Olpinski,Paula Bockenstedt,Wolfgang Sperl,Randal J. Kaufman,William C. Nichols,Edward G. D. Tuddenham,David Ginsburg

View Articletitled, Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2

Zebrafish to humans: evolution of the α3-chain of type IV collagen and emergence of the autoimmune epitopes associated with Goodpasture syndrome

Brian A. MacDonald,Malin Sund,Marianne A. Grant,Kathleen L. Pfaff,Kathryn Holthaus,Leonard I. Zon,Raghu Kalluri

View Articletitled, Zebrafish to humans: evolution of the α3-chain of type IV collagen and emergence of the autoimmune epitopes associated with Goodpasture syndrome

Pathogenic anti-β₂-glycoprotein I antibodies recognize domain I of β₂-glycoprotein I only after a conformational change

Bas de Laat,Ronald H. W. M. Derksen,Menno van Lummel,Maarten T. T. Pennings,Philip G. de Groot

View Articletitled, Pathogenic anti-β2-glycoprotein I antibodies recognize domain I of β2-glycoprotein I only after a conformational change

The structure of the GPIb–filamin A complex

Fumihiko Nakamura,Regina Pudas,Outi Heikkinen,Perttu Permi,Ilkka Kilpeläinen,Adam D. Munday,John H. Hartwig,Thomas P. Stossel,Jari Ylänne

View Articletitled, The structure of the GPIb–filamin A complex

Supplemental data

Neutrophils, lymphocytes, and monocytes exhibit diverse behaviors in transendothelial and subendothelial migrations under coculture with smooth muscle cells in disturbed flow

Cheng-Nan Chen,Shun-Fu Chang,Pei-Ling Lee,Kyle Chang,Li-Jing Chen,Shunichi Usami,Shu Chien,Jeng-Jiann Chiu

View Articletitled, Neutrophils, lymphocytes, and monocytes exhibit diverse behaviors in transendothelial and subendothelial migrations under coculture with smooth muscle cells in disturbed flow

Supplemental data

Size regulation of von Willebrand factor–mediated platelet thrombi by ADAMTS13 in flowing blood

Roberta Donadelli,Jennifer N. Orje,Cristina Capoferri,Giuseppe Remuzzi,Zaverio M. Ruggeri

View Articletitled, Size regulation of von Willebrand factor–mediated platelet thrombi by ADAMTS13 in flowing blood

Supplemental data

Functional analysis of mutations in the kinase domain of the TGF-β receptor ALK1 reveals different mechanisms for induction of hereditary hemorrhagic telangiectasia

Yi Gu,Peng Jin,Long Zhang,Xingang Zhao,Xia Gao,Yuanheng Ning,Anming Meng,Ye-Guang Chen

View Articletitled, Functional analysis of mutations in the kinase domain of the TGF-β receptor ALK1 reveals different mechanisms for induction of hereditary hemorrhagic telangiectasia

IMMUNOBIOLOGY

A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo

Elke Pogge von Strandmann,Hinrich P. Hansen,Katrin S. Reiners,Roland Schnell,Peter Borchmann,Sabine Merkert,Venkateswara R. Simhadri,Andreas Draube,Marcel Reiser,Ingvill Purr,Michael Hallek,Andreas Engert

View Articletitled, A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo

Expansion of HIV-specific CD4⁺ and CD8⁺ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef

Daniel G. Kavanagh,Daniel E. Kaufmann,Sherzana Sunderji,Nicole Frahm,Sylvie Le Gall,David Boczkowski,Eric S. Rosenberg,David R. Stone,Mary N. Johnston,Bradford S. Wagner,Mohammad T. Zaman,Christian Brander,Eli Gilboa,Bruce D. Walker,Nina Bhardwaj

View Articletitled, Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef

Human leukocyte antigen (HLA) DR15 is associated with reduced incidence of acute GVHD in HLA-matched allogeneic transplantation but does not impact chronic GVHD incidence
Clinical Trials & Observations

Minoo Battiwalla,Theresa Hahn,Marija Radovic,Hilary Roy,Afrin Wahab,Eileen Duman,Rajinder Bajwa,Swaminathan Padmanabhan,Joanne Becker,A. John Barrett,Philip L. McCarthy, Jr

View Articletitled, Human leukocyte antigen (HLA) DR15 is associated with reduced incidence of acute GVHD in HLA-matched allogeneic transplantation but does not impact chronic GVHD incidence

Transforming growth factor-β2 is involved in quantitative genetic variation in thymic involution

Ritu Kumar,Jessica C. Langer,Hans-Willem Snoeck

View Articletitled, Transforming growth factor-β2 is involved in quantitative genetic variation in thymic involution

PDZ binding motif of HTLV-1 Tax promotes virus-mediated T-cell proliferation in vitro and persistence in vivo

Li Xie,Brenda Yamamoto,Abdelali Haoudi,O. John Semmes,Patrick L. Green

View Articletitled, PDZ binding motif of HTLV-1 Tax promotes virus-mediated T-cell proliferation in vitro and persistence in vivo

Failure of HIV-exposed CD4⁺ T cells to activate dendritic cells is reversed by restoration of CD40/CD154 interactions

Rui Zhang,Jeffrey D. Lifson,Claire Chougnet

View Articletitled, Failure of HIV-exposed CD4+ T cells to activate dendritic cells is reversed by restoration of CD40/CD154 interactions

The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils

Ariel Munitz,Ido Bachelet,Ron Eliashar,Alessandro Moretta,Lorenzo Moretta,Francesca Levi-Schaffer

View Articletitled, The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils

CD4⁺/CD8⁺ macrophages infiltrating at inflammatory sites: a population of monocytes/macrophages with a cytotoxic phenotype

Tomohisa Baba,Akihiro Ishizu,Sari Iwasaki,Akira Suzuki,Utano Tomaru,Hitoshi Ikeda,Takashi Yoshiki,Masanori Kasahara

View Articletitled, CD4+/CD8+ macrophages infiltrating at inflammatory sites: a population of monocytes/macrophages with a cytotoxic phenotype

Tumor-derived lactic acid modulates dendritic cell activation and antigen expression

Eva Gottfried,Leoni A. Kunz-Schughart,Stephanie Ebner,Wolfgang Mueller-Klieser,Sabine Hoves,Reinhard Andreesen,Andreas Mackensen,Marina Kreutz

View Articletitled, Tumor-derived lactic acid modulates dendritic cell activation and antigen expression

CD11c⁺ dendritic cells and plasmacytoid DCs are activated by human cytomegalovirus and retain efficient T cell-stimulatory capability upon infection

Espen Ø. Kvale,Jakob Dalgaard,Fridtjof Lund-Johansen,Halvor Rollag,Lorant Farkas,Karsten Midtvedt,Frode L. Jahnsen,Jan E. Brinchmann,Johanna Olweus

View Articletitled, CD11c+ dendritic cells and plasmacytoid DCs are activated by human cytomegalovirus and retain efficient T cell-stimulatory capability upon infection

Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction

Daniela Pende,Roberta Castriconi,Paola Romagnani,Grazia Maria Spaggiari,Stefania Marcenaro,Alessandra Dondero,Elena Lazzeri,Laura Lasagni,Stefania Martini,Paola Rivera,Andrea Capobianco,Lorenzo Moretta,Alessandro Moretta,Cristina Bottino

View Articletitled, Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction

Supplemental data

GILZ expression in human dendritic cells redirects their maturation and prevents antigen-specific T lymphocyte response

Nicolas Cohen,Enguerran Mouly,Haifa Hamdi,Marie-Christine Maillot,Marc Pallardy,Véronique Godot,Francis Capel,Axel Balian,Sylvie Naveau,Pierre Galanaud,François M. Lemoine,Dominique Emilie

View Articletitled, GILZ expression in human dendritic cells redirects their maturation and prevents antigen-specific T lymphocyte response

Remodeling specific immunity by use of MHC tetramers: demonstration in a graft-versus-host disease model

Barry J. Kappel,Javier Pinilla-Ibarz,Adam A. Kochman,Jeffrey M. Eng,Vanessa M. Hubbard,Ingrid Leiner,Eric G. Pamer,Glen Heller,Marcel R. M. van den Brink,David A. Scheinberg

View Articletitled, Remodeling specific immunity by use of MHC tetramers: demonstration in a graft-versus-host disease model

Beta-agonists modulate T-cell functions via direct actions on type 1 and type 2 cells

Matthew J. Loza,Susan Foster,Stephen P. Peters,Raymond B. Penn

View Articletitled, Beta-agonists modulate T-cell functions via direct actions on type 1 and type 2 cells

NEOPLASIA

Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemia
Clinical Trials & Observations

Stefan Schmidt,Johannes Rainer,Stefan Riml,Christian Ploner,Simone Jesacher,Clemens Achmüller,Elisabeth Presul,Sergej Skvortsov,Roman Crazzolara,Michael Fiegl,Taneli Raivio,Olli A. Jänne,Stephan Geley,Bernhard Meister,Reinhard Kofler

View Articletitled, Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemia

Supplemental data

EBV latency III immortalization program sensitizes B cells to induction of CD95-mediated apoptosis via LMP1: role of NF-κB, STAT1, and p53

Christophe Le Clorennec,Ibtissam Youlyouz-Marfak,Eric Adriaenssens,Jean Coll,Georg W. Bornkamm,Jean Feuillard

View Articletitled, EBV latency III immortalization program sensitizes B cells to induction of CD95-mediated apoptosis via LMP1: role of NF-κB, STAT1, and p53

Targeting receptor kinases by a novel indolinone derivative in multiple myeloma: abrogation of stroma-derived interleukin-6 secretion and induction of apoptosis in cytogenetically defined subgroups

Guido Bisping,Martin Kropff,Doris Wenning,Britta Dreyer,Sergey Bessonov,Frank Hilberg,Gerald J. Roth,Gerd Munzert,Martin Stefanic,Matthias Stelljes,Christian Scheffold,Carsten Müller-Tidow,Peter Liebisch,Nicola Lang,Jöelle Tchinda,Hubert L. Serve,Rolf M. Mesters,Wolfgang E. Berdel,Joachim Kienast

View Articletitled, Targeting receptor kinases by a novel indolinone derivative in multiple myeloma: abrogation of stroma-derived interleukin-6 secretion and induction of apoptosis in cytogenetically defined subgroups

Distinct gene expression patterns in chronic lymphocytic leukemia defined by usage of specific VH genes

Dirk Kienle,Axel Benner,Alexander Kröber,Dirk Winkler,Daniel Mertens,Andreas Bühler,Till Seiler,Ulrich Jäger,Peter Lichter,Hartmut Döhner,Stephan Stilgenbauer

View Articletitled, Distinct gene expression patterns in chronic lymphocytic leukemia defined by usage of specific VH genes

Supplemental data

FLT3-ITD–, but not BCR/ABL-transformed cells require concurrent Akt/mTor blockage to undergo apoptosis after histone deacetylase inhibitor treatment

Dali Cai,Ying Wang,Oliver G. Ottmann,Peter J. Barth,Andreas Neubauer,Andreas Burchert

View Articletitled, FLT3-ITD–, but not BCR/ABL-transformed cells require concurrent Akt/mTor blockage to undergo apoptosis after histone deacetylase inhibitor treatment

Supplemental data

V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis
Clinical Trials & Observations

Peter J. Campbell,Martin Griesshammer,Konstanze Döhner,Hartmut Döhner,Rajko Kusec,Hans C. Hasselbalch,Thomas Stauffer Larsen,Niels Pallisgaard,Stéphane Giraudier,Marie-Caroline Le Bousse-Kerdilès,Christophe Desterke,Bernadette Guerton,Brigitte Dupriez,Dominique Bordessoule,Pierre Fenaux,Jean-Jacques Kiladjian,Jean-François Viallard,Jean Brière,Claire N. Harrison,Anthony R. Green,John T. Reilly

View Articletitled, V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis

PHAGOCYTES

Dynamic shifts in LFA-1 affinity regulate neutrophil rolling, arrest, and transmigration on inflamed endothelium

Chad E. Green,Ulrich Y. Schaff,Melissa R. Sarantos,Aaron F. H. Lum,Donald E. Staunton,Scott I. Simon

View Articletitled, Dynamic shifts in LFA-1 affinity regulate neutrophil rolling, arrest, and transmigration on inflamed endothelium

Supplemental data

A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-κB and enhanced IRF-3/STAT1 activation)

Subhra K. Biswas,Lisa Gangi,Saki Paul,Tiziana Schioppa,Alessandra Saccani,Marina Sironi,Barbara Bottazzi,Andrea Doni,Bronte Vincenzo,Fabio Pasqualini,Luca Vago,Manuela Nebuloni,Alberto Mantovani,Antonio Sica

View Articletitled, A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-κB and enhanced IRF-3/STAT1 activation)

Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement

Richard P. G. Hayhoe,Ahmad M. Kamal,Egle Solito,Roderick J. Flower,Dianne Cooper,Mauro Perretti

View Articletitled, Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement

RED CELLS

Protection of erythrocytes from human complement–mediated lysis by membrane-targeted recombinant soluble CD59: a new approach to PNH therapy

Anita Hill,Simon H. Ridley,Dirk Esser,Rodney G. Oldroyd,Matthew J. Cullen,Paula Kareclas,Seán Gallagher,Geoffrey P. Smith,Stephen J. Richards,Jennifer White,Richard A. G. Smith,Peter Hillmen

View Articletitled, Protection of erythrocytes from human complement–mediated lysis by membrane-targeted recombinant soluble CD59: a new approach to PNH therapy

Repression of human γ-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter

Quan Zhao,Wenlai Zhou,Gerhard Rank,Rosemary Sutton,Xi Wang,Helen Cumming,Loretta Cerruti,John M. Cunningham,Stephen M. Jane

View Articletitled, Repression of human γ-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter

STEM CELLS IN HEMATOLOGY

Primitive human hematopoietic cells give rise to differentially specified daughter cells upon their initial cell division

Bernd Giebel,Tao Zhang,Julia Beckmann,Jan Spanholtz,Peter Wernet,Anthony D. Ho,Michael Punzel

View Articletitled, Primitive human hematopoietic cells give rise to differentially specified daughter cells upon their initial cell division

A subset of human rapidly self-renewing marrow stromal cells preferentially engraft in mice

Ryang Hwa Lee,Shu Ching Hsu,James Munoz,Jin Sup Jung,Na Rea Lee,Radhika Pochampally,Darwin J. Prockop

View Articletitled, A subset of human rapidly self-renewing marrow stromal cells preferentially engraft in mice

Supplemental data

Selection based on CD133 and high aldehyde dehydrogenase activity isolates long-term reconstituting human hematopoietic stem cells

David A. Hess,Louisa Wirthlin,Timothy P. Craft,Phillip E. Herrbrich,Sarah A. Hohm,Ryan Lahey,William C. Eades,Michael H. Creer,Jan A. Nolta

View Articletitled, Selection based on CD133 and high aldehyde dehydrogenase activity isolates long-term reconstituting human hematopoietic stem cells

The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion

Leonie M. Kamminga,Leonid V. Bystrykh,Aletta de Boer,Sita Houwer,José Douma,Ellen Weersing,Bert Dontje,Gerald de Haan

View Articletitled, The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion

Supplemental data

Human embryonic stem cell–derived hematopoietic cells are capable of engrafting primary as well as secondary fetal sheep recipients

A. Daisy Narayan,Jessica L. Chase,Rachel L. Lewis,Xinghui Tian,Dan S. Kaufman,James A. Thomson,Esmail D. Zanjani

View Articletitled, Human embryonic stem cell–derived hematopoietic cells are capable of engrafting primary as well as secondary fetal sheep recipients

Supplemental data

TRANSPLANTATION

131I–anti-CD45 antibody plus busulfan and cyclophosphamide before allogeneic hematopoietic cell transplantation for treatment of acute myeloid leukemia in first remission
Clinical Trials & Observations

John M. Pagel,Frederick R. Appelbaum,Janet F. Eary,Joseph Rajendran,Darrell R. Fisher,Ted Gooley,Katherine Ruffner,Eneida Nemecek,Eileen Sickle,Larry Durack,Jeanette Carreras,Mary M. Horowitz,Oliver W. Press,Ajay K. Gopal,Paul J. Martin,Irwin D. Bernstein,Dana C. Matthews

View Articletitled, 131I–anti-CD45 antibody plus busulfan and cyclophosphamide before allogeneic hematopoietic cell transplantation for treatment of acute myeloid leukemia in first remission

G-CSF–treated granulocytes inhibit acute graft-versus-host disease

Zilton F. M. Vasconcelos,Bruna M. dos Santos,Julia Farache,Tereza S. S. Palmeira,Rômulo B. Areal,José Marcos T. Cunha,Marcello A. Barcinski,Adriana Bonomo

View Articletitled, G-CSF–treated granulocytes inhibit acute graft-versus-host disease

Genetic variation in bactericidal/permeability-increasing protein influences the risk of developing rapid airflow decline after hematopoietic cell transplantation
Clinical Trials & Observations

Jason W. Chien,Lue Ping Zhao,John A. Hansen,Wen Hong Fan,Tanyalak Parimon,Joan G. Clark

View Articletitled, Genetic variation in bactericidal/permeability-increasing protein influences the risk of developing rapid airflow decline after hematopoietic cell transplantation

Supplemental data

CORRESPONDENCE

Hemoglobin levels in African-Americans

Geraldine P. Schechter

View Articletitled, Hemoglobin levels in African-Americans

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Issue Archive

Table of Contents

INSIDE BLOOD

BLOOD WORK

PERSPECTIVES

The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration? Clinical Trials & Observations

ERRATA

REVIEW ARTICLES

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

CLINICAL TRIALS AND OBSERVATIONS

Evaluation of the efficacy and safety of etoricoxib in the treatment of hemophilic arthropathy Clinical Trials & Observations

KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival Clinical Trials & Observations

Long-term acyclovir for prevention of varicella zoster virus disease after allogeneic hematopoietic cell transplantation—a randomized double-blind placebo-controlled study Clinical Trials & Observations

KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study Group Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2 Clinical Trials & Observations

IMMUNOBIOLOGY

Human leukocyte antigen (HLA) DR15 is associated with reduced incidence of acute GVHD in HLA-matched allogeneic transplantation but does not impact chronic GVHD incidence Clinical Trials & Observations

NEOPLASIA

Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemia Clinical Trials & Observations

V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis Clinical Trials & Observations

PHAGOCYTES

RED CELLS

STEM CELLS IN HEMATOLOGY

TRANSPLANTATION

131I–anti-CD45 antibody plus busulfan and cyclophosphamide before allogeneic hematopoietic cell transplantation for treatment of acute myeloid leukemia in first remission Clinical Trials & Observations

Genetic variation in bactericidal/permeability-increasing protein influences the risk of developing rapid airflow decline after hematopoietic cell transplantation Clinical Trials & Observations

CORRESPONDENCE

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ASH Publications

American Society of Hematology

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The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration?
Clinical Trials & Observations

Evaluation of the efficacy and safety of etoricoxib in the treatment of hemophilic arthropathy
Clinical Trials & Observations

KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival
Clinical Trials & Observations

Long-term acyclovir for prevention of varicella zoster virus disease after allogeneic hematopoietic cell transplantation—a randomized double-blind placebo-controlled study
Clinical Trials & Observations

KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study Group
Clinical Trials & Observations

Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2
Clinical Trials & Observations

Human leukocyte antigen (HLA) DR15 is associated with reduced incidence of acute GVHD in HLA-matched allogeneic transplantation but does not impact chronic GVHD incidence
Clinical Trials & Observations

Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemia
Clinical Trials & Observations

V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis
Clinical Trials & Observations

131I–anti-CD45 antibody plus busulfan and cyclophosphamide before allogeneic hematopoietic cell transplantation for treatment of acute myeloid leukemia in first remission
Clinical Trials & Observations

Genetic variation in bactericidal/permeability-increasing protein influences the risk of developing rapid airflow decline after hematopoietic cell transplantation
Clinical Trials & Observations