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Volume 107, Issue 10

May 15 2006

In this Issue

INSIDE BLOOD
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
ERRATA
CLINICAL TRIALS AND OBSERVATIONS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION

INSIDE BLOOD

IMMUNOBIOLOGY

HTLV-1 HBZ: stop making sense

Gerold Feuer

View Articletitled, HTLV-1 HBZ: stop making sense

CLINICAL OBSERVATIONS

Monitoring organ response in amyloidosis

Morie A. Gertz

View Articletitled, Monitoring organ response in amyloidosis

NEOPLASIA

p53 activation comes to the rescue in CLL

Neil E. Kay

View Articletitled, p53 activation comes to the rescue in CLL

HEMATOPOIESIS

Proplatelet formation: unraveling the megakaryocyte swan song

Andrew D. Leavitt

View Articletitled, Proplatelet formation: unraveling the megakaryocyte swan song

GENE THERAPY

Bringing home the bacon for hemophilia

Katherine P. Ponder

View Articletitled, Bringing home the bacon for hemophilia

NEOPLASIA

Oncogenic pathways in distinct DLBCL subgroups

Hans Konrad Müller-Hermelink,Thomas Rüdiger

View Articletitled, Oncogenic pathways in distinct DLBCL subgroups

IMMUNOBIOLOGY

T_regs control B-cell life and death

James J. Campbell

View Articletitled, Tregs control B-cell life and death

CLINICAL OBSERVATIONS

Simplified prognostic indicators for AIDS-related lymphoma

David J. Straus

View Articletitled, Simplified prognostic indicators for AIDS-related lymphoma

TRANSPLANTATION

Transplantation for CML: lifelong PCR monitoring?

Richard T. Maziarz

View Articletitled, Transplantation for CML: lifelong PCR monitoring?

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Role of CXCR3 carboxyl terminus and third intracellular loop in receptor-mediated migration, adhesion and internalization in response to CXCL11

Michal Dagan-Berger,Rotem Feniger-Barish,Shani Avniel,Hanna Wald,Eithan Galun,Valentin Grabovsky,Ronen Alon,Arnon Nagler,Adit Ben-Baruch,Amnon Peled

View Articletitled, Role of CXCR3 carboxyl terminus and third intracellular loop in receptor-mediated migration, adhesion and internalization in response to CXCL11

Supplemental data

ERRATA

Erratum for vol. 107, p. 3229

View Articletitled, Erratum for vol. 107, p. 3229

CLINICAL TRIALS AND OBSERVATIONS

AIDS-related non-Hodgkin lymphoma: final analysis of 485 patients treated with risk-adapted intensive chemotherapy
Clinical Trials & Observations

Nicolas Mounier,Michele Spina,Jean Gabarre,Martine Raphael,Giuliano Rizzardini,Jean-Baptiste Golfier,Emanuela Vaccher,Antonino Carbone,Bertrand Coiffier,Guido Chichino,Andre Bosly,Umberto Tirelli,Christian Gisselbrecht,for the French-Italian cooperative group

View Articletitled, AIDS-related non-Hodgkin lymphoma: final analysis of 485 patients treated with risk-adapted intensive chemotherapy

Impact of anemia on hospitalization and mortality in older adults
Clinical Trials & Observations

Bruce F. Culleton,Braden J. Manns,Jianguo Zhang,Marcello Tonelli,Scott Klarenbach,Brenda R. Hemmelgarn

View Articletitled, Impact of anemia on hospitalization and mortality in older adults

Implications of NRAS mutations in AML: a study of 2502 patients
Clinical Trials & Observations

Ulrike Bacher,Torsten Haferlach,Claudia Schoch,Wolfgang Kern,Susanne Schnittger

View Articletitled, Implications of NRAS mutations in AML: a study of 2502 patients

Circulating amyloidogenic free light chains and serum N-terminal natriuretic peptide type B decrease simultaneously in association with improvement of survival in AL
Clinical Trials & Observations

Giovanni Palladini,Francesca Lavatelli,Paola Russo,Stefano Perlini,Vittorio Perfetti,Tiziana Bosoni,Laura Obici,Arthur R. Bradwell,GianVico Melzi D'Eril,Roberto Fogari,Remigio Moratti,Giampaolo Merlini

View Articletitled, Circulating amyloidogenic free light chains and serum N-terminal natriuretic peptide type B decrease simultaneously in association with improvement of survival in AL

GENE THERAPY

High-level expression of porcine factor VIII from genetically modified bone marrow–derived stem cells

Bagirath Gangadharan,Ernest T. Parker,Lucienne M. Ide,H. Trent Spencer,Christopher B. Doering

View Articletitled, High-level expression of porcine factor VIII from genetically modified bone marrow–derived stem cells

Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque

Ruth Seggewiss,Stefania Pittaluga,Rima L. Adler,F. Javier Guenaga,Cole Ferguson,Ingo H. Pilz,Byoung Ryu,Brian P. Sorrentino,W. Scott Young, III,Robert E. Donahue,Christof von Kalle,Arthur W. Nienhuis,Cynthia E. Dunbar

View Articletitled, Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque

Supplemental data

HEMATOPOIESIS

Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis

Harald Schulze,Manav Korpal,Jonathan Hurov,Sang-We Kim,Jinghang Zhang,Lewis C. Cantley,Thomas Graf,Ramesh A. Shivdasani

View Articletitled, Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis

Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Depolymerized holothurian glycosaminoglycan and heparin inhibit the intrinsic tenase complex by a common antithrombin-independent mechanism

John P. Sheehan,Erik N. Walke

View Articletitled, Depolymerized holothurian glycosaminoglycan and heparin inhibit the intrinsic tenase complex by a common antithrombin-independent mechanism

A fibrinogen deficiency accelerates the initiation of LDL cholesterol–driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice

Takayuki Iwaki,Mayra J. Sandoval-Cooper,Markus Brechmann,Victoria A. Ploplis,Francis J. Castellino

View Articletitled, A fibrinogen deficiency accelerates the initiation of LDL cholesterol–driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice

Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF₁₆₅ and semaphorin3A

Masashi Narazaki,Giovanna Tosato

View Articletitled, Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3A

Glycoprotein VI–dependent and –independent pathways of thrombus formation in vivo

Christophe Dubois,Laurence Panicot-Dubois,Glenn Merrill-Skoloff,Bruce Furie,Barbara C. Furie

View Articletitled, Glycoprotein VI–dependent and –independent pathways of thrombus formation in vivo

Supplemental data

Cellular prion protein is released on exosomes from activated platelets

Catherine Robertson,Stephanie A. Booth,Daniel R. Beniac,Michael B. Coulthart,Timothy F. Booth,Archibald McNicol

View Articletitled, Cellular prion protein is released on exosomes from activated platelets

Roles of protease-activated receptors in a mouse model of endotoxemia

Eric Camerer,Ivo Cornelissen,Hiroshi Kataoka,Daniel N. Duong,Yao-Wu Zheng,Shaun R. Coughlin

View Articletitled, Roles of protease-activated receptors in a mouse model of endotoxemia

P-selectin binds to the D′-D3 domains of von Willebrand factor in Weibel-Palade bodies
Brief Report

Grégoire Michaux,Timothy J. Pullen,Sandra L. Haberichter,Daniel F. Cutler

View Articletitled, P-selectin binds to the D′-D3 domains of von Willebrand factor in Weibel-Palade bodies

Supplemental data

IMMUNOBIOLOGY

Activated CD4⁺CD25⁺ T cells selectively kill B lymphocytes

Dong-Mei Zhao,Angela M. Thornton,Richard J. DiPaolo,Ethan M. Shevach

View Articletitled, Activated CD4+CD25+ T cells selectively kill B lymphocytes

HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP)

Andreas Krueger,Stefanie C. Fas,Marco Giaisi,Marc Bleumink,Anette Merling,Christine Stumpf,Sven Baumann,Denise Holtkotte,Valerie Bosch,Peter H. Krammer,Min Li-Weber

View Articletitled, HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP)

Supplemental data

In vivo peripheral expansion of naive CD4⁺CD25^highFoxP3⁺ regulatory T cells in patients with multiple myeloma

Marc Beyer,Matthias Kochanek,Thomas Giese,Elmar Endl,Martin R. Weihrauch,Percy A. Knolle,Sabine Classen,Joachim L. Schultze

View Articletitled, In vivo peripheral expansion of naive CD4+CD25highFoxP3+ regulatory T cells in patients with multiple myeloma

Supplemental data

DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine production

Esther Caparrós,Pilar Munoz,Elena Sierra-Filardi,Diego Serrano-Gómez,Amaya Puig-Kröger,José L. Rodríguez-Fernández,Mario Mellado,Jaime Sancho,Mercedes Zubiaur,Angel L. Corbí

View Articletitled, DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine production

Leukocyte adhesion deficiency II patients with a dual defect of the GDP-fucose transporter
Clinical Trials & Observations

Yvonne Helmus,Jonas Denecke,Sviatlana Yakubenia,Peter Robinson,Kerstin Lühn,Diana L. Watson,Paraic J. McGrogan,Dietmar Vestweber,Thorsten Marquardt,Martin K. Wild

View Articletitled, Leukocyte adhesion deficiency II patients with a dual defect of the GDP-fucose transporter

Supplemental data

Nuclear and cytoplasmic AID in extrafollicular and germinal center B cells

Giorgio Cattoretti,Maike Büttner,Rita Shaknovich,Elisabeth Kremmer,Bachir Alobeid,Gerald Niedobitek

View Articletitled, Nuclear and cytoplasmic AID in extrafollicular and germinal center B cells

Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1

Joshua Arnold,Brenda Yamamoto,Min Li,Andrew J. Phipps,Ihab Younis,Michael D. Lairmore,Patrick L. Green

View Articletitled, Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1

T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia

Elena E. Solomou,Keyvan Keyvanfar,Neal S. Young

View Articletitled, T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia

c-Myc acts downstream of IL-15 in the regulation of memory CD8 T-cell homeostasis

Teresa Bianchi,Stephan Gasser,Andreas Trumpp,H. Robson MacDonald

View Articletitled, c-Myc acts downstream of IL-15 in the regulation of memory CD8 T-cell homeostasis

Bacterial lipopolysaccharide fever is initiated via Toll-like receptor 4 on hematopoietic cells

Alexandre A. Steiner,Sumana Chakravarty,Alla Y. Rudaya,Miles Herkenham,Andrej A. Romanovsky

View Articletitled, Bacterial lipopolysaccharide fever is initiated via Toll-like receptor 4 on hematopoietic cells

NEOPLASIA

Bcr-Abl reduces endoplasmic reticulum releasable calcium levels by a Bcl-2–independent mechanism and inhibits calcium-dependent apoptotic signaling

Katarzyna Piwocka,Susanne Vejda,Thomas G. Cotter,Gerald C. O'Sullivan,Sharon L. McKenna

View Articletitled, Bcr-Abl reduces endoplasmic reticulum releasable calcium levels by a Bcl-2–independent mechanism and inhibits calcium-dependent apoptotic signaling

Supplemental data

Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)
Clinical Trials & Observations

Christian Thiede,Sina Koch,Eva Creutzig,Christine Steudel,Thomas Illmer,Markus Schaich,Gerhard Ehninger,for the Deutsche Studieninitiative Leukämie (DSIL)

View Articletitled, Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)

Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-κB activation

Rihab Nasr,Estelle Chiari,Marwan El-Sabban,Renaud Mahieux,Youmna Kfoury,Maher Abdulhay,Victor Yazbeck,Olivier Hermine,Hugues de Thé,Claudine Pique,Ali Bazarbachi

View Articletitled, Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-κB activation

Significance of circulating T-cell clones in Sézary syndrome
Clinical Trials & Observations

Nicolas Ortonne,Delphine Huet,Caroline Gaudez,Anne Marie-Cardine,Valérie Schiavon,Martine Bagot,Philippe Musette,Armand Bensussan

View Articletitled, Significance of circulating T-cell clones in Sézary syndrome

The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells

Suzanne Trudel,A. Keith Stewart,Eran Rom,Ellen Wei,Zhi Hua Li,Sarit Kotzer,Irina Chumakov,Yossi Singer,Hong Chang,Sheng-Ben Liang,Avner Yayon

View Articletitled, The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells

Diffuse large B-cell lymphoma in pediatric patients belongs predominantly to the germinal-center type B-cell lymphomas: a clinicopathologic analysis of cases included in the German BFM (Berlin-Frankfurt-Münster) Multicenter Trial
Clinical Trials & Observations

Ilske Oschlies,Wolfram Klapper,Martin Zimmermann,Matthias Krams,Hans-Heinrich Wacker,Birgit Burkhardt,Lana Harder,Reiner Siebert,Alfred Reiter,Reza Parwaresch

View Articletitled, Diffuse large B-cell lymphoma in pediatric patients belongs predominantly to the germinal-center type B-cell lymphomas: a clinicopathologic analysis of cases included in the German BFM (Berlin-Frankfurt-Münster) Multicenter Trial

Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

Teru Hideshima,Laurence Catley,Hiroshi Yasui,Kenji Ishitsuka,Noopur Raje,Constantine Mitsiades,Klaus Podar,Nikhil C. Munshi,Dharminder Chauhan,Paul G. Richardson,Kenneth C. Anderson

View Articletitled, Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

Synergistic activity of the proteasome inhibitor PS-341 with non-myeloablative 153-Sm-EDTMP skeletally targeted radiotherapy in an orthotopic model of multiple myeloma

Apollina Goel,Angela Dispenzieri,Susan M. Geyer,Suzanne Greiner,Kah-Whye Peng,Stephen J. Russell

View Articletitled, Synergistic activity of the proteasome inhibitor PS-341 with non-myeloablative 153-Sm-EDTMP skeletally targeted radiotherapy in an orthotopic model of multiple myeloma

The FIP1L1-PDGFRA fusion gene cooperates with IL-5 to induce murine hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL)–like disease

Yoshiyuki Yamada,Marc E. Rothenberg,Andrew W. Lee,Hiroko Saito Akei,Eric B. Brandt,David A. Williams,Jose A. Cancelas

View Articletitled, The FIP1L1-PDGFRA fusion gene cooperates with IL-5 to induce murine hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL)–like disease

Inducible activation of CEBPB, a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BCR/ABL-expressing cells

Clara Guerzoni,Michela Bardini,Samanta A. Mariani,Giovanna Ferrari-Amorotti,Paolo Neviani,Maria Luisa Panno,Ying Zhang,Robert Martinez,Danilo Perrotti,Bruno Calabretta

View Articletitled, Inducible activation of CEBPB, a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BCR/ABL-expressing cells

Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas

Wayne Tam,Mario Gomez,Amy Chadburn,Joong W. Lee,Wing C. Chan,Daniel M. Knowles

View Articletitled, Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas

Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma
Clinical Trials & Observations

Qing Lan,Tongzhang Zheng,Nathaniel Rothman,Yawei Zhang,Sophia S. Wang,Min Shen,Sonja I. Berndt,Shelia H. Zahm,Theodore R. Holford,Brian Leaderer,Meredith Yeager,Robert Welch,Peter Boyle,Bing Zhang,Kaiyong Zou,Yong Zhu,Stephen Chanock

View Articletitled, Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma

Supplemental data

MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells

Llorenç Coll-Mulet,Daniel Iglesias-Serret,Antonio F. Santidrián,Ana M. Cosialls,Mercè de Frias,Esther Castaño,Clara Campàs,Montserrat Barragán,Alberto Fernández de Sevilla,Alicia Domingo,Lyubomir T. Vassilev,Gabriel Pons,Joan Gil

View Articletitled, MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells

Supplemental data

Notch1 promotes survival of E2A-deficient T cell lymphomas through pre–T cell receptor–dependent and –independent mechanisms

Erica J. Reschly,Christina Spaulding,Tomas Vilimas,W. Vallen Graham,Rachel L. Brumbaugh,Iannis Aifantis,Warren S. Pear,Barbara L. Kee

View Articletitled, Notch1 promotes survival of E2A-deficient T cell lymphomas through pre–T cell receptor–dependent and –independent mechanisms

Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL)

Paola Secchiero,Elisa Barbarotto,Mario Tiribelli,Carlotta Zerbinati,Maria Grazia di Iasio,Arianna Gonelli,Francesco Cavazzini,Diana Campioni,Renato Fanin,Antonio Cuneo,Giorgio Zauli

View Articletitled, Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL)

SHP1 tyrosine phosphatase negatively regulates NPM-ALK tyrosine kinase signaling

Jean-François Honorat,Ashraf Ragab,Laurence Lamant,Georges Delsol,Jeannie Ragab-Thomas

View Articletitled, SHP1 tyrosine phosphatase negatively regulates NPM-ALK tyrosine kinase signaling

X-inactivation–based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis
Clinical Trials & Observations Brief Report

Ross L. Levine,Claude Belisle,Martha Wadleigh,David Zahrieh,Stephanie Lee,Pierre Chagnon,D. Gary Gilliland,Lambert Busque

View Articletitled, X-inactivation–based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis

PHAGOCYTES

Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease
Clinical Trials & Observations

Igor Theurl,Verena Mattle,Markus Seifert,Mariagabriella Mariani,Christian Marth,Günter Weiss

View Articletitled, Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease

CD44 is a phagocytic receptor

Eric Vachon,Raiza Martin,Jonathan Plumb,Vivian Kwok,R. William Vandivier,Michael Glogauer,Andras Kapus,Xiaomin Wang,Chung-Wai Chow,Sergio Grinstein,Gregory P. Downey

View Articletitled, CD44 is a phagocytic receptor

RED CELLS

Remodeling the regulation of iron metabolism during erythroid differentiation to ensure efficient heme biosynthesis

Matthias Schranzhofer,Manfred Schifrer,Javier Antonio Cabrera,Stephan Kopp,Peter Chiba,Hartmut Beug,Ernst W. Müllner

View Articletitled, Remodeling the regulation of iron metabolism during erythroid differentiation to ensure efficient heme biosynthesis

Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload
Clinical Trials & Observations Brief Report

Carole Beaumont,Jean Delaunay,Gilles Hetet,Bernard Grandchamp,Mariane de Montalembert,Gil Tchernia

View Articletitled, Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload

Supplemental data

TRANSPLANTATION

Serial measurement of BCR-ABL transcripts in the peripheral blood after allogeneic stem cell transplantation for chronic myeloid leukemia: an attempt to define patients who may not require further therapy
Clinical Trials & Observations

Jaspal Kaeda,Derville O'Shea,Richard M. Szydlo,Eduardo Olavarria,Francesco Dazzi,David Marin,Susan Saunders,Jamshid S. Khorashad,Nicholas C. P. Cross,John M. Goldman,Jane F. Apperley

View Articletitled, Serial measurement of BCR-ABL transcripts in the peripheral blood after allogeneic stem cell transplantation for chronic myeloid leukemia: an attempt to define patients who may not require further therapy

Treatment of acute graft-versus-host disease with prednisolone: significant survival advantage for day +5 responders and no advantage for nonresponders receiving anti–thymocyte globulin
Clinical Trials & Observations

Maria Teresa Van Lint,Giuseppe Milone,Salvatore Leotta,Cornelio Uderzo,Rosanna Scimè,Sandro Dallorso,Anna Locasciulli,Stefano Guidi,Nicola Mordini,Simona Sica,Laura Cudillo,Franca Fagioli,Carmine Selleri,Barbara Bruno,William Arcese,Andrea Bacigalupo,for the Gruppo Italiano Trapianto Midollo Osseo (GITMO)

View Articletitled, Treatment of acute graft-versus-host disease with prednisolone: significant survival advantage for day +5 responders and no advantage for nonresponders receiving anti–thymocyte globulin

Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells

Jakub Tolar,Matthew J. O'Shaughnessy,Angela Panoskaltsis-Mortari,Ron T. McElmurry,Scott Bell,Megan Riddle,R. Scott McIvor,Stephen R. Yant,Mark A. Kay,Diane Krause,Catherine M. Verfaillie,Bruce R. Blazar

View Articletitled, Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells

Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination
Clinical Trials & Observations

Ernst Holler,Gerhard Rogler,Julia Brenmoehl,Joachim Hahn,Hans Herfarth,Hildegard Greinix,Anne M. Dickinson,Gerard Socié,Daniel Wolff,Gottfried Fischer,Graham Jackson,Vanderson Rocha,Beate Steiner,Guenther Eissner,Jeorg Marienhagen,Juergen Schoelmerich,Reinhard Andreesen

View Articletitled, Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination

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Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation

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Diagnosis and classification of myelodysplastic syndromes

FISH for EBV genome in a patient with diffuse large B-cell lymphoma harboring t(14;18)(q32;q21)

Balsas P, Veloza L, Clot G, et al. SOX11, CD70, and T_reg cells configure the tumor-immune microenvironment of aggressive mantle cell lymphoma. Blood. 2021;138(22):2202-2215.

Issue Archive

Table of Contents

INSIDE BLOOD

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

ERRATA

CLINICAL TRIALS AND OBSERVATIONS

AIDS-related non-Hodgkin lymphoma: final analysis of 485 patients treated with risk-adapted intensive chemotherapy Clinical Trials & Observations

Impact of anemia on hospitalization and mortality in older adults Clinical Trials & Observations

Implications of NRAS mutations in AML: a study of 2502 patients Clinical Trials & Observations

Circulating amyloidogenic free light chains and serum N-terminal natriuretic peptide type B decrease simultaneously in association with improvement of survival in AL Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

P-selectin binds to the D′-D3 domains of von Willebrand factor in Weibel-Palade bodies Brief Report

IMMUNOBIOLOGY

Leukocyte adhesion deficiency II patients with a dual defect of the GDP-fucose transporter Clinical Trials & Observations

NEOPLASIA

Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML) Clinical Trials & Observations

Significance of circulating T-cell clones in Sézary syndrome Clinical Trials & Observations

Diffuse large B-cell lymphoma in pediatric patients belongs predominantly to the germinal-center type B-cell lymphomas: a clinicopathologic analysis of cases included in the German BFM (Berlin-Frankfurt-Münster) Multicenter Trial Clinical Trials & Observations

Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma Clinical Trials & Observations

X-inactivation–based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis Clinical Trials & Observations Brief Report

PHAGOCYTES

Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease Clinical Trials & Observations

RED CELLS

Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload Clinical Trials & Observations Brief Report

TRANSPLANTATION

Serial measurement of BCR-ABL transcripts in the peripheral blood after allogeneic stem cell transplantation for chronic myeloid leukemia: an attempt to define patients who may not require further therapy Clinical Trials & Observations

Treatment of acute graft-versus-host disease with prednisolone: significant survival advantage for day +5 responders and no advantage for nonresponders receiving anti–thymocyte globulin Clinical Trials & Observations

Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination Clinical Trials & Observations

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AIDS-related non-Hodgkin lymphoma: final analysis of 485 patients treated with risk-adapted intensive chemotherapy
Clinical Trials & Observations

Impact of anemia on hospitalization and mortality in older adults
Clinical Trials & Observations

Implications of NRAS mutations in AML: a study of 2502 patients
Clinical Trials & Observations

Circulating amyloidogenic free light chains and serum N-terminal natriuretic peptide type B decrease simultaneously in association with improvement of survival in AL
Clinical Trials & Observations

P-selectin binds to the D′-D3 domains of von Willebrand factor in Weibel-Palade bodies
Brief Report

Leukocyte adhesion deficiency II patients with a dual defect of the GDP-fucose transporter
Clinical Trials & Observations

Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)
Clinical Trials & Observations

Significance of circulating T-cell clones in Sézary syndrome
Clinical Trials & Observations

Diffuse large B-cell lymphoma in pediatric patients belongs predominantly to the germinal-center type B-cell lymphomas: a clinicopathologic analysis of cases included in the German BFM (Berlin-Frankfurt-Münster) Multicenter Trial
Clinical Trials & Observations

Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma
Clinical Trials & Observations

X-inactivation–based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis
Clinical Trials & Observations Brief Report

Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease
Clinical Trials & Observations

Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload
Clinical Trials & Observations Brief Report

Serial measurement of BCR-ABL transcripts in the peripheral blood after allogeneic stem cell transplantation for chronic myeloid leukemia: an attempt to define patients who may not require further therapy
Clinical Trials & Observations

Treatment of acute graft-versus-host disease with prednisolone: significant survival advantage for day +5 responders and no advantage for nonresponders receiving anti–thymocyte globulin
Clinical Trials & Observations

Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination
Clinical Trials & Observations