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Volume 106, Issue 9

November 1 2005

In this Issue

INSIDE BLOOD
BLOOD WORK
EDITORIALS
PLENARY PAPERS
REVIEW ARTICLES
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
CLINICAL TRIALS AND OBSERVATIONS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
STEM CELLS IN HEMATOLOGY
TRANSPLANTATION

INSIDE BLOOD

RED CELLS

Unraveling the hemolytic subphenotype of sickle cell disease

Mark T. Gladwin

View Articletitled, Unraveling the hemolytic subphenotype of sickle cell disease

IMMUNOBIOLOGY

Costimulatory blockade: act II

David H. Munn

View Articletitled, Costimulatory blockade: act II

PHAGOCYTES

Mac-1 mediates migration to lymph nodes

Joseph P. Mizgerd

View Articletitled, Mac-1 mediates migration to lymph nodes

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

RGS16 “tightens the reins” on CXCR4

Mariusz Z. Ratajczak

View Articletitled, RGS16 “tightens the reins” on CXCR4

HEMOSTASIS

The SLAM family of receptors: new players in platelet aggregation

José A.López

View Articletitled, The SLAM family of receptors: new players in platelet aggregation

CLINICAL TRIALS AND OBSERVATIONS

Interferon-α: still useful after all these years
Clinical Trials & Observations

Eric J. Feldman

View Articletitled, Interferon-α: still useful after all these years

HEMOSTASIS

Unfractionated LMWH and the risk of HIT: are medical patients different?

Theodore E. Warkentin,Andreas Greinacher

View Articletitled, Unfractionated LMWH and the risk of HIT: are medical patients different?

TRANSPLANTATION

To T-cell deplete or not

Helen E. Heslop

View Articletitled, To T-cell deplete or not

HEMOSTASIS

Fibrin A-knob caught in the act

Dennis K. Galanakis

View Articletitled, Fibrin A-knob caught in the act

BLOOD WORK

Homozygous hemoglobin C disease

View Articletitled, Homozygous hemoglobin C disease

EDITORIALS

Springtime for stem cells

Sanford J. Shattil, MD

View Articletitled, Springtime for stem cells

PLENARY PAPERS

Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression

Peng H. Tan,John B. Yates,Shao-An Xue,Cliburn Chan,William J. Jordan,Jennifer E. Harper,Martin P. Watson,Rong Dong,Mary A. Ritter,Robert I. Lechler,Giovanna Lombardi,Andrew J. T. George

View Articletitled, Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression

Polymerization of fibrin: specificity, strength, and stability of knob-hole interactions studied at the single-molecule level

Rustem I. Litvinov,Oleg V. Gorkun,Scott F. Owen,Henry Shuman,John W. Weisel

View Articletitled, Polymerization of fibrin: specificity, strength, and stability of knob-hole interactions studied at the single-molecule level

REVIEW ARTICLES

Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions

Philip J. S. Stork,Tara J. Dillon

View Articletitled, Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

RGS16 is a negative regulator of SDF-1–CXCR4 signaling in megakaryocytes

Magali Berthebaud,Christel Rivière,Peggy Jarrier,Adlen Foudi,Yanyan Zhang,Daniel Compagno,Anne Galy,William Vainchenker,Fawzia Louache

View Articletitled, RGS16 is a negative regulator of SDF-1–CXCR4 signaling in megakaryocytes

CLINICAL TRIALS AND OBSERVATIONS

Outcomes of reduced-intensity transplantation for chronic myeloid leukemia: an analysis of prognostic factors from the Chronic Leukemia Working Party of the EBMT
Clinical Trials & Observations

Charles Crawley,Richard Szydlo,Marc Lalancette,Andrea Bacigalupo,Andrzej Lange,Mats Brune,Gunnar Juliusson,Arnon Nagler,Alois Gratwohl,Jakob Passweg,Mieczysław Komarnicki,Antonin Vitek,Jiri Mayer,Axel Zander,Jorge Sierra,Alessandro Rambaldi,Olle Ringden,Dietger Niederwieser,Jane F. Apperley,for the Chronic Leukemia Working Party of the EBMT

View Articletitled, Outcomes of reduced-intensity transplantation for chronic myeloid leukemia: an analysis of prognostic factors from the Chronic Leukemia Working Party of the EBMT

Clinical factors predictive of outcome with bortezomib in patients with relapsed, refractory multiple myeloma
Clinical Trials & Observations

Paul Gerard Guy Richardson,Bart Barlogie,James Berenson,Seema Singhal,Sundar Jagannath,David Irwin,S. Vincent Rajkumar,Teru Hideshima,Hugh Xiao,Dixie Esseltine,David Schenkein,Kenneth C. Anderson,for the SUMMIT Investigators

View Articletitled, Clinical factors predictive of outcome with bortezomib in patients with relapsed, refractory multiple myeloma

Evidence for reduced B-cell progenitors in early (low-risk) myelodysplastic syndrome
Clinical Trials & Observations

Alexander Sternberg,Sally Killick,Tim Littlewood,Chris Hatton,Andy Peniket,Thomas Seidl,Shamit Soneji,Joanne Leach,David Bowen,Claire Chapman,Graham Standen,Edwin Massey,Lisa Robinson,Bipin Vadher,Richard Kaczmarski,Riaz Janmohammed,Kim Clipsham,Andrew Carr,Paresh Vyas

View Articletitled, Evidence for reduced B-cell progenitors in early (low-risk) myelodysplastic syndrome

Supplemental data

Successful treatment of Erdheim-Chester disease, a non–Langerhans-cell histiocytosis, with interferon-α
Clinical Trials & Observations Brief Report

Fadi Braiteh,Cynthia Boxrud,Bita Esmaeli,Razelle Kurzrock

View Articletitled, Successful treatment of Erdheim-Chester disease, a non–Langerhans-cell histiocytosis, with interferon-α

GENE THERAPY

Adoptive transfer of gene-engineered CD4⁺ helper T cells induces potent primary and secondary tumor rejection

Maria Moeller,Nicole M. Haynes,Michael H. Kershaw,Jacob T. Jackson,Michele W. L. Teng,Shayna E. Street,Loretta Cerutti,Stephen M. Jane,Joseph A. Trapani,Mark J. Smyth,Phillip K. Darcy

View Articletitled, Adoptive transfer of gene-engineered CD4+ helper T cells induces potent primary and secondary tumor rejection

HEMATOPOIESIS

Three pathways to mature macrophages in the early mouse yolk sac

Julien Y. Bertrand,Abdelali Jalil,Michèle Klaine,Steffen Jung,Ana Cumano,Isabelle Godin

View Articletitled, Three pathways to mature macrophages in the early mouse yolk sac

Supplemental data

Soluble factor cross-talk between human bone marrow-derived hematopoietic and mesenchymal cells enhances in vitro CFU-F and CFU-O growth and reveals heterogeneity in the mesenchymal progenitor cell compartment

Dolores Baksh,John E. Davies,Peter W. Zandstra

View Articletitled, Soluble factor cross-talk between human bone marrow-derived hematopoietic and mesenchymal cells enhances in vitro CFU-F and CFU-O growth and reveals heterogeneity in the mesenchymal progenitor cell compartment

G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow

Craig L. Semerad,Matthew J. Christopher,Fulu Liu,Brenton Short,Paul J. Simmons,Ingrid Winkler,Jean-Pierre Levesque,Jean Chappel,F. Patrick Ross,Daniel C. Link

View Articletitled, G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling

Nisha Nanda,Patrick Andre,Ming Bao,Karl Clauser,Francis Deguzman,Duncan Howie,Pamela B. Conley,Cox Terhorst,David R. Phillips

View Articletitled, Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling

A novel nanobody that detects the gain-of-function phenotype of von Willebrand factor in ADAMTS13 deficiency and von Willebrand disease type 2B

Janine J. J. Hulstein,Philip G. de Groot,Karen Silence,Agnès Veyradier,Rob Fijnheer,Peter J. Lenting

View Articletitled, A novel nanobody that detects the gain-of-function phenotype of von Willebrand factor in ADAMTS13 deficiency and von Willebrand disease type 2B

Aminoglycoside suppression of nonsense mutations in severe hemophilia
Clinical Trials & Observations

Paula D. James,Sanj Raut,Georges E. Rivard,Man-Chiu Poon,Margaret Warner,Susan McKenna,Jayne Leggo,David Lillicrap

View Articletitled, Aminoglycoside suppression of nonsense mutations in severe hemophilia

The incidence of heparin-induced thrombocytopenia in medical patients treated with low-molecular-weight heparin: a prospective cohort study
Clinical Trials & Observations

Paolo Prandoni,Sergio Siragusa,Bruno Girolami,Fabrizio Fabris,for the BELZONI Investigators Group

View Articletitled, The incidence of heparin-induced thrombocytopenia in medical patients treated with low-molecular-weight heparin: a prospective cohort study

The effects of intrinsic pathway protease deficiencies on plasminogen-deficient mice
Brief Report

Qiufang Cheng,Yong Zhao,William E. Lawson,Vasiliy V. Polosukhin,Joyce E. Johnson,Timothy S. Blackwell,David Gailani

View Articletitled, The effects of intrinsic pathway protease deficiencies on plasminogen-deficient mice

Optimal biologic dose of metronomic chemotherapy regimens is associated with maximum antiangiogenic activity
Brief Report

Yuval Shaked,Urban Emmenegger,Shan Man,Dave Cervi,Francesco Bertolini,Yaacov Ben-David,Robert S. Kerbel

View Articletitled, Optimal biologic dose of metronomic chemotherapy regimens is associated with maximum antiangiogenic activity

IMMUNOBIOLOGY

Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene–transduced human T cells

Shao-An Xue,Liquan Gao,Daniel Hart,Roopinder Gillmore,Waseem Qasim,Adrian Thrasher,Jane Apperley,Boris Engels,Wolfgang Uckert,Emma Morris,Hans Stauss

View Articletitled, Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene–transduced human T cells

CD4⁺CD25⁺ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy

Lequn Li,Wayne R. Godfrey,Stephen B. Porter,Ying Ge,Carle H. June,Bruce R. Blazar,Vassiliki A. Boussiotis

View Articletitled, CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy

MHC class II/CD38/CD9: a lipid-raft–dependent signaling complex in human monocytes

Marie-Thérèse Zilber,Niclas Setterblad,Thierry Vasselon,Christelle Doliger,Dominique Charron,Nuala Mooney,Catherine Gelin

View Articletitled, MHC class II/CD38/CD9: a lipid-raft–dependent signaling complex in human monocytes

Discovery of novel immunostimulants by dendritic-cell–based functional screening

Norikatsu Mizumoto,Jimin Gao,Hironori Matsushima,Yasushi Ogawa,Hiroaki Tanaka,Akira Takashima

View Articletitled, Discovery of novel immunostimulants by dendritic-cell–based functional screening

Epstein-Barr virus LMP1 inhibits the expression of SAP gene and upregulates Th1 cytokines in the pathogenesis of hemophagocytic syndrome
Clinical Trials & Observations

Huai-Chia Chuang,Jong-Ding Lay,Wen-Chuan Hsieh,Hui-Ching Wang,Yao Chang,Shuang-En Chuang,Ih-Jen Su

View Articletitled, Epstein-Barr virus LMP1 inhibits the expression of SAP gene and upregulates Th1 cytokines in the pathogenesis of hemophagocytic syndrome

Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo

Kerstin Siegmund,Markus Feuerer,Christiane Siewert,Saeed Ghani,Uta Haubold,Anja Dankof,Veit Krenn,Michael P. Schön,Alexander Scheffold,John B. Lowe,Alf Hamann,Uta Syrbe,Jochen Huehn

View Articletitled, Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo

Supplemental data

Identification of an epitope derived from the cancer testis antigen HOM-TES-14/SCP1 and presented by dendritic cells to circulating CD4⁺ T cells

Frank Neumann,Claudia Wagner,Klaus-Dieter Preuss,Boris Kubuschok,Claudia Schormann,Stefan Stevanovic,Michael Pfreundschuh

View Articletitled, Identification of an epitope derived from the cancer testis antigen HOM-TES-14/SCP1 and presented by dendritic cells to circulating CD4+ T cells

LPS induces CD40 gene expression through the activation of NF-κB and STAT-1α in macrophages and microglia

Hongwei Qin,Cynthia A. Wilson,Sun Jung Lee,Xueyan Zhao,Etty N. Benveniste

View Articletitled, LPS induces CD40 gene expression through the activation of NF-κB and STAT-1α in macrophages and microglia

CD molecules 2005: human cell differentiation molecules

Heddy Zola,Bernadette Swart,Ian Nicholson,Bent Aasted,Armand Bensussan,Laurence Boumsell,Chris Buckley,Georgina Clark,Karel Drbal,Pablo Engel,Derek Hart,Václav Horejsí,Clare Isacke,Peter Macardle,Fabio Malavasi,David Mason,Daniel Olive,Armin Saalmueller,Stuart F. Schlossman,Reinhard Schwartz-Albiez,Paul Simmons,Thomas F. Tedder,Mariagrazia Uguccioni,Hilary Warren

View Articletitled, CD molecules 2005: human cell differentiation molecules

Human CTLA4 knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti–CTLA-4 antibodies

Kenneth D. Lute,Kenneth F. May, Jr,Ping Lu,Huiming Zhang,Ergun Kocak,Bedrick Mosinger,Christopher Wolford,Gary Phillips,Michael A. Caligiuri,Pan Zheng,Yang Liu

View Articletitled, Human CTLA4 knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti–CTLA-4 antibodies

Supplemental data

NEOPLASIA

RAS-blocking bisphosphonate zoledronic acid inhibits the abnormal proliferation and differentiation of juvenile myelomonocytic leukemia cells in vitro

Yoshitoshi Ohtsuka,Atsushi Manabe,Hirohide Kawasaki,Daisuke Hasegawa,Yuji Zaike,Sumiko Watanabe,Takakuni Tanizawa,Tatsutoshi Nakahata,Kohichiro Tsuji

View Articletitled, RAS-blocking bisphosphonate zoledronic acid inhibits the abnormal proliferation and differentiation of juvenile myelomonocytic leukemia cells in vitro

Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia

Rongzhen Xu,Yingzi Yu,Shu Zheng,Xiaoying Zhao,Qinghua Dong,Zhiwen He,Yun Liang,Qinghua Lu,Yongmin Fang,Xiaoxian Gan,Xiaohua Xu,Suzhan Zhang,Qi Dong,Xiaohong Zhang,Gen-Sheng Feng

View Articletitled, Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia

MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

Kensuke Kojima,Marina Konopleva,Ismael J. Samudio,Masato Shikami,Maria Cabreira-Hansen,Teresa McQueen,Vivian Ruvolo,Twee Tsao,Zhihong Zeng,Lyubomir T. Vassilev,Michael Andreeff

View Articletitled, MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2

Takashi Oshima,Masahiro Abe,Jin Asano,Tomoko Hara,Kenichi Kitazoe,Etsuko Sekimoto,Yoichi Tanaka,Hironobu Shibata,Toshihiro Hashimoto,Shuji Ozaki,Shinsuke Kido,Daisuke Inoue,Toshio Matsumoto

View Articletitled, Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2

Loss of EBNA1-specific memory CD4⁺ and CD8⁺ T cells in HIV-infected patients progressing to AIDS-related non-Hodgkin lymphoma

Erwan Piriou,Karel van Dort,Nening M. Nanlohy,Marinus H. J. van Oers,Frank Miedema,Debbie van Baarle

View Articletitled, Loss of EBNA1-specific memory CD4+ and CD8+ T cells in HIV-infected patients progressing to AIDS-related non-Hodgkin lymphoma

Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL
Clinical Trials & Observations

Belinda Austen,Judith E. Powell,Azra Alvi,Ian Edwards,Laura Hooper,Jane Starczynski,A. Malcolm R. Taylor,Christopher Fegan,Paul Moss,Tatjana Stankovic

View Articletitled, Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL

Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction
Clinical Trials & Observations

Silvia Bea,Andreas Zettl,George Wright,Itziar Salaverria,Philipp Jehn,Victor Moreno,Christof Burek,German Ott,Xavier Puig,Liming Yang,Armando Lopez-Guillermo,Wing C. Chan,Timothy C. Greiner,Dennis D. Weisenburger,James O. Armitage,Randy D. Gascoyne,Joseph M. Connors,Thomas M. Grogan,Rita Braziel,Richard I. Fisher,Erlend B. Smeland,Stein Kvaloy,Harald Holte,Jan Delabie,Richard Simon,John Powell,Wyndham H. Wilson,Elaine S. Jaffe,Emili Montserrat,Hans-Konrad Muller-Hermelink,Louis M. Staudt,Elias Campo,Andreas Rosenwald,for the Lymphoma/Leukemia Molecular Profiling Project

View Articletitled, Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction

Supplemental data

Tachpyridine, a metal chelator, induces G₂ cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation

JoLyn Turner,Constantinos Koumenis,Timothy E. Kute,Roy P. Planalp,Martin W. Brechbiel,Dillon Beardsley,Brooke Cody,Kevin D. Brown,Frank M. Torti,Suzy V. Torti

View Articletitled, Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation

Tumor necrosis factor-α inhibits hTERT gene expression in human myeloid normal and leukemic cells

Odile Beyne-Rauzy,Naïs Prade-Houdellier,Cécile Demur,Christian Recher,Jacques Ayel,Guy Laurent,Véronique Mansat-De Mas

View Articletitled, Tumor necrosis factor-α inhibits hTERT gene expression in human myeloid normal and leukemic cells

The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRβ and FIP1L1-PDGFRα in vitro and in vivo

Elizabeth H. Stover,Jing Chen,Benjamin H. Lee,Jan Cools,Elizabeth McDowell,Jennifer Adelsperger,Dana Cullen,Allison Coburn,Sandra A. Moore,Rachel Okabe,Doriano Fabbro,Paul W. Manley,James D. Griffin,D. Gary Gilliland

View Articletitled, The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRβ and FIP1L1-PDGFRα in vitro and in vivo

Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes

Fanny Rubio-Moscardo,David Blesa,Cinta Mestre,Reiner Siebert,Theo Balasas,Adalberto Benito,Andreas Rosenwald,Joan Climent,Jose I. Martinez,Markus Schilhabel,E. Lorraine Karran,Stefan Gesk,Manel Esteller,Ronald deLeeuw,Louis M. Staudt,Jose Luis Fernandez-Luna,Daniel Pinkel,Martin J. S. Dyer,Jose A. Martinez-Climent

View Articletitled, Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes

Supplemental data

Transduction of CLL cells by CD40 ligand enhances an antigen-specific immune recognition by autologous T cells
Brief Report

Christine Mayr,David M. Kofler,Hildegard Büning,Dagmar Bund,Michael Hallek,Clemens-Martin Wendtner

View Articletitled, Transduction of CLL cells by CD40 ligand enhances an antigen-specific immune recognition by autologous T cells

PHAGOCYTES

Jak3 negatively regulates dendritic-cell cytokine production and survival

Kunihiro Yamaoka,Booki Min,Yong-Jie Zhou,William E. Paul,John J. O'Shea

View Articletitled, Jak3 negatively regulates dendritic-cell cytokine production and survival

Supplemental data

A specific role of integrin Mac-1 in accelerated macrophage efflux to the lymphatics

Chunzhang Cao,Daniel A. Lawrence,Dudley K. Strickland,Li Zhang

View Articletitled, A specific role of integrin Mac-1 in accelerated macrophage efflux to the lymphatics

Supplemental data

RED CELLS

Intracellular labile iron pools as direct targets of iron chelators: a fluorescence study of chelator action in living cells

Hava Glickstein,Rinat Ben El,Maya Shvartsman,Z. Ioav Cabantchik

View Articletitled, Intracellular labile iron pools as direct targets of iron chelators: a fluorescence study of chelator action in living cells

A novel molecular basis for β thalassemia intermedia poses new questions about its pathophysiology
Clinical Trials & Observations

Anuja Premawardhena,Christopher A. Fisher,Nancy F. Olivieri,Shanthimala de Silva,Jackie Sloane-Stanley,William G. Wood,David J. Weatherall

View Articletitled, A novel molecular basis for β thalassemia intermedia poses new questions about its pathophysiology

The hydroxyurea-induced small GTP-binding protein SAR modulates γ-globin gene expression in human erythroid cells

Delia C. Tang,Jianqiong Zhu,Wenli Liu,Kyung Chin,Jun Sun,Ling Chen,John A. Hanover,Griffin P. Rodgers

View Articletitled, The hydroxyurea-induced small GTP-binding protein SAR modulates γ-globin gene expression in human erythroid cells

Hemolysis-associated priapism in sickle cell disease
Clinical Trials & Observations

Vikki G. Nolan,Diego F. Wyszynski,Lindsay A. Farrer,Martin H. Steinberg

View Articletitled, Hemolysis-associated priapism in sickle cell disease

Novel urine hepcidin assay by mass spectrometry
Brief Report

Erwin Kemna,Harold Tjalsma,Coby Laarakkers,Elizabeta Nemeth,Hans Willems,Dorine Swinkels

View Articletitled, Novel urine hepcidin assay by mass spectrometry

STEM CELLS IN HEMATOLOGY

Mitochondrial DNA spectra of single human CD34⁺ cells, T cells, B cells, and granulocytes

Yoji Ogasawara,Kazutaka Nakayama,Magdalena Tarnowka,J. Philip McCoy, Jr,Sachiko Kajigaya,Barbara C. Levin,Neal S. Young

View Articletitled, Mitochondrial DNA spectra of single human CD34+ cells, T cells, B cells, and granulocytes

TRANSPLANTATION

Absence of inducible costimulator on alloreactive T cells reduces graft versus host disease and induces Th2 deviation

Vanessa M. Hubbard,Jeffrey M. Eng,Teresa Ramirez-Montagut,Kartono H. Tjoe,Stephanie J. Muriglan,Adam A. Kochman,Theis H. Terwey,Lucy M. Willis,Rafaella Schiro,Glen Heller,George F. Murphy,Chen Liu,Onder Alpdogan,Marcel R. M. van den Brink

View Articletitled, Absence of inducible costimulator on alloreactive T cells reduces graft versus host disease and induces Th2 deviation

Differential effects of proteasome inhibition by bortezomib on murine acute graft-versus-host disease (GVHD): delayed administration of bortezomib results in increased GVHD-dependent gastrointestinal toxicity

Kai Sun,Danice E. C. Wilkins,Miriam R. Anver,Thomas J. Sayers,Angela Panoskaltsis-Mortari,Bruce R. Blazar,Lisbeth A. Welniak,William J. Murphy

View Articletitled, Differential effects of proteasome inhibition by bortezomib on murine acute graft-versus-host disease (GVHD): delayed administration of bortezomib results in increased GVHD-dependent gastrointestinal toxicity

Critical role for CCR5 in the function of donor CD4⁺CD25⁺ regulatory T cells during acute graft-versus-host disease

Christian A. Wysocki,Qi Jiang,Angela Panoskaltsis-Mortari,Patricia A. Taylor,Karen P. McKinnon,Lishan Su,Bruce R. Blazar,Jonathan S. Serody

View Articletitled, Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease

Supplemental data

Influence of T-cell depletion on chronic graft-versus-host disease: results of a multicenter randomized trial in unrelated marrow donor transplantation
Clinical Trials & Observations

Steven Z. Pavletic,Shelly L. Carter,Nancy A. Kernan,Jean Henslee-Downey,Adam M. Mendizabal,Esperanza Papadopoulos,Roger Gingrich,James Casper,Saul Yanovich,Daniel Weisdorf,for the members of the National Heart, Lung, and Blood Institute Unrelated Donor Marrow Transplantation Trial

View Articletitled, Influence of T-cell depletion on chronic graft-versus-host disease: results of a multicenter randomized trial in unrelated marrow donor transplantation

Conditioning with 8-Gy total body irradiation and fludarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia
Clinical Trials & Observations

Matthias Stelljes,Martin Bornhauser,Matthias Kroger,Joerg Beyer,Maria C. Sauerland,Achim Heinecke,Bjorna Berning,Christian Scheffold,Gerda Silling,Thomas Buchner,Andreas Neubauer,Axel A. Fauser,Gerhard Ehninger,Wolfgang E. Berdel,Joachim Kienast,for the Cooperative German Transplant Study Group

View Articletitled, Conditioning with 8-Gy total body irradiation and fludarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia

CCR2 is required for CD8-induced graft-versus-host disease

Theis H. Terwey,Theo D. Kim,Adam A. Kochman,Vanessa M. Hubbard,Sydney Lu,Johannes L. Zakrzewski,Teresa Ramirez-Montagut,Jeffrey M. Eng,Stephanie J. Muriglan,Glenn Heller,George F. Murphy,Chen Liu,Tulin Budak-Alpdogan,Onder Alpdogan,Marcel R. M. van den Brink

View Articletitled, CCR2 is required for CD8-induced graft-versus-host disease

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Safety and Efficacy of Standard of Care Ciltacabtagene Autoleucel for Relapsed/Refractory Multiple Myeloma

Tripartite RAR fusions explain RA resistance

Is inflammation key in Kaposi sarcoma?

A rare glimpse of Fessas bodies in a patient with β-thalassemia major postsplenectomy

Sakemura RL, Manriquez Roman C, Horvei P, et al. CD19 occupancy with tafasitamab increases therapeutic index of CART19 cell therapy and diminishes severity of CRS. Blood. 2024;143(3):258-271.

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Issue Archive

Table of Contents

INSIDE BLOOD

Interferon-α: still useful after all these years Clinical Trials & Observations

BLOOD WORK

EDITORIALS

PLENARY PAPERS

REVIEW ARTICLES

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

CLINICAL TRIALS AND OBSERVATIONS

Outcomes of reduced-intensity transplantation for chronic myeloid leukemia: an analysis of prognostic factors from the Chronic Leukemia Working Party of the EBMT Clinical Trials & Observations

Clinical factors predictive of outcome with bortezomib in patients with relapsed, refractory multiple myeloma Clinical Trials & Observations

Evidence for reduced B-cell progenitors in early (low-risk) myelodysplastic syndrome Clinical Trials & Observations

Successful treatment of Erdheim-Chester disease, a non–Langerhans-cell histiocytosis, with interferon-α Clinical Trials & Observations Brief Report

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Aminoglycoside suppression of nonsense mutations in severe hemophilia Clinical Trials & Observations

The incidence of heparin-induced thrombocytopenia in medical patients treated with low-molecular-weight heparin: a prospective cohort study Clinical Trials & Observations

The effects of intrinsic pathway protease deficiencies on plasminogen-deficient mice Brief Report

Optimal biologic dose of metronomic chemotherapy regimens is associated with maximum antiangiogenic activity Brief Report

IMMUNOBIOLOGY

Epstein-Barr virus LMP1 inhibits the expression of SAP gene and upregulates Th1 cytokines in the pathogenesis of hemophagocytic syndrome Clinical Trials & Observations

NEOPLASIA

Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL Clinical Trials & Observations

Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction Clinical Trials & Observations

Transduction of CLL cells by CD40 ligand enhances an antigen-specific immune recognition by autologous T cells Brief Report

PHAGOCYTES

RED CELLS

A novel molecular basis for β thalassemia intermedia poses new questions about its pathophysiology Clinical Trials & Observations

Hemolysis-associated priapism in sickle cell disease Clinical Trials & Observations

Novel urine hepcidin assay by mass spectrometry Brief Report

STEM CELLS IN HEMATOLOGY

TRANSPLANTATION

Influence of T-cell depletion on chronic graft-versus-host disease: results of a multicenter randomized trial in unrelated marrow donor transplantation Clinical Trials & Observations

Conditioning with 8-Gy total body irradiation and fludarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia Clinical Trials & Observations

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ASH Publications

American Society of Hematology

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Interferon-α: still useful after all these years
Clinical Trials & Observations

Outcomes of reduced-intensity transplantation for chronic myeloid leukemia: an analysis of prognostic factors from the Chronic Leukemia Working Party of the EBMT
Clinical Trials & Observations

Clinical factors predictive of outcome with bortezomib in patients with relapsed, refractory multiple myeloma
Clinical Trials & Observations

Evidence for reduced B-cell progenitors in early (low-risk) myelodysplastic syndrome
Clinical Trials & Observations

Successful treatment of Erdheim-Chester disease, a non–Langerhans-cell histiocytosis, with interferon-α
Clinical Trials & Observations Brief Report

Aminoglycoside suppression of nonsense mutations in severe hemophilia
Clinical Trials & Observations

The incidence of heparin-induced thrombocytopenia in medical patients treated with low-molecular-weight heparin: a prospective cohort study
Clinical Trials & Observations

The effects of intrinsic pathway protease deficiencies on plasminogen-deficient mice
Brief Report

Optimal biologic dose of metronomic chemotherapy regimens is associated with maximum antiangiogenic activity
Brief Report

Epstein-Barr virus LMP1 inhibits the expression of SAP gene and upregulates Th1 cytokines in the pathogenesis of hemophagocytic syndrome
Clinical Trials & Observations

Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL
Clinical Trials & Observations

Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction
Clinical Trials & Observations

Transduction of CLL cells by CD40 ligand enhances an antigen-specific immune recognition by autologous T cells
Brief Report

A novel molecular basis for β thalassemia intermedia poses new questions about its pathophysiology
Clinical Trials & Observations

Hemolysis-associated priapism in sickle cell disease
Clinical Trials & Observations

Novel urine hepcidin assay by mass spectrometry
Brief Report

Influence of T-cell depletion on chronic graft-versus-host disease: results of a multicenter randomized trial in unrelated marrow donor transplantation
Clinical Trials & Observations

Conditioning with 8-Gy total body irradiation and fludarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia
Clinical Trials & Observations