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Volume 106, Issue 8

October 15 2005

In this Issue

INSIDE BLOOD
REVIEW ARTICLES
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
CLINICAL TRIALS AND OBSERVATIONS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

IMMUNOBIOLOGY

Anti-CD40: Janus or gatekeeper?

Tim Illidge

View Articletitled, Anti-CD40: Janus or gatekeeper?

GENE THERAPY

Viral rescue of murine Glanzmann thrombasthenia

Jerry Ware

View Articletitled, Viral rescue of murine Glanzmann thrombasthenia

HEMOSTASIS

Transplantation for SLE?

Steven Z. Pavletic

View Articletitled, Transplantation for SLE?

NEOPLASIA

The ABCCs of myelofibrosis

Richard T. Silver

View Articletitled, The ABCCs of myelofibrosis

NEOPLASIA

Let's not get too JAKed up!

Ronald Hoffman

View Articletitled, Let's not get too JAKed up!

HEMOSTASIS

HIT as a preventable disease?

Theodore E. Warkentin

View Articletitled, HIT as a preventable disease?

NEOPLASIA

Gefitinib adopts orphan kinases in leukemia

Animesh Pardanani,Ayalew Tefferi

View Articletitled, Gefitinib adopts orphan kinases in leukemia

TRANSPLANTATION

Will radioimmunotherapy replace TBI?

Jane N. Winter

View Articletitled, Will radioimmunotherapy replace TBI?

TRANSPLANTATION

HCT outcomes: a new tool?

Roy B. Jones

View Articletitled, HCT outcomes: a new tool?

HEMOSTASIS

It's the trophoblast!

Hartmut Weiler

View Articletitled, It's the trophoblast!

REVIEW ARTICLES

Directing thrombin

David A. Lane,Helen Philippou,James A. Huntington

View Articletitled, Directing thrombin

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

CXCL13 is an arrest chemokine for B cells in high endothelial venules

Naotoshi Kanemitsu,Yukihiko Ebisuno,Toshiyuki Tanaka,Kazuhiro Otani,Haruko Hayasaka,Tsuneyasu Kaisho,Shizuo Akira,Koko Katagiri,Tatsuo Kinashi,Naoya Fujita,Takashi Tsuruo,Masayuki Miyasaka

View Articletitled, CXCL13 is an arrest chemokine for B cells in high endothelial venules

Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN

Ping Gao,Ronald L. Wange,Ning Zhang,Joost J. Oppenheim,O. M. Zack Howard

View Articletitled, Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN

CLINICAL TRIALS AND OBSERVATIONS

Humanized anti–interleukin-6 receptor antibody treatment of multicentric Castleman disease
Clinical Trials & Observations

Norihiro Nishimoto,Yuzuru Kanakura,Katsuyuki Aozasa,Takeshi Johkoh,Minoru Nakamura,Shuji Nakano,Nobuaki Nakano,Yasuo Ikeda,Takeshi Sasaki,Kiyoshi Nishioka,Masamichi Hara,Hirokuni Taguchi,Yukihiko Kimura,Yoshiro Kato,Hideki Asaoku,Shunichi Kumagai,Fumio Kodama,Hideko Nakahara,Keisuke Hagihara,Kazuyuki Yoshizaki,Tadamitsu Kishimoto

View Articletitled, Humanized anti–interleukin-6 receptor antibody treatment of multicentric Castleman disease

Difference in clinical features between Japanese and German patients with refractory anemia in myelodysplastic syndromes
Clinical Trials & Observations

Akira Matsuda,Ulrich Germing,Itsuro Jinnai,Motohiro Misumi,Andrea Kuendgen,Sabine Knipp,Manuel Aivado,Masako Iwanaga,Yasushi Miyazaki,Hideki Tsushima,Mari Sakai,Masami Bessho,Masao Tomonaga

View Articletitled, Difference in clinical features between Japanese and German patients with refractory anemia in myelodysplastic syndromes

Improved outcome in central nervous system aspergillosis, using voriconazole treatment
Clinical Trials & Observations

Stefan Schwartz,Markus Ruhnke,Patricia Ribaud,Lawrence Corey,Timothy Driscoll,Oliver A. Cornely,Ulrich Schuler,Irja Lutsar,Peter Troke,Eckhard Thiel

View Articletitled, Improved outcome in central nervous system aspergillosis, using voriconazole treatment

The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosis
Clinical Trials & Observations

Bronno van der Holt,Bob Löwenberg,Alan K. Burnett,Wolfgang U. Knauf,John Shepherd,Pier Paolo Piccaluga,Gert J. Ossenkoppele,Gregor E. G. Verhoef,Augustin Ferrant,Michael Crump,Dominik Selleslag,Matthias Theobald,Martin F. Fey,Edo Vellenga,Margaret Dugan,Pieter Sonneveld,on behalf of the Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON) and the United Kingdom Medical Research Council (MRC)

View Articletitled, The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosis

GENE THERAPY

In vivo gene transfer into rat bone marrow progenitor cells using rSV40 viral vectors

Bianling Liu,Judy Daviau,Carmen N. Nichols,David S. Strayer

View Articletitled, In vivo gene transfer into rat bone marrow progenitor cells using rSV40 viral vectors

Genomic stability and functional activity may be lost in telomerase-transduced human CD8⁺ T lymphocytes

Marco W. J. Schreurs,Mario A. J. A. Hermsen,Ramon I. Klein Geltink,Kirsten B. J. Scholten,Antoinette A. T. P. Brink,Esther W. M. Kueter,Marianne Tijssen,Chris J. L. M. Meijer,Bauke Ylstra,Gerrit A. Meijer,Erik Hooijberg

View Articletitled, Genomic stability and functional activity may be lost in telomerase-transduced human CD8+ T lymphocytes

Therapeutic expression of the platelet-specific integrin, αIIbβ3, in a murine model for Glanzmann thrombasthenia

Juan Fang,Kairbaan Hodivala-Dilke,Bryon D. Johnson,Lily M. Du,Richard O. Hynes,Gilbert C. White, II,David A. Wilcox

View Articletitled, Therapeutic expression of the platelet-specific integrin, αIIbβ3, in a murine model for Glanzmann thrombasthenia

HEMATOPOIESIS

Fli1, Elf1, and Ets1 regulate the proximal promoter of the LMO2 gene in endothelial cells

Josette-Renée Landry,Sarah Kinston,Kathy Knezevic,Ian J. Donaldson,Anthony R. Green,Berthold Göttgens

View Articletitled, Fli1, Elf1, and Ets1 regulate the proximal promoter of the LMO2 gene in endothelial cells

Supplemental data

The kinetics of clonal dominance in myeloproliferative disorders

Sandra N. Catlin,Peter Guttorp,Janis L. Abkowitz

View Articletitled, The kinetics of clonal dominance in myeloproliferative disorders

Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells

Colleen Delaney,Barbara Varnum-Finney,Keisuke Aoyama,Carolyn Brashem-Stein,Irwin D. Bernstein

View Articletitled, Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Antiphospholipid syndrome in patients with systemic lupus erythematosus treated by autologous hematopoietic stem cell transplantation

Laisvyde Statkute,Ann Traynor,Yu Oyama,Kim Yaung,Larissa Verda,Nela Krosnjar,Richard K. Burt

View Articletitled, Antiphospholipid syndrome in patients with systemic lupus erythematosus treated by autologous hematopoietic stem cell transplantation

Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis
Clinical Trials & Observations

Nadine Martel,James Lee,Philip S. Wells

View Articletitled, Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis

Extraembryonic expression of EPCR is essential for embryonic viability

Weihong Li,Xunzhen Zheng,Jian-Ming Gu,Gary L. Ferrell,Mingming Brady,Naomi L. Esmon,Charles T. Esmon

View Articletitled, Extraembryonic expression of EPCR is essential for embryonic viability

Aggregometry detects platelet hyperreactivity in healthy individuals
Clinical Trials & Observations

Donald L. Yee,Carol W. Sun,Angela L. Bergeron,Jing-fei Dong,Paul F. Bray

View Articletitled, Aggregometry detects platelet hyperreactivity in healthy individuals

Studies on the basis for the properties of fibrin produced from fibrinogen-containing γ′ chains

Kevin R. Siebenlist,Michael W. Mosesson,Irene Hernandez,Leslie A. Bush,Enrico Di Cera,John R. Shainoff,James P. Di Orio,Laurie Stojanovic

View Articletitled, Studies on the basis for the properties of fibrin produced from fibrinogen-containing γ′ chains

In vivo aspirin supplementation inhibits nitric oxide consumption by human platelets

P. Claire Williams,Marcus J. Coffey,Barbara Coles,Stephanie Sanchez,Jason D. Morrow,John R. Cockcroft,Malcolm J. Lewis,Valerie B. O'Donnell

View Articletitled, In vivo aspirin supplementation inhibits nitric oxide consumption by human platelets

The influence of N-linked glycosylation on the function of platelet glycoprotein VI

Thomas J. Kunicki,Yann Cheli,Masaaki Moroi,Kenichi Furihata

View Articletitled, The influence of N-linked glycosylation on the function of platelet glycoprotein VI

Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an αIIbβ3- and aggregation-independent manner

Junling Liu,Tamara I. Pestina,Michael C. Berndt,Carl W. Jackson,T. Kent Gartner

View Articletitled, Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an αIIbβ3- and aggregation-independent manner

Platelet NAD(P)H-oxidase–generated ROS production regulates αIIbβ3-integrin activation independent of the NO/cGMP pathway
Brief Report

Antonija Jurak Begonja,Stepan Gambaryan,Jörg Geiger,Barsom Aktas,Miroslava Pozgajova,Bernhard Nieswandt,Ulrich Walter

View Articletitled, Platelet NAD(P)H-oxidase–generated ROS production regulates αIIbβ3-integrin activation independent of the NO/cGMP pathway

IMMUNOBIOLOGY

A thrombomodulin mutation that impairs activated protein C generation results in uncontrolled lung inflammation during murine tuberculosis

Sebastiaan Weijer,Catharina W. Wieland,Sandrine Florquin,Tom van der Poll

View Articletitled, A thrombomodulin mutation that impairs activated protein C generation results in uncontrolled lung inflammation during murine tuberculosis

Pathologic clonal cytotoxic T-cell responses: nonrandom nature of the T-cell–receptor restriction in large granular lymphocyte leukemia

Marcin W. Wlodarski,Christine O'Keefe,Evan C. Howe,Antonio M. Risitano,Alexander Rodriguez,Ilka Warshawsky,Thomas P. Loughran, Jr,Jaroslaw P. Maciejewski

View Articletitled, Pathologic clonal cytotoxic T-cell responses: nonrandom nature of the T-cell–receptor restriction in large granular lymphocyte leukemia

An alternative exon 1 of the CD5 gene regulates CD5 expression in human B lymphocytes

Yves Renaudineau,Sophie Hillion,Alain Saraux,Rizgar A. Mageed,Pierre Youinou

View Articletitled, An alternative exon 1 of the CD5 gene regulates CD5 expression in human B lymphocytes

Human herpesvirus 8 enhances human immunodeficiency virus replication in acutely infected cells and induces reactivation in latently infected cells

Elisabetta Caselli,Monica Galvan,Enzo Cassai,Arnaldo Caruso,Laura Sighinolfi,Dario Di Luca

View Articletitled, Human herpesvirus 8 enhances human immunodeficiency virus replication in acutely infected cells and induces reactivation in latently infected cells

Functional avidity directs T-cell fate in autoreactive CD4⁺ T cells

Roberto Mallone,Sharon A. Kochik,Helena Reijonen,Bryan Carson,Steven F. Ziegler,William W. Kwok,Gerald T. Nepom

View Articletitled, Functional avidity directs T-cell fate in autoreactive CD4+ T cells

Differential effect of agonistic anti-CD40 on human mature and immature dendritic cells: the Janus face of anti-CD40

Marie-Ghislaine de Goër de Herve,Deniz Durali,Tú-Anh Tran,Gwénola Maigné,Federico Simonetta,Philippe Leclerc,Jean-François Delfraissy,Yassine Taoufik

View Articletitled, Differential effect of agonistic anti-CD40 on human mature and immature dendritic cells: the Janus face of anti-CD40

Mosaicism of NK cells in a patient with Wiskott-Aldrich syndrome

Maxim I. Lutskiy,Diana S. Beardsley,Fred S. Rosen,Eileen Remold-O'Donnell

View Articletitled, Mosaicism of NK cells in a patient with Wiskott-Aldrich syndrome

Monocyte-derived dendritic cells activated by bacteria or by bacteria-stimulated epithelial cells are functionally different

Monica Rimoldi,Marcello Chieppa,Paola Larghi,Marisa Vulcano,Paola Allavena,Maria Rescigno

View Articletitled, Monocyte-derived dendritic cells activated by bacteria or by bacteria-stimulated epithelial cells are functionally different

Supplemental data

NEOPLASIA

Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia

Sigal Gery,Adrian F. Gombart,William S. Yi,Chloe Koeffler,Wolf-K. Hofmann,H. Phillip Koeffler

View Articletitled, Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia

Supplemental data

Clinical implications of t(11;14)(q13;q32), t(4;14)(p16.3;q32), and -17p13 in myeloma patients treated with high-dose therapy
Clinical Trials & Observations

Morie A. Gertz,Martha Q. Lacy,Angela Dispenzieri,Philip R. Greipp,Mark R. Litzow,Kimberly J. Henderson,Scott A. Van Wier,Greg J. Ahmann,Rafael Fonseca

View Articletitled, Clinical implications of t(11;14)(q13;q32), t(4;14)(p16.3;q32), and -17p13 in myeloma patients treated with high-dose therapy

Gefitinib induces myeloid differentiation of acute myeloid leukemia

Kimberly Stegmaier,Steven M. Corsello,Kenneth N. Ross,Jenny S. Wong,Daniel J. DeAngelo,Todd R. Golub

View Articletitled, Gefitinib induces myeloid differentiation of acute myeloid leukemia

Supplemental data

Response criteria for myelofibrosis with myeloid metaplasia: results of an initiative of the European Myelofibrosis Network (EUMNET)
Clinical Trials & Observations

Giovanni Barosi,Dominique Bordessoule,Jean Briere,Francisco Cervantes,Jean-Loup Demory,Brigitte Dupriez,Heinz Gisslinger,Martin Griesshammer,Hans Hasselbalch,Rajko Kusec,Marie-Caroline Le Bousse-Kerdiles,Nicola L. Liberato,Monia Marchetti,John T. Reilly,Jurgen Thiele

View Articletitled, Response criteria for myelofibrosis with myeloid metaplasia: results of an initiative of the European Myelofibrosis Network (EUMNET)

Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia
Clinical Trials & Observations

Tatsuya Suzuki,Hitoshi Kiyoi,Kazutaka Ozeki,Akihiro Tomita,Satomi Yamaji,Ritsuro Suzuki,Yoshihisa Kodera,Shuichi Miyawaki,Norio Asou,Kazutaka Kuriyama,Fumiharu Yagasaki,Chihiro Shimazaki,Hideki Akiyama,Miki Nishimura,Toshiko Motoji,Katsuji Shinagawa,Akihiro Takeshita,Ryuzo Ueda,Tomohiro Kinoshita,Nobuhiko Emi,Tomoki Naoe

View Articletitled, Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia

Supplemental data

The Jak2V617F mutation, PRV-1 overexpression, and EEC formation define a similar cohort of MPD patients
Clinical Trials & Observations Brief Report

Philipp S. Goerttler,Cordula Steimle,Edith März,Peter L. Johansson,Björn Andreasson,Martin Griesshammer,Heinz Gisslinger,Hermann Heimpel,Heike L. Pahl

View Articletitled, The Jak2V617F mutation, PRV-1 overexpression, and EEC formation define a similar cohort of MPD patients

Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation
Clinical Trials & Observations Brief Report

Jason Gotlib,Caroline Berubé,Joseph D. Growney,Ching-Cheng Chen,Tracy I. George,Christopher Williams,Tomohiro Kajiguchi,Jia Ruan,Stan L. Lilleberg,Jeffrey A. Durocher,Jack H. Lichy,Yanfeng Wang,Pamela S. Cohen,Daniel A. Arber,Michael C. Heinrich,Len Neckers,Stephen J. Galli,D. Gary Gilliland,Steven E. Coutré

View Articletitled, Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation

PHAGOCYTES

Quiescent and activated mouse granulocytes do not express granzyme A and B or perforin: similarities or differences with human polymorphonuclear leukocytes?

Praxedis Martin,Reinhard Wallich,Julian Pardo,Arno Müllbacher,Markus Munder,Manuel Modolell,Markus M. Simon

View Articletitled, Quiescent and activated mouse granulocytes do not express granzyme A and B or perforin: similarities or differences with human polymorphonuclear leukocytes?

RED CELLS

Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice

Hiromi Gunshin,Carolyn N. Starr,Cristina DiRenzo,Mark D. Fleming,Jie Jin,Eric L. Greer,Vera M. Sellers,Stephanie M. Galica,Nancy C. Andrews

View Articletitled, Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice

Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin

Lan Lin,Y. Paul Goldberg,Tomas Ganz

View Articletitled, Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin

Supplemental data

TRANSFUSION MEDICINE

Persistent B19 infection in immunocompetent individuals: implications for transfusion safety
Clinical Trials & Observations

Jean-Jacques Lefrère,Annabelle Servant-Delmas,Daniel Candotti,Martine Mariotti,Isabelle Thomas,Yvon Brossard,François Lefrère,Robert Girot,Jean-Pierre Allain,Syria Laperche

View Articletitled, Persistent B19 infection in immunocompetent individuals: implications for transfusion safety

TRANSPLANTATION

A phase 1/2 trial of high-dose yttrium-90-ibritumomab tiuxetan in combination with high-dose etoposide and cyclophosphamide followed by autologous stem cell transplantation in patients with poor-risk or relapsed non-Hodgkin lymphoma
Clinical Trials & Observations

Auayporn Nademanee,Stephen Forman,Arturo Molina,Henry Fung,David Smith,Andy Dagis,Cheuk Kwok,Dave Yamauchi,Anne-Line Anderson,Peter Falk,Amrita Krishnan,Mark Kirschbaum,Neil Kogut,Ryotaro Nakamura,Margaret O'Donnell,Pablo Parker,Leslie Popplewell,Vinod Pullarkat,Roberto Rodriguez,Firoozeh Sahebi,Eileen Smith,David Snyder,Anthony Stein,Ricardo Spielberger,Jasmine Zain,Christine White,Andrew Raubitschek

View Articletitled, A phase 1/2 trial of high-dose yttrium-90-ibritumomab tiuxetan in combination with high-dose etoposide and cyclophosphamide followed by autologous stem cell transplantation in patients with poor-risk or relapsed non-Hodgkin lymphoma

Reduced frequency of FOXP3⁺ CD4⁺CD25⁺ regulatory T cells in patients with chronic graft-versus-host disease
Clinical Trials & Observations

Emmanuel Zorn,Haesook T. Kim,Stephanie J. Lee,Blair H. Floyd,Despina Litsa,Sankari Arumugarajah,Roberto Bellucci,Edwin P. Alyea,Joseph H. Antin,Robert J. Soiffer,Jerome Ritz

View Articletitled, Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease

Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT
Clinical Trials & Observations

Mohamed L. Sorror,Michael B. Maris,Rainer Storb,Frederic Baron,Brenda M. Sandmaier,David G. Maloney,Barry Storer

View Articletitled, Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT

CORRESPONDENCE

The V617F JAK2 mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disorders

Linda M. Scott,Peter J. Campbell,E. Joanna Baxter,Tony Todd,Philip Stephens,Sarah Edkins,Richard Wooster,Michael R. Stratton,P. Andrew Futreal,Anthony R. Green

View Articletitled, The V617F JAK2 mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disorders

Replacement of unfractionated heparin by low-molecular-weight heparin for postorthopedic surgery antithrombotic prophylaxis lowers the overall risk of symptomatic thrombosis because of a lower frequency of heparin-induced thrombocytopenia

Andreas Greinacher,Petra Eichler,Theresia Lietz,Theodore E. Warkentin

View Articletitled, Replacement of unfractionated heparin by low-molecular-weight heparin for postorthopedic surgery antithrombotic prophylaxis lowers the overall risk of symptomatic thrombosis because of a lower frequency of heparin-induced thrombocytopenia

A Portuguese patient homozygous for the -25G>A mutation of the HAMP promoter shows evidence of steady-state transcription but fails to up-regulate hepcidin levels by iron

Graça Porto,Antonella Roetto,Filomena Daraio,Jorge Pereira Pinto,Susana Almeida,Conceição Bacelar,Elizabeth Nemeth,Tomas Ganz,Clara Camaschella

View Articletitled, A Portuguese patient homozygous for the -25G>A mutation of the HAMP promoter shows evidence of steady-state transcription but fails to up-regulate hepcidin levels by iron

CD146 (Mel-CAM), an adhesion marker of endothelial cells, is a novel marker of lymphocyte subset activation in normal peripheral blood

Mohamed F. Elshal,Sameena S. Khan,Yoshiyuki Takahashi,Michael A. Solomon,J. Philip McCoy, Jr

View Articletitled, CD146 (Mel-CAM), an adhesion marker of endothelial cells, is a novel marker of lymphocyte subset activation in normal peripheral blood

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Issue Archive

Table of Contents

INSIDE BLOOD

REVIEW ARTICLES

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

CLINICAL TRIALS AND OBSERVATIONS

Humanized anti–interleukin-6 receptor antibody treatment of multicentric Castleman disease Clinical Trials & Observations

Difference in clinical features between Japanese and German patients with refractory anemia in myelodysplastic syndromes Clinical Trials & Observations

Improved outcome in central nervous system aspergillosis, using voriconazole treatment Clinical Trials & Observations

The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosis Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis Clinical Trials & Observations

Aggregometry detects platelet hyperreactivity in healthy individuals Clinical Trials & Observations

Platelet NAD(P)H-oxidase–generated ROS production regulates αIIbβ3-integrin activation independent of the NO/cGMP pathway Brief Report

IMMUNOBIOLOGY

NEOPLASIA

Clinical implications of t(11;14)(q13;q32), t(4;14)(p16.3;q32), and -17p13 in myeloma patients treated with high-dose therapy Clinical Trials & Observations

Response criteria for myelofibrosis with myeloid metaplasia: results of an initiative of the European Myelofibrosis Network (EUMNET) Clinical Trials & Observations

Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia Clinical Trials & Observations

The Jak2V617F mutation, PRV-1 overexpression, and EEC formation define a similar cohort of MPD patients Clinical Trials & Observations Brief Report

Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation Clinical Trials & Observations Brief Report

PHAGOCYTES

RED CELLS

TRANSFUSION MEDICINE

Persistent B19 infection in immunocompetent individuals: implications for transfusion safety Clinical Trials & Observations

TRANSPLANTATION

A phase 1/2 trial of high-dose yttrium-90-ibritumomab tiuxetan in combination with high-dose etoposide and cyclophosphamide followed by autologous stem cell transplantation in patients with poor-risk or relapsed non-Hodgkin lymphoma Clinical Trials & Observations

Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease Clinical Trials & Observations

Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT Clinical Trials & Observations

CORRESPONDENCE

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American Society of Hematology

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Humanized anti–interleukin-6 receptor antibody treatment of multicentric Castleman disease
Clinical Trials & Observations

Difference in clinical features between Japanese and German patients with refractory anemia in myelodysplastic syndromes
Clinical Trials & Observations

Improved outcome in central nervous system aspergillosis, using voriconazole treatment
Clinical Trials & Observations

The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosis
Clinical Trials & Observations

Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis
Clinical Trials & Observations

Aggregometry detects platelet hyperreactivity in healthy individuals
Clinical Trials & Observations

Platelet NAD(P)H-oxidase–generated ROS production regulates αIIbβ3-integrin activation independent of the NO/cGMP pathway
Brief Report

Clinical implications of t(11;14)(q13;q32), t(4;14)(p16.3;q32), and -17p13 in myeloma patients treated with high-dose therapy
Clinical Trials & Observations

Response criteria for myelofibrosis with myeloid metaplasia: results of an initiative of the European Myelofibrosis Network (EUMNET)
Clinical Trials & Observations

Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia
Clinical Trials & Observations

The Jak2V617F mutation, PRV-1 overexpression, and EEC formation define a similar cohort of MPD patients
Clinical Trials & Observations Brief Report

Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation
Clinical Trials & Observations Brief Report

Persistent B19 infection in immunocompetent individuals: implications for transfusion safety
Clinical Trials & Observations

A phase 1/2 trial of high-dose yttrium-90-ibritumomab tiuxetan in combination with high-dose etoposide and cyclophosphamide followed by autologous stem cell transplantation in patients with poor-risk or relapsed non-Hodgkin lymphoma
Clinical Trials & Observations

Reduced frequency of FOXP3⁺ CD4⁺CD25⁺ regulatory T cells in patients with chronic graft-versus-host disease
Clinical Trials & Observations

Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT
Clinical Trials & Observations