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Volume 106, Issue 7

October 1 2005

In this Issue

INSIDE BLOOD
BLOOD WORK
PLENARY PAPERS
ERRATA
HOW I TREAT
REVIEW ARTICLES
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
CORRESPONDENCE

INSIDE BLOOD

HEMOSTASIS

Platelets trigger endothelial exocytosis

Charles J. Lowenstein

View Articletitled, Platelets trigger endothelial exocytosis

RED CELLS

New dawn for a nocturnal disease

Monica Bessler

View Articletitled, New dawn for a nocturnal disease

RED CELLS

Handling heme

Mitchell J. Weiss

View Articletitled, Handling heme

NEOPLASIA

Fighting CLL cells: deciphering the enemy

Emili Montserrat

View Articletitled, Fighting CLL cells: deciphering the enemy

IMMUNOBIOLOGY

B cells in autoimmunity: more than antibodies?

Falk Hiepe,Andreas Radbruch

View Articletitled, B cells in autoimmunity: more than antibodies?

CLINICAL OBSERVATIONS

Hydroxyurea therapy in SS children

George J. Dover

View Articletitled, Hydroxyurea therapy in SS children

IMMUNOBIOLOGY

IDO production, adaptive immunity, and CTL killing

Thomas Luft,Eugene Maraskovsky,Max Schnurr

View Articletitled, IDO production, adaptive immunity, and CTL killing

HEMOSTASIS

β1-tubulin in human platelets: not simply a structural cell frame

Paolo Gresele,Emanuela Falcinelli

View Articletitled, β1-tubulin in human platelets: not simply a structural cell frame

RED CELLS

An unexpected entry into the globin real estate market

James J. Bieker

View Articletitled, An unexpected entry into the globin real estate market

HEMOSTASIS

Circulating endothelial precursors: identification of functional subpopulations

Stefanie Dimmeler

View Articletitled, Circulating endothelial precursors: identification of functional subpopulations

BLOOD WORK

Acute myelomonocytic leukemia with eosinophilia

View Articletitled, Acute myelomonocytic leukemia with eosinophilia

PLENARY PAPERS

B-cell depletion inhibits arthritis in a collagen-induced arthritis (CIA) model, but does not adversely affect humoral responses in a respiratory syncytial virus (RSV) vaccination model

Kyri Dunussi-Joannopoulos,Gerald E. Hancock,Arthur Kunz,Martin Hegen,Xiaochuan X. Zhou,Barbara J. Sheppard,Jennifer Lamothe,Evelyn Li,Hak-Ling Ma,Philip R. Hamann,Nitin K. Damle,Mary Collins

View Articletitled, B-cell depletion inhibits arthritis in a collagen-induced arthritis (CIA) model, but does not adversely affect humoral responses in a respiratory syncytial virus (RSV) vaccination model

ERRATA

Erratum for vol. 106, p. 1154

View Articletitled, Erratum for vol. 106, p. 1154

Erratum for vol. 106, p. 833

View Articletitled, Erratum for vol. 106, p. 833

HOW I TREAT

How I treat idiopathic thrombocytopenic purpura (ITP)
Clinical Trials & Observations

Douglas B. Cines,James B. Bussel

View Articletitled, How I treat idiopathic thrombocytopenic purpura (ITP)

REVIEW ARTICLES

Natural-killer cells and dendritic cells: “l'union fait la force”

Thierry Walzer,Marc Dalod,Scott H. Robbins,Laurence Zitvogel,Eric Vivier

View Articletitled, Natural-killer cells and dendritic cells: “l'union fait la force”

CHEMOKINES

Chemokine-induced recruitment of genetically modified bone marrow cells into the CNS of G_M1-gangliosidosis mice corrects neuronal pathology

Renata Sano,Alessandra Tessitore,Angela Ingrassia,Alessandra d'Azzo

View Articletitled, Chemokine-induced recruitment of genetically modified bone marrow cells into the CNS of GM1-gangliosidosis mice corrects neuronal pathology

Supplemental data

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Long-term hydroxyurea therapy for infants with sickle cell anemia: the HUSOFT extension study
Clinical Trials & Observations

Jane S. Hankins,Russell E. Ware,Zora R. Rogers,Lynn W. Wynn,Peter A. Lane,J. Paul Scott,Winfred C. Wang

View Articletitled, Long-term hydroxyurea therapy for infants with sickle cell anemia: the HUSOFT extension study

Circulating plasma cells detected by flow cytometry as a predictor of survival in 302 patients with newly diagnosed multiple myeloma
Clinical Trials & Observations

Grzegorz S. Nowakowski,Thomas E. Witzig,David Dingli,Michal J. Tracz,Morie A. Gertz,Martha Q. Lacy,John A. Lust,Angela Dispenzieri,Philip R. Greipp,Robert A. Kyle,S. Vincent Rajkumar

View Articletitled, Circulating plasma cells detected by flow cytometry as a predictor of survival in 302 patients with newly diagnosed multiple myeloma

GENE THERAPY

Human erythropoietin gene therapy for patients with chronic renal failure

Yitzhak Lippin,Michal Dranitzki-Elhalel,Einat Brill-Almon,Chava Mei-Zahav,Sarah Mizrachi,Yael Liberman,Adrian Iaina,Eli Kaplan,Eduardo Podjarny,Evelyne Zeira,Menahem Harati,Nicole Casadevall,Noam Shani,Eithan Galun

View Articletitled, Human erythropoietin gene therapy for patients with chronic renal failure

Oncolytic measles virus in cutaneous T-cell lymphomas mounts antitumor immune responses in vivo and targets interferon-resistant tumor cells

Lucie Heinzerling,Valerie Künzi,Patrick A. Oberholzer,Thomas Kündig,Hussein Naim,Reinhard Dummer

View Articletitled, Oncolytic measles virus in cutaneous T-cell lymphomas mounts antitumor immune responses in vivo and targets interferon-resistant tumor cells

In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice

Doreen E. Wesche-Soldato,Chun-Shiang Chung,Joanne Lomas-Neira,Lesley A. Doughty,Stephen H. Gregory,Alfred Ayala

View Articletitled, In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice

HEMATOPOIESIS

Membrane-bound and soluble IL-15/IL-15Rα complexes display differential signaling and functions on human hematopoietic progenitors

Julien Giron-Michel,Massimo Giuliani,Manuela Fogli,Danièle Brouty-Boyé,Silvano Ferrini,Florence Baychelier,Pierre Eid,Caroline Lebousse-Kerdilès,Deniz Durali,Roberto Biassoni,Bernard Charpentier,Aimé Vasquez,Salem Chouaib,Anne Caignard,Lorenzo Moretta,Bruno Azzarone

View Articletitled, Membrane-bound and soluble IL-15/IL-15Rα complexes display differential signaling and functions on human hematopoietic progenitors

Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact

Kathrin Doege,Sandra Heine,Inga Jensen,Wolfgang Jelkmann,Eric Metzen

View Articletitled, Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact

SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment

Damien Reynaud,Emmanuel Ravet,Monique Titeux,Frédéric Mazurier,Laurent Rénia,Anne Dubart-Kupperschmitt,Paul-Henri Roméo,Françoise Pflumio

View Articletitled, SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment

Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen
Clinical Trials & Observations

Elizabeth A. Sconce,Tayyaba I. Khan,Hilary A. Wynne,Peter Avery,Louise Monkhouse,Barry P. King,Peter Wood,Patrick Kesteven,Ann K. Daly,Farhad Kamali

View Articletitled, The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen

Activated platelets induce Weibel-Palade–body secretion and leukocyte rolling in vivo: role of P-selectin

Vandana S. Dole,Wolfgang Bergmeier,Heather A. Mitchell,Sarah C. Eichenberger,Denisa D. Wagner

View Articletitled, Activated platelets induce Weibel-Palade–body secretion and leukocyte rolling in vivo: role of P-selectin

Thrombus formation induced by antibodies to β2-glycoprotein I is complement dependent and requires a priming factor

Fabio Fischetti,Paolo Durigutto,Valentina Pellis,Alessandra Debeus,Paolo Macor,Roberta Bulla,Fleur Bossi,Federica Ziller,Daniele Sblattero,Pierluigi Meroni,Francesco Tedesco

View Articletitled, Thrombus formation induced by antibodies to β2-glycoprotein I is complement dependent and requires a priming factor

Only a specific subset of human peripheral-blood monocytes has endothelial-like functional capacity

Elzafir Elsheikh,Mehmet Uzunel,Zhong He,Jan Holgersson,Grzegorz Nowak,Suchitra Sumitran-Holgersson

View Articletitled, Only a specific subset of human peripheral-blood monocytes has endothelial-like functional capacity

The TUBB1 Q43P functional polymorphism reduces the risk of cardiovascular disease in men by modulating platelet function and structure
Clinical Trials & Observations

Kathleen Freson,Rita De Vos,Christine Wittevrongel,Chantal Thys,Johan Defoor,Luc Vanhees,Jos Vermylen,Kathelijne Peerlinck,Chris Van Geet

View Articletitled, The TUBB1 Q43P functional polymorphism reduces the risk of cardiovascular disease in men by modulating platelet function and structure

Supplemental data

An underestimated combination of opposites resulting in enhanced thrombotic tendency
Clinical Trials & Observations Brief Report

Paolo Simioni,Elisabetta Castoldi,Barbara Lunghi,Daniela Tormene,Jan Rosing,Francesco Bernardi

View Articletitled, An underestimated combination of opposites resulting in enhanced thrombotic tendency

IMMUNOBIOLOGY

Chemokine up-regulation in SARS-coronavirus–infected, monocyte-derived human dendritic cells

Helen K. W. Law,Chung Yan Cheung,Hoi Yee Ng,Sin Fun Sia,Yuk On Chan,Winsie Luk,John M. Nicholls,J. S. Malik Peiris,Yu Lung Lau

View Articletitled, Chemokine up-regulation in SARS-coronavirus–infected, monocyte-derived human dendritic cells

A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation

Deborah Braun,Randy S. Longman,Matthew L. Albert

View Articletitled, A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation

Supplemental data

Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis

Raghava Potula,Larisa Poluektova,Bryan Knipe,Jesse Chrastil,David Heilman,Huanyu Dou,Osamu Takikawa,David H. Munn,Howard E. Gendelman,Yuri Persidsky

View Articletitled, Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis

Vav proteins regulate peripheral B-cell survival

Elena Vigorito,Laure Gambardella,Francesco Colucci,Simon McAdam,Martin Turner

View Articletitled, Vav proteins regulate peripheral B-cell survival

Patients with paroxysmal nocturnal hemoglobinuria have a high frequency of peripheral-blood T cells expressing activating isoforms of inhibiting superfamily receptors

Alessandro Poggi,Simone Negrini,Maria Raffaella Zocchi,Anna-Maria Massaro,Lucia Garbarino,Sonia Lastraioli,Lucia Gargiulo,Lucio Luzzatto,Rosario Notaro

View Articletitled, Patients with paroxysmal nocturnal hemoglobinuria have a high frequency of peripheral-blood T cells expressing activating isoforms of inhibiting superfamily receptors

Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking

Xin Chen,Takaya Murakami,Joost J. Oppenheim,O. M. Zack Howard

View Articletitled, Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking

Platelets express functional Toll-like receptor-4

Graciela Andonegui,Steven M. Kerfoot,Kelly McNagny,Kirsten V. J. Ebbert,Kamala D. Patel,Paul Kubes

View Articletitled, Platelets express functional Toll-like receptor-4

Systemic administration of a TLR7 ligand leads to transient immune incompetence due to peripheral-blood leukocyte depletion

Matthias Gunzer,Helge Riemann,Yasmin Basoglu,Anja Hillmer,Carsten Weishaupt,Sandra Balkow,Bernd Benninghoff,Beat Ernst,Meike Steinert,Thomas Scholzen,Cord Sunderkötter,Stephan Grabbe

View Articletitled, Systemic administration of a TLR7 ligand leads to transient immune incompetence due to peripheral-blood leukocyte depletion

Supplemental data

IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease
Brief Report

Sameek Roychowdhury,Bradley W. Blaser,Aharon G. Freud,Kerry Katz,Darshna Bhatt,Amy K. Ferketich,Valerie Bergdall,Donna Kusewitt,Robert A. Baiocchi,Michael A. Caligiuri

View Articletitled, IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease

NEOPLASIA

Differential regulation of the p70 S6 kinase pathway by interferon α (IFNα) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells

Simrit Parmar,Jessica Smith,Antonella Sassano,Shahab Uddin,Efstratios Katsoulidis,Beata Majchrzak,Suman Kambhampati,Elizabeth A. Eklund,Martin S. Tallman,Eleanor N. Fish,Leonidas C. Platanias

View Articletitled, Differential regulation of the p70 S6 kinase pathway by interferon α (IFNα) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells

Impact of tumor Epstein-Barr virus status on presenting features and outcome in age-defined subgroups of patients with classic Hodgkin lymphoma: a population-based study
Clinical Trials & Observations

Ruth F. Jarrett,Gail L. Stark,Jo White,Brian Angus,Freda E. Alexander,Andrew S. Krajewski,June Freeland,G. Malcolm Taylor,Penelope R. A. Taylor,for the Scotland and Newcastle Epidemiology of Hodgkin Disease Study Group

View Articletitled, Impact of tumor Epstein-Barr virus status on presenting features and outcome in age-defined subgroups of patients with classic Hodgkin lymphoma: a population-based study

c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations

Hui Luo,Qing Li,Julie O'Neal,Friederike Kreisel,Michelle M. Le Beau,Michael H. Tomasson

View Articletitled, c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations

Supplemental data

Dual targeting of transformed and untransformed HTLV-1–infected T cells by DHMEQ, a potent and selective inhibitor of NF-κB, as a strategy for chemoprevention and therapy of adult T-cell leukemia

Mariko Watanabe,Takeo Ohsugi,Momoko Shoda,Takaomi Ishida,Shigemi Aizawa,Masae Maruyama-Nagai,Atae Utsunomiya,Shin Koga,Yasuaki Yamada,Shimeru Kamihira,Akihiko Okayama,Hiroshi Kikuchi,Kimiharu Uozumi,Kazunari Yamaguchi,Masaaki Higashihara,Kazuo Umezawa,Toshiki Watanabe,Ryouichi Horie

View Articletitled, Dual targeting of transformed and untransformed HTLV-1–infected T cells by DHMEQ, a potent and selective inhibitor of NF-κB, as a strategy for chemoprevention and therapy of adult T-cell leukemia

Supplemental data

Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation

Nicola Giuliani,Simona Colla,Francesca Morandi,Mirca Lazzaretti,Roberto Sala,Sabrina Bonomini,Maria Grano,Silvia Colucci,Mirija Svaldi,Vittorio Rizzoli

View Articletitled, Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation

Targeting FLT3 in primary MLL-gene–rearranged infant acute lymphoblastic leukemia

Ronald W. Stam,Monique L. den Boer,Pauline Schneider,Peter Nollau,Martin Horstmann,H. Berna Beverloo,Ella van der Voort,Maria G. Valsecchi,Paola de Lorenzo,Stephen E. Sallan,Scott A. Armstrong,Rob Pieters

View Articletitled, Targeting FLT3 in primary MLL-gene–rearranged infant acute lymphoblastic leukemia

Primary cutaneous large B-cell lymphomas: clinicopathologic features, classification, and prognostic factors in a large series of patients
Clinical Trials & Observations

Kazuo Kodama,Cesare Massone,Andreas Chott,Dieter Metze,Helmut Kerl,Lorenzo Cerroni

View Articletitled, Primary cutaneous large B-cell lymphomas: clinicopathologic features, classification, and prognostic factors in a large series of patients

Cooperating cancer-gene identification through oncogenic-retrovirus–induced insertional mutagenesis

Yang Du,Sally E. Spence,Nancy A. Jenkins,Neal G. Copeland

View Articletitled, Cooperating cancer-gene identification through oncogenic-retrovirus–induced insertional mutagenesis

ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia

Januario E. Castro,Carlos E. Prada,Olivier Loria,Adeela Kamal,Liguang Chen,Francis J. Burrows,Thomas J. Kipps

View Articletitled, ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia

Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death

Rong Chen,Michael J. Keating,Varsha Gandhi,William Plunkett

View Articletitled, Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death

In vitro sensitivity to imatinib-induced inhibition of ABL kinase activity is predictive of molecular response in patients with de novo CML
Clinical Trials & Observations

Deborah White,Verity Saunders,A. Bruce Lyons,Susan Branford,Andrew Grigg,L. Bik To,Timothy Hughes

View Articletitled, In vitro sensitivity to imatinib-induced inhibition of ABL kinase activity is predictive of molecular response in patients with de novo CML

Diphtheria toxin fused to variant human interleukin-3 induces cytotoxicity of blasts from patients with acute myeloid leukemia according to the level of interleukin-3 receptor expression
Brief Report

Ugo Testa,Roberta Riccioni,Mauro Biffoni,Daniela Diverio,Francesco Lo-Coco,Robin Foà,Cesare Peschle,Arthur E. Frankel

View Articletitled, Diphtheria toxin fused to variant human interleukin-3 induces cytotoxicity of blasts from patients with acute myeloid leukemia according to the level of interleukin-3 receptor expression

Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells
Brief Report

Boris Calmels,Cole Ferguson,Mikko O. Laukkanen,Rima Adler,Marion Faulhaber,Hyeoung-Joon Kim,Stephanie Sellers,Peiman Hematti,Manfred Schmidt,Christof von Kalle,Keiko Akagi,Robert E. Donahue,Cynthia E. Dunbar

View Articletitled, Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells

Supplemental data

PHAGOCYTES

C/EBPα functionally and physically interacts with GABP to activate the human myeloid IgA Fc receptor (FcαR, CD89) gene promoter

Toshibumi Shimokawa,Chisei Ra

View Articletitled, C/EBPα functionally and physically interacts with GABP to activate the human myeloid IgA Fc receptor (FcαR, CD89) gene promoter

Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production

David M. Underhill,Eddie Rossnagle,Clifford A. Lowell,Randi M. Simmons

View Articletitled, Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production

Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity

Ju Hyun Cho,Iain P. Fraser,Koichi Fukase,Shoichi Kusumoto,Yukari Fujimoto,Gregory L. Stahl,R. Alan B. Ezekowitz

View Articletitled, Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity

Supplemental data

RED CELLS

Sustained response and long-term safety of eculizumab in paroxysmal nocturnal hemoglobinuria
Clinical Trials & Observations

Anita Hill,Peter Hillmen,Stephen J. Richards,Dupe Elebute,Judith C. Marsh,Jason Chan,Christopher F. Mojcik,Russell P. Rother

View Articletitled, Sustained response and long-term safety of eculizumab in paroxysmal nocturnal hemoglobinuria

KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic β-like globin genes in vivo

Priyadarshi Basu,Pamela E. Morris,Jack L. Haar,Maqsood A. Wani,Jerry B. Lingrel,Karin M. L. Gaensler,Joyce A. Lloyd

View Articletitled, KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic β-like globin genes in vivo

Identification of the receptor scavenging hemopexin-heme complexes

Vibeke Hvidberg,Maciej B. Maniecki,Christian Jacobsen,Peter Højrup,Holger J. Møller,Søren K. Moestrup

View Articletitled, Identification of the receptor scavenging hemopexin-heme complexes

Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)

Bruno Galy,Dunja Ferring,Belen Minana,Oliver Bell,Heinz G. Janser,Martina Muckenthaler,Klaus Schümann,Matthias W. Hentze

View Articletitled, Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)

Supplemental data

CORRESPONDENCE

MTHFR genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia

Ranjit K. Thirumaran,Andreas Gast,Thomas Flohr,Barbara Burwinkel,Claus Bartram,Kari Hemminki,Rajiv Kumar

View Articletitled, MTHFR genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia

Final height after transplantation in childhood

Boudewijn Bakker,Wilma Oostdijk,Jan M. Wit

View Articletitled, Final height after transplantation in childhood

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Blunted CD40-responsive enhancer activation in CREBBP-mutant lymphomas can be restored by enforced CD4 T-cell engagement

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Safety and efficacy of rilzabrutinib vs placebo in adults with immune thrombocytopenia: the phase 3 LUNA3 study

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Issue Archive

Table of Contents

INSIDE BLOOD

BLOOD WORK

PLENARY PAPERS

ERRATA

HOW I TREAT

How I treat idiopathic thrombocytopenic purpura (ITP) Clinical Trials & Observations

REVIEW ARTICLES

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Long-term hydroxyurea therapy for infants with sickle cell anemia: the HUSOFT extension study Clinical Trials & Observations

Circulating plasma cells detected by flow cytometry as a predictor of survival in 302 patients with newly diagnosed multiple myeloma Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen Clinical Trials & Observations

The TUBB1 Q43P functional polymorphism reduces the risk of cardiovascular disease in men by modulating platelet function and structure Clinical Trials & Observations

An underestimated combination of opposites resulting in enhanced thrombotic tendency Clinical Trials & Observations Brief Report

IMMUNOBIOLOGY

IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease Brief Report

NEOPLASIA

Impact of tumor Epstein-Barr virus status on presenting features and outcome in age-defined subgroups of patients with classic Hodgkin lymphoma: a population-based study Clinical Trials & Observations

Primary cutaneous large B-cell lymphomas: clinicopathologic features, classification, and prognostic factors in a large series of patients Clinical Trials & Observations

In vitro sensitivity to imatinib-induced inhibition of ABL kinase activity is predictive of molecular response in patients with de novo CML Clinical Trials & Observations

Diphtheria toxin fused to variant human interleukin-3 induces cytotoxicity of blasts from patients with acute myeloid leukemia according to the level of interleukin-3 receptor expression Brief Report

Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells Brief Report

PHAGOCYTES

RED CELLS

Sustained response and long-term safety of eculizumab in paroxysmal nocturnal hemoglobinuria Clinical Trials & Observations

CORRESPONDENCE

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ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

How I treat idiopathic thrombocytopenic purpura (ITP)
Clinical Trials & Observations

Long-term hydroxyurea therapy for infants with sickle cell anemia: the HUSOFT extension study
Clinical Trials & Observations

Circulating plasma cells detected by flow cytometry as a predictor of survival in 302 patients with newly diagnosed multiple myeloma
Clinical Trials & Observations

The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen
Clinical Trials & Observations

The TUBB1 Q43P functional polymorphism reduces the risk of cardiovascular disease in men by modulating platelet function and structure
Clinical Trials & Observations

An underestimated combination of opposites resulting in enhanced thrombotic tendency
Clinical Trials & Observations Brief Report

IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease
Brief Report

Impact of tumor Epstein-Barr virus status on presenting features and outcome in age-defined subgroups of patients with classic Hodgkin lymphoma: a population-based study
Clinical Trials & Observations

Primary cutaneous large B-cell lymphomas: clinicopathologic features, classification, and prognostic factors in a large series of patients
Clinical Trials & Observations

In vitro sensitivity to imatinib-induced inhibition of ABL kinase activity is predictive of molecular response in patients with de novo CML
Clinical Trials & Observations

Diphtheria toxin fused to variant human interleukin-3 induces cytotoxicity of blasts from patients with acute myeloid leukemia according to the level of interleukin-3 receptor expression
Brief Report

Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells
Brief Report

Sustained response and long-term safety of eculizumab in paroxysmal nocturnal hemoglobinuria
Clinical Trials & Observations