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Volume 106, Issue 6

September 15 2005

In this Issue

INSIDE BLOOD
REVIEW ARTICLES
REVIEW IN TRANSLATIONAL HEMATOLOGY
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
RED CELLS
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

IMMUNOBIOLOGY

Watching ANCAs work

Ingeborg M. Bajema

View Articletitled, Watching ANCAs work

TRANSPLANTATION

Chimera: from bane to blessing

Dan L. Longo

View Articletitled, Chimera: from bane to blessing

CHEMOKINES

Where you are is what you are

Peter Lane

View Articletitled, Where you are is what you are

NEOPLASIA

DC therapy? Let the natural killer answer

Sherif S. Farag

View Articletitled, DC therapy? Let the natural killer answer

RED CELLS

The iron sensor: macrophage, hepatocyte, both?

Robert E. Fleming

View Articletitled, The iron sensor: macrophage, hepatocyte, both?

NEOPLASIA

Role for α-DGK in ALK⁺ ALCL

H. Denis Alexander

View Articletitled, Role for α-DGK in ALK+ ALCL

IMMUNOBIOLOGY

CD40 brings the shuttle down

Cees van Kooten,Andrea M. Woltman

View Articletitled, CD40 brings the shuttle down

CLINICAL OBSERVATIONS

Controlling chronic TTP

James N. George

View Articletitled, Controlling chronic TTP

NEOPLASIA

Mutation detection in CML: is it a useful tool?

François Guilhot

View Articletitled, Mutation detection in CML: is it a useful tool?

IMMUNOBIOLOGY

The marriage of cancer vaccines and antiangiogenesis

Jeffrey Schlom

View Articletitled, The marriage of cancer vaccines and antiangiogenesis

NEOPLASIA

LPA signaling stimulates Hodgkin research

Gerald Niedobitek

View Articletitled, LPA signaling stimulates Hodgkin research

IMMUNOBIOLOGY

p38 MAP kinase in HIV-1 infection: the enemy within

Jean-Luc Perfettini,Guido Kroemer

View Articletitled, p38 MAP kinase in HIV-1 infection: the enemy within

RED CELLS

To condense is not to die

James Palis

View Articletitled, To condense is not to die

REVIEW ARTICLES

How do stem cells find their way home?

Tsvee Lapidot,Ayelet Dar,Orit Kollet

View Articletitled, How do stem cells find their way home?

REVIEW IN TRANSLATIONAL HEMATOLOGY

Oncogenes as molecular targets in lymphoma

Ali Hachem,Ronald B. Gartenhaus

View Articletitled, Oncogenes as molecular targets in lymphoma

CHEMOKINES

Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help

Svenja Hardtke,Lars Ohl,Reinhold Förster

View Articletitled, Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Efficiency of curative and prophylactic treatment with rituximab in ADAMTS13-deficient thrombotic thrombocytopenic purpura: a study of 11 cases
Clinical Trials & Observations

Fadi Fakhouri,Jean-Paul Vernant,Agnès Veyradier,Martine Wolf,Gilles Kaplanski,Raynald Binaut,Manfred Rieger,Friedrich Scheiflinger,Pascale Poullin,Benjamin Deroure,Richard Delarue,Philippe Lesavre,Philippe Vanhille,Olivier Hermine,Giuseppe Remuzzi,Jean-Pierre Grünfeld

View Articletitled, Efficiency of curative and prophylactic treatment with rituximab in ADAMTS13-deficient thrombotic thrombocytopenic purpura: a study of 11 cases

HEMATOPOIESIS

Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages

Tomohiko Tamura,Pratima Thotakura,Tetsuya S. Tanaka,Minoru S. H. Ko,Keiko Ozato

View Articletitled, Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages

Supplemental data

Involvement of Runx1 in the down-regulation of fetal liver kinase-1 expression during transition of endothelial cells to hematopoietic cells

Hideyo Hirai,Igor M Samokhvalov,Tetsuhiro Fujimoto,Satomi Nishikawa,Jiro Imanishi,Shin-Ichi Nishikawa

View Articletitled, Involvement of Runx1 in the down-regulation of fetal liver kinase-1 expression during transition of endothelial cells to hematopoietic cells

Functional abnormalities of heparan sulfate in mucopolysaccharidosis-I are associated with defective biologic activity of FGF-2 on human multipotent progenitor cells

Chendong Pan,Matthew S. Nelson,Morayma Reyes,Lisa Koodie,Joseph J. Brazil,Elliot J. Stephenson,Robert C. Zhao,Charles Peters,Scott B. Selleck,Sally E. Stringer,Pankaj Gupta

View Articletitled, Functional abnormalities of heparan sulfate in mucopolysaccharidosis-I are associated with defective biologic activity of FGF-2 on human multipotent progenitor cells

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Novel pathway for megakaryocyte production after in vivo conditional eradication of integrin αIIb-expressing cells

Beatrice Jacquelin,Thierry Kortulewski,Pierre Vaigot,Alexandre Pawlik,Gaetan Gruel,Olivier Alibert,Pascal Soularue,Christophe Joubert,Xavier Gidrol,Diana Tronik-Le Roux

View Articletitled, Novel pathway for megakaryocyte production after in vivo conditional eradication of integrin αIIb-expressing cells

Supplemental data

A critical role for 14-3-3ζ protein in regulating the VWF binding function of platelet glycoprotein Ib-IX and its therapeutic implications

Kesheng Dai,Richard Bodnar,Michael C. Berndt,Xiaoping Du

View Articletitled, A critical role for 14-3-3ζ protein in regulating the VWF binding function of platelet glycoprotein Ib-IX and its therapeutic implications

Gain of von Willebrand factor–binding function by mutagenesis of a species-conserved residue within the leucine-rich repeat region of platelet glycoprotein Ibα

Yuandong Peng,Corie N. Shrimpton,Jing-fei Dong,José A. López

View Articletitled, Gain of von Willebrand factor–binding function by mutagenesis of a species-conserved residue within the leucine-rich repeat region of platelet glycoprotein Ibα

Bombay phenotype is associated with reduced plasma-VWF levels and an increased susceptibility to ADAMTS13 proteolysis
Clinical Trials & Observations Brief Report

James S. O'Donnell,Thomas A. J. McKinnon,James T. B. Crawley,David A. Lane,Michael A. Laffan

View Articletitled, Bombay phenotype is associated with reduced plasma-VWF levels and an increased susceptibility to ADAMTS13 proteolysis

Tumor necrosis factor-α as trigger of platelet activation in patients with heart failure
Clinical Trials & Observations Brief Report

Pasquale Pignatelli,Luciano De Biase,Luisa Lenti,Giuliano Tocci,Alessandra Brunelli,Roberto Cangemi,Silvia Riondino,Susanna Grego,Massimo Volpe,Francesco Violi

View Articletitled, Tumor necrosis factor-α as trigger of platelet activation in patients with heart failure

IMMUNOBIOLOGY

Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development

Emma M. K. Smith,Peter Åkerblad,Tom Kadesch,Håkan Axelson,Mikael Sigvardsson

View Articletitled, Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development

The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells

Bruce Y. Ma,Sebastian A. Mikolajczak,Ali Danesh,Karoline A. Hosiawa,Cheryl M. Cameron,Akifumi Takaori-Kondo,Takashi Uchiyama,David J. Kelvin,Atsuo Ochi

View Articletitled, The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells

Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance

Shigeaki Hida,Masumi Tadachi,Takashi Saito,Shinsuke Taki

View Articletitled, Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance

Reduced frequencies and suppressive function of CD4⁺CD25^hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine

Marc Beyer,Matthias Kochanek,Kamruz Darabi,Alexey Popov,Markus Jensen,Elmar Endl,Percy A. Knolle,Roman K. Thomas,Michael von Bergwelt-Baildon,Svenja Debey,Michael Hallek,Joachim L. Schultze

View Articletitled, Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine

Supplemental data

T cell–mediated suppression of angiogenesis results in tumor protective immunity

He Zhou,Yunping Luo,Masato Mizutani,Noriko Mizutani,Ralph A. Reisfeld,Rong Xiang

View Articletitled, T cell–mediated suppression of angiogenesis results in tumor protective immunity

Fas signal links innate and adaptive immunity by promoting dendritic-cell secretion of CC and CXC chemokines

Zhenhong Guo,Minghui Zhang,Hua Tang,Xuetao Cao

View Articletitled, Fas signal links innate and adaptive immunity by promoting dendritic-cell secretion of CC and CXC chemokines

Expression of 11β-hydroxysteroid dehydrogenase type 1 permits regulation of glucocorticoid bioavailability by human dendritic cells

Lisa Freeman,Martin Hewison,Susan V. Hughes,Katie N. Evans,Deborah Hardie,Terry K. Means,Ronjon Chakraverty

View Articletitled, Expression of 11β-hydroxysteroid dehydrogenase type 1 permits regulation of glucocorticoid bioavailability by human dendritic cells

Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo

Mark A. Little,C. Lucy Smyth,Rashmi Yadav,Lyn Ambrose,H. Terence Cook,Sussan Nourshargh,Charles D. Pusey

View Articletitled, Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo

Supplemental data

HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation

Karuppiah Muthumani,Andrew Y. Choo,Daniel S. Hwang,Arumugam Premkumar,Nathanael S. Dayes,Crafford Harris,Douglas R. Green,Scott A. Wadsworth,John J. Siekierka,David B. Weiner

View Articletitled, HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation

Impaired Ig class switch in mice deficient for the X-linked lymphoproliferative disease gene Sap

Umaima Al-Alem,Cuiling Li,Nathalie Forey,Francis Relouzat,Marie-Claude Fondanèche,Sean V. Tavtigian,Zhao-Qi Wang,Sylvain Latour,Luo Yin

View Articletitled, Impaired Ig class switch in mice deficient for the X-linked lymphoproliferative disease gene Sap

Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44

Anja Fuchs,Marina Cella,Takayuki Kondo,Marco Colonna

View Articletitled, Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44

The development of functional B lymphocytes in conditional PU.1 knock-out mice

Matthew Polli,Aleksandar Dakic,Amanda Light,Li Wu,David M. Tarlinton,Stephen L. Nutt

View Articletitled, The development of functional B lymphocytes in conditional PU.1 knock-out mice

IL-7 receptor α chain expression distinguishes functional subsets of virus-specific human CD8⁺ T cells

Ester M. M. van Leeuwen,Godelieve J. de Bree,Ester B. M. Remmerswaal,Si-La Yong,Kiki Tesselaar,Ineke J. M. ten Berge,René A. W. van Lier

View Articletitled, IL-7 receptor α chain expression distinguishes functional subsets of virus-specific human CD8+ T cells

Oligoclonal expansion of T lymphocytes with multiple second-site mutations leads to Omenn syndrome in a patient with RAG1-deficient severe combined immunodeficiency
Clinical Trials & Observations Brief Report

Taizo Wada,Tomoko Toma,Hiroyuki Okamoto,Yoshihito Kasahara,Shoichi Koizumi,Kazunaga Agematsu,Hirokazu Kimura,Akira Shimada,Yasuhide Hayashi,Masahiko Kato,Akihiro Yachie

View Articletitled, Oligoclonal expansion of T lymphocytes with multiple second-site mutations leads to Omenn syndrome in a patient with RAG1-deficient severe combined immunodeficiency

Immunosuppressive therapy for aplastic anemia in children: a more severe disease predicts better survival
Clinical Trials & Observations Brief Report

Monika Führer,Udo Rampf,Irith Baumann,Andreas Faldum,Charlotte Niemeyer,Gritta Janka-Schaub,Wilhelm Friedrich,Wolfram Ebell,Arndt Borkhardt,Christine Bender-Goetze,for the German/Austrian Aplastic Anemia Working Group

View Articletitled, Immunosuppressive therapy for aplastic anemia in children: a more severe disease predicts better survival

NEOPLASIA

Bcl10 can promote survival of antigen-stimulated B lymphocytes

Maoxin Tim Tian,Gabriel Gonzalez,Barbara Scheer,Anthony L. DeFranco

View Articletitled, Bcl10 can promote survival of antigen-stimulated B lymphocytes

RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years
Clinical Trials & Observations

David T. Bowen,Marion E. Frew,Robert Hills,Rosemary E. Gale,Keith Wheatley,Michael J. Groves,Stephen E. Langabeer,Panagiotis D. Kottaridis,Anthony V. Moorman,Alan K. Burnett,David C. Linch

View Articletitled, RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years

Motility, proliferation, and egress to the circulation of human AML cells are elastase dependent in NOD/SCID chimeric mice

Sigal Tavor,Isabelle Petit,Svetlana Porozov,Polina Goichberg,Abraham Avigdor,Sari Sagiv,Arnon Nagler,Elizabeth Naparstek,Tsvee Lapidot

View Articletitled, Motility, proliferation, and egress to the circulation of human AML cells are elastase dependent in NOD/SCID chimeric mice

High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy
Clinical Trials & Observations

Stephanie G. Willis,Thoralf Lange,Shadmehr Demehri,Sandra Otto,Lucy Crossman,Dietger Niederwieser,Eric P. Stoffregen,Shannon McWeeney,Ines Kovacs,Byung Park,Brian J. Druker,Michael W. Deininger

View Articletitled, High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy

Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells

Karl R. N. Baumforth,Joanne R. Flavell,Gary M. Reynolds,Gillian Davies,Trevor R. Pettit,Wenbin Wei,Susan Morgan,Tanya Stankovic,Yasuhiro Kishi,Hiroyuki Arai,Marketa Nowakova,Guy Pratt,Junken Aoki,Michael J. O. Wakelam,Lawrence S. Young,Paul G. Murray

View Articletitled, Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells

Dysplastic definitive hematopoiesis in AML1/EVI1 knock-in embryos

Kazuhiro Maki,Tetsuya Yamagata,Takashi Asai,Ieharu Yamazaki,Hideaki Oda,Hisamaru Hirai,Kinuko Mitani

View Articletitled, Dysplastic definitive hematopoiesis in AML1/EVI1 knock-in embryos

A validated FISH trisomy index demonstrates the hyperdiploid and nonhyperdiploid dichotomy in MGUS

Wee Joo Chng,Scott A. Van Wier,Gregory J. Ahmann,Jerry M. Winkler,Syed M. Jalal,Peter Leif Bergsagel,Marta Chesi,Mike C. Trendle,Martin M. Oken,Emily Blood,Kim Henderson,Rafael Santana-Dávila,Robert A. Kyle,Morie A. Gertz,Martha Q. Lacy,Angela Dispenzieri,Philip R. Greipp,Rafael Fonseca

View Articletitled, A validated FISH trisomy index demonstrates the hyperdiploid and nonhyperdiploid dichotomy in MGUS

Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders
Clinical Trials & Observations

Amy V. Jones,Sebastian Kreil,Katerina Zoi,Katherine Waghorn,Claire Curtis,Lingyan Zhang,Joannah Score,Rachel Seear,Andrew J. Chase,Francis H. Grand,Helen White,Christine Zoi,Dimitris Loukopoulos,Evangelos Terpos,Elisavet-Christine Vervessou,Beate Schultheis,Michael Emig,Thomas Ernst,Eva Lengfelder,Rüdiger Hehlmann,Andreas Hochhaus,David Oscier,Richard T. Silver,Andreas Reiter,Nicholas C. P. Cross

View Articletitled, Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders

Analysis of multiple biomarkers shows that lymphoma-associated macrophage (LAM) content is an independent predictor of survival in follicular lymphoma (FL)
Clinical Trials & Observations

Pedro Farinha,Hamid Masoudi,Brian F. Skinnider,Karey Shumansky,John J. Spinelli,Karamjit Gill,Richard Klasa,Nicolas Voss,Joseph M. Connors,Randy D. Gascoyne

View Articletitled, Analysis of multiple biomarkers shows that lymphoma-associated macrophage (LAM) content is an independent predictor of survival in follicular lymphoma (FL)

Activation of α-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase

Roberta Bacchiocchi,Gianluca Baldanzi,Damiano Carbonari,Catia Capomagi,Emanuela Colombo,Wim J. van Blitterswijk,Andrea Graziani,Francesca Fazioli

View Articletitled, Activation of α-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase

The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease
Brief Report

Christian P. Kratz,Charlotte M. Niemeyer,Robert P. Castleberry,Mualla Cetin,Eva Bergsträsser,Peter D. Emanuel,Henrik Hasle,Gabriela Kardos,Cornelia Klein,Seiji Kojima,Jan Stary,Monika Trebo,Marco Zecca,Bruce D. Gelb,Marco Tartaglia,Mignon L. Loh

View Articletitled, The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease

Defective killing of dendritic cells by autologous natural killer cells from acute myeloid leukemia patients
Brief Report

Cyril Fauriat,Alessandro Moretta,Daniel Olive,Régis T. Costello

View Articletitled, Defective killing of dendritic cells by autologous natural killer cells from acute myeloid leukemia patients

RED CELLS

Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading

Hortence Makui,Ricardo J. Soares,Wenlei Jiang,Marco Constante,Manuela M. Santos

View Articletitled, Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading

Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs

Seth Rivera,Elizabeta Nemeth,Victoria Gabayan,Miguel A. Lopez,Dina Farshidi,Tomas Ganz

View Articletitled, Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs

Nuclear substructure reorganization during late-stage erythropoiesis is selective and does not involve caspase cleavage of major nuclear substructural proteins

Sharon Wald Krauss,Annie J. Lo,Sarah A. Short,Mark J. Koury,Narla Mohandas,Joel Anne Chasis

View Articletitled, Nuclear substructure reorganization during late-stage erythropoiesis is selective and does not involve caspase cleavage of major nuclear substructural proteins

TRANSPLANTATION

TGF-β in allogeneic stem cell transplantation: friend or foe?

Tatjana Banovic,Kelli P. A. MacDonald,Edward S. Morris,Vanessa Rowe,Rachel Kuns,Alistair Don,Jane Kelly,Steve Ledbetter,Andrew D. Clouston,Geoffrey R. Hill

View Articletitled, TGF-β in allogeneic stem cell transplantation: friend or foe?

Long-term mixed chimerism after immunologic conditioning and MHC-mismatched stem-cell transplantation is dependent on NK-cell tolerance

Geert Westerhuis,Wendy G. E. Maas,Roel Willemze,René E. M. Toes,Willem E. Fibbe

View Articletitled, Long-term mixed chimerism after immunologic conditioning and MHC-mismatched stem-cell transplantation is dependent on NK-cell tolerance

CORRESPONDENCE

Analysis of the E399D mutation in SLC11A2

Hiromi Gunshin,Jie Jin,Yuko Fujiwara,Nancy C. Andrews

View Articletitled, Analysis of the E399D mutation in SLC11A2

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Issue Archive

Table of Contents

INSIDE BLOOD

REVIEW ARTICLES

REVIEW IN TRANSLATIONAL HEMATOLOGY

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Efficiency of curative and prophylactic treatment with rituximab in ADAMTS13-deficient thrombotic thrombocytopenic purpura: a study of 11 cases Clinical Trials & Observations

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Bombay phenotype is associated with reduced plasma-VWF levels and an increased susceptibility to ADAMTS13 proteolysis Clinical Trials & Observations Brief Report

Tumor necrosis factor-α as trigger of platelet activation in patients with heart failure Clinical Trials & Observations Brief Report

IMMUNOBIOLOGY

Oligoclonal expansion of T lymphocytes with multiple second-site mutations leads to Omenn syndrome in a patient with RAG1-deficient severe combined immunodeficiency Clinical Trials & Observations Brief Report

Immunosuppressive therapy for aplastic anemia in children: a more severe disease predicts better survival Clinical Trials & Observations Brief Report

NEOPLASIA

RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years Clinical Trials & Observations

High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy Clinical Trials & Observations

Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders Clinical Trials & Observations

Analysis of multiple biomarkers shows that lymphoma-associated macrophage (LAM) content is an independent predictor of survival in follicular lymphoma (FL) Clinical Trials & Observations

The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease Brief Report

Defective killing of dendritic cells by autologous natural killer cells from acute myeloid leukemia patients Brief Report

RED CELLS

TRANSPLANTATION

CORRESPONDENCE

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American Society of Hematology

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Efficiency of curative and prophylactic treatment with rituximab in ADAMTS13-deficient thrombotic thrombocytopenic purpura: a study of 11 cases
Clinical Trials & Observations

Bombay phenotype is associated with reduced plasma-VWF levels and an increased susceptibility to ADAMTS13 proteolysis
Clinical Trials & Observations Brief Report

Tumor necrosis factor-α as trigger of platelet activation in patients with heart failure
Clinical Trials & Observations Brief Report

Oligoclonal expansion of T lymphocytes with multiple second-site mutations leads to Omenn syndrome in a patient with RAG1-deficient severe combined immunodeficiency
Clinical Trials & Observations Brief Report

Immunosuppressive therapy for aplastic anemia in children: a more severe disease predicts better survival
Clinical Trials & Observations Brief Report

RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years
Clinical Trials & Observations

High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy
Clinical Trials & Observations

Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders
Clinical Trials & Observations

Analysis of multiple biomarkers shows that lymphoma-associated macrophage (LAM) content is an independent predictor of survival in follicular lymphoma (FL)
Clinical Trials & Observations

The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease
Brief Report

Defective killing of dendritic cells by autologous natural killer cells from acute myeloid leukemia patients
Brief Report