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Volume 106, Issue 3

August 1 2005

In this Issue

INSIDE BLOOD
BLOOD WORK
PLENARY PAPERS
REVIEW IN TRANSLATIONAL HEMATOLOGY
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

IMMUNOBIOLOGY

Structure of a Janus kinase: molecular insights and prospects for optimizing a new class of immunosuppressants

John J. O'Shea,Massimo Gadina,Xiaomin Chen

View Articletitled, Structure of a Janus kinase: molecular insights and prospects for optimizing a new class of immunosuppressants

NEOPLASIA

APRIL showers cause CLL and myeloma to flower

John Shaughnessy, Jr

View Articletitled, APRIL showers cause CLL and myeloma to flower

CLINICAL OBSERVATIONS

Determining the undetermined

Nikhil C. Munshi

View Articletitled, Determining the undetermined

CLINICAL OBSERVATIONS

Erythropoietin for the anemia of low-risk myelodysplastic syndromes

Pierre Fenaux,Lionel Ades

View Articletitled, Erythropoietin for the anemia of low-risk myelodysplastic syndromes

HEMATOPOIESIS

Endothelial cell–specific markers: going... going... gone

William H. Fleming

View Articletitled, Endothelial cell–specific markers: going... going... gone

HEMOSTASIS

Finally, the LDL receptor joins in

Steven L. Gonias

View Articletitled, Finally, the LDL receptor joins in

HEMATOPOIESIS

Extrathymic commitment to T-cell lineage

Louise M. C. Webb

View Articletitled, Extrathymic commitment to T-cell lineage

TRANSFUSION MEDICINE

Yin and yang in transfusion medicine

Steven L. Spitalnik

View Articletitled, Yin and yang in transfusion medicine

TRANSPLANTATION

GVHD: in vivo veritas

James L. M. Ferrara

View Articletitled, GVHD: in vivo veritas

INSIDE BLOOD

Immune surveillance against common cancers: the great escape

Michael A. Caligiuri

View Articletitled, Immune surveillance against common cancers: the great escape

RED CELLS

Iron regulatory protein 2 and anemia

Victor R. Gordeuk

View Articletitled, Iron regulatory protein 2 and anemia

HEMATOPOIESIS

Unraveling the mysteries of B-Raf: the clot thickens!

Philip J. S. Stork

View Articletitled, Unraveling the mysteries of B-Raf: the clot thickens!

BLOOD WORK

Polychromasia

View Articletitled, Polychromasia

PLENARY PAPERS

The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8⁺ T-cell responses through the cell-surface receptor CRTAM

Kent S. Boles,Winfried Barchet,Tom Diacovo,Marina Cella,Marco Colonna

View Articletitled, The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM

Supplemental data

REVIEW IN TRANSLATIONAL HEMATOLOGY

RNA interference in biology and disease

Carol A. Sledz,Bryan R. G. Williams

View Articletitled, RNA interference in biology and disease

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

B-cell recovery following rituximab-based therapy is associated with perturbations in stromal derived factor-1 and granulocyte homeostasis
Clinical Trials & Observations

Kieron Dunleavy,Frances Hakim,Hyun Kyung Kim,John E. Janik,Nicole Grant,Takayuki Nakayama,Therese White,George Wright,Larry Kwak,Ronald Gress,Giovanna Tosato,Wyndham H. Wilson

View Articletitled, B-cell recovery following rituximab-based therapy is associated with perturbations in stromal derived factor-1 and granulocyte homeostasis

Long-term outcome of treatment of anemia in MDS with erythropoietin and G-CSF
Clinical Trials & Observations

Martin Jädersten,Scott M. Montgomery,Ingunn Dybedal,Anna Porwit-MacDonald,Eva Hellström-Lindberg

View Articletitled, Long-term outcome of treatment of anemia in MDS with erythropoietin and G-CSF

Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance
Clinical Trials & Observations

S. Vincent Rajkumar,Robert A. Kyle,Terry M. Therneau,L. Joseph Melton, III,Arthur R. Bradwell,Raynell J. Clark,Dirk R. Larson,Matthew F. Plevak,Angela Dispenzieri,Jerry A. Katzmann

View Articletitled, Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance

GENE THERAPY

Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV

Sang-Kyung Lee,Derek M. Dykxhoorn,Priti Kumar,Shahin Ranjbar,Erwei Song,Laura E. Maliszewski,Vanessa François-Bongarçon,Anne Goldfeld,N. Manjunath Swamy,Judy Lieberman,Premlata Shankar

View Articletitled, Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV

HEMATOPOIESIS

A limited role for p16^Ink4a and p19^Arf in the loss of hematopoietic stem cells during proliferative stress

Lilia Stepanova,Brian P. Sorrentino

View Articletitled, A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress

A critical function for B-Raf at multiple stages of myelopoiesis

Tamihiro Kamata,Jing Kang,Tzong-Hae Lee,Leszek Wojnowski,Catrin A. Pritchard,Andrew D. Leavitt

View Articletitled, A critical function for B-Raf at multiple stages of myelopoiesis

Preferential suppression of trisomy 8 compared with normal hematopoietic cell growth by autologous lymphocytes in patients with trisomy 8 myelodysplastic syndrome

Elaine M. Sloand,Lori Mainwaring,Monika Fuhrer,Shakti Ramkissoon,Antonio M. Risitano,Keyvan Keyvanafar,Jun Lu,Atanu Basu,A. John Barrett,Neal S. Young

View Articletitled, Preferential suppression of trisomy 8 compared with normal hematopoietic cell growth by autologous lymphocytes in patients with trisomy 8 myelodysplastic syndrome

A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation

Na Kyung Lee,Young Geum Choi,Ji Youn Baik,Song Yi Han,Dae-won Jeong,Yun Soo Bae,Nacksung Kim,Soo Young Lee

View Articletitled, A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation

Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development

Elias T. Zambidis,Bruno Peault,Tea Soon Park,Fred Bunz,Curt I. Civin

View Articletitled, Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development

Supplemental data

Egr-1 abrogates the block imparted by c-Myc on terminal M1 myeloid differentiation

Marianna Shafarenko,Dan A. Liebermann,Barbara Hoffman

View Articletitled, Egr-1 abrogates the block imparted by c-Myc on terminal M1 myeloid differentiation

IL-6 blocks a discrete early step in lymphopoiesis

Kazuhiko Maeda,Yoshihiro Baba,Yoshinori Nagai,Kozo Miyazaki,Alexander Malykhin,Koji Nakamura,Paul W. Kincade,Nobuo Sakaguchi,K. Mark Coggeshall

View Articletitled, IL-6 blocks a discrete early step in lymphopoiesis

T/B lineage choice occurs prior to intrathymic Notch signaling

Benjamin C. Harman,William E. Jenkinson,Sonia M. Parnell,Simona W. Rossi,Eric J. Jenkinson,Graham Anderson

View Articletitled, T/B lineage choice occurs prior to intrathymic Notch signaling

Efficient marking of human cells with rapid but transient repopulating activity in autografted recipients

Hanno Glimm,Manfred Schmidt,Marlene Fischer,Kerstin Schwarzwaelder,Manuela Wissler,Silke Klingenberg,Claudia Prinz,Cornelius F. Waller,Winand Lange,Connie J. Eaves,Christof von Kalle

View Articletitled, Efficient marking of human cells with rapid but transient repopulating activity in autografted recipients

Supplemental data

Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc⁺ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance
Brief Report

Myriam Alcalay,Enrico Tiacci,Roberta Bergomas,Barbara Bigerna,Elisa Venturini,Simone P. Minardi,Natalia Meani,Daniela Diverio,Loris Bernard,Laura Tizzoni,Sara Volorio,Lucilla Luzi,Emanuela Colombo,Francesco Lo Coco,Cristina Mecucci,Brunangelo Falini,Pier Giuseppe Pelicci,for the Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto (GIMEMA) Acute Leukemia Working Party

View Articletitled, Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance

Supplemental data

CD144 (VE-cadherin) is transiently expressed by fetal liver hematopoietic stem cells
Brief Report

Injune Kim,Ömer H. Yilmaz,Sean J. Morrison

View Articletitled, CD144 (VE-cadherin) is transiently expressed by fetal liver hematopoietic stem cells

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

LDL receptor cooperates with LDL receptor–related protein in regulating plasma levels of coagulation factor VIII in vivo

Niels Bovenschen,Koen Mertens,Lihui Hu,Louis M. Havekes,Bart J. M. van Vlijmen

View Articletitled, LDL receptor cooperates with LDL receptor–related protein in regulating plasma levels of coagulation factor VIII in vivo

Negative regulation of platelet function by a secreted cell repulsive protein, semaphorin 3A

Hirokazu Kashiwagi,Masamichi Shiraga,Hisashi Kato,Tsuyoshi Kamae,Naoko Yamamoto,Seiji Tadokoro,Yoshiyuki Kurata,Yoshiaki Tomiyama,Yuzuru Kanakura

View Articletitled, Negative regulation of platelet function by a secreted cell repulsive protein, semaphorin 3A

Localization of ADAMTS13 to the stellate cells of human liver
Brief Report

Masahito Uemura,Kouko Tatsumi,Masanori Matsumoto,Masao Fujimoto,Tomomi Matsuyama,Masatoshi Ishikawa,Taka-aki Iwamoto,Toshio Mori,Akio Wanaka,Hiroshi Fukui,Yoshihiro Fujimura

View Articletitled, Localization of ADAMTS13 to the stellate cells of human liver

Supplemental data

Rituximab prevents recurrence of thrombotic thrombocytopenic purpura: a case report
Clinical Trials & Observations Brief Report

Miriam Galbusera,Elena Bresin,Marina Noris,Sara Gastoldi,Daniela Belotti,Cristina Capoferri,Erica Daina,Paolo Perseghin,Friedrich Scheiflinger,Fadi Fakhouri,Jean-Pierre Grünfeld,Enrico Pogliani,Giuseppe Remuzzi

View Articletitled, Rituximab prevents recurrence of thrombotic thrombocytopenic purpura: a case report

PF4/heparin complexes are T cell–dependent antigens
Brief Report

Shayela Suvarna,Lubica Rauova,Emily K. E. McCracken,Christina M. Goss,Bruce S. Sachais,Steven E. McKenzie,Michael P. Reilly,Michael Dee Gunn,Douglas B. Cines,Mortimer Poncz,Gowthami Arepally

View Articletitled, PF4/heparin complexes are T cell–dependent antigens

IMMUNOBIOLOGY

A single amino acid change, A91V, leads to conformational changes that can impair processing to the active form of perforin
Clinical Trials & Observations

Christina Trambas,Federico Gallo,Daniela Pende,Stefania Marcenaro,Lorenzo Moretta,Carmela De Fusco,Alessandra Santoro,Luigi Notarangelo,Maurizio Arico,Gillian M. Griffiths

View Articletitled, A single amino acid change, A91V, leads to conformational changes that can impair processing to the active form of perforin

Identification and characterization of epitopes of the receptor for hyaluronic acid–mediated motility (RHAMM/CD168) recognized by CD8⁺ T cells of HLA-A2–positive patients with acute myeloid leukemia

Jochen Greiner,Li Li,Mark Ringhoffer,Thomas F. E. Barth,Krzysztof Giannopoulos,Phillipe Guillaume,Gerd Ritter,Markus Wiesneth,Hartmut Döhner,Michael Schmitt

View Articletitled, Identification and characterization of epitopes of the receptor for hyaluronic acid–mediated motility (RHAMM/CD168) recognized by CD8+ T cells of HLA-A2–positive patients with acute myeloid leukemia

Osteopontin functionally activates dendritic cells and induces their differentiation toward a Th1-polarizing phenotype

Andreas C. Renkl,Julia Wussler,Thomas Ahrens,Käthe Thoma,Shigeyuki Kon,Toshimitsu Uede,Stefan F. Martin,Jan C. Simon,Johannes M. Weiss

View Articletitled, Osteopontin functionally activates dendritic cells and induces their differentiation toward a Th1-polarizing phenotype

Ly49 and CD94/NKG2 receptor acquisition by NK cells does not require lymphotoxin-β receptor expression

Frederik Stevenaert,Katrien Van Beneden,Veerle De Colvenaer,Ann Sophie Franki,Veronique Debacker,Tom Boterberg,Dieter Deforce,Klaus Pfeffer,Jean Plum,Dirk Elewaut,Georges Leclercq

View Articletitled, Ly49 and CD94/NKG2 receptor acquisition by NK cells does not require lymphotoxin-β receptor expression

Impaired interferon-γ production as a consequence of STAT4 deficiency after autologous hematopoietic stem cell transplantation for lymphoma

Michael J. Robertson,Hua-Chen Chang,David Pelloso,Mark H. Kaplan

View Articletitled, Impaired interferon-γ production as a consequence of STAT4 deficiency after autologous hematopoietic stem cell transplantation for lymphoma

HFE cross-talks with the MHC class I antigen presentation pathway

Sérgio F. de Almeida,Isabel F. Carvalho,Carla S. Cardoso,João V. Cordeiro,Jorge E. Azevedo,Jacques Neefjes,Maria de Sousa

View Articletitled, HFE cross-talks with the MHC class I antigen presentation pathway

Supplemental data

TLR3-induced activation of mast cells modulates CD8⁺ T-cell recruitment

Zane Orinska,Elena Bulanova,Vadim Budagian,Martin Metz,Marcus Maurer,Silvia Bulfone-Paus

View Articletitled, TLR3-induced activation of mast cells modulates CD8+ T-cell recruitment

Engagement of specific T-cell surface molecules regulates cytoskeletal polarization in HTLV-1–infected lymphocytes

Amanda L. Barnard,Tadahiko Igakura,Yuetsu Tanaka,Graham P. Taylor,Charles R.M. Bangham

View Articletitled, Engagement of specific T-cell surface molecules regulates cytoskeletal polarization in HTLV-1–infected lymphocytes

Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog

Titus J. Boggon,Yiqun Li,Paul W. Manley,Michael J. Eck

View Articletitled, Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog

Conservation of unique cell-surface CD antigen mosaics in HIV-1–infected individuals
Brief Report

Adrian Woolfson,Justin Stebbing,Brian D. M. Tom,Kerryn J. Stoner,Walter R. Gilks,David P. Kreil,Stephen P. Mulligan,Larissa Belov,Jeremy S. Chrisp,Will Errington,Adrian Wildfire,Wendy N. Erber,Mark Bower,Brian Gazzard,Richard I. Christopherson,Mike A. Scott

View Articletitled, Conservation of unique cell-surface CD antigen mosaics in HIV-1–infected individuals

CD4⁺ CD25⁺ regulatory T cells control the induction of antigen-specific CD4⁺ helper T cell responses in cancer patients
Clinical Trials & Observations Brief Report

Hiroyoshi Nishikawa,Elke Jäger,Gerd Ritter,Lloyd J. Old,Sacha Gnjatic

View Articletitled, CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients

Supplemental data

NEOPLASIA

Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1α

Mitsufumi Nishio,Tomoyuki Endo,Nobuhiro Tsukada,Junko Ohata,Shinichi Kitada,John C. Reed,Nathan J. Zvaifler,Thomas J. Kipps

View Articletitled, Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1α

The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature

Jérôme Moreaux,Friedrich W. Cremer,Thierry Reme,Marc Raab,Karene Mahtouk,Philine Kaukel,Veronique Pantesco,John De Vos,Eric Jourdan,Anna Jauch,Eric Legouffe,Marion Moos,Genevieve Fiol,Hartmut Goldschmidt,Jean François Rossi,Dirk Hose,Bernard Klein

View Articletitled, The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature

Supplemental data

Immunoglobulin gene analysis reveals 2 distinct cells of origin for EBV-positive and EBV-negative Burkitt lymphomas

Cristiana Bellan,Stefano Lazzi,Michael Hummel,Nazzareno Palummo,Margherita de Santi,Teresa Amato,Joshua Nyagol,Elena Sabattini,Thierry Lazure,Stefano A. Pileri,Martine Raphael,Harald Stein,Piero Tosi,Lorenzo Leoncini

View Articletitled, Immunoglobulin gene analysis reveals 2 distinct cells of origin for EBV-positive and EBV-negative Burkitt lymphomas

Nuclear expression of BCL10 or nuclear factor kappa B helps predict Helicobacter pylori–independent status of low-grade gastric mucosa–associated lymphoid tissue lymphomas with or without t(11;18)(q21;q21)

Kun-Huei Yeh,Sung-Hsin Kuo,Li-Tzong Chen,Tsui-Lien Mao,Shin-Lian Doong,Ming-Shiang Wu,Hui-Chen Hsu,Yi-Shin Tzeng,Chi-Long Chen,Jaw-Town Lin,Ann-Lii Cheng

View Articletitled, Nuclear expression of BCL10 or nuclear factor kappa B helps predict Helicobacter pylori–independent status of low-grade gastric mucosa–associated lymphoid tissue lymphomas with or without t(11;18)(q21;q21)

Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma

Noopur Raje,Shaji Kumar,Teru Hideshima,Aldo Roccaro,Kenji Ishitsuka,Hiroshi Yasui,Norihiko Shiraishi,Dharminder Chauhan,Nikhil C. Munshi,Simon R. Green,Kenneth C. Anderson

View Articletitled, Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma

Preferential selection of human T-cell leukemia virus type I provirus integration sites in leukemic versus carrier states

Keitarou Doi,Xiaolin Wu,Yuko Taniguchi,Jun-ichirou Yasunaga,Yorifumi Satou,Akihiko Okayama,Kisato Nosaka,Masao Matsuoka

View Articletitled, Preferential selection of human T-cell leukemia virus type I provirus integration sites in leukemic versus carrier states

Repressible transgenic model of NRAS oncogene–driven mast cell disease in the mouse

Stephen M. Wiesner,Jamie M. Jones,Diane E. Hasz,David A. Largaespada

View Articletitled, Repressible transgenic model of NRAS oncogene–driven mast cell disease in the mouse

Essential role for the p110δ isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia
Brief Report

Pierre Sujobert,Valerie Bardet,Pascale Cornillet-Lefebvre,Joel S. Hayflick,Nolwen Prie,Frederic Verdier,Bart Vanhaesebroeck,Odile Muller,Florence Pesce,Norbert Ifrah,Mathilde Hunault-Berger,Christian Berthou,Bruno Villemagne,Eric Jourdan,Bruno Audhuy,Eric Solary,Brigitte Witz,Jean Luc Harousseau,Chantal Himberlin,Thierry Lamy,Bruno Lioure,Jean Yves Cahn,Francois Dreyfus,Patrick Mayeux,Catherine Lacombe,Didier Bouscary

View Articletitled, Essential role for the p110δ isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia

PHAGOCYTES

Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase

Carlos H. C. Serezani,David M. Aronoff,Sonia Jancar,Peter Mancuso,Marc Peters-Golden

View Articletitled, Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase

Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function

Sandra Verploegen,Laurien Ulfman,Hanneke W. M. van Deutekom,Corneli van Aalst,Henk Honing,Jan-Willem J. Lammers,Leo Koenderman,Paul J. Coffer

View Articletitled, Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function

RED CELLS

Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2

Sharon S. Cooperman,Esther G. Meyron-Holtz,Hayden Olivierre-Wilson,Manik C. Ghosh,Joseph P. McConnell,Tracey A. Rouault

View Articletitled, Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2

Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin
Clinical Trials & Observations

Hal Drakesmith,Lisa M. Schimanski,Emma Ormerod,Alison T. Merryweather-Clarke,Vip Viprakasit,Jon P. Edwards,Emma Sweetland,Judy M. Bastin,Diana Cowley,Yingyong Chinthammitr,Kathryn J. H. Robson,Alain R. M. Townsend

View Articletitled, Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin

Production and characterization of erythropoietic protoporphyric heterodimeric ferrochelatases

Wided Najahi-Missaoui,Harry A. Dailey

View Articletitled, Production and characterization of erythropoietic protoporphyric heterodimeric ferrochelatases

TRANSFUSION MEDICINE

Nonhemolytic antibody-induced loss of erythrocyte surface antigen

James C. Zimring,Gregory A. Hair,Traci E. Chadwick,Seema S. Deshpande,Kimberly M. Anderson,Christopher D. Hillyer,John D. Roback

View Articletitled, Nonhemolytic antibody-induced loss of erythrocyte surface antigen

TRANSPLANTATION

In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets

Andreas Beilhack,Stephan Schulz,Jeanette Baker,Georg F. Beilhack,Courtney B. Wieland,Edward I. Herman,Enosh M. Baker,Yu-An Cao,Christopher H. Contag,Robert S. Negrin

View Articletitled, In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets

Selective depletion of alloreactive donor lymphocytes: a novel method to reduce the severity of graft-versus-host disease in older patients undergoing matched sibling donor stem cell transplantation
Clinical Trials & Observations

Scott R. Solomon,Stephan Mielke,Bipin N. Savani,Aldemar Montero,Laura Wisch,Richard Childs,Nancy Hensel,John Schindler,Victor Ghetie,Susan F. Leitman,Thao Mai,Charles S. Carter,Roger Kurlander,Elizabeth J. Read,Ellen S. Vitetta,A. John Barrett

View Articletitled, Selective depletion of alloreactive donor lymphocytes: a novel method to reduce the severity of graft-versus-host disease in older patients undergoing matched sibling donor stem cell transplantation

BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients
Clinical Trials & Observations Brief Report

Veronique Erard,Hyung Woo Kim,Lawrence Corey,Ajit Limaye,Meei-Li Huang,David Myerson,Chris Davis,Michael Boeckh

View Articletitled, BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients

CORRESPONDENCE

hOCT 1 and resistance to imatinib

Lucy C. Crossman,Brian J. Druker,Michael W. N. Deininger

View Articletitled, hOCT 1 and resistance to imatinib

Bevacizumab therapy for POEMS syndrome

Ashraf Badros,Neil Porter,Ann Zimrin

View Articletitled, Bevacizumab therapy for POEMS syndrome

Cobalamin-responsive disorders and unreliability of cobalamin, methylmalonic acid, and homocysteine testing

A. Majid Shojania

View Articletitled, Cobalamin-responsive disorders and unreliability of cobalamin, methylmalonic acid, and homocysteine testing

Is testing for clinical cobalamin deficiency truly unreliable?

Ralph Carmel

View Articletitled, Is testing for clinical cobalamin deficiency truly unreliable?

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Issue Archive

Table of Contents

INSIDE BLOOD

BLOOD WORK

PLENARY PAPERS

REVIEW IN TRANSLATIONAL HEMATOLOGY

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

B-cell recovery following rituximab-based therapy is associated with perturbations in stromal derived factor-1 and granulocyte homeostasis Clinical Trials & Observations

Long-term outcome of treatment of anemia in MDS with erythropoietin and G-CSF Clinical Trials & Observations

Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance Brief Report

CD144 (VE-cadherin) is transiently expressed by fetal liver hematopoietic stem cells Brief Report

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Localization of ADAMTS13 to the stellate cells of human liver Brief Report

Rituximab prevents recurrence of thrombotic thrombocytopenic purpura: a case report Clinical Trials & Observations Brief Report

PF4/heparin complexes are T cell–dependent antigens Brief Report

IMMUNOBIOLOGY

A single amino acid change, A91V, leads to conformational changes that can impair processing to the active form of perforin Clinical Trials & Observations

Conservation of unique cell-surface CD antigen mosaics in HIV-1–infected individuals Brief Report

CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients Clinical Trials & Observations Brief Report

NEOPLASIA

Essential role for the p110δ isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia Brief Report

PHAGOCYTES

RED CELLS

Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin Clinical Trials & Observations

TRANSFUSION MEDICINE

TRANSPLANTATION

Selective depletion of alloreactive donor lymphocytes: a novel method to reduce the severity of graft-versus-host disease in older patients undergoing matched sibling donor stem cell transplantation Clinical Trials & Observations

BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients Clinical Trials & Observations Brief Report

CORRESPONDENCE

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American Society of Hematology

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B-cell recovery following rituximab-based therapy is associated with perturbations in stromal derived factor-1 and granulocyte homeostasis
Clinical Trials & Observations

Long-term outcome of treatment of anemia in MDS with erythropoietin and G-CSF
Clinical Trials & Observations

Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance
Clinical Trials & Observations

Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc⁺ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance
Brief Report

CD144 (VE-cadherin) is transiently expressed by fetal liver hematopoietic stem cells
Brief Report

Localization of ADAMTS13 to the stellate cells of human liver
Brief Report

Rituximab prevents recurrence of thrombotic thrombocytopenic purpura: a case report
Clinical Trials & Observations Brief Report

PF4/heparin complexes are T cell–dependent antigens
Brief Report

A single amino acid change, A91V, leads to conformational changes that can impair processing to the active form of perforin
Clinical Trials & Observations

Conservation of unique cell-surface CD antigen mosaics in HIV-1–infected individuals
Brief Report

CD4⁺ CD25⁺ regulatory T cells control the induction of antigen-specific CD4⁺ helper T cell responses in cancer patients
Clinical Trials & Observations Brief Report

Essential role for the p110δ isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia
Brief Report

Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin
Clinical Trials & Observations

Selective depletion of alloreactive donor lymphocytes: a novel method to reduce the severity of graft-versus-host disease in older patients undergoing matched sibling donor stem cell transplantation
Clinical Trials & Observations

BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients
Clinical Trials & Observations Brief Report