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Volume 106, Issue 13

December 15 2005

In this Issue

INSIDE BLOOD
HOW I TREAT
REVIEW ARTICLES
CLINICAL TRIALS AND OBSERVATIONS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

RED CELLS

A cell by any other name

Narla Mohandas

View Articletitled, A cell by any other name

CLINICAL TRIALS AND OBSERVATIONS

ALL in children with Down syndrome
Clinical Trials & Observations

Franklin O. Smith

View Articletitled, ALL in children with Down syndrome

CLINICAL TRIALS AND OBSERVATIONS

Myeloma therapy: the future is bright
Clinical Trials & Observations

Michele Cavo

View Articletitled, Myeloma therapy: the future is bright

HEMATOPOIESIS

Packing platelets to go

Charles S. Abrams

View Articletitled, Packing platelets to go

NEOPLASIA

EBV meets BCR^- B cells

Daniel Re

View Articletitled, EBV meets BCR- B cells

HEMATOPOIESIS

Therapeutically targeting leukemia stem cells

Eyal C. Attar

View Articletitled, Therapeutically targeting leukemia stem cells

HEMOSTASIS

VPS33B: let there be α-granules

Robert Flaumenhaft

View Articletitled, VPS33B: let there be α-granules

TRANSPLANTATION

T-cell therapy for viral and fungal infections

Hermann Einsele

View Articletitled, T-cell therapy for viral and fungal infections

HEMOSTASIS

ADAMTS13 and VWF: not just for TTP anymore?

Karl Desch,David Motto

View Articletitled, ADAMTS13 and VWF: not just for TTP anymore?

RED CELLS

Band 3 “Neapolis”: ciao ciao aldolase

Carlo Brugnara

View Articletitled, Band 3 “Neapolis”: ciao ciao aldolase

NEOPLASIA

Not all that glitters is gold

Yair Gazitt

View Articletitled, Not all that glitters is gold

HOW I TREAT

How I treat venous thromboembolism in patients with cancer
Clinical Trials & Observations

Paolo Prandoni

View Articletitled, How I treat venous thromboembolism in patients with cancer

REVIEW ARTICLES

The energy-less red blood cell is lost: erythrocyte enzyme abnormalities of glycolysis

Richard van Wijk,Wouter W. van Solinge

View Articletitled, The energy-less red blood cell is lost: erythrocyte enzyme abnormalities of glycolysis

CLINICAL TRIALS AND OBSERVATIONS

Clinical characteristics and outcome of children with Down syndrome and acute lymphoblastic leukemia: a Children's Cancer Group study
Clinical Trials & Observations

James A. Whitlock,Harland N. Sather,Paul Gaynon,Leslie L. Robison,Robert J. Wells,Michael Trigg,Nyla A. Heerema,Smita Bhatia

View Articletitled, Clinical characteristics and outcome of children with Down syndrome and acute lymphoblastic leukemia: a Children's Cancer Group study

Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma
Clinical Trials & Observations

S. Vincent Rajkumar,Suzanne R. Hayman,Martha Q. Lacy,Angela Dispenzieri,Susan M. Geyer,Brian Kabat,Steven R. Zeldenrust,Shaji Kumar,Philip R. Greipp,Rafael Fonseca,John A. Lust,Stephen J. Russell,Robert A. Kyle,Thomas E. Witzig,Morie A. Gertz

View Articletitled, Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma

CD10^- pre-B acute lymphoblastic leukemia (ALL) is a distinct high-risk subgroup of adult ALL associated with a high frequency of MLL aberrations: results of the German Multicenter Trials for Adult ALL (GMALL)
Clinical Trials & Observations Brief Report

Beate Gleissner,Nicola Goekbuget,Harald Rieder,Renate Arnold,Stefan Schwartz,Helmut Diedrich,Claudia Schoch,Barbara Heinze,Christa Fonatsch,Claus R. Bartram,Dieter Hoelzer,Eckhard Thiel,for the GMALL Study Group

View Articletitled, CD10- pre-B acute lymphoblastic leukemia (ALL) is a distinct high-risk subgroup of adult ALL associated with a high frequency of MLL aberrations: results of the German Multicenter Trials for Adult ALL (GMALL)

GENE THERAPY

Allogeneic marrow stromal cells are immune rejected by MHC class I– and class II–mismatched recipient mice

Nicoletta Eliopoulos,John Stagg,Laurence Lejeune,Sandra Pommey,Jacques Galipeau

View Articletitled, Allogeneic marrow stromal cells are immune rejected by MHC class I– and class II–mismatched recipient mice

HEMATOPOIESIS

Mechanisms of organelle transport and capture along proplatelets during platelet production

Jennifer L. Richardson,Ramesh A. Shivdasani,Chad Boers,John H. Hartwig,Joseph E. Italiano, Jr

View Articletitled, Mechanisms of organelle transport and capture along proplatelets during platelet production

Supplemental data

Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes

Sunita R. Patel,Jennifer L. Richardson,Harald Schulze,Eden Kahle,Niels Galjart,Ksenija Drabek,Ramesh A. Shivdasani,John H. Hartwig,Joseph E. Italiano, Jr

View Articletitled, Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes

Supplemental data

Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia

David C. Taussig,Daniel J. Pearce,Catherine Simpson,Ama Z. Rohatiner,T. Andrew Lister,Gavin Kelly,Jennifer L. Luongo,Gwenn-aël H. Danet-Desnoyers,Dominique Bonnet

View Articletitled, Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia

Supplemental data

Bone marrow dysfunction in mice lacking the cytokine receptor gp130 in endothelial cells

Longbiao Yao,Takafumi Yokota,Lijun Xia,Paul W. Kincade,Rodger P. McEver

View Articletitled, Bone marrow dysfunction in mice lacking the cytokine receptor gp130 in endothelial cells

Supplemental data

Variegation of the phenotype induced by the Gata1^low mutation in mice of different genetic backgrounds

Fabrizio Martelli,Barbara Ghinassi,Barbara Panetta,Elena Alfani,Valentina Gatta,Alessandro Pancrazzi,Costanza Bogani,Alessandro Maria Vannucchi,Francesco Paoletti,Giovanni Migliaccio,Anna Rita Migliaccio

View Articletitled, Variegation of the phenotype induced by the Gata1low mutation in mice of different genetic backgrounds

The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells

Jurgen A.F. Marteijn,Liesbeth van Emst,Claudia A.J. Erpelinck-Verschueren,Gorica Nikoloski,Aswin Menke,Theo de Witte,Bob Löwenberg,Joop H. Jansen,Bert A. van der Reijden

View Articletitled, The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells

Supplemental data

Enhanced TNF-α–induced apoptosis in Fanconi anemia type C–deficient cells is dependent on apoptosis signal-regulating kinase 1

Khadijeh Bijangi-Vishehsaraei,M. Reza Saadatzadeh,Adam Werne,Kristina A. Wilson McKenzie,Reuben Kapur,Hidenori Ichijo,Laura S. Haneline

View Articletitled, Enhanced TNF-α–induced apoptosis in Fanconi anemia type C–deficient cells is dependent on apoptosis signal-regulating kinase 1

BH3-only proteins Puma and Bim are rate-limiting for γ-radiation– and glucocorticoid-induced apoptosis of lymphoid cells in vivo

Miriam Erlacher,Ewa M. Michalak,Priscilla N. Kelly,Verena Labi,Harald Niederegger,Leigh Coultas,Jerry M. Adams,Andreas Strasser,Andreas Villunger

View Articletitled, BH3-only proteins Puma and Bim are rate-limiting for γ-radiation– and glucocorticoid-induced apoptosis of lymphoid cells in vivo

Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions

Zhenyin Tao,Yuandong Peng,Leticia Nolasco,Santiago Cal,Carlos Lopez-Otin,Renhao Li,Joel L. Moake,José A. López,Jing-fei Dong

View Articletitled, Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions

Role of FcRγ and factor XIIIA in coated platelet formation

Shawn M. Jobe,Lorie Leo,Joshua S. Eastvold,Gerhard Dickneite,Timothy L. Ratliff,Steven R. Lentz,Jorge Di Paola

View Articletitled, Role of FcRγ and factor XIIIA in coated platelet formation

Predictive value of persistent versus transient antiphospholipid antibody subtypes for the risk of thrombotic events in pediatric patients with systemic lupus erythematosus
Clinical Trials & Observations

Christoph Male,Denise Foulon,Hugh Hoogendoorn,Patricia Vegh,Earl Silverman,Michèle David,Lesley Mitchell

View Articletitled, Predictive value of persistent versus transient antiphospholipid antibody subtypes for the risk of thrombotic events in pediatric patients with systemic lupus erythematosus

Requirement of VPS33B, a member of the Sec1/Munc18 protein family, in megakaryocyte and platelet α-granule biogenesis

Bryan Lo,Ling Li,Paul Gissen,Hilary Christensen,Patrick J. McKiernan,Charles Ye,Mohamed Abdelhaleem,Jason A. Hayes,Michael D. Williams,David Chitayat,Walter H. A. Kahr

View Articletitled, Requirement of VPS33B, a member of the Sec1/Munc18 protein family, in megakaryocyte and platelet α-granule biogenesis

Ligand-specific glucocorticoid receptor activation in human platelets

Leonardo A. Moraes,Mark J. Paul-Clark,Alice Rickman,Roderick J. Flower,Nicolas J. Goulding,Mauro Perretti

View Articletitled, Ligand-specific glucocorticoid receptor activation in human platelets

Genetic variation in the fibrinogen gamma gene increases the risk for deep venous thrombosis by reducing plasma fibrinogen γ′ levels
Clinical Trials & Observations

Shirley Uitte de Willige,Marieke C. H. de Visser,Jeanine J. Houwing-Duistermaat,Frits R. Rosendaal,Hans L. Vos,Rogier M. Bertina

View Articletitled, Genetic variation in the fibrinogen gamma gene increases the risk for deep venous thrombosis by reducing plasma fibrinogen γ′ levels

Presence of bone marrow–derived circulating progenitor endothelial cells in the newly formed lymphatic vessels

Piotr Religa,Renhai Cao,Meit Bjorndahl,Zhongjun Zhou,Zhenping Zhu,Yihai Cao

View Articletitled, Presence of bone marrow–derived circulating progenitor endothelial cells in the newly formed lymphatic vessels

Supplemental data

Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysis in the pulmonary vasculature

Bi-Sen Ding,Claudia Gottstein,Andrea Grunow,Alice Kuo,Kumkum Ganguly,Steven M. Albelda,Douglas B. Cines,Vladimir R. Muzykantov

View Articletitled, Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysis in the pulmonary vasculature

Hemolytic uremic syndrome–associated Shiga toxins promote endothelial-cell secretion and impair ADAMTS13 cleavage of unusually large von Willebrand factor multimers

Leticia H. Nolasco,Nancy A. Turner,Aubrey Bernardo,Zhenyin Tao,Thomas G. Cleary,Jing-fei Dong,Joel L. Moake

View Articletitled, Hemolytic uremic syndrome–associated Shiga toxins promote endothelial-cell secretion and impair ADAMTS13 cleavage of unusually large von Willebrand factor multimers

IMMUNOBIOLOGY

MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10

Masao Nakagawa,Yoshitaka Hosokawa,Masakatsu Yonezumi,Koh Izumiyama,Ritsuro Suzuki,Shinobu Tsuzuki,Masahiro Asaka,Masao Seto

View Articletitled, MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10

Supplemental data

CD8⁺T cells specific for cancer germline gene antigens are found in many patients with multiple myeloma, and their frequency correlates with disease burden

Oliver Goodyear,Karen Piper,Naeem Khan,Jane Starczynski,Prem Mahendra,Guy Pratt,Paul Moss

View Articletitled, CD8+T cells specific for cancer germline gene antigens are found in many patients with multiple myeloma, and their frequency correlates with disease burden

Supplemental data

Immunomodulatory dendritic cells require autologous serum to circumvent nonspecific immunosuppressive activity in vivo

Claus Haase,Mette Ejrnaes,Amy E. Juedes,Tom Wolfe,Helle Markholst,Matthias G. von Herrath

View Articletitled, Immunomodulatory dendritic cells require autologous serum to circumvent nonspecific immunosuppressive activity in vivo

Supplemental data

TGF-β type II receptor–deficient thymocytes develop normally but demonstrate increased CD8⁺ proliferation in vivo

Per Levéen,Maria Carlsén,Anna Makowska,Saemundur Oddsson,Jonas Larsson,Marie-José Goumans,Corrado M. Cilio,Stefan Karlsson

View Articletitled, TGF-β type II receptor–deficient thymocytes develop normally but demonstrate increased CD8+ proliferation in vivo

Costimulation of mast cells by 4-1BB, a member of the tumor necrosis factor receptor superfamily, with the high-affinity IgE receptor

Hajime Nishimoto,Seung-Woo Lee,Hong Hong,Karen G. Potter,Mari Maeda-Yamamoto,Tatsuya Kinoshita,Yuko Kawakami,Robert S. Mittler,Byoung S. Kwon,Carl F. Ware,Michael Croft,Toshiaki Kawakami

View Articletitled, Costimulation of mast cells by 4-1BB, a member of the tumor necrosis factor receptor superfamily, with the high-affinity IgE receptor

Supplemental data

Epstein-Barr virus infection in vitro can rescue germinal center B cells with inactivated immunoglobulin genes
Brief Report

Sridhar Chaganti,Andrew I. Bell,Noelia Begue Pastor,Anne E. Milner,Mark Drayson,John Gordon,Alan B. Rickinson

View Articletitled, Epstein-Barr virus infection in vitro can rescue germinal center B cells with inactivated immunoglobulin genes

NEOPLASIA

A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine)

Varsha Gandhi,John M. Kilpatrick,William Plunkett,Mary Ayres,Leigh Harman,Min Du,Shanta Bantia,Jan Davisson,William G. Wierda,Stefan Faderl,Hagop Kantarjian,Deborah Thomas

View Articletitled, A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine)

mTOR regulates cell survival after etoposide treatment in primary AML cells

Qing Xu,James E. Thompson,Martin Carroll

View Articletitled, mTOR regulates cell survival after etoposide treatment in primary AML cells

Conditional MN1-TEL knock-in mice develop acute myeloid leukemia in conjunction with overexpression of HOXA9

Hiroyuki Kawagoe,Gerard C. Grosveld

View Articletitled, Conditional MN1-TEL knock-in mice develop acute myeloid leukemia in conjunction with overexpression of HOXA9

Supplemental data

MN1-TEL myeloid oncoprotein expressed in multipotent progenitors perturbs both myeloid and lymphoid growth and causes T-lymphoid tumors in mice

Hiroyuki Kawagoe,Gerard C. Grosveld

View Articletitled, MN1-TEL myeloid oncoprotein expressed in multipotent progenitors perturbs both myeloid and lymphoid growth and causes T-lymphoid tumors in mice

Supplemental data

Elevated NF-κB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large-cell, and other peripheral T-cell lymphomas

Stephan Mathas,Korinna Jöhrens,Stefan Joos,Andreas Lietz,Franziska Hummel,Martin Janz,Franziska Jundt,Ioannis Anagnostopoulos,Kurt Bommert,Peter Lichter,Harald Stein,Claus Scheidereit,Bernd Dörken

View Articletitled, Elevated NF-κB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large-cell, and other peripheral T-cell lymphomas

HTLV-1 Tax transgenic mice develop spontaneous osteolytic bone metastases prevented by osteoclast inhibition

Ling Gao,Hongju Deng,Haibo Zhao,Angela Hirbe,John Harding,Lee Ratner,Katherine Weilbaecher

View Articletitled, HTLV-1 Tax transgenic mice develop spontaneous osteolytic bone metastases prevented by osteoclast inhibition

Supplemental data

Angiogenic factors may have a different prognostic role in adult acute lymphoblastic leukemia
Clinical Trials & Observations

Stefan Faderl,Kim-Anh Do,Marcella M. Johnson,Michael Keating,Susan O'Brien,Iman Jilani,Alessandra Ferrajoli,Farhad Ravandi-Kashani,Christine Aguilar,Amanda Dey,Deborah A. Thomas,Francis J. Giles,Hagop M. Kantarjian,Maher Albitar

View Articletitled, Angiogenic factors may have a different prognostic role in adult acute lymphoblastic leukemia

Effective therapy of human lymphoma xenografts with a novel recombinant ribonuclease/anti-CD74 humanized IgG₄ antibody immunotoxin

Chien-Hsing Chang,Puja Sapra,Sailaja S. Vanama,Hans J. Hansen,Ivan D. Horak,David M. Goldenberg

View Articletitled, Effective therapy of human lymphoma xenografts with a novel recombinant ribonuclease/anti-CD74 humanized IgG4 antibody immunotoxin

Cyclin D1–negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling
Clinical Trials & Observations

Kai Fu,Dennis D. Weisenburger,Timothy C. Greiner,Sandeep Dave,George Wright,Andreas Rosenwald,Michael Chiorazzi,Javeed Iqbal,Stefan Gesk,Reiner Siebert,Daphne De Jong,Elaine S. Jaffe,Wyndham H. Wilson,Jan Delabie,German Ott,Bhavana J. Dave,Warren G. Sanger,Lynette M. Smith,Lisa Rimsza,Rita M. Braziel,H. Konrad Müller-Hermelink,Elias Campo,Randy D. Gascoyne,Louis M. Staudt,Wing C. Chan,for the Lymphoma/Leukemia Molecular Profiling Project

View Articletitled, Cyclin D1–negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling

Supplemental data

The combination of the farnesyl transferase inhibitor lonafarnib and the proteasome inhibitor bortezomib induces synergistic apoptosis in human myeloma cells that is associated with down-regulation of p-AKT

Ebenezer David,Shi-Yong Sun,Edmund K. Waller,Jing Chen,Fadlo R. Khuri,Sagar Lonial

View Articletitled, The combination of the farnesyl transferase inhibitor lonafarnib and the proteasome inhibitor bortezomib induces synergistic apoptosis in human myeloma cells that is associated with down-regulation of p-AKT

Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non–COX-2 inhibitory analog of celecoxib

Adel Kardosh,Nathaniel Soriano,Yen-Ting Liu,Jasim Uddin,Nicos A. Petasis,Florence M. Hofman,Thomas C. Chen,Axel H. Schönthal

View Articletitled, Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non–COX-2 inhibitory analog of celecoxib

Rescue of “crippled” germinal center B cells from apoptosis by Epstein-Barr virus

Christoph Mancao,Markus Altmann,Berit Jungnickel,Wolfgang Hammerschmidt

View Articletitled, Rescue of “crippled” germinal center B cells from apoptosis by Epstein-Barr virus

Transformation of BCR-deficient germinal-center B cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and posttransplantation lymphomas

Dörte Bechtel,Julia Kurth,Claus Unkel,Ralf Küppers

View Articletitled, Transformation of BCR-deficient germinal-center B cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and posttransplantation lymphomas

PHAGOCYTES

1α,25-dihydroxyvitamin D₃ is a potent suppressor of interferon γ–mediated macrophage activation

Laura Helming,Jens Böse,Jan Ehrchen,Stefanie Schiebe,Thomas Frahm,Robert Geffers,Michael Probst-Kepper,Rudi Balling,Andreas Lengeling

View Articletitled, 1α,25-dihydroxyvitamin D3 is a potent suppressor of interferon γ–mediated macrophage activation

Supplemental data

RED CELLS

The N-terminal 11 amino acids of human erythrocyte band 3 are critical for aldolase binding and protein phosphorylation: implications for band 3 function

Silverio Perrotta,Adriana Borriello,Andrea Scaloni,Lucia De Franceschi,Anna Maria Brunati,Francesco Turrini,Vincenzo Nigro,Emanuele Miraglia del Giudice,Bruno Nobili,Maria Luisa Conte,Francesca Rossi,Achille Iolascon,Arianna Donella-Deana,Vincenzo Zappia,Vincenzo Poggi,William Anong,Philip Low,Narla Mohandas,Fulvio Della Ragione

View Articletitled, The N-terminal 11 amino acids of human erythrocyte band 3 are critical for aldolase binding and protein phosphorylation: implications for band 3 function

A novel splicing mutation of the α-spectrin gene in the original hereditary pyropoikilocytosis kindred
Brief Report

Daniel B. Costa,Larisa Lozovatsky,Patrick G. Gallagher,Bernard G. Forget

View Articletitled, A novel splicing mutation of the α-spectrin gene in the original hereditary pyropoikilocytosis kindred

TRANSPLANTATION

KIR reconstitution is altered by T cells in the graft and correlates with clinical outcomes after unrelated donor transplantation

Sarah Cooley,Valarie McCullar,Rosanna Wangen,Tracy L. Bergemann,Stephen Spellman,Daniel J. Weisdorf,Jeffrey S. Miller

View Articletitled, KIR reconstitution is altered by T cells in the graft and correlates with clinical outcomes after unrelated donor transplantation

First report of donor cell–derived acute leukemia as a complication of umbilical cord blood transplantation
Clinical Trials & Observations

Christopher J. Fraser,Betsy A. Hirsch,Vanessa Dayton,Michael H. Creer,Joseph P. Neglia,John E. Wagner,K. Scott Baker

View Articletitled, First report of donor cell–derived acute leukemia as a complication of umbilical cord blood transplantation

Pharmacodynamics of mycophenolate mofetil after nonmyeloablative conditioning and unrelated donor hematopoietic cell transplantation

Luisa Giaccone,Jeannine S. McCune,Michael B. Maris,Theodore A. Gooley,Brenda M. Sandmaier,John T. Slattery,Scott Cole,Richard A. Nash,Rainer F. Storb,George E. Georges

View Articletitled, Pharmacodynamics of mycophenolate mofetil after nonmyeloablative conditioning and unrelated donor hematopoietic cell transplantation

Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia
Clinical Trials & Observations

John G. Gribben,David Zahrieh,Katherine Stephans,Lini Bartlett-Pandite,Edwin P. Alyea,David C. Fisher,Arnold S. Freedman,Peter Mauch,Robert Schlossman,Lecia V. Sequist,Robert J. Soiffer,Blossom Marshall,Donna Neuberg,Jerome Ritz,Lee M. Nadler

View Articletitled, Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia

Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation

Katia Perruccio,Antonella Tosti,Emanuela Burchielli,Fabiana Topini,Loredana Ruggeri,Alessandra Carotti,Marusca Capanni,Elena Urbani,Antonella Mancusi,Franco Aversa,Massimo F. Martelli,Luigina Romani,Andrea Velardi

View Articletitled, Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation

Inflammatory cytokines and acute graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation
Brief Report

Mohamad Mohty,Didier Blaise,Catherine Faucher,Norbert Vey,Reda Bouabdallah,Anne-Marie Stoppa,Frederic Viret,Gwenaelle Gravis,Daniel Olive,Béatrice Gaugler

View Articletitled, Inflammatory cytokines and acute graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation

CORRESPONDENCE

T-cell grit: large clonal expansions of virus-specific CD8⁺ T cells can dominate in the peripheral circulation for at least 18 years

John J. Miles,Sharon L. Silins,Andrew G. Brooks,Joanne E. Davis,Ihor Misko,Scott R. Burrows

View Articletitled, T-cell grit: large clonal expansions of virus-specific CD8+ T cells can dominate in the peripheral circulation for at least 18 years

The role of duodenal cytochrome b in intestinal iron absorption remains unclear

David M. Frazer,Sarah J. Wilkins,Christopher D. Vulpe,Gregory J. Anderson

View Articletitled, The role of duodenal cytochrome b in intestinal iron absorption remains unclear

Activating FLT3 mutations in CD4⁺/CD8^- pediatric T-cell acute lymphoblastic leukemias

Pieter Van Vlierberghe,Jules P. P. Meijerink,Ronald W. Stam,Wendy van der Smissen,Elisabeth R. van Wering,H. Berna Beverloo,Rob Pieters

View Articletitled, Activating FLT3 mutations in CD4+/CD8- pediatric T-cell acute lymphoblastic leukemias

Sickle cell disease and hyperreactive malarial splenomegaly (HMS) in young immigrants from Africa

Lucia De Franceschi,Simona Sada,Annalisa Andreoli,Andrea Angheben,Stefania Marocco,Zeno Bisoffi

View Articletitled, Sickle cell disease and hyperreactive malarial splenomegaly (HMS) in young immigrants from Africa

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Issue Archive

Table of Contents

INSIDE BLOOD

ALL in children with Down syndrome Clinical Trials & Observations

Myeloma therapy: the future is bright Clinical Trials & Observations

HOW I TREAT

How I treat venous thromboembolism in patients with cancer Clinical Trials & Observations

REVIEW ARTICLES

CLINICAL TRIALS AND OBSERVATIONS

Clinical characteristics and outcome of children with Down syndrome and acute lymphoblastic leukemia: a Children's Cancer Group study Clinical Trials & Observations

Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma Clinical Trials & Observations

CD10- pre-B acute lymphoblastic leukemia (ALL) is a distinct high-risk subgroup of adult ALL associated with a high frequency of MLL aberrations: results of the German Multicenter Trials for Adult ALL (GMALL) Clinical Trials & Observations Brief Report

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Predictive value of persistent versus transient antiphospholipid antibody subtypes for the risk of thrombotic events in pediatric patients with systemic lupus erythematosus Clinical Trials & Observations

Genetic variation in the fibrinogen gamma gene increases the risk for deep venous thrombosis by reducing plasma fibrinogen γ′ levels Clinical Trials & Observations

IMMUNOBIOLOGY

Epstein-Barr virus infection in vitro can rescue germinal center B cells with inactivated immunoglobulin genes Brief Report

NEOPLASIA

Angiogenic factors may have a different prognostic role in adult acute lymphoblastic leukemia Clinical Trials & Observations

Cyclin D1–negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling Clinical Trials & Observations

PHAGOCYTES

RED CELLS

A novel splicing mutation of the α-spectrin gene in the original hereditary pyropoikilocytosis kindred Brief Report

TRANSPLANTATION

First report of donor cell–derived acute leukemia as a complication of umbilical cord blood transplantation Clinical Trials & Observations

Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia Clinical Trials & Observations

Inflammatory cytokines and acute graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation Brief Report

CORRESPONDENCE

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ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

ALL in children with Down syndrome
Clinical Trials & Observations

Myeloma therapy: the future is bright
Clinical Trials & Observations

How I treat venous thromboembolism in patients with cancer
Clinical Trials & Observations

Clinical characteristics and outcome of children with Down syndrome and acute lymphoblastic leukemia: a Children's Cancer Group study
Clinical Trials & Observations

Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma
Clinical Trials & Observations

CD10^- pre-B acute lymphoblastic leukemia (ALL) is a distinct high-risk subgroup of adult ALL associated with a high frequency of MLL aberrations: results of the German Multicenter Trials for Adult ALL (GMALL)
Clinical Trials & Observations Brief Report

Predictive value of persistent versus transient antiphospholipid antibody subtypes for the risk of thrombotic events in pediatric patients with systemic lupus erythematosus
Clinical Trials & Observations

Genetic variation in the fibrinogen gamma gene increases the risk for deep venous thrombosis by reducing plasma fibrinogen γ′ levels
Clinical Trials & Observations

Epstein-Barr virus infection in vitro can rescue germinal center B cells with inactivated immunoglobulin genes
Brief Report

Angiogenic factors may have a different prognostic role in adult acute lymphoblastic leukemia
Clinical Trials & Observations

Cyclin D1–negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling
Clinical Trials & Observations

A novel splicing mutation of the α-spectrin gene in the original hereditary pyropoikilocytosis kindred
Brief Report

First report of donor cell–derived acute leukemia as a complication of umbilical cord blood transplantation
Clinical Trials & Observations

Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia
Clinical Trials & Observations

Inflammatory cytokines and acute graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation
Brief Report