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Issue Archive

Volume 106, Issue 1
July 1 2005
Blood Cover Image for Volume 106, Issue 1

Table of Contents

INSIDE BLOOD

NEOPLASIA
Multiple myeloma: all roads lead to cyclin D
Bruno Quesnel
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CLINICAL OBSERVATIONS
Multiple myeloma: the death of VAD as initial therapy
S. Vincent Rajkumar
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CLINICAL OBSERVATIONS
Divide and conquer: stomping leukemia cells by stimulating them to grow
Charles A. Schiffer
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HEMATOPOIESIS
A little grease helps the cell to stick
Charles S. Abrams
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IMMUNOBIOLOGY
Should MAGE be the rage in myeloma?
Carol Ann Huff,Judith E. Karp
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NEOPLASIA
The HOX-MEIS connection in AML
H. Jeffrey Lawrence,Corey Largman
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HEMOSTASIS
The sticky matter of young versus old platelets
Peter W. Marks
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GENE THERAPY
Improved human stem-cell transduction: the cat's meow
Brian P. Sorrentino
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BLOOD WORK

Platelet formation
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REVIEW IN TRANSLATIONAL HEMATOLOGY

ADAMTS13 turns 3
Clinical Trials & Observations
Gallia G. Levy,David G. Motto,David Ginsburg
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CHEMOKINES

CCR6 regulates CD4+ T-cell–mediated acute graft-versus-host disease responses
Rosa Varona,Vanesa Cadenas,Lucio Gómez,Carlos Martínez-A,Gabriel Márquez
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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Use of glycosylated recombinant human G-CSF (lenograstim) during and/or after induction chemotherapy in patients 61 years of age and older with acute myeloid leukemia: final results of AML-13, a randomized phase-3 study
Clinical Trials & Observations
Sergio Amadori,Stefan Suciu,Ulrich Jehn,Roberto Stasi,Xavier Thomas,Jean-Pierre Marie,Petra Muus,Francois Lefrère,Zwi Berneman,George Fillet,Claudio Denzlinger,Roel Willemze,Pietro Leoni,Giuseppe Leone,Marco Casini,Francesco Ricciuti,Marco Vignetti,Filip Beeldens,Franco Mandelli,Theo De Witte,for the EORTC/GIMEMA Leukemia Groups
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Superiority of thalidomide and dexamethasone over vincristine-doxorubicindexamethasone (VAD) as primary therapy in preparation for autologous transplantation for multiple myeloma
Clinical Trials & Observations
Michele Cavo,Elena Zamagni,Patrizia Tosi,Paola Tacchetti,Claudia Cellini,Delia Cangini,Antonio de Vivo,Nicoletta Testoni,Chiara Nicci,Carolina Terragna,Tiziana Grafone,Giulia Perrone,Michela Ceccolini,Sante Tura,Michele Baccarani,for the writing committee of the Bologna 2002 study
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Progressive neurologic dysfunctions 20 years after allogeneic bone marrow transplantation for Chediak-Higashi syndrome
Clinical Trials & Observations Brief Report
Marc Tardieu,Catherine Lacroix,Bénédicte Neven,Pierre Bordigoni,Geneviève de Saint Basile,Stéphane Blanche,Alain Fischer
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GENE THERAPY

Telomere loss, senescence, and genetic instability in CD4+ T lymphocytes overexpressing hTERT
Alexander Röth,Gabriela M. Baerlocher,Mike Schertzer,Elizabeth Chavez,Ulrich Dührsen,Peter M. Lansdorp
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Improved transduction of human sheep repopulating cells by retrovirus vectors pseudotyped with feline leukemia virus type C or RD114 envelopes
M. Lee Lucas,Nancy E. Seidel,Christopher D. Porada,John G. Quigley,Stacie M. Anderson,Harry L. Malech,Janis L. Abkowitz,Esmail D. Zanjani,David M. Bodine
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HEMATOPOIESIS

HB-EGF/HER-1 signaling in bone marrow mesenchymal stem cells: inducing cell expansion and reversibly preventing multilineage differentiation
Mauro Krampera,Annalisa Pasini,Antonella Rigo,Maria Teresa Scupoli,Cristina Tecchio,Giorgio Malpeli,Aldo Scarpa,Francesco Dazzi,Giovanni Pizzolo,Fabrizio Vinante
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The effects of iron deficiency on estradiol-induced suppression of erythropoietin induction in rats: implications of pregnancy-related anemia
Hyogo Horiguchi,Etsuko Oguma,Fujio Kayama
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Hypoxia-reoxygenation induces premature senescence in FA bone marrow hematopoietic cells
Xiaoling Zhang,June Li,Daniel P. Sejas,Qishen Pang
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VCAM-1 expression in adult hematopoietic and nonhematopoietic cells is controlled by tissue-inductive signals and reflects their developmental origin
Tatiana Ulyanova,Linda M. Scott,Gregory V. Priestley,Yi Jiang,Betty Nakamoto,Pandelakis A. Koni,Thalia Papayannopoulou
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Supplemental data
Distinct hematopoietic progenitor compartments are delineated by the expression of aldehyde dehydrogenase and CD34
Robert W. Storms,Patrick D. Green,Kristine M. Safford,Donna Niedzwiecki,Christopher R. Cogle,O. Michael Colvin,Nelson J. Chao,Henry E. Rice,Clayton A. Smith
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p85α subunit of class IA PI-3 kinase is crucial for macrophage growth and migration
Veerendra Munugalavadla,Jovencio Borneo,David A. Ingram,Reuben Kapur
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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

The relative role of PLCβ and PI3Kγ in platelet activation
Lurong Lian,Yanfeng Wang,Julia Draznin,Don Eslin,Joel S. Bennett,Mortimer Poncz,Dianqing Wu,Charles S. Abrams
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Young thrombocytes initiate the formation of arterial thrombi in zebrafish
Bijoy Thattaliyath,Matthew Cykowski,Pudur Jagadeeswaran
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Supplemental data
Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate
Takeshi Yabu,Hidekazu Tomimoto,Yoshimitsu Taguchi,Shohei Yamaoka,Yasuyuki Igarashi,Toshiro Okazaki
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Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity
Clinical Trials & Observations
Laurent Bodin,Céline Verstuyft,David-Alexandre Tregouet,Annie Robert,Liliane Dubert,Christian Funck-Brentano,Patrice Jaillon,Philippe Beaune,Pierre Laurent-Puig,Laurent Becquemont,Marie-Anne Loriot
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Cleavage of ultralarge multimers of von Willebrand factor by C-terminal–truncated mutants of ADAMTS-13 under flow
Brief Report
Zhenyin Tao,Yongtao Wang,Huiwei Choi,Aubrey Bernardo,Kenji Nishio,J. Evan Sadler,José A. López,Jing-fei Dong
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IMMUNOBIOLOGY

Cytotoxic minor histocompatibility antigen HA-1–specific CD8+ effector memory T cells: artificial APCs pave the way for clinical application by potent primary in vitro induction
Karin Schilbach,Gunter Kerst,Steffen Walter,Matthias Eyrich,Dorothee Wernet,Rupert Handgretinger,Weidong Xie,Hans-Georg Rammensee,Ingo Müller,Hans-Jörg Bühring,Dietrich Niethammer
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Supplemental data
The role of endothelial PI3Kγ activity in neutrophil trafficking
Kamal D. Puri,Teresa A. Doggett,Ching-Yu Huang,Jason Douangpanya,Joel S. Hayflick,Martin Turner,Josef Penninger,Thomas G. Diacovo
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A potential role for hydrocortisone in the positive regulation of IL-15–activated NK-cell proliferation and survival
Sonia A. Perez,Louisa G. Mahaira,Fillio J. Demirtzoglou,Panagiota A. Sotiropoulou,Panayotis Ioannidis,Eleni G. Iliopoulou,Angelos D. Gritzapis,Nectaria N. Sotiriadou,Constantin N. Baxevanis,Michael Papamichail
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The cancer-testis antigens CT7 (MAGE-C1) and MAGE-A3/6 are commonly expressed in multiple myeloma and correlate with plasma-cell proliferation
Achim A. Jungbluth,Scott Ely,Maurizio DiLiberto,Ruben Niesvizky,Barbara Williamson,Denise Frosina,Yao-Tseng Chen,Nina Bhardwaj,Selina Chen-Kiang,Lloyd J. Old,Hearn Jay Cho
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Balance between NF-κB and JNK/AP-1 activity controls dendritic cell life and death
Ernst Kriehuber,Wolfgang Bauer,Anne-Sophie Charbonnier,Dorian Winter,Stefan Amatschek,Dietmar Tamandl,Norbert Schweifer,Georg Stingl,Dieter Maurer
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Supplemental data
IFN-γ–mediated negative feedback regulation of NKT-cell function by CD94/NKG2
Tsuyoshi Ota,Kazuyoshi Takeda,Hisaya Akiba,Yoshihiro Hayakawa,Kouetsu Ogasawara,Yoshinori Ikarashi,Sachiko Miyake,Hiro Wakasugi,Takashi Yamamura,Mitchell Kronenberg,David H. Raulet,Katsuyuki Kinoshita,Hideo Yagita,Mark J. Smyth,Ko Okumura
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T-cell generation by lymph node resident progenitor cells
Rafik Terra,Isabelle Louis,Richard Le Blanc,Sophie Ouellet,Juan Carlos Zúñiga-Pflücker,Claude Perreault
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CD8α–11b+ dendritic cells but not CD8α+ dendritic cells mediate cross-tolerance toward intestinal antigens
Yeonseok Chung,Jae-Hoon Chang,Mi-Na Kweon,Paul D. Rennert,Chang-Yuil Kang
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Supplemental data
Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a
Kayoko Sato,Yasuyuki Imai,Nobuaki Higashi,Yosuke Kumamoto,Thandi M. Onami,Stephen M. Hedrick,Tatsuro Irimura
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ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming
Elodie Segura,Carole Nicco,Bérangère Lombard,Philippe Véron,Graça Raposo,Frédéric Batteux,Sebastian Amigorena,Clotilde Théry
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Supplemental data
SUMO-1 conjugation selectively modulates STAT1-mediated gene responses
Brief Report
Daniela Ungureanu,Sari Vanhatupa,Juha Grönholm,Jorma J. Palvimo,Olli Silvennoinen
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NEOPLASIA

In vitro and in vivo activity of ATP-based kinase inhibitors AP23464 and AP23848 against activation-loop mutants of Kit
Amie S. Corbin,Shadmehr Demehri,Ian J. Griswold,Yihan Wang,Chester A. Metcalf, III,Raji Sundaramoorthi,William C. Shakespeare,Joseph Snodgrass,Scott Wardwell,David Dalgarno,John Iuliucci,Tomi K. Sawyer,Michael C. Heinrich,Brian J. Druker,Michael W. N. Deininger
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Supplemental data
Azidothymidine inhibits NF-κB and induces Epstein-Barr virus gene expression in Burkitt lymphoma
Motoki Kurokawa,Subrata K. Ghosh,Juan Carlos Ramos,Abdul M. Mian,Ngoc L. Toomey,Lisa Cabral,Denise Whitby,Glen N. Barber,Dirk P. Dittmer,William J. Harrington, Jr
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Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA): long-term follow-up of the Northwestern University experience
Clinical Trials & Observations
Punit Chadha,Alfred W. Rademaker,Prateek Mendiratta,Benjamin Kim,Darren M. Evanchuk,David Hakimian,LoAnn C. Peterson,Martin S. Tallman
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Aberrant mitochondrial iron distribution and maturation arrest characterize early erythroid precursors in low-risk myelodysplastic syndromes
Ramin Tehranchi,Rosangela Invernizzi,Alf Grandien,Boris Zhivotovsky,Bengt Fadeel,Ann-Mari Forsblom,Erica Travaglino,Jan Samuelsson,Robert Hast,Lars Nilsson,Mario Cazzola,Rolf Wibom,Eva Hellström-Lindberg
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Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus
Gang G. Wang,Martina P. Pasillas,Mark P. Kamps
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Supplemental data
AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations
Chunaram Choudhary,Joachim Schwäble,Christian Brandts,Lara Tickenbrock,Bülent Sargin,Thomas Kindler,Thomas Fischer,Wolfgang E. Berdel,Carsten Müller-Tidow,Hubert Serve
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HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL)
Jean Soulier,Emmanuelle Clappier,Jean-Michel Cayuela,Armelle Regnault,Marina García-Peydró,Hervé Dombret,André Baruchel,Maria-Luisa Toribio,François Sigaux
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Supplemental data
NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia
Ying-Wei Lin,Christopher Slape,Zhenhua Zhang,Peter D. Aplan
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Supplemental data
Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma
P. Leif Bergsagel,W. Michael Kuehl,Fenghuang Zhan,Jeffrey Sawyer,Bart Barlogie,John Shaughnessy, Jr
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Supplemental data
Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation
Wen-Chien Chou,Hsuan-Yu Chen,Sung-Liang Yu,Linzhao Cheng,Pan-Chyr Yang,Chi V. Dang
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Supplemental data
Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells
Suzanne Schubbert,Kenneth Lieuw,Sara L. Rowe,Connie M. Lee,XiaXin Li,Mignon L. Loh,D. Wade Clapp,Kevin M. Shannon
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Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine
Ruben A. Mesa,David Loegering,Heather L. Powell,Karen Flatten,Sonnet J. H. Arlander,Nga T. Dai,Michael P. Heldebrant,Benjamin T. Vroman,B. Douglas Smith,Judith E. Karp,Cynthia J. Ten Eyck,Charles Erlichman,Scott H. Kaufmann,Larry M. Karnitz
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Constitutively activated FGFR3 mutants signal through PLCγ-dependent and -independent pathways for hematopoietic transformation
Jing Chen,Ifor R. Williams,Benjamin H. Lee,Nicole Duclos,Brian J. P. Huntly,Daniel J. Donoghue,D. Gary Gilliland
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DC-NK cell cross talk as a novel CD4+ T-cell–independent pathway for antitumor CTL induction
Christian Adam,Susan King,Thomas Allgeier,Heidi Braumüller,Carolin Lüking,Josef Mysliwietz,Anja Kriegeskorte,Dirk H. Busch,Martin Röcken,Ralph Mocikat
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The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy
Clinical Trials & Observations
Susan P. Whitman,Shujun Liu,Tamara Vukosavljevic,Laura J. Rush,Li Yu,Chunhui Liu,Marko I. Klisovic,Kati Maharry,Martin Guimond,Matthew P. Strout,Brian Becknell,Adrienne Dorrance,Rebecca B. Klisovic,Christoph Plass,Clara D. Bloomfield,Guido Marcucci,Michael A. Caligiuri
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Immunohistochemistry accurately predicts FGFR3 aberrant expression and t(4;14) in multiple myeloma
Brief Report
Hong Chang,A. Keith Stewart,Xiao Ying Qi,Zhi Hua Li,Qi Long Yi,Suzanne Trudel
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PHAGOCYTES

Hematologic abnormalities in Shwachman Diamond syndrome: lack of genotype-phenotype relationship
Clinical Trials & Observations
Taco W. Kuijpers,Mariel Alders,Anton T. J. Tool,Clemens Mellink,Dirk Roos,Raoul C. M. Hennekam
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RED CELLS

Hemoglobin levels correlate with interleukin-6 levels in patients with advanced untreated epithelial ovarian cancer: role of inflammation in cancer-related anemia
Clinical Trials & Observations
Antonio Macciò,Clelia Madeddu,Daniela Massa,Maria C. Mudu,Maria R. Lusso,Giulia Gramignano,Roberto Serpe,Gian Benedetto Melis,Giovanni Mantovani
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Both heterozygous and homozygous α+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya
Clinical Trials & Observations Brief Report
Thomas N. Williams,Sammy Wambua,Sophie Uyoga,Alex Macharia,Jedidah K. Mwacharo,Charles R. J. C. Newton,Kathryn Maitland
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Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis
Clinical Trials & Observations Brief Report
Clinton Baldwin,Vikki G. Nolan,Diego F. Wyszynski,Qian-Li Ma,Paola Sebastiani,Stephen H. Embury,Alice Bisbee,John Farrell,Lindsay Farrer,Martin H. Steinberg
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Supplemental data

TRANSPLANTATION

Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells
Chihaya Imai,Shotaro Iwamoto,Dario Campana
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CORRESPONDENCE

Expression of the chemokine receptors CXCR4, CXCR5, and CCR7 in primary central nervous system lymphoma
Kristoph Jahnke,Sarah E. Coupland,Il-Kang Na,Christoph Loddenkemper,Ulrich Keilholz,Agnieszka Korfel,Harald Stein,Eckhard Thiel,Carmen Scheibenbogen
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All Issues

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