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Volume 105, Issue 7

April 1 2005

In this Issue

INSIDE BLOOD
BLOOD WORK
REVIEW ARTICLES
REVIEW IN TRANSLATIONAL HEMATOLOGY
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
TRANSPLANTATION
CORRESPONDENCE
ERRATA

INSIDE BLOOD

NEOPLASIA

Retrovirus uncovers potent collaboration

Linda Wolff

View Articletitled, Retrovirus uncovers potent collaboration

GENE THERAPY

An ounce of prevention potentiates a pound of cure for hemophilia A

Katherine Parker Ponder

View Articletitled, An ounce of prevention potentiates a pound of cure for hemophilia A

HEMOSTASIS

Functional tissue factor in blood?

Kenneth A. Bauer

View Articletitled, Functional tissue factor in blood?

CLINICAL OBSERVATIONS

Plug the hole

Louis M. Aledort

View Articletitled, Plug the hole

HEMATOPOIESIS

Creative stem cell assays

Mervin C. Yoder

View Articletitled, Creative stem cell assays

TRANSPLANTATION

From animals to clinic: nonmyeloablative conditioning and allogeneic bone marrow transplantation in autoimmune disease

Richard K. Burt

View Articletitled, From animals to clinic: nonmyeloablative conditioning and allogeneic bone marrow transplantation in autoimmune disease

NEOPLASIA

Showing the way: large cell lymphoma

Michael M. Quigley

View Articletitled, Showing the way: large cell lymphoma

NEOPLASIA

Light chains ahoy: pirating Thal/Dex for AL too

Raymond L. Comenzo

View Articletitled, Light chains ahoy: pirating Thal/Dex for AL too

NEOPLASIA

How to interfere with FLT3

Martin Sattler

View Articletitled, How to interfere with FLT3

CLINICAL OBSERVATIONS

Primary immunodeficiencies: the tip of an iceberg?

Claudio Pignata

View Articletitled, Primary immunodeficiencies: the tip of an iceberg?

TRANSPLANTATION

GVHD and relapse: to B or not to B

Stephen G. Emerson

View Articletitled, GVHD and relapse: to B or not to B

BLOOD WORK

Multiple myeloma

View Articletitled, Multiple myeloma

REVIEW ARTICLES

Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche

Russell S. Taichman

View Articletitled, Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche

REVIEW IN TRANSLATIONAL HEMATOLOGY

The development of imatinib as a therapeutic agent for chronic myeloid leukemia
Clinical Trials & Observations

Michael Deininger,Elisabeth Buchdunger,Brian J. Druker

View Articletitled, The development of imatinib as a therapeutic agent for chronic myeloid leukemia

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Successful treatment of severe bleeding in hemophilic target joints by selective angiographic embolization
Clinical Trials & Observations

Eveline P. Mauser-Bunschoten,Jacco A. C. Zijl,Willem Mali,A. Cees van Rinsum,H. Marijke van den Berg,Goris Roosendaal

View Articletitled, Successful treatment of severe bleeding in hemophilic target joints by selective angiographic embolization

Severe and progressive encephalitis as a presenting manifestation of a novel missense perforin mutation and impaired cytolytic activity
Clinical Trials & Observations

Jérôme Feldmann,Gaël Ménasché,Isabelle Callebaut,Véronique Minard-Colin,Brigitte Bader-Meunier,Laurence Le Clainche,Alain Fischer,Françoise Le Deist,Marc Tardieu,Geneviève de Saint Basile

View Articletitled, Severe and progressive encephalitis as a presenting manifestation of a novel missense perforin mutation and impaired cytolytic activity

Acute leukemia in polycythemia vera: an analysis of 1638 patients enrolled in a prospective observational study
Clinical Trials & Observations

Guido Finazzi,Vanesa Caruso,Roberto Marchioli,Giovanni Capnist,Teodoro Chisesi,Carlo Finelli,Luigi Gugliotta,Raffaele Landolfi,Jack Kutti,Heinz Gisslinger,Raphael Marilus,Carlo Patrono,Enrico Maria Pogliani,Maria Luigia Randi,Ana Villegas,Gianni Tognoni,Tiziano Barbui,for the ECLAP Investigators

View Articletitled, Acute leukemia in polycythemia vera: an analysis of 1638 patients enrolled in a prospective observational study

Genetic complementation reveals a novel human congenital disorder of glycosylation of type II, due to inactivation of the Golgi CMP–sialic acid transporter
Clinical Trials & Observations

Ivan Martinez-Duncker,Thierry Dupré,Véronique Piller,Friedrich Piller,Jean-Jacques Candelier,Catherine Trichet,Gil Tchernia,Rafael Oriol,Rosella Mollicone

View Articletitled, Genetic complementation reveals a novel human congenital disorder of glycosylation of type II, due to inactivation of the Golgi CMP–sialic acid transporter

Early consolidation by myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission significantly prolongs progression-free survival in mantle-cell lymphoma: results of a prospective randomized trial of the European MCL Network
Clinical Trials & Observations

Martin Dreyling,Georg Lenz,Eva Hoster,Achiel Van Hoof,Christian Gisselbrecht,Rudolf Schmits,Bernd Metzner,Lorenz Truemper,Marcel Reiser,Hjalmar Steinhauer,Jean-Michel Boiron,Marc A. Boogaerts,Ali Aldaoud,Vittorio Silingardi,Hanneke C. Kluin-Nelemans,Joerg Hasford,Reza Parwaresch,Michael Unterhalt,Wolfgang Hiddemann

View Articletitled, Early consolidation by myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission significantly prolongs progression-free survival in mantle-cell lymphoma: results of a prospective randomized trial of the European MCL Network

Hydroxyurea for sickle cell disease in children and for prevention of cerebrovascular events: the Belgian experience
Clinical Trials & Observations

Béatrice Gulbis,David Haberman,Dominique Dufour,Catherine Christophe,Christiane Vermylen,Faustin Kagambega,Francis Corazza,Christine Devalck,Marie-Françoise Dresse,Kathleen Hunninck,Axel Klein,Phu Quoc Le,Michèle Loop,Philip Maes,Pierre Philippet,Eric Sariban,Chris Van Geet,Alina Ferster

View Articletitled, Hydroxyurea for sickle cell disease in children and for prevention of cerebrovascular events: the Belgian experience

GENE THERAPY

Phenotypic correction and long-term expression of factor VIII in hemophilic mice by immunotolerization and nonviral gene transfer using the Sleeping Beauty transposon system

John R. Ohlfest,Joel L. Frandsen,Sabine Fritz,Paul D. Lobitz,Scott G. Perkinson,Karl J. Clark,Gary Nelsestuen,Nigel S. Key,R. Scott McIvor,Perry B. Hackett,David A. Largaespada

View Articletitled, Phenotypic correction and long-term expression of factor VIII in hemophilic mice by immunotolerization and nonviral gene transfer using the Sleeping Beauty transposon system

Clonal evidence for the transduction of CD34⁺ cells with lymphomyeloid differentiation potential and self-renewal capacity in the SCID-X1 gene therapy trial

Manfred Schmidt,Salima Hacein-Bey-Abina,Manuela Wissler,Frederique Carlier,Annick Lim,Claudia Prinz,Hanno Glimm,Isabelle Andre-Schmutz,Christophe Hue,Alexandrine Garrigue,Francoise Le Deist,Chantal Lagresle,Alain Fischer,Marina Cavazzana-Calvo,Christof von Kalle

View Articletitled, Clonal evidence for the transduction of CD34+ cells with lymphomyeloid differentiation potential and self-renewal capacity in the SCID-X1 gene therapy trial

HEMATOPOIESIS

Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate

Youssef Bakri,Sandrine Sarrazin,Ulrich P. Mayer,Silke Tillmanns,Claus Nerlov,Annie Boned,Michael H. Sieweke

View Articletitled, Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate

Identification of Lin^–Sca1⁺kit⁺CD34⁺Flt3^– short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients

Liping Yang,David Bryder,Jörgen Adolfsson,Jens Nygren,Robert Månsson,Mikael Sigvardsson,Sten Eirik W. Jacobsen

View Articletitled, Identification of Lin–Sca1+kit+CD34+Flt3– short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients

In vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis

Joachim R. Göthert,Sonja E. Gustin,Mark A. Hall,Anthony R. Green,Berthold Göttgens,David J. Izon,C. Glenn Begley

View Articletitled, In vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis

Identification of human chronic myelogenous leukemia progenitor cells with hemangioblastic characteristics

Baijun Fang,Chunmei Zheng,Lianming Liao,Qin Han,Zhao Sun,Xueying Jiang,Robert C. H. Zhao

View Articletitled, Identification of human chronic myelogenous leukemia progenitor cells with hemangioblastic characteristics

BMP4 and Madh5 regulate the erythroid response to acute anemia

Laurie E. Lenox,John M. Perry,Robert F. Paulson

View Articletitled, BMP4 and Madh5 regulate the erythroid response to acute anemia

Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Differential requirements for calcium and Src family kinases in platelet GPIIb/IIIa activation and thromboxane generation downstream of different G-protein pathways

Robert T. Dorsam,Soochong Kim,Swaminathan Murugappan,Swathi Rachoor,Haripriya Shankar,Jianguo Jin,Satya P. Kunapuli

View Articletitled, Differential requirements for calcium and Src family kinases in platelet GPIIb/IIIa activation and thromboxane generation downstream of different G-protein pathways

Hematopoietic cells regulate the angiogenic switch during tumorigenesis

Rika Okamoto,Masaya Ueno,Yoshihiro Yamada,Naoko Takahashi,Hideto Sano,Toshio Suda,Nobuyuki Takakura

View Articletitled, Hematopoietic cells regulate the angiogenic switch during tumorigenesis

Tissue factor activity in whole blood

Saulius Butenas,Beth A. Bouchard,Kathleen E. Brummel-Ziedins,Behnaz Parhami-Seren,Kenneth G. Mann

View Articletitled, Tissue factor activity in whole blood

VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly

Christopher V. Crosby,Paul A. Fleming,W. Scott Argraves,Monica Corada,Lucia Zanetta,Elisabetta Dejana,Christopher J. Drake

View Articletitled, VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly

A balance between tissue factor and tissue factor pathway inhibitor is required for embryonic development and hemostasis in adult mice

Brian Pedersen,Todd Holscher,Yuichiro Sato,Rafal Pawlinski,Nigel Mackman

View Articletitled, A balance between tissue factor and tissue factor pathway inhibitor is required for embryonic development and hemostasis in adult mice

Vessel wall–derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells
Brief Report

David A. Ingram,Laura E. Mead,Daniel B. Moore,Wayne Woodard,Amy Fenoglio,Mervin C. Yoder

View Articletitled, Vessel wall–derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells

IMMUNOBIOLOGY

Ly49Q defines 2 pDC subsets in mice

Yumiko Kamogawa-Schifter,Jun Ohkawa,Sahori Namiki,Naoko Arai,Ken-ichi Arai,YongJun Liu

View Articletitled, Ly49Q defines 2 pDC subsets in mice

Generation of CMV-specific T lymphocytes using protein-spanning pools of pp65-derived overlapping pentadecapeptides for adoptive immunotherapy

Deepa Trivedi,Roxanne Y. Williams,Richard J. O'Reilly,Guenther Koehne

View Articletitled, Generation of CMV-specific T lymphocytes using protein-spanning pools of pp65-derived overlapping pentadecapeptides for adoptive immunotherapy

Cell surface–associated Tat modulates HIV-1 infection and spreading through a specific interaction with gp120 viral envelope protein

Serena Marchiò,Massimo Alfano,Luca Primo,Daniela Gramaglia,Luca Butini,Luisa Gennero,Enrico De Vivo,Wadih Arap,Mauro Giacca,Renata Pasqualini,Federico Bussolino

View Articletitled, Cell surface–associated Tat modulates HIV-1 infection and spreading through a specific interaction with gp120 viral envelope protein

Tumor protein D52 (TPD52): a novel B-cell/plasma-cell molecule with unique expression pattern and Ca²⁺-dependent association with annexin VI

Enrico Tiacci,Pier-Luigi Orvietani,Barbara Bigerna,Alessandra Pucciarini,Garry L. Corthals,Valentina Pettirossi,Maria P. Martelli,Arcangelo Liso,Roberta Benedetti,Roberta Pacini,Niccolò Bolli,Stefano Pileri,Karen Pulford,Marcello Gambacorta,Antonino Carbone,Carla Pasquarello,Alexander Scherl,Helen Robertson,Maria Teresa Sciurpi,Giovanni Alunni-Bistocchi,Luciano Binaglia,Jennifer A. Byrne,Brunangelo Falini

View Articletitled, Tumor protein D52 (TPD52): a novel B-cell/plasma-cell molecule with unique expression pattern and Ca2+-dependent association with annexin VI

Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells

Sarah Glennie,Inês Soeiro,Peter J. Dyson,Eric W.-F. Lam,Francesco Dazzi

View Articletitled, Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells

Isolation and characterization of human antigen-specific TCRαβ⁺ CD4^-CD8^- double-negative regulatory T cells

Karin Fischer,Simon Voelkl,Jana Heymann,Grzegorz K. Przybylski,Krishna Mondal,Monika Laumer,Leoni Kunz-Schughart,Christian A. Schmidt,Reinhard Andreesen,Andreas Mackensen

View Articletitled, Isolation and characterization of human antigen-specific TCRαβ+ CD4-CD8- double-negative regulatory T cells

CD97, an adhesion receptor on inflammatory cells, stimulates angiogenesis through binding integrin counterreceptors on endothelial cells

Tao Wang,Yvona Ward,Linhua Tian,Ross Lake,Liliana Guedez,William G. Stetler-Stevenson,Kathleen Kelly

View Articletitled, CD97, an adhesion receptor on inflammatory cells, stimulates angiogenesis through binding integrin counterreceptors on endothelial cells

Triggering of OX40 (CD134) on CD4⁺CD25⁺ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR

Barbara Valzasina,Cristiana Guiducci,Heidrun Dislich,Nigel Killeen,Andrew D. Weinberg,Mario P. Colombo

View Articletitled, Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR

Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation

Olga Barreiro,María Yáñez-Mó,Mónica Sala-Valdés,María Dolores Gutiérrez-López,Susana Ovalle,Adrian Higginbottom,Peter N. Monk,Carlos Cabañas,Francisco Sánchez-Madrid

View Articletitled, Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation

Supplemental data

Inhibition of CD4⁺25⁺ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide

M. E. Christine Lutsiak,Roshanak T. Semnani,Roberto De Pascalis,Syed V. S. Kashmiri,Jeffrey Schlom,Helen Sabzevari

View Articletitled, Inhibition of CD4+25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide

Supplemental data

Ephrin-A1 binding to CD4⁺ T lymphocytes stimulates migration and induces tyrosine phosphorylation of PYK2

Hans-Christian Aasheim,Jan Delabie,Eivind Farmen Finne

View Articletitled, Ephrin-A1 binding to CD4+ T lymphocytes stimulates migration and induces tyrosine phosphorylation of PYK2

CCR6 expression defines regulatory effector/memory-like cells within the CD25⁺CD4⁺ T-cell subset

Markus Kleinewietfeld,Fabiola Puentes,Giovanna Borsellino,Luca Battistini,Olaf Rötzschke,Kirsten Falk

View Articletitled, CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T-cell subset

Supplemental data

Abnormal interleukin-7 function in common variable immunodeficiency
Brief Report

Are Martin Holm,Pål Aukrust,Jan Kristian Damås,Fredrik Müller,Bente Halvorsen,Stig S. Frøland

View Articletitled, Abnormal interleukin-7 function in common variable immunodeficiency

NEOPLASIA

MALT1 and the API2-MALT1 fusion act between CD40 and IKK and confer NF-κB-dependent proliferative advantage and resistance against FAS-induced cell death in B cells

Liza Ho,R. Eric Davis,Béatrice Conne,Richard Chappuis,Margaret Berczy,Paulette Mhawech,Louis M. Staudt,Juerg Schwaller

View Articletitled, MALT1 and the API2-MALT1 fusion act between CD40 and IKK and confer NF-κB-dependent proliferative advantage and resistance against FAS-induced cell death in B cells

Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11

Sean F. Landrette,Ya-Huei Kuo,Karen Hensen,Sahar Barjesteh van Waalwijk van Doorn-Khosrovani,Paola N. Perrat,Wim J. M. Van de Ven,Ruud Delwel,Lucio H. Castilla

View Articletitled, Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11

High expression of cyclin B1 predicts a favorable outcome in patients with follicular lymphoma
Clinical Trials & Observations

Erik Björck,Sara Ek,Ola Landgren,Mats Jerkeman,Mats Ehinger,Magnus Björkholm,Carl A. K. Borrebaeck,Anna Porwit-MacDonald,Magnus Nordenskjöld

View Articletitled, High expression of cyclin B1 predicts a favorable outcome in patients with follicular lymphoma

Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas
Clinical Trials & Observations

Jettie J. F. Muris,Saskia A. G. M. Cillessen,Wim Vos,Inge S. van Houdt,J. Alain Kummer,Johan H. J. M. van Krieken,N. Mehdi Jiwa,Patty M. Jansen,Hanneke C. Kluin-Nelemans,Gert J. Ossenkoppele,Chad Gundy,Chris J. L. M. Meijer,Joost J. Oudejans

View Articletitled, Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas

Distinct IL-4-induced gene expression, proliferation, and intracellular signaling in germinal center B-cell-like and activated B-cell-like diffuse large-cell lymphomas

Xiaoqing Lu,Hovav Nechushtan,Feiying Ding,Manuel F. Rosado,Rakesh Singal,Ash A. Alizadeh,Izidore S. Lossos

View Articletitled, Distinct IL-4-induced gene expression, proliferation, and intracellular signaling in germinal center B-cell-like and activated B-cell-like diffuse large-cell lymphomas

Supplemental data

Lower levels of surface B-cell-receptor expression in chronic lymphocytic leukemia are associated with glycosylation and folding defects of the μ and CD79a chains

Françoise Vuillier,Gérard Dumas,Christian Magnac,Marie-Christine Prevost,Ana Inés Lalanne,Pablo Oppezzo,Evie Melanitou,Guillaume Dighiero,Béatrice Payelle-Brogard

View Articletitled, Lower levels of surface B-cell-receptor expression in chronic lymphocytic leukemia are associated with glycosylation and folding defects of the μ and CD79a chains

CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma

Suzanne Trudel,Zhi Hua Li,Ellen Wei,Marion Wiesmann,Hong Chang,Christine Chen,Donna Reece,Carla Heise,A. Keith Stewart

View Articletitled, CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma

The combination of thalidomide and intermediate-dose dexamethasone is an effective but toxic treatment for patients with primary amyloidosis (AL)
Clinical Trials & Observations Brief Report

Giovanni Palladini,Vittorio Perfetti,Stefano Perlini,Laura Obici,Francesca Lavatelli,Riccardo Caccialanza,Rosangela Invernizzi,Benedetto Comotti,Giampaolo Merlini

View Articletitled, The combination of thalidomide and intermediate-dose dexamethasone is an effective but toxic treatment for patients with primary amyloidosis (AL)

RNAi-induced down-regulation of FLT3 expression in AML cell lines increases sensitivity to MLN518
Brief Report

Denise K. Walters,Eric P. Stoffregen,Michael C. Heinrich,Michael W. Deininger,Brian J. Druker

View Articletitled, RNAi-induced down-regulation of FLT3 expression in AML cell lines increases sensitivity to MLN518

PHAGOCYTES

Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells

Dorothee Viemann,Anke Strey,Annette Janning,Kerstin Jurk,Kerstin Klimmek,Thomas Vogl,Keiichi Hirono,Fukiko Ichida,Dirk Foell,Beate Kehrel,Volker Gerke,Clemens Sorg,Johannes Roth

View Articletitled, Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells

Supplemental data

Monokine induced by interferon-γ is induced by receptor activator of nuclear factor κB ligand and is involved in osteoclast adhesion and migration

Han Bok Kwak,Soo Woong Lee,Hye Mi Jin,Hyunil Ha,Sang Ho Lee,Sunao Takeshita,Sakae Tanaka,Hyun-Man Kim,Hong-Hee Kim,Zang Hee Lee

View Articletitled, Monokine induced by interferon-γ is induced by receptor activator of nuclear factor κB ligand and is involved in osteoclast adhesion and migration

z-VAD-fmk augmentation of TNFα-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species
Brief Report

Andrew S. Cowburn,Jessica F. White,John Deighton,Sarah R. Walmsley,Edwin R. Chilvers

View Articletitled, z-VAD-fmk augmentation of TNFα-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species

TRANSPLANTATION

Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission
Clinical Trials & Observations

David B. Miklos,Haesook T. Kim,Katherine H. Miller,Luxuan Guo,Emmanuel Zorn,Stephanie J. Lee,Ephraim P. Hochberg,Catherine J. Wu,Edwin P. Alyea,Corey Cutler,Vincent Ho,Robert J. Soiffer,Joseph H. Antin,Jerome Ritz

View Articletitled, Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission

Supplemental data

Association of transplant center and physician factors on mortality after hematopoietic stem cell transplantation in the United States
Clinical Trials & Observations

Fausto R. Loberiza, Jr,Mei-Jie Zhang,Stephanie J. Lee,John P. Klein,Charles F. LeMaistre,Derek S. Serna,Mary Eapen,Christopher N. Bredeson,Mary M. Horowitz,J. Douglas Rizzo

View Articletitled, Association of transplant center and physician factors on mortality after hematopoietic stem cell transplantation in the United States

Leydig cell injury as a consequence of an acute graft-versus-host reaction
Brief Report

Anna-Margaretha Wagner,Konstantin Beier,Elli Christen,Georg A. Holländer,Werner Krenger

View Articletitled, Leydig cell injury as a consequence of an acute graft-versus-host reaction

Control of systemic B cell-mediated autoimmune disease by nonmyeloablative conditioning and major histocompatibility complex-mismatched allogeneic bone marrow transplantation
Brief Report

Roelof Flierman,Hendrik J. Witteveen,Ellen I. H. van der Voort,Tom W. J. Huizinga,René R. P. de Vries,Willem E. Fibbe,René E. M. Toes,Jacob M. van Laar

View Articletitled, Control of systemic B cell-mediated autoimmune disease by nonmyeloablative conditioning and major histocompatibility complex-mismatched allogeneic bone marrow transplantation

CORRESPONDENCE

Is the prothrombin 19911A>G polymorphism a functional noncoding variant?

Haidy H. A. G. M. van der Putten,Rogier M. Bertina,Hans L. Vos

View Articletitled, Is the prothrombin 19911A>G polymorphism a functional noncoding variant?

Treatment with cyclosporin A cream for the cutaneous reactions associated with imatinib therapy

Alejandro Schamun,Eduardo Bullorsky,German Stemmelin,Ricardo Saxton,Daniel Ricchione

View Articletitled, Treatment with cyclosporin A cream for the cutaneous reactions associated with imatinib therapy

Quantitative RT-PCR analysis of activation-induced cytidine deaminase expression in tissue samples from mantle cell lymphoma and B-cell chronic lymphocytic leukemia patients

Jeroen E. J. Guikema,Stefano Rosati,Karine Akkermans,Richard J. Bende,Carel J. M. van Noesel,Johan H. van Krieken,Martin L. Hansmann,Ed Schuuring,Philip M. Kluin

View Articletitled, Quantitative RT-PCR analysis of activation-induced cytidine deaminase expression in tissue samples from mantle cell lymphoma and B-cell chronic lymphocytic leukemia patients

ERRATA

Erratum for vol. 105, p. 1660

View Articletitled, Erratum for vol. 105, p. 1660

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Issue Archive

Table of Contents

INSIDE BLOOD

BLOOD WORK

REVIEW ARTICLES

REVIEW IN TRANSLATIONAL HEMATOLOGY

The development of imatinib as a therapeutic agent for chronic myeloid leukemia Clinical Trials & Observations

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Successful treatment of severe bleeding in hemophilic target joints by selective angiographic embolization Clinical Trials & Observations

Severe and progressive encephalitis as a presenting manifestation of a novel missense perforin mutation and impaired cytolytic activity Clinical Trials & Observations

Acute leukemia in polycythemia vera: an analysis of 1638 patients enrolled in a prospective observational study Clinical Trials & Observations

Genetic complementation reveals a novel human congenital disorder of glycosylation of type II, due to inactivation of the Golgi CMP–sialic acid transporter Clinical Trials & Observations

Early consolidation by myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission significantly prolongs progression-free survival in mantle-cell lymphoma: results of a prospective randomized trial of the European MCL Network Clinical Trials & Observations

Hydroxyurea for sickle cell disease in children and for prevention of cerebrovascular events: the Belgian experience Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Vessel wall–derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells Brief Report

IMMUNOBIOLOGY

Abnormal interleukin-7 function in common variable immunodeficiency Brief Report

NEOPLASIA

High expression of cyclin B1 predicts a favorable outcome in patients with follicular lymphoma Clinical Trials & Observations

Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas Clinical Trials & Observations

The combination of thalidomide and intermediate-dose dexamethasone is an effective but toxic treatment for patients with primary amyloidosis (AL) Clinical Trials & Observations Brief Report

RNAi-induced down-regulation of FLT3 expression in AML cell lines increases sensitivity to MLN518 Brief Report

PHAGOCYTES

z-VAD-fmk augmentation of TNFα-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species Brief Report

TRANSPLANTATION

Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission Clinical Trials & Observations

Association of transplant center and physician factors on mortality after hematopoietic stem cell transplantation in the United States Clinical Trials & Observations

Leydig cell injury as a consequence of an acute graft-versus-host reaction Brief Report

Control of systemic B cell-mediated autoimmune disease by nonmyeloablative conditioning and major histocompatibility complex-mismatched allogeneic bone marrow transplantation Brief Report

CORRESPONDENCE

ERRATA

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ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

The development of imatinib as a therapeutic agent for chronic myeloid leukemia
Clinical Trials & Observations

Successful treatment of severe bleeding in hemophilic target joints by selective angiographic embolization
Clinical Trials & Observations

Severe and progressive encephalitis as a presenting manifestation of a novel missense perforin mutation and impaired cytolytic activity
Clinical Trials & Observations

Acute leukemia in polycythemia vera: an analysis of 1638 patients enrolled in a prospective observational study
Clinical Trials & Observations

Genetic complementation reveals a novel human congenital disorder of glycosylation of type II, due to inactivation of the Golgi CMP–sialic acid transporter
Clinical Trials & Observations

Early consolidation by myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission significantly prolongs progression-free survival in mantle-cell lymphoma: results of a prospective randomized trial of the European MCL Network
Clinical Trials & Observations

Hydroxyurea for sickle cell disease in children and for prevention of cerebrovascular events: the Belgian experience
Clinical Trials & Observations

Vessel wall–derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells
Brief Report

Abnormal interleukin-7 function in common variable immunodeficiency
Brief Report

High expression of cyclin B1 predicts a favorable outcome in patients with follicular lymphoma
Clinical Trials & Observations

Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas
Clinical Trials & Observations

The combination of thalidomide and intermediate-dose dexamethasone is an effective but toxic treatment for patients with primary amyloidosis (AL)
Clinical Trials & Observations Brief Report

RNAi-induced down-regulation of FLT3 expression in AML cell lines increases sensitivity to MLN518
Brief Report

z-VAD-fmk augmentation of TNFα-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species
Brief Report

Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission
Clinical Trials & Observations

Association of transplant center and physician factors on mortality after hematopoietic stem cell transplantation in the United States
Clinical Trials & Observations

Leydig cell injury as a consequence of an acute graft-versus-host reaction
Brief Report

Control of systemic B cell-mediated autoimmune disease by nonmyeloablative conditioning and major histocompatibility complex-mismatched allogeneic bone marrow transplantation
Brief Report