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Volume 105, Issue 6

March 15 2005

In this Issue

INSIDE BLOOD
PLENARY PAPERS
ERRATA
REVIEW ARTICLES
REVIEW IN TRANSLATIONAL HEMATOLOGY
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

Mouldy oldy: how fungus lives among us

Brahm H. Segal

View Articletitled, Mouldy oldy: how fungus lives among us

HEMATOPOIESIS

Mutant Kit: thwarting the message down below

Ayalew Tefferi

View Articletitled, Mutant Kit: thwarting the message down below

IMMUNOBIOLOGY

On the TRAIL of HIV-induced immunosuppression

Pierre-Olivier Vidalain

View Articletitled, On the TRAIL of HIV-induced immunosuppression

IMMUNOBIOLOGY

B7-H1 connection of innate and adaptive immunity against tumor dormancy

Lieping Chen

View Articletitled, B7-H1 connection of innate and adaptive immunity against tumor dormancy

GENE THERAPY

Gain-of-function proteins for gene transfer in hemophilia

Francesco Bernardi

View Articletitled, Gain-of-function proteins for gene transfer in hemophilia

NEOPLASIA

Holes in SOCS in primary mediastinal large B-cell lymphoma

Elias Campo

View Articletitled, Holes in SOCS in primary mediastinal large B-cell lymphoma

IMMUNOBIOLOGY

CD47 and SIRPs: new openings

Per-Arne Oldenborg

View Articletitled, CD47 and SIRPs: new openings

HEMOSTASIS

VEGF, sunburn, and wrinkles

Stephen C. Ekker

View Articletitled, VEGF, sunburn, and wrinkles

CLINICAL OBSERVATIONS

Inflammation gone awry: aging or disease

William B. Ershler

View Articletitled, Inflammation gone awry: aging or disease

INSIDE BLOOD

Cascading lung injury in allogeneic SCT

Georgia B. Vogelsang

View Articletitled, Cascading lung injury in allogeneic SCT

HEMATOPOIESIS

Challenging the role of Notch in HSC biology

Mickie Bhatia

View Articletitled, Challenging the role of Notch in HSC biology

PLENARY PAPERS

Donor T-cell production of RANTES significantly contributes to the development of idiopathic pneumonia syndrome after allogeneic stem cell transplantation

Gerhard C. Hildebrandt,Krystyna M. Olkiewicz,Sung Choi,Leigh A. Corrion,Shawn G. Clouthier,Chen Liu,Jonathan S. Serody,Kenneth R. Cooke

View Articletitled, Donor T-cell production of RANTES significantly contributes to the development of idiopathic pneumonia syndrome after allogeneic stem cell transplantation

Aspergillus fumigatus suppresses the human cellular immune response via gliotoxin-mediated apoptosis of monocytes

Marta Stanzani,Enrico Orciuolo,Russell Lewis,Dimitrios P. Kontoyiannis,Sergio L. R. Martins,Lisa S. St. John,Krishna V. Komanduri

View Articletitled, Aspergillus fumigatus suppresses the human cellular immune response via gliotoxin-mediated apoptosis of monocytes

ERRATA

Erratum for vol. 104, p. 3858

View Articletitled, Erratum for vol. 104, p. 3858

REVIEW ARTICLES

Transfusion-related acute lung injury
Clinical Trials & Observations

Christopher C. Silliman,Daniel R. Ambruso,Lynn K. Boshkov

View Articletitled, Transfusion-related acute lung injury

REVIEW IN TRANSLATIONAL HEMATOLOGY

Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms
Clinical Trials & Observations

Tahseen Al-Saleem,Hamid Al-Mondhiry

View Articletitled, Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Imatinib mesylate therapy may overcome the poor prognostic significance of deletions of derivative chromosome 9 in patients with chronic myelogenous leukemia
Clinical Trials & Observations

Alfonso Quintas-Cardama,Hagop Kantarjian,Moshe Talpaz,Susan O'Brien,Guillermo Garcia-Manero,Srdan Verstovsek,Mary Beth Rios,Kimberly Hayes,Armand Glassman,B. Nebiyou Bekele,Xian Zhou,Jorge Cortes

View Articletitled, Imatinib mesylate therapy may overcome the poor prognostic significance of deletions of derivative chromosome 9 in patients with chronic myelogenous leukemia

Treatment of acquired hemophilia by the Bonn-Malmö Protocol: documentation of an in vivo immunomodulating concept
Clinical Trials & Observations

Heike Zeitler,Gudrun Ulrich-Merzenich,Lothar Hess,Eligius Konsek,Christoph Unkrig,Peter Walger,Hans Vetter,Hans-Hermann Brackmann

View Articletitled, Treatment of acquired hemophilia by the Bonn-Malmö Protocol: documentation of an in vivo immunomodulating concept

The origins of age-related proinflammatory state
Clinical Trials & Observations

Luigi Ferrucci,Annamaria Corsi,Fulvio Lauretani,Stefania Bandinelli,Benedetta Bartali,Dennis D. Taub,Jack M. Guralnik,Dan L. Longo

View Articletitled, The origins of age-related proinflammatory state

Engraftment and survival following reduced-intensity allogeneic peripheral blood hematopoietic cell transplantation is affected by CD8⁺ T-cell dose
Clinical Trials & Observations

Thai M. Cao,Judith A. Shizuru,Ruby M. Wong,Kevin Sheehan,Ginna G. Laport,Keith E. Stockerl-Goldstein,Laura J. Johnston,Monic J. Stuart,F. Carl Grumet,Robert S. Negrin,Robert Lowsky

View Articletitled, Engraftment and survival following reduced-intensity allogeneic peripheral blood hematopoietic cell transplantation is affected by CD8+ T-cell dose

Supplemental data

GENE THERAPY

Promoter trapping reveals significant differences in integration site selection between MLV and HIV vectors in primary hematopoietic cells

Michele De Palma,Eugenio Montini,Francesca R. Santoni de Sio,Fabrizio Benedicenti,Alessandra Gentile,Enzo Medico,Luigi Naldini

View Articletitled, Promoter trapping reveals significant differences in integration site selection between MLV and HIV vectors in primary hematopoietic cells

Factor IX variants improve gene therapy efficacy for hemophilia B

Joerg Schuettrumpf,Roland W. Herzog,Alexander Schlachterman,Antje Kaufhold,Darrel W. Stafford,Valder R. Arruda

View Articletitled, Factor IX variants improve gene therapy efficacy for hemophilia B

HEMATOPOIESIS

A novel NF-κB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors

Akane Tanaka,Masayo Konno,Susumu Muto,Naotomo Kambe,Eiichi Morii,Tatsutoshi Nakahata,Akiko Itai,Hiroshi Matsuda

View Articletitled, A novel NF-κB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors

Functional characterization of telomerase RNA variants found in patients with hematologic disorders

Hinh Ly,Rodrigo T. Calado,Paulette Allard,Gabriela M. Baerlocher,Peter M. Lansdorp,Neal S. Young,Tristram G. Parslow

View Articletitled, Functional characterization of telomerase RNA variants found in patients with hematologic disorders

Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation
Brief Report

Stéphane J. C. Mancini,Ned Mantei,Alexis Dumortier,Ueli Suter,H. Robson MacDonald,Freddy Radtke

View Articletitled, Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Mechanism by which H-2g, a glucose analog of blood group H antigen, mediates angiogenesis

Kui Zhu,Mohammed Asif Amin,Yuanyuan Zha,Lisa A. Harlow,Alisa E. Koch

View Articletitled, Mechanism by which H-2g, a glucose analog of blood group H antigen, mediates angiogenesis

C1 inhibitor prevents Gram-negative bacterial lipopolysaccharide-induced vascular permeability

Dongxu Liu,Dong Zhang,Jennifer Scafidi,Xiao Wu,Cort C. Cramer,Alvin E. Davis, III

View Articletitled, C1 inhibitor prevents Gram-negative bacterial lipopolysaccharide-induced vascular permeability

Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter

Makoto Sugaya,Takahiro Watanabe,Aparche Yang,Matthew F. Starost,Hisataka Kobayashi,April M. Atkins,Debra L. Borris,Elisabeth A. Hanan,Daniel Schimel,Mark A. Bryant,Nicole Roberts,Mihaela Skobe,Katherine A. Staskus,Philipp Kaldis,Andrew Blauvelt

View Articletitled, Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter

A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse

Takayuki Iwaki,Diana T. Cruz,J. Andrew Martin,Francis J. Castellino

View Articletitled, A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse

Roles of vascular endothelial growth factor receptor 3 signaling in differentiation of mouse embryonic stem cell–derived vascular progenitor cells into endothelial cells

Hiroyuki Suzuki,Tetsuro Watabe,Mitsuyasu Kato,Keiji Miyazawa,Kohei Miyazono

View Articletitled, Roles of vascular endothelial growth factor receptor 3 signaling in differentiation of mouse embryonic stem cell–derived vascular progenitor cells into endothelial cells

Supplemental data

The single nucleotide polymorphism Ser128Arg in the E-selectin gene is associated with enhanced coagulation during human endotoxemia

Bernd Jilma,Claudia Marsik,Florian Kovar,Oswald F. Wagner,Petra Jilma-Stohlawetz,Georg Endler

View Articletitled, The single nucleotide polymorphism Ser128Arg in the E-selectin gene is associated with enhanced coagulation during human endotoxemia

Regulation of tissue factor–induced signaling by endogenous and recombinant tissue factor pathway inhibitor 1

Jasimuddin Ahamed,Mattias Belting,Wolfram Ruf

View Articletitled, Regulation of tissue factor–induced signaling by endogenous and recombinant tissue factor pathway inhibitor 1

Vascular endothelial growth factor promotes sensitivity to ultraviolet B–induced cutaneous photodamage

Satoshi Hirakawa,Seishiro Fujii,Kentaro Kajiya,Kiichiro Yano,Michael Detmar

View Articletitled, Vascular endothelial growth factor promotes sensitivity to ultraviolet B–induced cutaneous photodamage

A role for bone marrow–derived cells in the vasculature of noninjured CNS
Brief Report

Francesco Galimi,Robert G. Summers,Henriette van Praag,Inder M. Verma,Fred H. Gage

View Articletitled, A role for bone marrow–derived cells in the vasculature of noninjured CNS

Supplemental data

IMMUNOBIOLOGY

Impact of bone marrow hematopoiesis failure on T-cell generation during pathogenic simian immunodeficiency virus infection in macaques

Hugues Thiebot,Bruno Vaslin,Sonia Derdouch,Jean-Marc Bertho,Franck Mouthon,Stéphane Prost,Gabriel Gras,Pierre Ducouret,Dominique Dormont,Roger Le Grand

View Articletitled, Impact of bone marrow hematopoiesis failure on T-cell generation during pathogenic simian immunodeficiency virus infection in macaques

De novo generation of CD4 T cells against viruses present in the host during immune reconstitution

Tomas Kalina,Hailing Lu,Zhao Zhao,Earl Blewett,Dirk P. Dittmer,Julie Randolph-Habecker,David G. Maloney,Robert G. Andrews,Hans-Peter Kiem,Jan Storek

View Articletitled, De novo generation of CD4 T cells against viruses present in the host during immune reconstitution

Supplemental data

Relevance of sexual dimorphism to regulatory T cells: estradiol promotes IFN-γ production by invariant natural killer T cells

Pierre Gourdy,Luiza M. Araujo,Ren Zhu,Barbara Garmy-Susini,Séverine Diem,Henrik Laurell,Maria Leite-de-Moraes,Michel Dy,Jean François Arnal,Francis Bayard,André Herbelin

View Articletitled, Relevance of sexual dimorphism to regulatory T cells: estradiol promotes IFN-γ production by invariant natural killer T cells

Adhesion of human T cells to antigen-presenting cells through SIRPβ2-CD47 interaction costimulates T-cell proliferation

Laura Piccio,William Vermi,Kent S. Boles,Anja Fuchs,Carey A. Strader,Fabio Facchetti,Marina Cella,Marco Colonna

View Articletitled, Adhesion of human T cells to antigen-presenting cells through SIRPβ2-CD47 interaction costimulates T-cell proliferation

NK cells that are activated by CXCL10 can kill dormant tumor cells that resist CTL-mediated lysis and can express B7-H1 that stimulates T cells

Aurore Saudemont,Nathalie Jouy,Dominique Hetuin,Bruno Quesnel

View Articletitled, NK cells that are activated by CXCL10 can kill dormant tumor cells that resist CTL-mediated lysis and can express B7-H1 that stimulates T cells

Molecular transfer of CD40 and OX40 ligands to leukemic human B cells induces expansion of autologous tumor–reactive cytotoxic T lymphocytes

Ettore Biagi,Gianpietro Dotti,Eric Yvon,Edward Lee,Martin Pule,Stephane Vigouroux,Stephen Gottschalk,Uday Popat,Raphael Rousseau,Malcolm Brenner

View Articletitled, Molecular transfer of CD40 and OX40 ligands to leukemic human B cells induces expansion of autologous tumor–reactive cytotoxic T lymphocytes

Unmasking Evans syndrome: T-cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS)

David T. Teachey,Catherine S. Manno,Kelly M. Axsom,Timothy Andrews,John K. Choi,Barbara H. Greenbaum,Joseph M. McMann,Kathleen E. Sullivan,Susan F. Travis,Stephan A. Grupp

View Articletitled, Unmasking Evans syndrome: T-cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS)

WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12
Clinical Trials & Observations

Karl Balabanian,Bernard Lagane,José Luis Pablos,Lysiane Laurent,Thierry Planchenault,Olivier Verola,Celeste Lebbe,Delphine Kerob,Alain Dupuy,Olivier Hermine,Jean-François Nicolas,Véronique Latger-Cannard,Danièle Bensoussan,Pierre Bordigoni,Françoise Baleux,Françoise Le Deist,Jean-Louis Virelizier,Fernando Arenzana-Seisdedos,Françoise Bachelerie

View Articletitled, WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12

TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1–infected patients and its in vitro production by antigen-presenting cells
Clinical Trials & Observations

Jean-Philippe Herbeuval,Adriano Boasso,Jean-Charles Grivel,Andrew W. Hardy,Stephanie A. Anderson,Matthew J. Dolan,Claire Chougnet,Jeffrey D. Lifson,Gene M. Shearer

View Articletitled, TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1–infected patients and its in vitro production by antigen-presenting cells

Tumor antigen processing and presentation depend critically on dendritic cell type and the mode of antigen delivery

Max Schnurr,Qiyuan Chen,Amanda Shin,Weisan Chen,Tracey Toy,Corinna Jenderek,Simon Green,Lena Miloradovic,Debbie Drane,Ian D. Davis,Jose Villadangos,Ken Shortman,Eugene Maraskovsky,Jonathan Cebon

View Articletitled, Tumor antigen processing and presentation depend critically on dendritic cell type and the mode of antigen delivery

Imatinib inhibits T-cell receptor–mediated T-cell proliferation and activation in a dose-dependent manner

Ruth Seggewiss,Karin Loré,Elisabeth Greiner,Magnus K. Magnusson,David A. Price,Daniel C. Douek,Cynthia E. Dunbar,Adrian Wiestner

View Articletitled, Imatinib inhibits T-cell receptor–mediated T-cell proliferation and activation in a dose-dependent manner

Regulation of human auto- and alloreactive T cells by indoleamine 2,3-dioxygenase (IDO)–producing dendritic cells: too much ado about IDO?

Peter Terness,Jing-Jing Chuang,Thomas Bauer,Lucian Jiga,Gerhard Opelz

View Articletitled, Regulation of human auto- and alloreactive T cells by indoleamine 2,3-dioxygenase (IDO)–producing dendritic cells: too much ado about IDO?

Supplemental data

Frizzled 9 knock-out mice have abnormal B-cell development

Erik A. Ranheim,Helen C. K. Kwan,Tannishtha Reya,Yu-Ker Wang,Irving L. Weissman,Uta Francke

View Articletitled, Frizzled 9 knock-out mice have abnormal B-cell development

Different isoforms of BSAP regulate expression of AID in normal and chronic lymphocytic leukemia B cells

Pablo Oppezzo,Gérard Dumas,Ana Inés Lalanne,Béatrice Payelle-Brogard,Christian Magnac,Otto Pritsch,Guillaume Dighiero,Françoise Vuillier

View Articletitled, Different isoforms of BSAP regulate expression of AID in normal and chronic lymphocytic leukemia B cells

NEOPLASIA

A novel celecoxib derivative, OSU03012, induces cytotoxicity in primary CLL cells and transformed B-cell lymphoma cell line via a caspase- and Bcl-2–independent mechanism

Amy J. Johnson,Lisa L. Smith,Jiuxiang Zhu,Nyla A. Heerema,Sara Jefferson,Andrew Mone,Michael Grever,Ching-Shih Chen,John C. Byrd

View Articletitled, A novel celecoxib derivative, OSU03012, induces cytotoxicity in primary CLL cells and transformed B-cell lymphoma cell line via a caspase- and Bcl-2–independent mechanism

Inhibiting primary effusion lymphoma by lentiviral vectors encoding short hairpin RNA

Andrew Godfrey,John Anderson,Antigoni Papanastasiou,Yasu Takeuchi,Chris Boshoff

View Articletitled, Inhibiting primary effusion lymphoma by lentiviral vectors encoding short hairpin RNA

Dexamethasone resistance in B-cell precursor childhood acute lymphoblastic leukemia occurs downstream of ligand-induced nuclear translocation of the glucocorticoid receptor

Petra S. Bachmann,Rosemary Gorman,Karen L. MacKenzie,Louise Lutze-Mann,Richard B. Lock

View Articletitled, Dexamethasone resistance in B-cell precursor childhood acute lymphoblastic leukemia occurs downstream of ligand-induced nuclear translocation of the glucocorticoid receptor

Antileukemic activity of rapamycin in acute myeloid leukemia
Clinical Trials & Observations

Christian Récher,Odile Beyne-Rauzy,Cécile Demur,Gaëtan Chicanne,Cédric Dos Santos,Véronique Mansat-De Mas,David Benzaquen,Guy Laurent,Françoise Huguet,Bernard Payrastre

View Articletitled, Antileukemic activity of rapamycin in acute myeloid leukemia

Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line

Ingo Melzner,Alexandra Juliana Bucur,Silke Brüderlein,Karola Dorsch,Cornelia Hasel,Thomas F. E. Barth,Frank Leithäuser,Peter Möller

View Articletitled, Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line

PHAGOCYTES

The CXC chemokine MIP-2 stimulates neutrophil mobilization from the rat bone marrow in a CD49d-dependent manner

Peter C. E. Burdon,Coralie Martin,Sara M. Rankin

View Articletitled, The CXC chemokine MIP-2 stimulates neutrophil mobilization from the rat bone marrow in a CD49d-dependent manner

Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity

Markus Munder,Faustino Mollinedo,Jero Calafat,Javier Canchado,Cristina Gil-Lamaignere,José M. Fuentes,Claudia Luckner,Gwendolyn Doschko,Germán Soler,Klaus Eichmann,Frank-Michael Müller,Anthony D. Ho,Martin Goerner,Manuel Modolell

View Articletitled, Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity

RED CELLS

Receptor-binding residues lie in central regions of Duffy-binding–like domains involved in red cell invasion and cytoadherence by malaria parasites

Alfredo Mayor,Nivedita Bir,Ritica Sawhney,Shailja Singh,Priyabrata Pattnaik,Saurabh Kumar Singh,Amit Sharma,Chetan E. Chitnis

View Articletitled, Receptor-binding residues lie in central regions of Duffy-binding–like domains involved in red cell invasion and cytoadherence by malaria parasites

The hereditary hemochromatosis protein, HFE, lowers intracellular iron levels independently of transferrin receptor 1 in TRVb cells

Hanqian Carlson,An-Sheng Zhang,William H. Fleming,Caroline A. Enns

View Articletitled, The hereditary hemochromatosis protein, HFE, lowers intracellular iron levels independently of transferrin receptor 1 in TRVb cells

Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels

Sheng Zhou,Yang Zong,Paul A. Ney,Geeta Nair,Clinton F. Stewart,Brian P. Sorrentino

View Articletitled, Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels

TRANSPLANTATION

Preconditioning of NOD mice with anti-CD8 mAb and costimulatory blockade enhances chimerism and tolerance and prevents diabetes, while depletion of αβ-TCR⁺ and CD4⁺ cells negates the effect

Suzanne T. Ildstad,Paula M. Chilton,Hong Xu,Michele A. Domenick,Mukunda B. Ray

View Articletitled, Preconditioning of NOD mice with anti-CD8 mAb and costimulatory blockade enhances chimerism and tolerance and prevents diabetes, while depletion of αβ-TCR+ and CD4+ cells negates the effect

Immune regulatory activity of CD34⁺ progenitor cells: evidence for a deletion-based mechanism mediated by TNF-α

Hilit Gur,Rita Krauthgamer,Esther Bachar-Lustig,Helena Katchman,Rinat Arbel-Goren,Alain Berrebi,Tirza Klein,Arnon Nagler,Antonio Tabilio,Massimo F. Martelli,Yair Reisner

View Articletitled, Immune regulatory activity of CD34+ progenitor cells: evidence for a deletion-based mechanism mediated by TNF-α

Genotypic inhibitory killer immunoglobulin-like receptor ligand incompatibility enhances the long-term antileukemic effect of unmodified allogeneic hematopoietic stem cell transplantation in patients with myeloid leukemias
Clinical Trials & Observations

Dietrich W. Beelen,Hellmut D. Ottinger,Stanislav Ferencik,Ahmet H. Elmaagacli,Rudolf Peceny,Rudolf Trenschel,Hans Grosse-Wilde

View Articletitled, Genotypic inhibitory killer immunoglobulin-like receptor ligand incompatibility enhances the long-term antileukemic effect of unmodified allogeneic hematopoietic stem cell transplantation in patients with myeloid leukemias

Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of life
Clinical Trials & Observations

Riccardo Saccardi,Gian Luigi Mancardi,Alessandra Solari,Alberto Bosi,Paolo Bruzzi,Paolo Di Bartolomeo,Amedea Donelli,Massimo Filippi,Angelo Guerrasio,Francesca Gualandi,Giorgio La Nasa,Alessandra Murialdo,Francesca Pagliai,Federico Papineschi,Barbara Scappini,Alberto M. Marmont,for the Italian GITMO-Neuro Intergroup

View Articletitled, Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of life

Prognostic value of pretransplantation host thymic function in HLA-identical sibling hematopoietic stem cell transplantation

Emmanuel Clave,Vanderson Rocha,Kimmo Talvensaari,Marc Busson,Corinne Douay,Marie-Lorraine Appert,Claire Rabian,Maryvonnick Carmagnat,Federico Garnier,Alain Filion,Gérard Socié,Eliane Gluckman,Dominique Charron,Antoine Toubert

View Articletitled, Prognostic value of pretransplantation host thymic function in HLA-identical sibling hematopoietic stem cell transplantation

CORRESPONDENCE

Lessened severe graft-versus-host after “minitransplantations”

Mohamed Sorror,Michael Maris,Razvan Diaconescu,Rainer Storb

View Articletitled, Lessened severe graft-versus-host after “minitransplantations”

Down syndrome in Down House: trisomy 21, GATA1 mutations, and Charles Darwin

David P. Steensma

View Articletitled, Down syndrome in Down House: trisomy 21, GATA1 mutations, and Charles Darwin

Clinical significance of intrahepatic hepatitis B virus covalently closed circular DNA in chronic hepatitis B patients who received cytotoxic chemotherapy

Chee-kin Hui,Scott Bowden,Kathy Jackson,Wing-yan Au,Daniel Y. T. Fong,Albert K. W. Lie,Chor-sang Chim,Raymond Liang,George K. K. Lau

View Articletitled, Clinical significance of intrahepatic hepatitis B virus covalently closed circular DNA in chronic hepatitis B patients who received cytotoxic chemotherapy

Dendritic cells have the option to express IDO-mediated suppression or not

David H. Munn,Andrew L. Mellor,Marco Rossi,James W. Young

View Articletitled, Dendritic cells have the option to express IDO-mediated suppression or not

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Issue Archive

Table of Contents

INSIDE BLOOD

PLENARY PAPERS

ERRATA

REVIEW ARTICLES

Transfusion-related acute lung injury Clinical Trials & Observations

REVIEW IN TRANSLATIONAL HEMATOLOGY

Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms Clinical Trials & Observations

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Imatinib mesylate therapy may overcome the poor prognostic significance of deletions of derivative chromosome 9 in patients with chronic myelogenous leukemia Clinical Trials & Observations

Treatment of acquired hemophilia by the Bonn-Malmö Protocol: documentation of an in vivo immunomodulating concept Clinical Trials & Observations

The origins of age-related proinflammatory state Clinical Trials & Observations

Engraftment and survival following reduced-intensity allogeneic peripheral blood hematopoietic cell transplantation is affected by CD8+ T-cell dose Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation Brief Report

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

A role for bone marrow–derived cells in the vasculature of noninjured CNS Brief Report

IMMUNOBIOLOGY

WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12 Clinical Trials & Observations

TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1–infected patients and its in vitro production by antigen-presenting cells Clinical Trials & Observations

NEOPLASIA

Antileukemic activity of rapamycin in acute myeloid leukemia Clinical Trials & Observations

PHAGOCYTES

RED CELLS

TRANSPLANTATION

Genotypic inhibitory killer immunoglobulin-like receptor ligand incompatibility enhances the long-term antileukemic effect of unmodified allogeneic hematopoietic stem cell transplantation in patients with myeloid leukemias Clinical Trials & Observations

Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of life Clinical Trials & Observations

CORRESPONDENCE

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American Society of Hematology

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Transfusion-related acute lung injury
Clinical Trials & Observations

Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms
Clinical Trials & Observations

Imatinib mesylate therapy may overcome the poor prognostic significance of deletions of derivative chromosome 9 in patients with chronic myelogenous leukemia
Clinical Trials & Observations

Treatment of acquired hemophilia by the Bonn-Malmö Protocol: documentation of an in vivo immunomodulating concept
Clinical Trials & Observations

The origins of age-related proinflammatory state
Clinical Trials & Observations

Engraftment and survival following reduced-intensity allogeneic peripheral blood hematopoietic cell transplantation is affected by CD8⁺ T-cell dose
Clinical Trials & Observations

Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation
Brief Report

A role for bone marrow–derived cells in the vasculature of noninjured CNS
Brief Report

WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12
Clinical Trials & Observations

TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1–infected patients and its in vitro production by antigen-presenting cells
Clinical Trials & Observations

Antileukemic activity of rapamycin in acute myeloid leukemia
Clinical Trials & Observations

Genotypic inhibitory killer immunoglobulin-like receptor ligand incompatibility enhances the long-term antileukemic effect of unmodified allogeneic hematopoietic stem cell transplantation in patients with myeloid leukemias
Clinical Trials & Observations

Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of life
Clinical Trials & Observations