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INSIDE BLOOD

NEOPLASIA

Meis and Hox: a mighty pair defeats apoptosis

Takuro Nakamura

View Articletitled, Meis and Hox: a mighty pair defeats apoptosis

CLINICAL OBSERVATIONS

Unreliability of current assays to detect cobalamin deficiency: “nothing gold can stay”

Ralph Green

View Articletitled, Unreliability of current assays to detect cobalamin deficiency: “nothing gold can stay”

HEMOSTASIS

Down-regulation of ADAMTS13 activity by serine proteases

Yoshihiro Fujimura

View Articletitled, Down-regulation of ADAMTS13 activity by serine proteases

IMMUNOBIOLOGY

Early-onset sarcoidosis gets the nod

Mathias Chamaillard,Christine McDonald,Gabriel Nuñez

View Articletitled, Early-onset sarcoidosis gets the nod

NEOPLASIA

Talk amongst yourselves

William Wachsman

View Articletitled, Talk amongst yourselves

GENE THERAPY

Selection without harm: drug resistance gene therapy hits the big time

Stanton L. Gerson

View Articletitled, Selection without harm: drug resistance gene therapy hits the big time

TRANSPLANTATION

Transplantation of 2 UCB units in adults

Mary J. Laughlin

View Articletitled, Transplantation of 2 UCB units in adults

RED CELLS

DMT1 mutations: mice and humans are not alike

Clara Camaschella

View Articletitled, DMT1 mutations: mice and humans are not alike

NEOPLASIA

Is hsp70 another target for Ph⁺ leukemias?

Gert Ossenkoppele

View Articletitled, Is hsp70 another target for Ph+ leukemias?

HEMOSTASIS

EPC: the ischemia warrior of the bone marrow

Edward W. Scott

View Articletitled, EPC: the ischemia warrior of the bone marrow

BLOOD WORK

Rouleaux

View Articletitled, Rouleaux

PERSPECTIVES

A case for developing North-South partnerships for research in sickle cell disease
Clinical Trials & Observations

David Weatherall,Karen Hofman,Griffin Rodgers,John Ruffin,Sharon Hrynkow

View Articletitled, A case for developing North-South partnerships for research in sickle cell disease

CHEMOKINES

Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium

Philipp von Hundelshausen,Rory R. Koenen,Markus Sack,Sebastian F. Mause,Wencke Adriaens,Amanda E. I. Proudfoot,Tilman M. Hackeng,Christian Weber

View Articletitled, Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium

Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation

Erich Piovan,Valeria Tosello,Stefano Indraccolo,Anna Cabrelle,Ilenia Baesso,Livio Trentin,Rita Zamarchi,Hirokazu Tamamura,Nobutaka Fujii,Gianpietro Semenzato,Luigi Chieco-Bianchi,Alberto Amadori

View Articletitled, Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation

ERRATA

Erratum for vol. 104, p. 3971

View Articletitled, Erratum for vol. 104, p. 3971

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias
Clinical Trials & Observations

Stefan Faderl,Varsha Gandhi,Susan O'Brien,Peter Bonate,Jorge Cortes,Elihu Estey,Miloslav Beran,William Wierda,Guillermo Garcia-Manero,Alessandra Ferrajoli,Zeev Estrov,Francis J. Giles,Min Du,Monica Kwari,Michael Keating,William Plunkett,Hagop Kantarjian

View Articletitled, Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias

The impact of the methotrexate administration schedule and dose in the treatment of children and adolescents with B-cell neoplasms: a report of the BFM Group Study NHL-BFM95
Clinical Trials & Observations

Wilhelm Woessmann,Kathrin Seidemann,Georg Mann,Martin Zimmermann,Birgit Burkhardt,Ilske Oschlies,Wolf-Dieter Ludwig,Thomas Klingebiel,Norbert Graf,Bernd Gruhn,Heribert Juergens,Felix Niggli,Reza Parwaresch,Helmut Gadner,Hansjoerg Riehm,Martin Schrappe,Alfred Reiter,for the BFM Group

View Articletitled, The impact of the methotrexate administration schedule and dose in the treatment of children and adolescents with B-cell neoplasms: a report of the BFM Group Study NHL-BFM95

A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia
Clinical Trials & Observations

John C. Byrd,Guido Marcucci,Mark R. Parthun,Jim J. Xiao,Rebecca B. Klisovic,Mollie Moran,Thomas S. Lin,Shujun Liu,Amy R. Sklenar,Melanie E. Davis,David M. Lucas,Beth Fischer,Roshini Shank,Sooraj L. Tejaswi,Philip Binkley,John Wright,Kenneth K. Chan,Michael R. Grever

View Articletitled, A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia

UGT1A1 variation and gallstone formation in sickle cell disease
Clinical Trials & Observations

Eden V. Haverfield,Colin A. McKenzie,Terrence Forrester,Nourdine Bouzekri,Rosalind Harding,Graham Serjeant,Thomas Walker,Tim E. A. Peto,Ryk Ward,David J. Weatherall

View Articletitled, UGT1A1 variation and gallstone formation in sickle cell disease

Leukemic transformation in myelofibrosis with myeloid metaplasia: a single-institution experience with 91 cases
Clinical Trials & Observations

Ruben A. Mesa,Chin-Yang Li,Rhett P. Ketterling,Georgene S. Schroeder,Ryan A. Knudson,Ayalew Tefferi

View Articletitled, Leukemic transformation in myelofibrosis with myeloid metaplasia: a single-institution experience with 91 cases

Cobalamin-responsive disorders in the ambulatory care setting: unreliability of cobalamin, methylmalonic acid, and homocysteine testing
Clinical Trials & Observations

Lawrence R. Solomon

View Articletitled, Cobalamin-responsive disorders in the ambulatory care setting: unreliability of cobalamin, methylmalonic acid, and homocysteine testing

A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease
Clinical Trials & Observations

Walter Fiedler,Hubert Serve,Hartmut Döhner,Michael Schwittay,Oliver G. Ottmann,Anne-Marie O'Farrell,Carlo L. Bello,Randy Allred,William C. Manning,Julie M. Cherrington,Sharianne G. Louie,Weiru Hong,Nicoletta M. Brega,Giorgio Massimini,Paul Scigalla,Wolfgang E. Berdel,Dieter K. Hossfeld

View Articletitled, A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease

Treatment of primary Epstein-Barr virus infection in patients with X-linked lymphoproliferative disease using B-cell–directed therapy
Clinical Trials & Observations Brief Report

Michael C. Milone,Donald E. Tsai,Richard L. Hodinka,Lewis B. Silverman,Alejandro Malbran,Mariusz A. Wasik,Kim E. Nichols

View Articletitled, Treatment of primary Epstein-Barr virus infection in patients with X-linked lymphoproliferative disease using B-cell–directed therapy

GENE THERAPY

Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy

Tobias Neff,Brian C. Beard,Laura J. Peterson,Ponni Anandakumar,Jesse Thompson,Hans-Peter Kiem

View Articletitled, Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy

HEMATOPOIESIS

Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin

Rocio Montes de Oca,Paul R. Andreassen,Steven P. Margossian,Richard C. Gregory,Toshiyasu Taniguchi,XiaoZhe Wang,Scott Houghtaling,Markus Grompe,Alan D. D'Andrea

View Articletitled, Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin

Low-dose total body irradiation causes clonal fluctuation of primate hematopoietic stem and progenitor cells

Mikko O. Laukkanen,Ken Kuramoto,Boris Calmels,Masaaki Takatoku,Christof von Kalle,Robert E. Donahue,Cynthia E. Dunbar

View Articletitled, Low-dose total body irradiation causes clonal fluctuation of primate hematopoietic stem and progenitor cells

Involvement of connective tissue–type mast cells in Th1 immune responses via Stat4 expression

Tatsuki R. Kataoka,Nobuyasu Komazawa,Eiichi Morii,Keisuke Oboki,Toru Nakano

View Articletitled, Involvement of connective tissue–type mast cells in Th1 immune responses via Stat4 expression

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Regulation of the single-chain urokinase–urokinase receptor complex activity by plasminogen and fibrin: novel mechanism of fibrin specificity

Abd Al-Roof Higazi,Feras Ajawi,Sa'ed Akkawi,Edna Hess,Alice Kuo,Douglas B. Cines

View Articletitled, Regulation of the single-chain urokinase–urokinase receptor complex activity by plasminogen and fibrin: novel mechanism of fibrin specificity

Mapping of genes that control the antibody response to human factor IX in mice

Jay N. Lozier,Nahid Tayebi,Pei Zhang

View Articletitled, Mapping of genes that control the antibody response to human factor IX in mice

Angiostatin is a novel anti-inflammatory factor by inhibiting leukocyte recruitment

Triantafyllos Chavakis,Athanasios Athanasopoulos,Joong-Sup Rhee,Valeria Orlova,Thomas Schmidt-Wöll,Angelika Bierhaus,Andreas E. May,Ilhan Celik,Peter P. Nawroth,Klaus T. Preissner

View Articletitled, Angiostatin is a novel anti-inflammatory factor by inhibiting leukocyte recruitment

Endostatin dramatically inhibits endothelial cell migration, vascular morphogenesis, and perivascular cell recruitment in vivo

Dag K. Skovseth,Marjan J. T. Veuger,Dag R. Sorensen,Paula M. De Angelis,Guttorm Haraldsen

View Articletitled, Endostatin dramatically inhibits endothelial cell migration, vascular morphogenesis, and perivascular cell recruitment in vivo

FbsA, a fibrinogen-binding protein from Streptococcus agalactiae, mediates platelet aggregation

Giampiero Pietrocola,Axel Schubert,Livia Visai,Mauro Torti,J. Ross Fitzgerald,Timothy J. Foster,Dieter J. Reinscheid,Pietro Speziale

View Articletitled, FbsA, a fibrinogen-binding protein from Streptococcus agalactiae, mediates platelet aggregation

The t-PA –7351C>T enhancer polymorphism decreases Sp1 and Sp3 protein binding affinity and transcriptional responsiveness to retinoic acid

Anna Tjärnlund Wolf,Robert L. Medcalf,Christina Jern

View Articletitled, The t-PA –7351C>T enhancer polymorphism decreases Sp1 and Sp3 protein binding affinity and transcriptional responsiveness to retinoic acid

Adult vasculogenesis occurs through in situ recruitment, proliferation, and tubulization of circulating bone marrow–derived cells

Oren M. Tepper,Jennifer M. Capla,Robert D. Galiano,Daniel J. Ceradini,Matthew J. Callaghan,Mark E. Kleinman,Geoffrey C. Gurtner

View Articletitled, Adult vasculogenesis occurs through in situ recruitment, proliferation, and tubulization of circulating bone marrow–derived cells

Von Willebrand factor accelerates platelet adhesion and thrombus formation on a collagen surface in platelet-reduced blood under flow conditions

Kazuhiko Tomokiyo,Yuichi Kamikubo,Takako Hanada,Tatsuya Araki,Yasushi Nakatomi,Yoichi Ogata,Stephanie M. Jung,Tomohiro Nakagaki,Masaaki Moroi

View Articletitled, Von Willebrand factor accelerates platelet adhesion and thrombus formation on a collagen surface in platelet-reduced blood under flow conditions

Proteolytic inactivation of ADAMTS13 by thrombin and plasmin

James T. B. Crawley,Jonathan K. Lam,James B. Rance,Luigina R. Mollica,James S. O'Donnell,David A. Lane

View Articletitled, Proteolytic inactivation of ADAMTS13 by thrombin and plasmin

Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization

Mario Berger,Gabriele Bergers,Bernd Arnold,Günter J. Hämmerling,Ruth Ganss

View Articletitled, Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization

Reduced plasma fibrinolytic potential is a risk factor for venous thrombosis
Clinical Trials & Observations

Ton Lisman,Philip G. de Groot,Joost C.M. Meijers,Frits R. Rosendaal

View Articletitled, Reduced plasma fibrinolytic potential is a risk factor for venous thrombosis

IMMUNOBIOLOGY

The adaptor protein 3BP2 associates with VAV guanine nucleotide exchange factors to regulate NFAT activation by the B-cell antigen receptor

Isabelle Foucault,Séverine Le Bras,Céline Charvet,Chéol Moon,Amnon Altman,Marcel Deckert

View Articletitled, The adaptor protein 3BP2 associates with VAV guanine nucleotide exchange factors to regulate NFAT activation by the B-cell antigen receptor

Anti–human CTLA-4 monoclonal antibody promotes T-cell expansion and immunity in a hu-PBL-SCID model: a new method for preclinical screening of costimulatory monoclonal antibodies

Kenneth F. May, Jr,Sameek Roychowdhury,Darshna Bhatt,Ergun Kocak,Xue-Feng Bai,Jin-Qing Liu,Amy K. Ferketich,Edward W. Martin, Jr,Michael A. Caligiuri,Pan Zheng,Yang Liu

View Articletitled, Anti–human CTLA-4 monoclonal antibody promotes T-cell expansion and immunity in a hu-PBL-SCID model: a new method for preclinical screening of costimulatory monoclonal antibodies

FcRH1: an activation coreceptor on human B cells

Chuen-Miin Leu,Randall S. Davis,Lanier A. Gartland,W. David Fine,Max D. Cooper

View Articletitled, FcRH1: an activation coreceptor on human B cells

Supplemental data

G_i-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A

Li V. Yang,Caius G. Radu,Li Wang,Mireille Riedinger,Owen N. Witte

View Articletitled, Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A

Supplemental data

Imatinib mesylate (STI-571) enhances antigen-presenting cell function and overcomes tumor-induced CD4⁺ T-cell tolerance

Hongwei Wang,Fengdong Cheng,Alex Cuenca,Pedro Horna,Zheng Zheng,Kapil Bhalla,Eduardo M. Sotomayor

View Articletitled, Imatinib mesylate (STI-571) enhances antigen-presenting cell function and overcomes tumor-induced CD4+ T-cell tolerance

Wiskott-Aldrich syndrome protein deficiency leads to reduced B-cell adhesion, migration, and homing, and a delayed humoral immune response

Lisa Westerberg,Malin Larsson,Samantha J. Hardy,Carmen Fernández,Adrian J. Thrasher,Eva Severinson

View Articletitled, Wiskott-Aldrich syndrome protein deficiency leads to reduced B-cell adhesion, migration, and homing, and a delayed humoral immune response

SPI-CI and SPI-6 cooperate in the protection from effector cell–mediated cytotoxicity

Michael Bots,Ingrid G. M. Kolfschoten,Sandra A. Bres,Mirjam T. G. A. Rademaker,Guido M. de Roo,Margreet Krüse,Kees L. M. C. Franken,Michael Hahne,Christopher J. Froelich,Cornelis J. M. Melief,Rienk Offringa,Jan Paul Medema

View Articletitled, SPI-CI and SPI-6 cooperate in the protection from effector cell–mediated cytotoxicity

Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25⁺CD4⁺ Tr cells

Megan K. Levings,Silvia Gregori,Eleonora Tresoldi,Sabrina Cazzaniga,Chiara Bonini,Maria Grazia Roncarolo

View Articletitled, Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells

The magnitude and breadth of hepatitis C virus–specific CD8⁺ T cells depend on absolute CD4⁺ T-cell count in individuals coinfected with HIV-1
Clinical Trials & Observations

Arthur Y. Kim,Georg M. Lauer,Kei Ouchi,Marylyn M. Addo,Michaela Lucas,Julian Schulze zur Wiesch,Joerg Timm,Melinda Boczanowski,Jared E. Duncan,Alysse G. Wurcel,Deborah Casson,Raymond T. Chung,Rika Draenert,Paul Klenerman,Bruce D. Walker

View Articletitled, The magnitude and breadth of hepatitis C virus–specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1

Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines

Carol Beadling,Mark K. Slifka

View Articletitled, Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines

Supplemental data

A novel apoptosis pathway activated by the carboxyl terminus of p21

Chen Dong,Qing Li,Shu-chen Lyu,Alan M. Krensky,Carol Clayberger

View Articletitled, A novel apoptosis pathway activated by the carboxyl terminus of p21

Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-κB activation: common genetic etiology with Blau syndrome
Brief Report

Nobuo Kanazawa,Ikuo Okafuji,Naotomo Kambe,Ryuta Nishikomori,Mami Nakata-Hizume,Sonoko Nagai,Akihiko Fuji,Takenosuke Yuasa,Akira Manki,Yoshihiko Sakurai,Mitsuru Nakajima,Hiroko Kobayashi,Ikuma Fujiwara,Hiroyuki Tsutsumi,Atsushi Utani,Chikako Nishigori,Toshio Heike,Tatsutoshi Nakahata,Yoshiki Miyachi

View Articletitled, Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-κB activation: common genetic etiology with Blau syndrome

NEOPLASIA

Glutathione-S-transferase π inhibits As₂O₃-induced apoptosis in lymphoma cells: involvement of hydrogen peroxide catabolism

Li Zhou,Yongkui Jing,Miroslav Styblo,Zhu Chen,Samuel Waxman

View Articletitled, Glutathione-S-transferase π inhibits As2O3-induced apoptosis in lymphoma cells: involvement of hydrogen peroxide catabolism

Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia

Hidenori Sasaki,Ichiro Nishikata,Toshiyuki Shiraga,Ena Akamatsu,Takeshi Fukami,Tomonori Hidaka,Yoko Kubuki,Akihiko Okayama,Kenji Hamada,Hisafumi Okabe,Yoshinori Murakami,Hirohito Tsubouchi,Kazuhiro Morishita

View Articletitled, Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia

Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway

Thomas Powles,Robert te Poele,Jonathan Shamash,Tracy Chaplin,David Propper,Simon Joel,Tim Oliver,Wai Man Liu

View Articletitled, Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway

Meis1-mediated apoptosis is caspase dependent and can be suppressed by coexpression of HoxA9 in murine and human cell lines

Peter J. Wermuth,Arthur M. Buchberg

View Articletitled, Meis1-mediated apoptosis is caspase dependent and can be suppressed by coexpression of HoxA9 in murine and human cell lines

Combination therapy for adult T-cell leukemia–xenografted mice: flavopiridol and anti-CD25 monoclonal antibody

Meili Zhang,Zhuo Zhang,Carolyn K. Goldman,John Janik,Thomas A. Waldmann

View Articletitled, Combination therapy for adult T-cell leukemia–xenografted mice: flavopiridol and anti-CD25 monoclonal antibody

Trolox selectively enhances arsenic-mediated oxidative stress and apoptosis in APL and other malignant cell lines

Zuanel Diaz,Myrian Colombo,Koren K. Mann,Haixiang Su,Kamilah N. Smith,D. Scott Bohle,Hyman M. Schipper,Wilson H. Miller, Jr

View Articletitled, Trolox selectively enhances arsenic-mediated oxidative stress and apoptosis in APL and other malignant cell lines

Mechanistic role of heat shock protein 70 in Bcr-Abl–mediated resistance to apoptosis in human acute leukemia cells

Fei Guo,Celia Sigua,Purva Bali,Prince George,Warren Fiskus,Anna Scuto,Srinivas Annavarapu,Abdelmoughite Mouttaki,Gautam Sondarva,Sheng Wei,Jie Wu,Julie Djeu,Kapil Bhalla

View Articletitled, Mechanistic role of heat shock protein 70 in Bcr-Abl–mediated resistance to apoptosis in human acute leukemia cells

Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells

View Articletitled, Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells

Motexafin gadolinium generates reactive oxygen species and induces apoptosis in sensitive and highly resistant multiple myeloma cells

Andrew M. Evens,Philip Lecane,Darren Magda,Sheila Prachand,Seema Singhal,Jeff Nelson,Richard A. Miller,Ronald B. Gartenhaus,Leo I. Gordon

View Articletitled, Motexafin gadolinium generates reactive oxygen species and induces apoptosis in sensitive and highly resistant multiple myeloma cells

Leukotriene B₄ plays a pivotal role in CD40-dependent activation of chronic B lymphocytic leukemia cells

Gudmundur Runarsson,Anquan Liu,Yilmaz Mahshid,Stina Feltenmark,Annika Pettersson,Eva Klein,Magnus Björkholm,Hans-Erik Claesson

View Articletitled, Leukotriene B4 plays a pivotal role in CD40-dependent activation of chronic B lymphocytic leukemia cells

PML mediates IFN-α–induced apoptosis in myeloma by regulating TRAIL induction

Chun Crowder,Øyvind Dahle,R. Eric Davis,Odd S. Gabrielsen,Stuart Rudikoff

View Articletitled, PML mediates IFN-α–induced apoptosis in myeloma by regulating TRAIL induction

Impaired T- and B-cell development in Tcl1-deficient mice

Sang-Moo Kang,Maria Grazia Narducci,Cristina Lazzeri,Adriana M. Mongiovì,Elisabetta Caprini,Antonella Bresin,Fabio Martelli,Jay Rothstein,Carlo Maria Croce,Max D. Cooper,Giandomenico Russo

View Articletitled, Impaired T- and B-cell development in Tcl1-deficient mice

Supplemental data

Influence of CD33 expression levels and ITIM-dependent internalization on gemtuzumab ozogamicin–induced cytotoxicity

Roland B. Walter,Brian W. Raden,Darren M. Kamikura,Jonathan A. Cooper,Irwin D. Bernstein

View Articletitled, Influence of CD33 expression levels and ITIM-dependent internalization on gemtuzumab ozogamicin–induced cytotoxicity

Heparanase promotes the spontaneous metastasis of myeloma cells to bone

Yang Yang,Veronica MacLeod,Manali Bendre,Yan Huang,Allison M. Theus,Hua-Quan Miao,Paul Kussie,Shmuel Yaccoby,Joshua Epstein,Larry J. Suva,Thomas Kelly,Ralph D. Sanderson

View Articletitled, Heparanase promotes the spontaneous metastasis of myeloma cells to bone

Ephrin B2 expression in Kaposi sarcoma is induced by human herpesvirus type 8: phenotype switch from venous to arterial endothelium

Rizwan Masood,Guangbin Xia,D. Lynne Smith,Piergips Scalia,Jonathan G. Still,Anil Tulpule,Parkash S. Gill

View Articletitled, Ephrin B2 expression in Kaposi sarcoma is induced by human herpesvirus type 8: phenotype switch from venous to arterial endothelium

PHAGOCYTES

Minute numbers of contaminant CD8⁺ T cells or CD11b⁺CD11c⁺ NK cells are the source of IFN-γ in IL-12/IL-18-stimulated mouse macrophage populations

Ulrike Schleicher,Andrea Hesse,Christian Bogdan

View Articletitled, Minute numbers of contaminant CD8+ T cells or CD11b+CD11c+ NK cells are the source of IFN-γ in IL-12/IL-18-stimulated mouse macrophage populations

Supplemental data

RED CELLS

Detection of somatic mosaicism and classification of Fanconi anemia patients by analysis of the FA/BRCA pathway
Clinical Trials & Observations

Jean Soulier,Thierry Leblanc,Jérôme Larghero,Hélène Dastot,Akiko Shimamura,Philippe Guardiola,Hélène Esperou,Christèle Ferry,Charlotte Jubert,Jean-Paul Feugeas,Annie Henri,Antoine Toubert,Gérard Socié,André Baruchel,François Sigaux,Alan D. D'Andrea,Eliane Gluckman

View Articletitled, Detection of somatic mosaicism and classification of Fanconi anemia patients by analysis of the FA/BRCA pathway

Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload
Clinical Trials & Observations

Martha P. Mims,Yongli Guan,Dagmar Pospisilova,Monika Priwitzerova,Karel Indrak,Prem Ponka,Vladimir Divoky,Josef T. Prchal

View Articletitled, Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload

TRANSPLANTATION

Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy
Clinical Trials & Observations

Juliet N. Barker,Daniel J. Weisdorf,Todd E. DeFor,Bruce R. Blazar,Philip B. McGlave,Jeffrey S. Miller,Catherine M. Verfaillie,John E. Wagner

View Articletitled, Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy

Final adult height of patients who received hematopoietic cell transplantation in childhood
Clinical Trials & Observations

Jean E. Sanders,Katherine A. Guthrie,Paul A. Hoffmeister,Ann E. Woolfrey,Paul A. Carpenter,Frederick R. Appelbaum

View Articletitled, Final adult height of patients who received hematopoietic cell transplantation in childhood

Prevention of lethal acute GVHD with an agonistic CD28 antibody and rapamycin

Michael H. Albert,Xue-Zhong Yu,Paul J. Martin,Claudio Anasetti

View Articletitled, Prevention of lethal acute GVHD with an agonistic CD28 antibody and rapamycin

Cross-recognition of human alloantigen by cytomegalovirus glycoprotein-specific CD4⁺ cytotoxic T lymphocytes: implications for graft-versus-host disease
Brief Report

Rebecca Elkington,Rajiv Khanna

View Articletitled, Cross-recognition of human alloantigen by cytomegalovirus glycoprotein-specific CD4+ cytotoxic T lymphocytes: implications for graft-versus-host disease

CORRESPONDENCE

SCL/Tal1 and lymphoid versus myeloid lineage assignment

Mark Hall,David Curtis

View Articletitled, SCL/Tal1 and lymphoid versus myeloid lineage assignment

Potential curability of newly diagnosed acute promyelocytic leukemia without use of chemotherapy: the example of liposomal all-trans retinoic acid

Elihu Estey,Charles Koller,Apostolia M. Tsimberidou,Susan O'Brien,Miloslav Beran,Jorge Cortes,Maribel Tirado-Gomez,Gabriel Lopez-Berestein,Hagop Kantarjian

View Articletitled, Potential curability of newly diagnosed acute promyelocytic leukemia without use of chemotherapy: the example of liposomal all-trans retinoic acid

Reproducible measurements of AML blast p-glycoprotein function in 2 center analyses

Monica Pallis,Janet Fisher,Louise Truran,Martin Grundy,Nigel Russell,Alan Burnett

View Articletitled, Reproducible measurements of AML blast p-glycoprotein function in 2 center analyses

Is immune thrombocytopenic purpura less common among black Americans?

Deirdra R. Terrell,Kristina K. Johnson,Sara K. Vesely,James N. George

View Articletitled, Is immune thrombocytopenic purpura less common among black Americans?

Issue Archive

Table of Contents

INSIDE BLOOD

BLOOD WORK

PERSPECTIVES

A case for developing North-South partnerships for research in sickle cell disease Clinical Trials & Observations

CHEMOKINES

ERRATA

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias Clinical Trials & Observations

The impact of the methotrexate administration schedule and dose in the treatment of children and adolescents with B-cell neoplasms: a report of the BFM Group Study NHL-BFM95 Clinical Trials & Observations

A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia Clinical Trials & Observations

UGT1A1 variation and gallstone formation in sickle cell disease Clinical Trials & Observations

Leukemic transformation in myelofibrosis with myeloid metaplasia: a single-institution experience with 91 cases Clinical Trials & Observations

Cobalamin-responsive disorders in the ambulatory care setting: unreliability of cobalamin, methylmalonic acid, and homocysteine testing Clinical Trials & Observations

A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease Clinical Trials & Observations

Treatment of primary Epstein-Barr virus infection in patients with X-linked lymphoproliferative disease using B-cell–directed therapy Clinical Trials & Observations Brief Report

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Reduced plasma fibrinolytic potential is a risk factor for venous thrombosis Clinical Trials & Observations

IMMUNOBIOLOGY

The magnitude and breadth of hepatitis C virus–specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1 Clinical Trials & Observations

Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-κB activation: common genetic etiology with Blau syndrome Brief Report

NEOPLASIA

PHAGOCYTES

RED CELLS

Detection of somatic mosaicism and classification of Fanconi anemia patients by analysis of the FA/BRCA pathway Clinical Trials & Observations

Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload Clinical Trials & Observations

TRANSPLANTATION

Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy Clinical Trials & Observations

Final adult height of patients who received hematopoietic cell transplantation in childhood Clinical Trials & Observations

Cross-recognition of human alloantigen by cytomegalovirus glycoprotein-specific CD4+ cytotoxic T lymphocytes: implications for graft-versus-host disease Brief Report

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ASH Publications

American Society of Hematology

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A case for developing North-South partnerships for research in sickle cell disease
Clinical Trials & Observations

Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias
Clinical Trials & Observations

The impact of the methotrexate administration schedule and dose in the treatment of children and adolescents with B-cell neoplasms: a report of the BFM Group Study NHL-BFM95
Clinical Trials & Observations

A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia
Clinical Trials & Observations

UGT1A1 variation and gallstone formation in sickle cell disease
Clinical Trials & Observations

Leukemic transformation in myelofibrosis with myeloid metaplasia: a single-institution experience with 91 cases
Clinical Trials & Observations

Cobalamin-responsive disorders in the ambulatory care setting: unreliability of cobalamin, methylmalonic acid, and homocysteine testing
Clinical Trials & Observations

A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease
Clinical Trials & Observations

Treatment of primary Epstein-Barr virus infection in patients with X-linked lymphoproliferative disease using B-cell–directed therapy
Clinical Trials & Observations Brief Report

Reduced plasma fibrinolytic potential is a risk factor for venous thrombosis
Clinical Trials & Observations

The magnitude and breadth of hepatitis C virus–specific CD8⁺ T cells depend on absolute CD4⁺ T-cell count in individuals coinfected with HIV-1
Clinical Trials & Observations

Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-κB activation: common genetic etiology with Blau syndrome
Brief Report

Detection of somatic mosaicism and classification of Fanconi anemia patients by analysis of the FA/BRCA pathway
Clinical Trials & Observations

Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload
Clinical Trials & Observations

Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy
Clinical Trials & Observations

Final adult height of patients who received hematopoietic cell transplantation in childhood
Clinical Trials & Observations

Cross-recognition of human alloantigen by cytomegalovirus glycoprotein-specific CD4⁺ cytotoxic T lymphocytes: implications for graft-versus-host disease
Brief Report